H Nakamura

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis
    H Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:15143-8. 2001
  2. ncbi request reprint Redox imbalance and its control in HIV infection
    Hajime Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Antioxid Redox Signal 4:455-64. 2002
  3. ncbi request reprint Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer
    H Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Cancer Detect Prev 24:53-60. 2000
  4. ncbi request reprint Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study
    M Kobayashi
    Department of Anatomy and Developmental Biology, Institute of Virus Research, Kyoto University, Japan
    Ital J Anat Embryol 106:137-42. 2001
  5. ncbi request reprint Therapeutic effect of basic fibroblast growth factor on experimental pancreatitis in rat
    M Hosokawa
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Pancreas 20:373-7. 2000
  6. ncbi request reprint Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes
    K Hirota
    Department of Anesthesia, Kyoto University Hospital, Kyoto University, 54 Shogoin Kawaharacho, Kyoto, Sakyo ku, 606 8507, Japan
    Biochem Biophys Res Commun 275:825-30. 2000
  7. ncbi request reprint Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression
    A Nishiyama
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 274:21645-50. 1999
  8. ncbi request reprint Adrenomedullin promotes epithelial restitution of rat and human gastric mucosa in vitro
    K Fukuda
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Peptides 20:127-32. 1999
  9. ncbi request reprint Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2
    T Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan
    Free Radic Res 31:357-65. 1999
  10. ncbi request reprint Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon
    K Fukuda
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Peptides 19:1043-7. 1998

Collaborators

Detail Information

Publications90

  1. pmc Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis
    H Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:15143-8. 2001
    ..We discuss these findings in the context of recent studies reporting beneficial effects of acutely elevated Trx in ischemic injury and negative effects associated with chronically elevated Trx in HIV disease...
  2. ncbi request reprint Redox imbalance and its control in HIV infection
    Hajime Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Antioxid Redox Signal 4:455-64. 2002
    ..Redox control will be an important therapeutic strategy for oxidative stress-associated disorders including HIV infection...
  3. ncbi request reprint Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer
    H Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Cancer Detect Prev 24:53-60. 2000
    ..5 fold) and GRX (1.6 fold) compared with parental HeLa cells by immunoblotting. These results indicate the possible association of TRX and GRX with malignant potential of pancreatic ductal carcinoma...
  4. ncbi request reprint Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study
    M Kobayashi
    Department of Anatomy and Developmental Biology, Institute of Virus Research, Kyoto University, Japan
    Ital J Anat Embryol 106:137-42. 2001
    ..These results suggest that TRX and GRX may be associated with tissue differentiation in embryos and fetuses are involved in the acquisition of the capacity of resistance against oxygen radicals...
  5. ncbi request reprint Therapeutic effect of basic fibroblast growth factor on experimental pancreatitis in rat
    M Hosokawa
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Pancreas 20:373-7. 2000
    ..Treatment with bFGF may represent a promising therapeutic concept for patients with acute pancreatitis...
  6. ncbi request reprint Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes
    K Hirota
    Department of Anesthesia, Kyoto University Hospital, Kyoto University, 54 Shogoin Kawaharacho, Kyoto, Sakyo ku, 606 8507, Japan
    Biochem Biophys Res Commun 275:825-30. 2000
    ..These results provide evidence suggesting that a possible novel molecular mechanism of GGA is to protect cells via the induction of TRX and the activation of transcription factors such as NF-kappaB and AP-1...
  7. ncbi request reprint Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression
    A Nishiyama
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 274:21645-50. 1999
    ..Therefore, the TRX-TBP-2/VDUP1 interaction may be an important redox regulatory mechanism in cellular processes, including differentiation of myeloid and macrophage lineages...
  8. ncbi request reprint Adrenomedullin promotes epithelial restitution of rat and human gastric mucosa in vitro
    K Fukuda
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Peptides 20:127-32. 1999
    ..AM probably promotes epithelial restitution primarily through the CGRP receptor, but it does not ameliorate more severe damage of gastric mucosa in vitro...
  9. ncbi request reprint Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2
    T Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan
    Free Radic Res 31:357-65. 1999
    ..This showed that GRX may be involved in the redox regulation of the DNA-binding activity of PEBP2 as is the case with thioredoxin...
  10. ncbi request reprint Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon
    K Fukuda
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Peptides 19:1043-7. 1998
    ..51%, 100 nM:33.4 +/- 12.7%, 100% contraction: 1.8 +/- 0.22 g), and TTX inhibits the response elicited by AM (90%). We conclude that AM modulates water and ion transport as well as bowel movement, mainly through the colonic nervous system...
  11. ncbi request reprint Redox regulation by thioredoxin and thioredoxin-binding proteins
    A Nishiyama
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan
    IUBMB Life 52:29-33. 2001
    ..TBP-2/VDUP1 negatively regulates the expression and reducing activity of thioredoxin. Thioredoxin interacting proteins may be involved in thioredoxin-mediating redox regulation...
  12. ncbi request reprint Difference in thioredoxin expression in viral myocarditis in inbred strains of mice
    M Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Jpn Circ J 65:561-4. 2001
    ..Thus, TRX may be specifically induced by the acute inflammatory stimuli in murine viral myocarditis, and the severity and development of acute viral myocarditis may be regulated by the cellular redox state...
  13. ncbi request reprint Serum thioredoxin (TRX) levels in patients with heart failure
    C Kishimoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Jpn Circ J 65:491-4. 2001
    ..The serum TRX levels were elevated in patients with ACS and DCM compared with the controls. These results indicate a possible association between TRX concentration and the severity of heart failure...
  14. ncbi request reprint Redox control of cellular function by thioredoxin; a new therapeutic direction in host defence
    Y Nishinaka
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Arch Immunol Ther Exp (Warsz) 49:285-92. 2001
    ..The modulation of TRX functions in association with other redox-regulatory molecules should give us a new therapeutic strategy in the treatment of oxidative stress-mediated disorders and diseases...
  15. ncbi request reprint Regulatory roles of thioredoxin in oxidative stress-induced cellular responses
    Y Nishinaka
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan
    Redox Rep 6:289-95. 2001
    ..Thus, the modulation of TRX functions may be a new therapeutic strategy for the treatment of oxidative stress-mediated diseases...
  16. ncbi request reprint Redox control of EBV infection: prevention by thiol-dependent modulation of functional CD21/EBV receptor expression
    Y Nishinaka
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Antioxid Redox Signal 3:1075-87. 2001
    ..These results suggest the possible modulation of EBV infection via thiol-dependent redox control of CD21, and thiol-antioxidants may be good candidates for controlling EBV infection...
  17. ncbi request reprint Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases
    M Kobayashi-Miura
    Departmrnt of Biological Responses, Institute for Virus Research, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 6068507, Japan
    Am J Physiol Heart Circ Physiol 292:H2040-50. 2007
    ..Here we discuss the roles of TRX on oxygen stress and redox regulation from different perspectives, in embryogenesis and in adult diseases focusing on cardiac disorders...
  18. ncbi request reprint Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes
    H Dekigai
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
    Free Radic Res 35:23-30. 2001
    ..These results indicate that GGA promotes the induction and secretion of TRX in a variety of types of cells and suggest that induced or secreted TRX may play an important role in the cytoprotective action of GGA on gastric mucosal cells...
  19. ncbi request reprint Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses
    M Kobayashi
    Department of Anatomy and Developmental Biology, Institute of Virus Research, Kyoto University, Kyoto 606 8501, Japan
    Antioxid Redox Signal 2:653-63. 2000
    ..These results suggest that TRX and GRX play some tissue-specific roles in mammalian morphogenesis as well as general roles as antioxidant enzymes...
  20. ncbi request reprint Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters
    H Hioki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Gene Ther 14:872-82. 2007
    ..Furthermore, the transcriptional activity and neuronal specificity of E/SYN promoter were sustained for up to 8 weeks. Thus, lentivirus with E/SYN promoter is the best vector for strong persistent expression in neurons...
  21. ncbi request reprint Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases
    Y Sumida
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto University, Kyoto, Japan
    Liver 21:295-9. 2001
    ..Serum thioredoxin (TRX) levels have recently been established as an indicator of oxidative stress in various diseases. The aim of the present study was to clarify the clinical significance of serum ferritin in chronic liver diseases...
  22. ncbi request reprint Dysregulation of adult T-cell leukemia-derived factor (ADF)/thioredoxin in HIV infection: loss of ADF high-producer cells in lymphoid tissues of AIDS patients
    H Masutani
    Department of Biological Responses, Kyoto University, Japan
    AIDS Res Hum Retroviruses 8:1707-15. 1992
    ..On the basis of the above in vivo and in vitro findings, we imply that the levels of ADF/TRX were down-regulated by HIV-1 infection and that the down-regulation may play a role for pathophysiology of HIV-infected individuals...
  23. ncbi request reprint Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats
    M Oya
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54, Shogoin, Kawara machi, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes Res Clin Pract 62:69-77. 2003
    ..These findings show that ARI partially prevented progression of impaired gastric emptying, ion transport, and water transport, and suggest that epalrestat might be useful in the treatment of diabetic gastroenteropathy...
  24. ncbi request reprint Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system
    A Nishiyama
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Immunol Lett 68:155-9. 1999
    ..These results showed that p40phox interacts with TRX and indicated the possibility of TRX-dependent regulation of phagocyte oxidase activity...
  25. ncbi request reprint Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis
    M Onomura
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    J Gastroenterol Hepatol 15:931-8. 2000
    ..We evaluated the effects of argatroban as an antithrombin drug on trinitrobenzene sulfonic acid (TNB)-induced colitis, an established model of IBD...
  26. ncbi request reprint Inverse correlation of thioredoxin expression with estrogen receptor- and p53-dependent tumor growth in breast cancer tissues
    Y Matsutani
    Department of Gastroenterological Surgery, Institute for Virus Research, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    Clin Cancer Res 7:3430-6. 2001
    ..In addition, TRX expression in ER+ and p53 intact (wild-type p53+) groups may mean better prognosis than in other conditions...
  27. doi request reprint Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models
    H Nakamura
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku Kitakyushu 807 8555, Japan
    Gut 57:788-98. 2008
    ..Smad6 is implicated in the inhibition of bone morphogenetic protein signalling. However, the function of Smad6 in the pancreas remains obscure...
  28. ncbi request reprint Molecular mechanisms of hyperplasia induction by human papillomavirus E7
    T Ueno
    Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
    Oncogene 25:4155-64. 2006
    ..However, analysis with the E7 variants indicated that other pocket proteins are also involved in the activity...
  29. ncbi request reprint Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia
    I Yoshikawa
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, Japan
    Aliment Pharmacol Ther 16:1805-9. 2002
    ..Therapy for the relief of symptoms of functional dyspepsia is unpredictable...
  30. ncbi request reprint Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice
    Aoi Son
    1Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cell Res 16:230-9. 2006
    ..As ROS are involved in mast cell activation and facilitate mediator release, TRX may be a key signaling molecule regulating the early events in the IgE signaling in mast cells and the allergic inflammation...
  31. ncbi request reprint The involvement of thioredoxin and thioredoxin binding protein-2 on cellular proliferation and aging process
    Toru Yoshida
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan 606 8507
    Ann N Y Acad Sci 1055:1-12. 2005
    ..These findings suggest that TRX and TBP-2/VDUP1 are involved not only in cytoprotective functions against oxidative stress, but also in the regulation of cellular proliferation and the aging process...
  32. ncbi request reprint [Protective role of thioredoxin-1 in Helicobacter felis-induced gastritis]
    Kimio Kawasaki
    Department of Gastroenterology and Endoscopic Medicine, Graduate School of Medicine, Kyoto University
    Nihon Rinsho 63:116-22. 2005
  33. ncbi request reprint Redox regulation of lung inflammation by thioredoxin
    Takayuki Nakamura
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Antioxid Redox Signal 7:60-71. 2005
    ..Promotion/modulation of the TRX system by the administration of recombinant TRX protein, induction of endogenous TRX, or gene therapies can be a therapeutic modality for oxidative stress-associated lung disorders...
  34. ncbi request reprint Increased plasma levels of thioredoxin in patients with glucose intolerance
    Shinzo Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 44:1127-32. 2005
    ..The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD)...
  35. ncbi request reprint Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis
    Shinya Ohashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G772-81. 2006
    ..The present study suggests that TRX-1 has potent antioxidant and anti-inflammatory actions in experimental acute pancreatitis and might be a new therapeutic strategy to improve the prognosis of severe acute pancreatitis...
  36. ncbi request reprint Recombinant human thioredoxin suppresses lipopolysaccharide-induced bronchoalveolar neutrophil infiltration in rat
    Shugo Ueda
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, 606 8507, Japan
    Life Sci 79:1170-7. 2006
    ..Administration of rhTRX did not promote the tumor growth nor affect chemosensitivity in the xenotransplantation model, suggesting the safety of rhTRX therapy for cancer patients...
  37. ncbi request reprint Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage
    Masaki Tanito
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Neurosci 25:2396-404. 2005
    ..Therefore, Trx is a neurotrophic factor released from RPE cells and plays a crucial role in maintaining photoreceptor cell integrity...
  38. ncbi request reprint Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt
    M Kaimul Ahsan
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawahara cho, Sakyo, Kyoto 606 8507, Japan
    Free Radic Biol Med 39:1549-59. 2005
    ..Collectively, the results suggest that Trx-1 exerts antioxidant effects in vivo and in vitro and that this plays a role in protection against DEP-induced lung damage by regulating Akt-mediated antiapoptotic signaling...
  39. ncbi request reprint Plasma thioredoxin levels in patients with unstable angina
    Jun Hokamaki
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Int J Cardiol 99:225-31. 2005
    ..Thioredoxin levels were associated with recurrent myocardial ischemia in patients with unstable angina...
  40. ncbi request reprint Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma
    Hiroko Ichiki
    Department of Internal Medicine 1, Kurume University School of Medicine, Kurume, Japan
    Biochem Biophys Res Commun 334:1141-8. 2005
    ..Thus, TRX inhibited the asthmatic response after sensitization, but did not prevent sensitization itself. TRX and redox-active protein may have clinical benefits in patients with asthma...
  41. ncbi request reprint Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1
    Kimio Kawasaki
    Department of Gastroenterology and Endoscopic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Lab Invest 85:1104-17. 2005
    ..The present study suggests that overexpression of TRX-1 suppresses H. felis-induced gastritis by inhibiting chemotaxis of neutrophils and reducing oxidative stress...
  42. ncbi request reprint Thioredoxin and its related molecules: update 2005
    Hajime Nakamura
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Antioxid Redox Signal 7:823-8. 2005
    ..Exogenous Trx1 shows cytoprotective and antiinflammatory effects and has a good potential for clinical application. This is an update review on Trx and its related molecules...
  43. ncbi request reprint Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice
    Shinya Ohashi
    Department of Gastroenterology and Hepatology, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka, Japan
    Antioxid Redox Signal 8:1835-45. 2006
    ..These results indicate that TRX-1 can potentially attenuate pancreatic fibrosis via the suppression of oxidative stress and MCP-1-mediated chronic inflammation...
  44. doi request reprint Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses
    Aoi Son
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Eur J Immunol 38:1358-67. 2008
    ..In vivo delayed-type hypersensitivity responses in TBP-2(-/-) mice immunized with ovalbumin were significantly reduced compared to WT mice. These results indicate that TBP-2 plays a crucial role in DC to induce T cell responses...
  45. ncbi request reprint Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome
    Chiyo Kurimoto
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Rheumatol 34:2035-43. 2007
    ..To demonstrate the existence of oxidative stress and the role of the antioxidant thioredoxin (TRX) in Sjögren's syndrome (SS)...
  46. ncbi request reprint Recombinant human thioredoxin-1 becomes oxidized in circulation and suppresses bleomycin-induced neutrophil recruitment in the rat airway
    Takayuki Nakamura
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Free Radic Res 41:1089-98. 2007
    ..These results suggest that rhTRX becomes oxidized in circulation and continuous infusion of rhTRX suppresses neutrophil recruitment in the airway...
  47. ncbi request reprint Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1
    Yuma Hoshino
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University, Kyoto, Japan
    Am J Respir Cell Mol Biol 37:438-46. 2007
    ....
  48. ncbi request reprint From oxygen sensing to heart failure: role of thioredoxin
    Yuma Hoshino
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Antioxid Redox Signal 9:689-99. 2007
    ..Here we discuss how TRX is useful as a biomarker of and therapeutic agent for cardiopulmonary disorders, especially focusing on ischemic heart disease, myocarditis and oxygen sensing, and acute respiratory distress syndrome...
  49. ncbi request reprint Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy
    Yasuhiro Hamada
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Nephrol Dial Transplant 22:1547-57. 2007
    ....
  50. ncbi request reprint Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite
    Hitoshi Ueno
    Department of Public Health and Preventive Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan
    Antioxid Redox Signal 9:115-21. 2007
    ....
  51. ncbi request reprint Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer
    Hajime Nakamura
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto 606 8507, Japan
    Semin Cancer Biol 16:444-51. 2006
    ..Thioredoxin-binding protein 2 (TBP-2) is an endogenous negative regulator of TRX and a tumor suppressor...
  52. ncbi request reprint Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls
    Tadaaki Yamada
    Department of Respiratory Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Pulm Pharmacol Ther 20:650-9. 2007
    ..Thioredoxin-1 (TRX-1) is a small ubiquitous protein that acts as an important radical scavenger. We investigated the effect of TRX-1 on apoptosis in hyperoxia-induced lung injury...
  53. ncbi request reprint Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production
    Hiroyuki Tamaki
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Gastroenterology 131:1110-21. 2006
    ..In this study, we investigated the significance of TRX in patients with inflammatory bowel disease (IBD) and the ability and mechanism to ameliorate experimental colitis...
  54. ncbi request reprint Thioredoxin-binding protein-2 (TBP-2): its potential roles in the aging process
    Toru Yoshida
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    Biofactors 27:47-51. 2006
    ..As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP-2 in the regulation of energy utilization connected to the aging process...
  55. ncbi request reprint Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
    Atsuyasu Sato
    Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Antioxid Redox Signal 8:1891-6. 2006
    ..These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking...
  56. ncbi request reprint Redox regulation of human thioredoxin network
    Norihiko Kondo
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Translational Research Center Kyoto University Hospital, Kyoto, Japan
    Antioxid Redox Signal 8:1881-90. 2006
    ..This review focuses on TRX and its related molecules, and discusses the role of TRX-dependent redox regulation in oxidative stress-induced signal transduction...
  57. doi request reprint Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells
    Xiaoping Zhu
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Arch Biochem Biophys 478:154-60. 2008
    ..Thus, acetyl-L-carnitine effectively suppressed the oxidative stress in and around mitochondria thereby preventing mitochondrial signaling pathway leading to apoptosis...
  58. ncbi request reprint Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice
    Hiroaki Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Hepatol 42:117-23. 2005
    ..We have previously reported that thioacetamide-induced acute hepatitis was attenuated in thioredoxin transgenic mice. The aim of the present study was to investigate the protective effect of thioredoxin for hepatic fibrosis...
  59. ncbi request reprint Thioredoxin, a redox-regulating protein, is expressed in spontaneous myocarditis in inbred strains of mice
    Miki Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Int J Cardiol 95:315-9. 2004
    ..Thus, TRX may be induced by the spontaneously developed myocarditis, and the redox-regulating system may play an important role in the development of aging-related myocarditis...
  60. ncbi request reprint Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells
    Jie Bai
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Kyoto 606 8507, Japan
    J Neurosci 23:503-9. 2003
    ..These results suggest that TRX plays a critical regulatory role in NGF-mediated signal transduction and outgrowth in PC12 cells...
  61. ncbi request reprint Thioredoxin, an anti-oxidant protein, protects mouse embryos from oxidative stress-induced developmental anomalies
    Mikiko Kobayashi-Miura
    Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Free Radic Res 36:949-56. 2002
    ..The TRX transgene appears to provide the embryo with the resistance against oxidative stress and may play a crucial role in the redox regulation in embryos...
  62. ncbi request reprint Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
    Akira Mitsui
    Pharmaceutical Research Laboratories, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki, 210 8681, Japan
    Antioxid Redox Signal 4:693-6. 2002
    ..These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals...
  63. ncbi request reprint Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity
    Keisuke Shioji
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circulation 106:1403-9. 2002
    ..Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity...
  64. ncbi request reprint Redox control of cell death
    Shugo Ueda
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Antioxid Redox Signal 4:405-14. 2002
    ..As mitochondria are the most redox-active organelle and indispensable for cells to initiate or inhibit the apoptosis process, the regulation of mitochondrial function is the central focus in the research field of apoptosis and redox...
  65. ncbi request reprint Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression
    Zuyi Yuan
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Cardiovasc Res 55:320-8. 2002
    ..This study was carried out to investigate whether temocapril, a novel non-sulfhydryl-containing ACE inhibitor, reduces the severity of myocarditis via redox regulation mechanisms involving TRX...
  66. ncbi request reprint Change of redox status and modulation by thiol replenishment in retinal photooxidative damage
    Masaki Tanito
    Department of Ophthalmology, Shimane Medical University, 89 1 Enya, Izumo, Shimane 693 8501, Japan
    Invest Ophthalmol Vis Sci 43:2392-400. 2002
    ..The present study was conducted to analyze how tissue redox status is affected by photooxidative stress and whether the exogenous thiol antioxidant N-acetylcysteine (NAC) affects photooxidative stress-induced retinal damage...
  67. ncbi request reprint Attenuation of retinal photooxidative damage in thioredoxin transgenic mice
    Masaki Tanito
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Kawahara cho, Shogoin Sakyo ku, Kyoto 606 8507, Japan
    Neurosci Lett 326:142-6. 2002
    ..These results suggest that overexpression of TRX suppresses retinal photooxidative damage. TRX intensification may be a useful therapeutic strategy to prevent retinal photic injury...
  68. ncbi request reprint Redox regulation of stress signals: possible roles of dendritic stellate TRX producer cells (DST cell types)
    Junji Yodoi
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Japan
    Biol Chem 383:585-90. 2002
    ....
  69. ncbi request reprint Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia
    Hajime Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaharacho, Sakyo, Kyoto, Japan
    Immunol Lett 82:165-70. 2002
    ..TRX may play some important roles in regulating the inflammatory process in the primary host defense against infection...
  70. ncbi request reprint Cytoprotective effect of thioredoxin against retinal photic injury in mice
    Masaki Tanito
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo, Kyoto, Japan
    Invest Ophthalmol Vis Sci 43:1162-7. 2002
    ..To determine the protective role of thioredoxin (TRX), an endogenous redox (reduction and oxidation) regulator, against retinal photic injury in mice...
  71. ncbi request reprint Thioredoxin overexpression in transgenic mice
    Hajime Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Methods Enzymol 347:436-40. 2002
  72. ncbi request reprint Effects of a new anti-rheumatic drug KE-298 and its active metabolite: KE-758 on secretion of thioredoxin and on the level of intracellular glutathione in human monocytes and T cells
    Masanori Sugimoto
    Department of Pharmacology, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, 330 8530, Saitama, Japan
    Mol Immunol 38:793-9. 2002
    ..The potential of KE-298 to suppress the secretion of TRX and to increase the level of intracellular GSH may partly explain the efficacy in cases of RA...
  73. ncbi request reprint Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis
    Takumi Jikimoto
    Department of Clinical Pathology and Immunology, Graduate School of Medicine, Kobe University, 7 5 2 Kusunoki cho, Chuou ku, Kobe, 650 0017, Hyogo, Japan
    Mol Immunol 38:765-72. 2002
    ..005). We concluded that plasma TRX level is a new biomarker for the disease activity of RA and may reflect higher levels of oxidative stress in RA patients...
  74. ncbi request reprint [Experimental and clinical aspects of oxidative stress and redox regulation]
    Hajime Nakamura
    Laboratory of Infection and Prevention, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507
    Rinsho Byori 51:109-14. 2003
    ..Redox regulation mechanisms by thioredoxin and other thioredoxin family members will clarify the pathophysiology of oxidative stress-associated disorders...
  75. ncbi request reprint Thioredoxin as a molecular target of cyclopentenone prostaglandins
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:26046-54. 2003
    ..These residues may represent the direct sensors of the electrophilic PGs that induce the intracellular redox alteration and neuronal cell death...
  76. ncbi request reprint Loss of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 in human T-cell leukemia virus type I-dependent T-cell transformation: implications for adult T-cell leukemia leukemogenesis
    Yumiko Nishinaka
    Biomedical Special Research Unit, Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Midorigaoka, Ikeda, Osaka, Japan
    Cancer Res 64:1287-92. 2004
    ....
  77. ncbi request reprint Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats
    Masaki Tanito
    Antioxid Redox Signal 6:89-97. 2004
    ..Redox imbalance in essential organs may play a crucial role in the development and pathogenesis of hypertension...
  78. ncbi request reprint Redox-sensing release of human thioredoxin from T lymphocytes with negative feedback loops
    Norihiko Kondo
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Immunol 172:442-8. 2004
    ....
  79. ncbi request reprint Increased plasma thioredoxin in patients with acute myocardial infarction
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Clin Cardiol 26:583-7. 2003
    ..Thioredoxin is an important biomarker for oxidative stress. We investigated whether thioredoxin levels were elevated in patients with acute myocardial infarction (AMI) and were associated with the results of coronary reperfusion...
  80. ncbi request reprint An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 42:13960-8. 2003
    ..These data suggest that the modulation of proteasome activity may be involved in the mechanism responsible for the accumulation of p53 and subsequent induction of apoptotic cell death induced by 15d-PGJ(2)...
  81. ncbi request reprint Redox regulation by thioredoxin in cardiovascular diseases
    Keisuke Shioji
    Department of Cardiovascular Medicine, Graduated School of Medicine, Kyoto University, Kyoto, Japan
    Antioxid Redox Signal 5:795-802. 2003
    ..These findings suggest that TRX and the redox system modulated by TRX have an important role in cellular defense against oxidative stress in cardiovascular diseases...
  82. ncbi request reprint Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt
    Hiroaki Murata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    J Biol Chem 278:50226-33. 2003
    ..Thus, GRX plays an important role in protecting cells from apoptosis by regulating the redox state of Akt...
  83. ncbi request reprint Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia/reperfusion injury
    Kenji Kasuno
    Department of Biological Responses, Institute for Virus Research, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Kidney Int 64:1273-82. 2003
    ..Although TRX is known to be induced in response to various forms of oxidative stress, including ischemia/reperfusion injury, the induction and the specific role of this protein in the kidney have not been fully investigated...
  84. ncbi request reprint Redox regulation of cell growth and cell death
    Yong Won Kwon
    Institute for Virus Research, Kyoto University, 53 Shogoin, Kawahara cho, Sakyo, Kyoto 606 8507, Japan
    Biol Chem 384:991-6. 2003
    ..This brief review describes the current knowledge on the redox regulation of cell growth and apoptosis...
  85. ncbi request reprint Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina
    Nobutaka Hirai
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Circulation 108:1446-50. 2003
    ..Recently, the renin-angiotensin system has been suggested to play an important role in the development of nitrate tolerance...
  86. ncbi request reprint Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression
    Zuyi Yuan
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Mol Cell Biochem 248:185-92. 2003
    ..Temocapril ameliorates myocarditis associated with inducing TRX increase in a preconditioning manner, although the mechanism of TRX induction by temocapril remains to be elucidated...
  87. ncbi request reprint Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury
    Tomoaki Hoshino
    Department of Internal Medicine 1, Kurume University, Kurume, Japan
    Am J Respir Crit Care Med 168:1075-83. 2003
    ..TRX may have clinical benefits in human ILD, including lung fibrosis, for which no effective therapeutic strategy currently exists...
  88. ncbi request reprint Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection
    Akihiko Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Kidney Int 63:2262-8. 2003
    ..The association between oxidative stress and hepatitis C virus (HCV) infection, however, remains unknown in hemodialysis patients...
  89. ncbi request reprint Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice
    Hiroaki Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Japan
    Hepatology 37:1015-25. 2003
    ..In addition to an antioxidant effect, Trx has the potential to protect acute liver injury via an antiapoptotic effect, which mainly inhibits mitochondria-mediated apoptosis signaling...
  90. ncbi request reprint Thioredoxin-mediated redox control of human T cell lymphotropic virus type I (HTLV-I) gene expression
    Tetsuro Sasada
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, 606 8507, Kyoto, Japan
    Mol Immunol 38:723-32. 2002
    ..Taken together, these findings suggest that overexpressed TRX, which is induced by HTLV-I Tax, may play an important role in HTLV-I infection through the negative regulation of viral gene expression...