Toshiki Mizuno

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. doi request reprint Low vitamin and carotenoid levels are related to cerebral white matter lesions
    Y Ohshima
    Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Nutr Health Aging 17:456-60. 2013
  2. doi request reprint Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine
    Toshiki Mizuno
    Department of Molecular Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Neuropharmacol 32:113-6. 2009
  3. ncbi request reprint Two Japanese CADASIL families exhibiting Notch3 mutation R75P not involving cysteine residue
    Toshiki Mizuno
    Department of Molecular Neurology, Kyoto Prefectural University of Medicine, Kyoto
    Intern Med 47:2067-72. 2008
  4. ncbi request reprint Discrepancy between clinical and pathological diagnoses of CBD and PSP
    Toshiki Mizuno
    Kyoto Prefectural University of Medicine, Dept of Neurology, Kajiicho 465, Kamigyo ku, 602 8566 Kyoto, Japan
    J Neurol 252:687-97. 2005
  5. ncbi request reprint A case of lymphomatoid granulomatosis/angiocentric immunoproliferative lesion with long clinical course and diffuse brain involvement
    Toshiki Mizuno
    Department of Neurology and Gerontology, Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Neurol Sci 213:67-76. 2003
  6. doi request reprint Predictive markers of blood cytokine and chemokine in recurrent brain infarction
    Nagato Kuriyama
    Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    J Interferon Cytokine Res 29:729-34. 2009
  7. doi request reprint Simultaneous impairment of intracranial and peripheral artery vasoreactivity in CADASIL patients
    Yasuhiro Fujiwara
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cerebrovasc Dis 33:128-34. 2012
  8. doi request reprint Evaluation of factors associated with elevated levels of platelet-derived microparticles in the acute phase of cerebral infarction
    Nagato Kuriyama
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Appl Thromb Hemost 16:26-32. 2010
  9. doi request reprint Extracellular neurosin degrades α-synuclein in cultured cells
    Harutsugu Tatebe
    Department of Neurology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neurosci Res 67:341-6. 2010
  10. doi request reprint Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography
    Koushun Matsuo
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neuroradiology 50:605-11. 2008

Collaborators

Detail Information

Publications53

  1. doi request reprint Low vitamin and carotenoid levels are related to cerebral white matter lesions
    Y Ohshima
    Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Nutr Health Aging 17:456-60. 2013
    ..To determine the effects of vitamins and carotenoids on brain white matter lesions (WMLs), we examined the associations between WMLs with vitamin and carotenoid levels in Japanese middle-aged and elderly subjects...
  2. doi request reprint Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine
    Toshiki Mizuno
    Department of Molecular Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Neuropharmacol 32:113-6. 2009
    ..Cognitive decline and cerebral hypoperfusion improved during 2-year administration of lomerizine in this CADASIL patient, and thus, lomerizine is a potential candidate for treating cognitive impairment in CADASIL patients...
  3. ncbi request reprint Two Japanese CADASIL families exhibiting Notch3 mutation R75P not involving cysteine residue
    Toshiki Mizuno
    Department of Molecular Neurology, Kyoto Prefectural University of Medicine, Kyoto
    Intern Med 47:2067-72. 2008
    ..These families provide new insights into the diagnosis and pathomechanisms of CADASIL...
  4. ncbi request reprint Discrepancy between clinical and pathological diagnoses of CBD and PSP
    Toshiki Mizuno
    Kyoto Prefectural University of Medicine, Dept of Neurology, Kajiicho 465, Kamigyo ku, 602 8566 Kyoto, Japan
    J Neurol 252:687-97. 2005
    ..The G-B staining was useful for differentiating between CBD and PSP, but our atypical cases bring up a new issue about differential diagnosis of CBD and PSP...
  5. ncbi request reprint A case of lymphomatoid granulomatosis/angiocentric immunoproliferative lesion with long clinical course and diffuse brain involvement
    Toshiki Mizuno
    Department of Neurology and Gerontology, Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Neurol Sci 213:67-76. 2003
    ..Cyclophosphamide was effective and there has been no recurrence of symptoms in the last 5 years. We reviewed the non-tumorous LYG/AIL involving the CNS, and discussed the clinical features, MRI imaging and diagnosis of the LYG/AIL...
  6. doi request reprint Predictive markers of blood cytokine and chemokine in recurrent brain infarction
    Nagato Kuriyama
    Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    J Interferon Cytokine Res 29:729-34. 2009
    ..05). In conclusion, the MCP-1 level as well as hsCRP in the blood can be a potential predictive marker of recurrent thrombotic brain infarction, and may reflect inflammation that promotes intracranial large-artery atherosclerosis...
  7. doi request reprint Simultaneous impairment of intracranial and peripheral artery vasoreactivity in CADASIL patients
    Yasuhiro Fujiwara
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cerebrovasc Dis 33:128-34. 2012
    ....
  8. doi request reprint Evaluation of factors associated with elevated levels of platelet-derived microparticles in the acute phase of cerebral infarction
    Nagato Kuriyama
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Appl Thromb Hemost 16:26-32. 2010
    ..The objective of this study was to determine the parameters associated with elevated PDMP levels and examine their relationship with atherosclerotic lesions of main intracranial and extracranial arteries...
  9. doi request reprint Extracellular neurosin degrades α-synuclein in cultured cells
    Harutsugu Tatebe
    Department of Neurology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neurosci Res 67:341-6. 2010
    ..These findings suggest that neurosin targets the extracellular alpha-synuclein...
  10. doi request reprint Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography
    Koushun Matsuo
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neuroradiology 50:605-11. 2008
    ..We used diffusion tensor imaging (DTI) to study white matter integrity in patients with frontotemporal dementia (FTD)...
  11. doi request reprint Parasympathetic Dominant Autonomic Dysfunction in Charcot-Marie-Tooth Disease Type 2J with the MPZ Thr124Met Mutation
    Naoki Tokuda
    Department of Neurology, Kyoto Prefectural University of Medicine, Graduate School of Medicine, Japan
    Intern Med 54:1919-22. 2015
    ..Our case suggests that mainly the parasympathetic autonomic function is disturbed in CMT2J. ..
  12. pmc p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions
    Yoshihisa Watanabe
    Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamikyo ku, Kyoto, Japan
    PLoS ONE 7:e52868. 2012
    ..Impaired mitochondria were almost completely eliminated after mitochondrial uncoupling even in the presence of α-synuclein inclusions, suggesting that mitochondrial clearance is not prevented by α-synuclein inclusions in HEK293 cells...
  13. ncbi request reprint Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease
    Yuriko Nakata-Kudo
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Dement Geriatr Cogn Disord 22:8-14. 2006
    ..Microbleeds not being related to common hemorrhagic risk factors, but being significantly related to white matter pathologies suggested that microbleeds in AD may be associated with CAA, but not with hypertension or CVD...
  14. doi request reprint Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts
    Akiko Hosomi
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    Neuroradiology 51:549-55. 2009
    ..A method enabling objective assessment of verbal function is needed for this purpose. We examined whether diffusion tensor (DT) tractography is of clinical value in assessing aphasia...
  15. pmc Decrease in plasma levels of α-synuclein is evident in patients with Parkinson's disease after elimination of heterophilic antibody interference
    Ryotaro Ishii
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    PLoS ONE 10:e0123162. 2015
    ....
  16. pmc Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study
    Teruhide Koyama
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    BMC Neurol 16:253. 2016
    ..However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD...
  17. doi request reprint Transendocytosis is impaired in CADASIL-mutant NOTCH3
    Akiko Watanabe-Hosomi
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Exp Neurol 233:303-11. 2012
    ..Such disturbance on the surface of vascular smooth muscle cells may contribute to the pathogenesis of CADASIL...
  18. pmc Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    PLoS ONE 11:e0147574. 2016
    ..Our findings suggest that serum CoQ10 can be used as a biomarker in the diagnosis of MSA and to provide supportive evidence for the hypothesis that decreased levels of CoQ10 in brain tissue lead to an increased risk of MSA. ..
  19. doi request reprint Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils
    Atsushi Tsujimura
    Department of Basic Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamikyo ku, Kyoto 602 8566, Japan
    Neurobiol Dis 73:244-53. 2015
    ..They then rapidly grew larger and moved outside the boundary of the lysosome within one day. These results suggest that the lysosomal protease cathepsin B is involved in triggering intracellular aggregate formation by α-Syn fibrils. ..
  20. doi request reprint Concomitant alpha-synuclein pathology in an autopsy case of amyotrophic lateral sclerosis presenting with orthostatic hypotension and cardiac arrests
    Takehiro Yamada
    Division of Neurology, Ohmihachiman Community Medical Center, Ohmihachiman, Japan Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan Division of Neurology, Kyoto First Red Cross Hospital, Kyoto, Japan
    Neuropathology 34:164-9. 2014
    ..The concomitant alpha-synuclein pathology may have been partly related to possible autonomic dysfunction underlying the two episodes of cardiac arrest. ..
  21. doi request reprint Sixty six-month follow-up of muscle power and respiratory function in a case with adult-type Pompe disease treated with enzyme replacement therapy
    Reina Isayama
    Departments of Neurology and Rehabilitation, Kyoto Prefectural University of Medicine, Kyoto, Japan and Kyoto Prefectural Support Center of Rehabilitation, Kyoto, Japan
    J Clin Neuromuscul Dis 15:152-6. 2014
    ..Our data may rationalize the long-term use of ERT for adult-type Pompe disease in terms of maintaining pulmonary function. ..
  22. doi request reprint Evaluation of autonomic malfunction in HTLV-1 associated myelopathy (HAM)
    Nagato Kuriyama
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Auton Neurosci 150:131-5. 2009
    ..In conclusion, cardiovascular autonomic dysfunction in HAM patients is mainly associated with cardiac sympathetic efferent abnormalities in the upper thoracic segments...
  23. doi request reprint A cross-sectional study of familial clustering in hyperhomocysteinemia
    Satoko Mitani
    Kyoto Prefectural University of Medicine, Kyoto, Japan
    Gerontology 56:15-9. 2010
    ..Hyperhomocysteinemia is correlated with diseases and lifestyle habits. However, there is no epidemiological evidence concerning the distribution and prevalence of hyperhomocysteinemia in a local community...
  24. pmc Myasthenic symptoms in anti-low-density lipoprotein receptor-related protein 4 antibody-seropositive amyotrophic lateral sclerosis: two case reports
    Hisashi Takahashi
    Department of Neurology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii cho, Kamigyo ku, Kyoto, 602 0841, Japan
    BMC Neurol 16:229. 2016
    ..Recent studies suggested that antibody to low-density lipoprotein receptor-related protein 4 (LRP4) was a pathogenic agent of myasthenia gravis (MG), and it was also detected in ALS patients...
  25. doi request reprint Nerve ultrasound depicts peripheral nerve enlargement in patients with genetically distinct Charcot-Marie-Tooth disease
    Yu Ichi Noto
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Neurol Neurosurg Psychiatry 86:378-84. 2015
    ....
  26. doi request reprint Definite familial multiple system atrophy with unknown genetics
    Kyoko Itoh
    Department of Pathology and Applied Neurobiology, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neuropathology 34:309-13. 2014
    ....
  27. pmc Differential expression of alpha-synuclein in hippocampal neurons
    Katsutoshi Taguchi
    Department of Basic Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamikyo ku, Kyoto, Japan
    PLoS ONE 9:e89327. 2014
    ..Furthermore, α-synuclein expression levels may determine the efficiency of intracellular aggregate formation in different neuronal subtypes. ..
  28. doi request reprint Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, 602 0841, Japan
    J Neurol 261:1203-9. 2014
    ..964) relative to an AUC of 0.943 for increased CSF t-tau alone. The combined use of CSF α-syn and t-tau levels may be a useful biomarker for the diagnosis of CJD...
  29. doi request reprint Detection of early neuronal damage in CADASIL patients by q-space MR imaging
    Kei Yamada
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii cho, Kawaramachi Hirokoji Sagaru, Kamigyo ku, Kyoto City, Japan
    Neuroradiology 55:283-90. 2013
    ..We hypothesized that this technique would facilitate the assessment of the progressive nature of neuronal damage seen in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
  30. ncbi request reprint [Gait disturbances related to dysfunction of the cerebral cortex and basal ganglia]
    Nobuo Takezawa
    Kyoto Prefectural Support Center of Rehabilitation, Kyoto, Japan
    Brain Nerve 62:1193-202. 2010
    ..These alternative systems are believed to be functionally intact in patients with PD...
  31. doi request reprint Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Neurosci Lett 436:52-6. 2008
    ....
  32. doi request reprint Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gray and white matter vulnerability
    Yoshinari Nagakane
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    Stroke 39:494-6. 2008
    ..Symptomatic progression is frequently observed in lacunar infarcts. The exact mechanisms of this phenomenon have not yet been clarified...
  33. pmc Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment
    Isao Watanabe
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, 6028566, Japan
    Sci Rep 6:38561. 2016
    ..mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction...
  34. doi request reprint Contrasting echogenicity in flexor digitorum profundus-flexor carpi ulnaris: a diagnostic ultrasound pattern in sporadic inclusion body myositis
    Yu Ichi Noto
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 0841, Japan
    Muscle Nerve 49:745-8. 2014
    ..In this study we aimed to clarify whether muscle ultrasound (US) of the forearm can be used to differentiate between patients with sporadic inclusion body myositis (s-IBM) and those with s-IBM-mimicking diseases...
  35. ncbi request reprint Hereditary diffuse leukoencephalopathy with spheroids characterized by spastic hemiplegia preceding mental impairment
    Fukiko Kitani-Morii
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Intern Med 53:1377-80. 2014
    ..DNA sequencing showed a heterozygous c.2381T>C mutation in colony-stimulating factor 1 receptor. HDLS with a pure motor phenotype is sometimes difficult to differentiate from MS. ..
  36. pmc Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches
    Hiroshi Sasayama
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    PLoS ONE 7:e39483. 2012
    ....
  37. doi request reprint Autonomic nervous dysfunction during acute cerebral infarction
    Nagato Kuriyama
    Department of Neurology, National Shiga Hospital, Shiga, Japan
    Neurol Res 32:821-7. 2010
    ..The mechanism by which these symptoms occur in patients with supratentorial lesions has not been elucidated. The objective of this study was to evaluate the autonomic dysfunction that occurs in these patients...
  38. doi request reprint Usefulness of serum S100B as a marker for the acute phase of aquaporin-4 autoimmune syndrome
    Chihiro Fujii
    Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    Neurosci Lett 494:86-8. 2011
    ..673, p=0.0390). Our results raise the possibility that serum levels of S100B, but not GFAP, examined in the acute phase of the disease might be a useful biomarker for the relapse of AQP4 autoimmune syndrome...
  39. pmc Regional Cerebral Blood Flow in [123]I-IMP Single-photon Emission Computed Tomography and the Wechsler Memory Scale-revised in Nondemented Elderly Subjects with Subjective Cognitive Impairment
    Fumitoshi Niwa
    Department of Neurology and Gerontology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Intern Med 55:3571-3578. 2016
    ..The correlation analysis with the WMS-R suggested the contribution of the LIFG to the memory function and indicated the significance of visual memory dysfunction in the neuropsychological assessment to determine the stage of SCI...
  40. doi request reprint CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline
    Nagato Kuriyama
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Japan Department of Neurology, Kyoto Prefectural University of Medicine, Japan Electronic address
    Arch Gerontol Geriatr 62:118-24. 2016
    ..This study was done to evaluate the usefulness of a new method to examine the function of activated platelets in order to assess DWMLs associated with cognitive decline...
  41. ncbi request reprint Self-remitting and reversible parkinsonism associated with neuro-Sweet disease
    Fumitoshi Niwa
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Intern Med 49:1201-4. 2010
    ..His clinical course and human leukocyte antigen typing suggested that he was suffering from NSD. This case is the first report of NSD presenting with self-remitting and reversible parkinsonism...
  42. ncbi request reprint Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy
    Kensuke Shiga
    Department of Neurology and Geriatrics, Department of Radiology, Kyoto Prefectural University of Medicine, Kaijicho 465 Kamigyo ku, Kyoto, 601 0841, Japan
    J Neurol 252:589-96. 2005
    ..The pathological changes of tissue microstructure can modify the diffusion behavior of water molecules, which can be assessed by diffusion tensor imaging (DTI)...
  43. ncbi request reprint Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
    Takahiko Tokuda
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan, and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biochem Biophys Res Commun 349:162-6. 2006
    ..0001), even after adjusting for age. These findings identify in the quantification of alpha-syn from CSF a potential laboratory marker to aid the clinical diagnosis of PD...
  44. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy due to the administration of pegylated interferon α-2b: a neuropathology case report
    Kensuke Shiga
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan
    Intern Med 51:217-21. 2012
    ..IFNα-induced CIDP is presumably a transient immunological condition that requires immunomodulatory therapy. The elevated serum TNFα may implicate the degree of downstream autoimmunity induced by IFNα...
  45. pmc Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy
    Chihiro Fujii
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Sci Rep 6:35314. 2016
    ..Further clinical studies are necessary to investigate whether altered T cell phenotypes are a biomarker for relapse under fingolimod therapy...
  46. doi request reprint An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals
    Soichiro Numa
    Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Intern Med 55:699-702. 2016
    ..This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis...
  47. ncbi request reprint Lack of association between NOTCH3 gene polymorphism and cerebrovascular disease in Japanese patients
    Toshiki Mizuno
    Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokouji, Kamigyo ku, Kyoto 602 8566, Japan
    Ann N Y Acad Sci 977:252-7. 2002
  48. ncbi request reprint Subclinical brain hemorrhages in Alzheimer's disease: evaluation by magnetic resonance T2*-weighted images
    Yuriko Nakata
    Department of Neurology and Radiology, Kyoto Prefectural University of Medicine, Kajiicho 465, Kamigyo ku, Kyoto 602 8566, Japan
    Ann N Y Acad Sci 977:169-72. 2002
  49. ncbi request reprint Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy
    Nagato Kuriyama
    Department of Neurology, National Shiga Hospital, Kyoto, Japan
    Auton Neurosci 123:87-93. 2005
    ..This study has also suggested the possible efficacy of urodynamic measurements in OPCA patients as an indicator of neuromuscular dysfunction in the lower urinary tract and of parasympathetic malfunction...
  50. ncbi request reprint Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Ann N Y Acad Sci 977:216-23. 2002
    ..Further, some such patients showed extremely low levels of CSF neurosin. Our results suggest that neurosin is an aging-related protease and that a decreased CSF concentration of neurosin may be a risk factor for developing AD...
  51. ncbi request reprint Angiotensinogen gene polymorphism as a risk factor for ischemic stroke
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita, Japan 010 0874
    J Clin Neurosci 14:943-7. 2007
    ..031 and 0.026, respectively). Synergistic effects of the AGT gene polymorphism and clinical risks were not observed. In conclusion, AGT M allele may present a risk of lacunar infarctions in Japanese men, independent of hypertension...
  52. ncbi request reprint [Distribution of ischemic leukoaraiosis in MRI: a difference from white matter lesions in CADASIL]
    Hidekazu Tomimoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    No To Shinkei 57:125-30. 2005
    ..These results indicated that Tp lesions were useful diagnostic marker in diagnosing CADASIL, whereas Fp and EC lesions were non-specifically observed...
  53. ncbi request reprint Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease
    Hidekazu Tomimoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Dement Geriatr Cogn Disord 21:162-9. 2006
    ..In contrast, hyperintensities in the external capsule were frequently observed in all groups. Therefore, temporopolar lesions can also serve as diagnostic markers for CADASIL in non-Caucasian patients...