Affiliation: Kyoto Prefectural University of Medicine
- Protective effects of preischemic treatment with pioglitazone, a peroxisome proliferator-activated receptor-gamma ligand, on lung ischemia-reperfusion injury in ratsKazuhiro Ito
Department of Cardiovascular and Thoracic Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Eur J Cardiothorac Surg 25:530-6. 2004..We examined the effects of pioglitazone, a synthetic ligand of PPAR-gamma, against lung ischemia-reperfusion injury in rats...
- Left ventricular apex venting during deep hypothermia in a case of difficult re-entry into the mediastinumK Ito
Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Cardiovasc Surg (Torino) 42:493-4. 2001..We found that this technique was easy, safe, and useful to prevent ventricular distention during cooling...
- Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosisC Sakakura
Dept of Surgery and Regenerative Medicine, Div of Surgery and Physiology of the Digestive System, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo ku, Kyoto 602 8566, Japan
Oncogene 26:5927-38. 2007..Examination of RUNX3 expression in pretreatment specimens may predict radiosensitivity, and induction of RUNX3 expression may increase tumor radiosensitivity...
- [Cardiac angiosarcoma with diagnostic difficulty]M Yanada
Department of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
Kyobu Geka 60:1148-51. 2007..Moreover, tumor marker CA125 was a good indicator of therapeutic efficacy...
- Decreased histone deacetylase activity in chronic obstructive pulmonary diseaseKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
N Engl J Med 352:1967-76. 2005..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
- Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanismsKarine Enesa
British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, W12 ONN, United Kingdom
J Biol Chem 283:18582-90. 2008..We conclude that H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha...
- Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3Kittipong Maneechotesuwan
Section of Airway Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
J Immunol 178:2491-8. 2007..This provides a means whereby allergen exposure leads to the expression of Th2 cytokines, and this novel mechanism may provide new approaches to treating allergic diseases...
- IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoterSilvana Morello
Airways Disease Section, NHLI Imperial College London, London, United Kingdom
J Immunol 177:7173-83. 2006....
- Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumoniaGaetano Caramori
Centro di Ricerca su Asma e BPCO, University of Ferrara, Italy
Curr Med Chem 13:2267-90. 2006..Clearly this is an exciting new area of ongoing research with promising therapeutic potential...
- Alteration of adenosine receptors in patients with chronic obstructive pulmonary diseaseKatia Varani
Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
Am J Respir Crit Care Med 173:398-406. 2006..Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality worldwide. Adenosine is an inflammatory regulator that acts through four distinct receptors to mediate pro- and antiinflammatory effects...
- Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary diseaseFabio L M Ricciardolo
Unit of Respiratory Disease, Istituto di Ricovero e Cura a Carattere Scientifico Gaslini Institute, Genoa, Italy
J Allergy Clin Immunol 116:1028-35. 2005..Reactive nitrogen species formation and nitrosative stress are potentially involved in chronic obstructive pulmonary disease (COPD) pathogenesis...
- Oral administration of a T cell epitope inhibits symptoms and reactions of allergic rhinitis in Japanese cedar pollen allergen-sensitized miceTakako Murasugi
Biological Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
Eur J Pharmacol 510:143-8. 2005....
- Targeting Th2 cells in asthmatic airwaysGaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Italy
Curr Drug Targets Inflamm Allergy 3:243-55. 2004..Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease...
- Transcription factors in asthma and COPDGaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, Italy
IDrugs 7:764-70. 2004..Several new compounds based on interactions with specific transcription factors or their activation pathways are now in development for the treatment of asthma and COPD...
- Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanismsLouise E Donnelly
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
Am J Physiol Lung Cell Mol Physiol 287:L774-83. 2004..3 microM), and cyclooxygenase-2 expression in these cells. This study demonstrates that resveratrol and quercetin have novel nonsteroidal anti-inflammatory activity that may have applications for the treatment of inflammatory diseases...
- Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthmaBorja G Cosio
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, United Kingdom
Am J Respir Crit Care Med 170:141-7. 2004..Glucocorticoids and theophylline may downregulate the inflammatory response by modulating HAT and HDAC activity, and nuclear factor-kappaB activation...
- Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA bindingMatthew C Catley
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
J Biol Chem 279:18457-66. 2004....