Tamotsu Hashimoto-Gotoh

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. pmc Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior
    Atsushi Tsujimura
    Department of Biochemistry and Molecular Genetics, RINDG, Kyoto Prefectural University of Medicine Kyoto, Japan
    Front Behav Neurosci 2:4. 2008
  2. pmc KF-1 Ubiquitin Ligase: An Anxiety Suppressor
    Tamotsu Hashimoto-Gotoh
    Department of Biochemistry and Molecular Genetics, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine Japan
    Front Neurosci 3:15-24. 2009
  3. ncbi request reprint A unifying model for functional difference and redundancy of presenilin-1 and -2 in cell apoptosis and differentiation
    Tamotsu Hashimoto-Gotoh
    Department of Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602 8566, Kyoto, Japan
    Gene 323:115-23. 2003
  4. ncbi request reprint Bone mass increase specific to the female in a line of transgenic mice overexpressing human osteoblast stimulating factor-1
    Tamotsu Hashimoto-Gotoh
    Genomic Medical Sciences, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Bone Miner Metab 22:278-82. 2004
  5. doi request reprint KF-1 ubiquitin ligase: anxiety suppressor model
    Tamotsu Hashimoto-Gotoh
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Cell Biochem Biophys 60:69-75. 2011
  6. ncbi request reprint Differential expression of presenilin-alpha and -beta (PSalpha and PSbeta) in Xenopus laevis: embryonic phosphorylation of PSalpha
    Yoshihisa Watanabe
    Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602 8566, Kyoto, Japan
    Gene 314:165-72. 2003
  7. ncbi request reprint [Future perspectives on the osteoporosis gene therapy]
    Atsushi Tsujimura
    Department of Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    Nihon Rinsho 62:794-8. 2004

Collaborators

Detail Information

Publications7

  1. pmc Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior
    Atsushi Tsujimura
    Department of Biochemistry and Molecular Genetics, RINDG, Kyoto Prefectural University of Medicine Kyoto, Japan
    Front Behav Neurosci 2:4. 2008
    ..Thus, the kf-1(-/-) mice provide a novel animal model for elucidating molecular mechanisms of psychiatric diseases such as anxiety/depression, and may be useful for screening novel anxiolytic/antidepressant compounds...
  2. pmc KF-1 Ubiquitin Ligase: An Anxiety Suppressor
    Tamotsu Hashimoto-Gotoh
    Department of Biochemistry and Molecular Genetics, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine Japan
    Front Neurosci 3:15-24. 2009
    ..Therefore, kf-1(-/-) mice may be a powerful tool for elucidating the molecular mechanisms involved in emotional regulation, and for screening novel anxiolytic/antidepressant compounds...
  3. ncbi request reprint A unifying model for functional difference and redundancy of presenilin-1 and -2 in cell apoptosis and differentiation
    Tamotsu Hashimoto-Gotoh
    Department of Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602 8566, Kyoto, Japan
    Gene 323:115-23. 2003
    ..The model explains not only the functional redundancy but also apparently conflicting observations reported so far for PS1 and PS2...
  4. ncbi request reprint Bone mass increase specific to the female in a line of transgenic mice overexpressing human osteoblast stimulating factor-1
    Tamotsu Hashimoto-Gotoh
    Genomic Medical Sciences, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Bone Miner Metab 22:278-82. 2004
    ..Twelve copies at most seemed to be functional, but no direct evidence supporting female-specific mRNA synthesis of the transgene was obtained...
  5. doi request reprint KF-1 ubiquitin ligase: anxiety suppressor model
    Tamotsu Hashimoto-Gotoh
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Cell Biochem Biophys 60:69-75. 2011
    ..The kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation and for screening novel anxiolytic compounds, which may block the putative anxiety promoter...
  6. ncbi request reprint Differential expression of presenilin-alpha and -beta (PSalpha and PSbeta) in Xenopus laevis: embryonic phosphorylation of PSalpha
    Yoshihisa Watanabe
    Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602 8566, Kyoto, Japan
    Gene 314:165-72. 2003
    ..Our results suggest that PS1 and PS2 may play different roles under physiological conditions despite their high structural similarity...
  7. ncbi request reprint [Future perspectives on the osteoporosis gene therapy]
    Atsushi Tsujimura
    Department of Genomic Medical Sciences, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    Nihon Rinsho 62:794-8. 2004