Masatoshi Fujita

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Trepopnea in patients with chronic heart failure
    Masatoshi Fujita
    College of Medical Technology, Kyoto University, 53 Kawaharacho, Shogoin, Kyoto, Japan
    Int J Cardiol 84:115-8. 2002
  2. ncbi request reprint Pericardial fluid as a new material for clinical heart research
    M Fujita
    College of Medical Technology, Kyoto University, 53 Kawaharacho, Shogoin, Sakyo ku, 606 8507, Kyoto, Japan
    Int J Cardiol 77:113-8. 2001
  3. pmc Stromal vascular fraction transplantation as an alternative therapy for ischemic heart failure: anti-inflammatory role
    Goditha U Premaratne
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    J Cardiothorac Surg 6:43. 2011
  4. pmc Recent insights into human coronary collateral development
    M Fujita
    College of Medical Technology, Kyoto University, Kyoto, Japan
    Heart 90:246-50. 2004
  5. doi request reprint Reappraisal of functional importance of coronary collateral circulation
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Japan
    Cardiology 117:246-52. 2010
  6. ncbi request reprint Comparison of cardiovascular events in patients with angiographically documented coronary narrowing with combined renin-angiotensin system inhibitor plus statin versus renin-angiotensin system inhibitor alone versus statin alone (from the Japanese Coronar
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Cardiol 100:1750-3. 2007
  7. doi request reprint Treatment effects of renin-angiotensin system inhibitor and calcium channel blocker in patients with coronary artery narrowing (from the Japanese Coronary Artery Disease Study)
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Heart Vessels 25:453-9. 2010
  8. ncbi request reprint Coronary collateral growth and its therapeutic application to coronary artery disease
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 74:1283-9. 2010
  9. ncbi request reprint Heparin potentiates collateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion
    M Fujita
    College of Medical Technology, Kyoto University, Japan
    Int J Cardiol 70:165-70. 1999
  10. ncbi request reprint Sarpogrelate treatment reduces restenosis after coronary stenting
    Masatoshi Fujita
    College of Medical Technology, Kyoto University, Kyoto, Japan
    Am Heart J 145:E16. 2003

Detail Information

Publications83

  1. ncbi request reprint Trepopnea in patients with chronic heart failure
    Masatoshi Fujita
    College of Medical Technology, Kyoto University, 53 Kawaharacho, Shogoin, Kyoto, Japan
    Int J Cardiol 84:115-8. 2002
    ....
  2. ncbi request reprint Pericardial fluid as a new material for clinical heart research
    M Fujita
    College of Medical Technology, Kyoto University, 53 Kawaharacho, Shogoin, Sakyo ku, 606 8507, Kyoto, Japan
    Int J Cardiol 77:113-8. 2001
    ..Intrapericardial drug administration may provide a reasonable therapeutic strategy for heart diseases. In conclusion, the analysis of pericardial fluid appears to be a logical approach for elucidation of the pathophysiology of the heart...
  3. pmc Stromal vascular fraction transplantation as an alternative therapy for ischemic heart failure: anti-inflammatory role
    Goditha U Premaratne
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    J Cardiothorac Surg 6:43. 2011
    ....
  4. pmc Recent insights into human coronary collateral development
    M Fujita
    College of Medical Technology, Kyoto University, Kyoto, Japan
    Heart 90:246-50. 2004
    ..A complete elucidation of the remaining practical and mechanistic questions of arteriogenesis may lead to a new remedy capable of developing collateral vessels more effectively...
  5. doi request reprint Reappraisal of functional importance of coronary collateral circulation
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Japan
    Cardiology 117:246-52. 2010
    ..Interaction between basic and clinical sciences in the fascinating field of CCC will contribute to the establishment of innovative collateral-promoting therapy for severe coronary artery disease...
  6. ncbi request reprint Comparison of cardiovascular events in patients with angiographically documented coronary narrowing with combined renin-angiotensin system inhibitor plus statin versus renin-angiotensin system inhibitor alone versus statin alone (from the Japanese Coronar
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Cardiol 100:1750-3. 2007
    ..0286) in the event rate with combined treatment. In conclusion, statins combined with RAS inhibitors may decrease cardiovascular events in patients with coronary artery disease...
  7. doi request reprint Treatment effects of renin-angiotensin system inhibitor and calcium channel blocker in patients with coronary artery narrowing (from the Japanese Coronary Artery Disease Study)
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Heart Vessels 25:453-9. 2010
    ..In conclusion, there may be no additional benefit beyond blood pressure lowering effects in the combination of an RASI and a CCB in patients with angiographically documented CAD...
  8. ncbi request reprint Coronary collateral growth and its therapeutic application to coronary artery disease
    Masatoshi Fujita
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 74:1283-9. 2010
    ....
  9. ncbi request reprint Heparin potentiates collateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion
    M Fujita
    College of Medical Technology, Kyoto University, Japan
    Int J Cardiol 70:165-70. 1999
    ..4+/-12.4% vs. 21.1+/-13.6%, p=NS). Heparin promotes nonsprouting angiogenesis (arteriogenesis) of preformed collateral vessels but not neovascularization toward the ischemic area in dogs with brief repetitive coronary occlusions...
  10. ncbi request reprint Sarpogrelate treatment reduces restenosis after coronary stenting
    Masatoshi Fujita
    College of Medical Technology, Kyoto University, Kyoto, Japan
    Am Heart J 145:E16. 2003
    ..The aim of this study was to investigate whether sarpogrelate reduces restenosis after coronary stenting as a result of prevention of intimal hyperplasia...
  11. ncbi request reprint Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes
    Yoshinori Yoshida
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circ J 74:156-62. 2010
    ..Spironolactone blocks the aldosterone system, which ameliorates heart failure in humans, but the precise molecular mechanisms of MR blockade are unclear...
  12. ncbi request reprint New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia
    Shyamal Chandra Bir
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 72:633-40. 2008
    ....
  13. ncbi request reprint Combined treatment with sustained-release basic fibroblast growth factor and heparin enhances neovascularization in hypercholesterolemic mouse hindlimb ischemia
    Yoshio Arai
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 71:412-7. 2007
    ..Whether the combined treatment with sustained-release basic fibroblast growth factor (bFGF) and heparin enhances neovascularization in hypercholesterolemic mouse hindlimb ischemia was investigated...
  14. ncbi request reprint Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats
    Xue Lin
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 73:2315-21. 2009
    ..The present study investigated whether administration of controlled release matrix metalloproteinase-1 (MMP-1) plasmid DNA prevents left ventricular (LV) remodeling in a rat chronic myocardial infarction (MI) model...
  15. ncbi request reprint Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia
    Xue Lin
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Circ J 71:132-7. 2007
    ..The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model...
  16. ncbi request reprint α1-Antitrypsin low-density-lipoprotein serves as a marker of smoking-specific oxidative stress
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Fushimi ku, Kyoto, Japan
    J Atheroscler Thromb 19:47-58. 2012
    ..Recently, two novel, oxidatively modified LDL markers, serum amyloid A-LDL (SAA-LDL) and α1-antitrypsin-LDL (AT-LDL), were identified; however, the significance of SAA-LDL and AT-LDL as cardiovascular risk markers is unknown...
  17. ncbi request reprint Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways
    Tatsuya Morimoto
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 72:1506-11. 2008
    ..The present study investigated the ubiquitin-dependent regulation of p53 by Dox and p300 in cardiac myocytes...
  18. ncbi request reprint Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts
    Tomohide Takaya
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    Circ J 74:723-9. 2010
    ..Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a multiple ligand receptor induced by oxidative stress. However, its role in chronic heart failure remains unknown...
  19. ncbi request reprint Combined treatment of sustained-release basic fibroblast growth factor and sarpogrelate enhances collateral blood flow effectively in rabbit hindlimb ischemia
    Keiichi Hirose
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Japan
    Circ J 70:1190-4. 2006
    ....
  20. pmc Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes
    Yoichi Sunagawa
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto, Japan
    J Biol Chem 285:9556-68. 2010
    ..These findings demonstrate that Cdk9 forms a functional complex with the p300/GATA4 and is required for p300/GATA4- transcriptional pathway during cardiomyocyte hypertrophy...
  21. ncbi request reprint Beneficial effect of candesartan treatment on cardiac autonomic nervous activity in patients with chronic heart failure: simultaneous recording of ambulatory electrocardiogram and posture
    Keiichi Tambara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cardiol 27:300-3. 2004
    ..Reclining in the right lateral decubitus position in chronic heart failure (CHF) is a self-protective mechanism for normalizing impaired cardiac autonomic nervous activity (CANA)...
  22. doi request reprint L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension
    Chika Ogura
    Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawaharacho, Shogoin, Sakyo ku, Kyoto606 8507, Japan
    Blood Press 21:367-71. 2012
    ..Antihypertensive monotherapy with efonidipine or cilnidipine attenuates cardiac sympathetic nerve activity more effectively than amlodipine monotherapy...
  23. ncbi request reprint A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats
    Yoichi Sunagawa
    Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Japan
    Circ J 75:2151-9. 2011
    ..However, it is unclear whether curcumin exhibits beneficial additive or synergistic effects on conventional therapy with angiotensin-converting enzyme inhibitors (ACEIs)...
  24. pmc The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    Tatsuya Morimoto
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    J Clin Invest 118:868-78. 2008
    ..From these results, we conclude that inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans...
  25. ncbi request reprint LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury
    Kazuaki Kataoka
    Department of Cardiovascular Medicine, Graduate School of Medicine Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 300:656-60. 2003
    ....
  26. ncbi request reprint Pericardial fluid level of heart-type cytoplasmic fatty acid-binding protein (H-FABP) is an indicator of severe myocardial ischemia
    Keiichi Tambara
    Department of Cardiovascular Surgery, Kyoto University, Kyoto, Japan
    Int J Cardiol 93:281-4. 2004
    ..Our hypothesis was that serum or pericardial fluid levels of H-FABP can reflect not only myocardial infarction but also myocardial ischemia...
  27. ncbi request reprint Difference in myocardial flow reserve between patients with dilated cardiomyopathy and those with dilated phase of hypertrophic cardiomyopathy: evaluation by 15O-water PET
    Muneo Ohba
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 71:884-90. 2007
    ..The purpose of this study was to assess the MFR of these 2 cardiomyopathies, using (15)O-water positron emission tomography (PET) to elucidate their differences...
  28. ncbi request reprint Shunt between the ventricular chamber and coronary arteries preserves left ventricular function in acute myocardial infarction
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, Japan
    Circ J 66:633-8. 2002
    ..Not only collateral circulation but also LV shunt contributes to the functional recovery of infarct myocardium in patients with AMI...
  29. ncbi request reprint Carvedilol reduces the severity of atherosclerosis in apolipoprotein E-deficient mice via reducing superoxide production
    Kana Shimada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Biol Med (Maywood) 237:1039-44. 2012
    ..The β-blocker treatment did not significantly modify the serum lipid profiles. Carvedilol may suppress atherosclerosis via reducing superoxide production, in addition to the hemodynamic modifications in this animal model...
  30. ncbi request reprint Circadian variation of cardiac autonomic nervous activity is well preserved in patients with mild to moderate chronic heart failure: effect of patient position
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cardiol 93:247-52. 2004
    ..We have demonstrated that CANA in CHF patients is largely affected by patient recumbent position...
  31. ncbi request reprint Effects of right lateral decubitus position on plasma norepinephrine and plasma atrial natriuretic peptide levels in patients with chronic congestive heart failure
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Kyoto, Japan
    Am J Cardiol 89:240-2. 2002
  32. doi request reprint Erythromycin treatment suppresses myocardial injury in autoimmune myocarditis in rats via suppression of superoxide production
    Emi Hirano
    Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cardiol 167:2228-33. 2013
    ..However, the effects of the drug upon inflammatory myocardial diseases are unknown. We tested the hypothesis that EM ameliorates experimental autoimmune myocarditis in rats attributing to the suppression of superoxide production...
  33. ncbi request reprint A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats
    Yoichi Sunagawa
    Human Health Sciences, Graduate School of Medicine, Kyoto University, Japan
    Biol Pharm Bull 35:139-44. 2012
    ..At the dosage of 0.5 mg/kg, DDS curcumin but not native curcumin restored left ventricular fractional shortening in post-myocardial infarction rats. Thus, our DDS strategy will be applicable to the clinical setting in humans...
  34. ncbi request reprint Intrinsic function of S100A8/A9 complex as an anti-inflammatory protein in liver injury induced by lipopolysaccharide in rats
    Masaki Ikemoto
    Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, 53 Kawaharacho, Shogoin, Kyoto 606 8507, Japan
    Clin Chim Acta 376:197-204. 2007
    ..We hypothesized that the S100A8/A9 complex is effective in the suppression of acute inflammatory changes...
  35. ncbi request reprint Myocardial metabolism of 123I-BMIPP under low-dose dobutamine infusion: implications for clinical SPECT imaging of ischemic heart disease
    Ryohei Hosokawa
    Department of Cardiovascular Medicine, and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Eur J Nucl Med Mol Imaging 32:75-83. 2005
    ..The purpose of this study was therefore to investigate the myocardial metabolism of 123I-BMIPP in the stunned myocardium under low-dose dobutamine infusion, and to elucidate the mechanism by which dobutamine improves BMIPP uptake...
  36. ncbi request reprint Improvement of oxygen metabolism in ischemic myocardium as a result of enhanced external counterpulsation with heparin pretreatment for patients with stable angina
    Daisuke Masuda
    Division of Cardiology, Jujo Hospital, Kyoto, Japan
    Heart Vessels 19:59-62. 2004
    ..05) from 0.038 +/- 0.004 to 0.053 +/- 0.007. In conclusion, EECP with heparin pretreatment appears to be a new treatment remedy for patients with stable angina...
  37. ncbi request reprint A case with transient increases in serum S100A8/A9 levels implying acute inflammatory responses after pancreatic islet transplantation
    Masaki Ikemoto
    Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Ann Clin Biochem 44:570-2. 2007
    ..Thus, the serial measurement of the serum S100A8/A9 complex concentration is useful for monitoring the patients with pancreatic islet transplantation...
  38. ncbi request reprint Effect of autogenic training on cardiac autonomic nervous activity in high-risk fire service workers for posttraumatic stress disorder
    Satoko Mitani
    Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Psychosom Res 60:439-44. 2006
    ....
  39. ncbi request reprint Impact of post-traumatic stress disorder and job-related stress on burnout: a study of fire service workers
    Satoko Mitani
    Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health, Kyoto, Japan
    J Emerg Med 31:7-11. 2006
    ..Countermeasures, not only against job stress, but also against PTSD-related stress, are essential to prevent burnout. Social support and the development of human relationships in the work place are crucial in mitigating burnout...
  40. ncbi request reprint Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries
    Atsushi Iwakura
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Thorac Cardiovasc Surg 126:1113-20. 2003
    ..The aim of this study was to evaluate the effects of this therapeutic modality on sternal healing in a large-animal model before performing a clinical trial...
  41. doi request reprint Therapy with granulocyte colony-stimulating factor in the chronic stage, but not in the acute stage, improves experimental autoimmune myocarditis in rats via nitric oxide
    Kana Shimada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Mol Cell Cardiol 49:469-81. 2010
    ..G-CSF therapy improved cardiac function via NO system in a rat model of myocarditis in the chronic stage, but not in the acute stage, possibly through the myocardial regeneration and acceleration of healing process...
  42. ncbi request reprint Repeated implantation is a more effective cell delivery method in skeletal myoblast transplantation for rat myocardial infarction
    Goditha U Premaratne
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Circ J 70:1184-9. 2006
    ..It remains unclear whether repeated skeletal myoblast implantation is a feasible and effective cell delivery method for the infarcted myocardium...
  43. ncbi request reprint Right lateral decubitus position reduces QT dispersion in patients with chronic heart failure
    Satoko Sakamoto
    School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Electrocardiol 37:201-6. 2004
    ..05 vs. R). In conclusion, reclining in R reduces the prolonged QT dispersion in CHF patients...
  44. pmc Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    PLoS ONE 6:e29351. 2011
    ..In conclusion, these findings demonstrate that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis...
  45. ncbi request reprint Effects of endothelin-1 on mitochondrial function during the protection against myocardial cell apoptosis
    Eri Iwai-Kanai
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 305:898-903. 2003
    ..These data suggest that endothelin-1 does not target the mitochondrial respiratory chain, but rather stabilizes the mitochondrial membrane during the protection against apoptosis...
  46. ncbi request reprint Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model
    Atsushi Iwakura
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Heart Vessels 18:93-9. 2003
    ..In conclusion, intramyocardial injection of bFGF-impregnated gelatin hydrogels induces functionally significant angiogenesis and improves left ventricular systolic and diastolic function in the infarcted myocardium of rats...
  47. ncbi request reprint Circadian variation of cardiac autonomic nervous profile is affected in Japanese ambulance men with a working system of 24-h shifts
    Satoko Mitani
    Department of Health Promotion and Human Behavior, Graduate School of Public Health, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    Int Arch Occup Environ Health 79:27-32. 2006
    ....
  48. doi request reprint Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training in experimental atherosclerosis
    Kana Shimada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Int J Cardiol 151:284-9. 2011
    ..We assessed the hypothesis whether behavioral stress may affect the development of atherosclerosis and whether regular exercise training may influence the composition of atherosclerotic plaques in apolipoprotein (apo) E-deficient mice...
  49. doi request reprint Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Atherosclerosis 208:512-7. 2010
    ..However, the balance between circulating levels of VEGF and its soluble receptors, which may reflect and/or affect cardiovascular VEGF signaling, in subjects with MetS is unknown...
  50. doi request reprint Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Heart Vessels 25:45-50. 2010
    ..In conclusion, diastolic abnormalities without LVH can be detected in Japanese patients with IGT or mild diabetes. The E/A ratio decreases in association with abdominal fat accumulation...
  51. ncbi request reprint Development of enzyme-linked immunosorbent assay for acidic fibroblast growth factor and its clinical application
    M Ikemoto
    College of Medical Technology, Kyoto University, Japan
    Clin Chim Acta 283:171-82. 1999
    ..Therefore, our ELISA system may be useful in determining unknown biological function(s) or pathological role(s) of aFGF in various disease entities...
  52. ncbi request reprint Nucleic acid-binding properties and subcellular localization of the 3a protein of brome mosaic bromovirus
    M Fujita
    Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Japan
    J Gen Virol 79:1273-80. 1998
    ..Immunogold labelling of thin sections of infected barley tissues revealed that B3a was associated with plasmodesmata and cytoplasmic inclusions...
  53. ncbi request reprint Xylan deposition on secondary wall of Fagus crenata fiber
    T Awano
    Laboratory of Plant Cell Structure, Division of Forest and Biomaterials Science, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    Protoplasma 219:106-15. 2002
    ..Successive deposition of xylan onto the cell wall increases the microfibril diameter. The large amounts of xylan that accumulated on microfibrils appear globular but are covered with lignin after they are deposited...
  54. ncbi request reprint Target preparation by the precipitation method for nuclear reactions
    K Takamiya
    Research Reactor Institute, Kyoto University, Sennan gun, Osaka 590 0494, Japan
    Appl Radiat Isot 65:32-5. 2007
    ..The preparation procedure is convenient and the method is appropriate for several target materials, including not only precious materials but also radioactive materials with low contamination...
  55. ncbi request reprint Sustained-release vancomycin sheet may help to prevent prosthetic graft methicillin-resistant Staphylococcus aureus infection
    Keiichi Hirose
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Vasc Surg 44:377-82. 2006
    ..The purpose of this study was to evaluate the effectiveness of a sustained-release sheet with vancomycin (VCM) to prevent prosthetic graft infection...
  56. doi request reprint Determinants of brachial-ankle pulse wave velocity in a Japanese population: a cohort study
    Satoko Mitani
    Unit for Liveable Cities, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Blood Press 21:338-44. 2012
    ..Multivariate linear regression analysis showed that factors of such as FRS, body mass index, alcohol consumption and AI P75 were significantly correlated with baPWV...
  57. ncbi request reprint Basic fibroblast growth factor protects cardiac myocytes from iNOS-mediated apoptosis
    Eri Iwai-Kanai
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawara cho, Shogoin Sakyo ku, Kyoto 606 8507, Japan
    J Cell Physiol 190:54-62. 2002
    ..The results also suggest that bFGF is a protective factor against myocardial cell apoptosis and that this protection requires the MEK-1-ERK pathway...
  58. ncbi request reprint Elevation of matrix metalloproteinase-2 level in pericardial fluid is closely associated with left ventricular remodeling
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, College of Medical Technology, Kyoto University, Kyoto, Japan
    Am J Cardiol 89:102-5. 2002
  59. ncbi request reprint New ELISA system for myeloid-related protein complex (MRP8/14) and its clinical significance as a sensitive marker for inflammatory responses associated with transplant rejection
    Masaki Ikemoto
    College of Medical Technology, Kyoto University, Japan
    Clin Chem 49:594-600. 2003
    ..The aim of this study was to develop a sensitive and specific method for detecting inflammatory responses associated with transplant rejection...
  60. ncbi request reprint Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable angina; evaluation by(13)N-ammonia positron emission tomography
    D Masuda
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Eur Heart J 22:1451-8. 2001
    ..These results suggest that one of the enhanced external counterpulsation mechanisms is development and recruitment of collateral vessels...
  61. doi request reprint Endothelial function progressively deteriorates during normal pregnancy
    Kohei Fujita
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Hypertens Pregnancy 32:129-38. 2013
    ..To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels...
  62. doi request reprint Alterations of circulating endothelial cell and endothelial progenitor cell counts around the ovulation
    Sunao Tanaka
    Department of Surgery Breast Surgery, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 97:4182-92. 2012
    ....
  63. ncbi request reprint Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway
    A Iwakura
    Department of Cardiovascular Surgery, Kyoto University, 53 Kawahara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
    J Mol Cell Cardiol 33:419-30. 2001
    ..A possible application of SB 203580 to preserve cardiac function in patients with ischemic heart disease should be discussed...
  64. ncbi request reprint Effects of exercise training on myocardial fatty acid metabolism in rats with depressed cardiac function induced by transient ischemia
    L Chen
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Jpn Circ J 65:550-5. 2001
    ..01 ml/beat, p<0.05) and adaptive cardiac hypertrophy. These findings demonstrate that adaptive improvements in myocardial perfusion, fatty-acid metabolism and LV function were induced by exercise training after transient ischemia...
  65. ncbi request reprint Myocardial metabolism of 123I-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and 18F-FDG
    R Hosokawa
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyoku, Kyoto City, 606-8507 Japan
    Eur J Nucl Med 28:1630-9. 2001
    ....
  66. doi request reprint Shunt flow of arteriovenous fistulas from plantar artery
    Y Yoshida
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Phlebology 26:32-4. 2011
    ..The purpose of this study was to visualize the shunt flow of arteriovenous fistulas (AVFs) passing towards the top side of the foot from the plantar artery...
  67. ncbi request reprint Myocardial lipid metabolism in compensated and advanced stages of heart failure: evaluation by canine pacing model with BMIPP
    K Kataoka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    J Nucl Med 42:124-9. 2001
    ..Therefore, as assessed by BMIPP, the myocardial lipid metabolism is related to the pathophysiology of the development and worsening of heart failure...
  68. ncbi request reprint Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT
    T Hirai
    Department of Cardiovascular Medicine, Graduate School of Medicine, and Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    J Nucl Cardiol 8:472-81. 2001
    ..Ten percent to 20% of it is metabolized through alpha-oxidation after beta-oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified...
  69. ncbi request reprint Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension
    T Yoneda
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo, Japan
    Life Sci 70:143-57. 2001
    ..Our findings support the role of SR proteins as the primary determinant of the contractile dysfunction that occurs during the heart-failure transition; however, post-translational modulators of these SR elements may also be critical...
  70. pmc Increased pericardial fluid concentrations of the mature form of adrenomedullin in patients with cardiac remodelling
    K Tambara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Heart 87:242-6. 2002
    ..There is evidence that adrenomedullin has autocrine or paracrine activities that oppose cardiac remodelling. However, it remains unclear whether it exerts those local functions in heart failure patients...
  71. ncbi request reprint Gelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats
    A Iwakura
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 104:I325-9. 2001
    ..05). Bone mineral density of the sternum was similar between the 2 groups. CONCLUSIONS: A gelatin sheet that incorporates bFGF may offset sternal ischemia and accelerate sternal bone regeneration and healing, even in diabetic patients...
  72. ncbi request reprint Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B
    M Otsuka
    Institute for Chemical Research, Kyoto University, Japan
    J Med Chem 38:3264-70. 1995
    ..Thus, it became possible to inhibit either one of the two kappa B site-binding proteins without inhibiting the other.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. ncbi request reprint Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension
    Bonpei Takase
    National Defense Medical College, Tokorozawa, Japan
    Circ J 72:764-9. 2008
    ..The aim of the study was to evaluate whether the combined treatment of calcium channel blocker, amlodipine and beta-blocker, betaxolol, favorably affects cardiac autonomic nervous activity (CANA) and health-related quality of life (HRQL)...
  74. ncbi request reprint Effectiveness of a novel serotonin blocker, sarpogrelate, for patients with angina pectoris
    Toru Kinugawa
    Division of Cardiology, First Department of Internal Medicine, Tottori University, Tottori, Japan
    Am Heart J 144:E1. 2002
    ..The aim of the current study was to investigate the effectiveness of 2-week treatment with sarpogrelate on anginal symptoms and exercise capacity in anginal patients...
  75. ncbi request reprint Prognostic significance of exercise plasma noradrenaline levels for cardiac death in patients with mild heart failure
    Toru Kinugawa
    The Division of Cardiology, The 1st Department of Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Circ J 66:261-6. 2002
    ....
  76. pmc Reactivation of lytic replication from B cells latently infected with Epstein-Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication
    Ayumi Kudoh
    Division of Virology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 77:851-61. 2003
    ..Such cellular conditions appear to especially favor viral lytic replication...
  77. ncbi request reprint Recent insights into the mechanisms, predisposing factors, and racial differences of coronary vasospasm
    Kunihisa Miwa
    Division of Medicine, Hamamatsu Rosai Hospital, 25 Shogen cho, Hamamatsu, Shizuoka 430 8525, Japan
    Heart Vessels 20:1-7. 2005
    ..Predisposing factors include smoking, lipid metabolic disorders, and gene expression, all of which may be interrelated issues...
  78. ncbi request reprint Cough reflex by ventricular premature contractions
    Akio Niimi
    Division of Respiratory Medicine, Kyoto University Hospital, Japan
    Int Heart J 46:923-6. 2005
    ..Premature contractions should be considered as a possible cause of chronic dry cough in the clinical setting...
  79. ncbi request reprint Multislice computed tomography accurately quantifies left atrial size and function after the MAZE procedure
    Kazuo Yamanaka
    Division of Cardiovascular Surgery, Takeda Hospital, Japan
    Circulation 114:I5-9. 2006
    ..We hypothesized that LA size and mechanical function in patients with chronic AF and mitral valvular disease are well restored after MAZE...
  80. pmc Regulation of Notch1 gene expression by p53 in epithelial cells
    Takashi Yugawa
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 27:3732-42. 2007
    ....
  81. ncbi request reprint Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Circ J 71:1545-50. 2007
    ..The expression of MRP8/14 in patients with cardiac sarcoidosis and idiopathic dilated cardiomyopathy (DCM) was investigated...
  82. ncbi request reprint Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochim Biophys Acta 1780:203-13. 2008
    ..The application of inhibitors for the formation of Cdt1-geminin complex is discussed...
  83. doi request reprint Statins activate GATA-6 and induce differentiated vascular smooth muscle cells
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Biochem Biophys Res Commun 374:731-6. 2008
    ..These findings suggest that statins activate GATA-6 and induce differentiated VSMCs...