H Endou

Summary

Affiliation: Kyorin University
Country: Japan

Publications

  1. doi request reprint Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181 8611 Tokyo, Japan
    J Biol Chem 283:26834-8. 2008
  2. ncbi request reprint Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices
    Chutima Srimaroeng
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Pharm Res 22:858-66. 2005
  3. ncbi request reprint Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1
    Kyu Yong Jung
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    Life Sci 70:1861-74. 2002
  4. doi request reprint Urate transport across the apical membrane of renal proximal tubules
    Hitoshi Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 27:578-84. 2008
  5. ncbi request reprint [Identification of a novel urate transporter URAT1 and current status on urate research]
    Hitoshi Endou
    Tanpakushitsu Kakusan Koso 48:18-25. 2003
  6. ncbi request reprint Renal urate handling: clinical relevance of recent advances
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Curr Rheumatol Rep 7:227-34. 2005
  7. ncbi request reprint Recent advances in molecular mechanisms of nephrotoxicity
    H Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Toxicol Lett 102:29-33. 1998
  8. ncbi request reprint Transport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:20787-93. 2000
  9. ncbi request reprint Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
    O Yanagida
    Second Department of Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Biochim Biophys Acta 1514:291-302. 2001
  10. ncbi request reprint Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells
    J Y Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Biochim Biophys Acta 1512:335-44. 2001

Collaborators

Detail Information

Publications98

  1. doi request reprint Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181 8611 Tokyo, Japan
    J Biol Chem 283:26834-8. 2008
    ....
  2. ncbi request reprint Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices
    Chutima Srimaroeng
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Pharm Res 22:858-66. 2005
    ..The current study examined the direct interactions of stevioside and steviol with specific organic anion transporters...
  3. ncbi request reprint Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1
    Kyu Yong Jung
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    Life Sci 70:1861-74. 2002
    ..48 to 1.32 mM, respectively. These results suggest that rOAT3, at least in part, mediates CER uptake and CER-induced nephrotoxicity as rOAT1. There was some difference of affinity between rOAT3 and rOAT1 for cephalosporin antibiotics...
  4. doi request reprint Urate transport across the apical membrane of renal proximal tubules
    Hitoshi Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 27:578-84. 2008
    ..Elucidation of urate transportsome will lead to the new drug development for hyperuricemia...
  5. ncbi request reprint [Identification of a novel urate transporter URAT1 and current status on urate research]
    Hitoshi Endou
    Tanpakushitsu Kakusan Koso 48:18-25. 2003
  6. ncbi request reprint Renal urate handling: clinical relevance of recent advances
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Curr Rheumatol Rep 7:227-34. 2005
    ..URAT1 is targeted by uricosuric and antiuricosuric agents that affect urate excretion. Molecular identification of urate transporting proteins will lead to the new drug development for hyperuricemia...
  7. ncbi request reprint Recent advances in molecular mechanisms of nephrotoxicity
    H Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Toxicol Lett 102:29-33. 1998
    ....
  8. ncbi request reprint Transport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:20787-93. 2000
    ..We further demonstrate that ry(+)LAT1, due to its peculiar cation dependence, mediates a heteroexchange, wherein the influx of substrate amino acids is accompanied by the efflux of basic amino acids...
  9. ncbi request reprint Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
    O Yanagida
    Second Department of Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Biochim Biophys Acta 1514:291-302. 2001
    ..The properties of the hLAT1/h4F2hc complex would support the roles of this transporter in providing cells with essential amino acids for cell growth and cellular responses, and in distributing amino acid-related compounds...
  10. ncbi request reprint Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells
    J Y Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Biochim Biophys Acta 1512:335-44. 2001
    ..Because of this highly regulated nature, xCT in glial cells would fulfill the task to protect neurons against oxidative stress by providing suitable amount of cystine to produce glutathione...
  11. ncbi request reprint Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids
    Y Fukasawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:9690-8. 2000
    ..The functional properties of Asc-1 seem to be consistent with those of a transporter subserving the Na(+)-independent small neutral amino acid transport system asc...
  12. ncbi request reprint Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
    D K Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 276:17221-8. 2001
    ....
  13. ncbi request reprint Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 56:2128-36. 1999
    ..Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity...
  14. ncbi request reprint Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain
    A Chairoungdua
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 276:49390-9. 2001
    ..The finding of Asc-2 would lead to the establishment of a new subgroup of heterodimeric amino acid transporter family which includes transporters associated not with 4F2hc or rBAT but with other unknown heavy chains...
  15. ncbi request reprint Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity
    H Segawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 274:19745-51. 1999
    ....
  16. ncbi request reprint The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Pharmacol Exp Ther 290:672-7. 1999
    ..Furthermore, the culture cell system expressing OAT1 was revealed to be useful for the prediction of the nephrotoxicity of beta-lactam antibiotics...
  17. ncbi request reprint Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    S H Cha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, 113 0033, Japan
    J Biol Chem 275:4507-12. 2000
    ..OAT4 is the first member of the multispecific organic anion transporter family, which is expressed abundantly in the placenta. OAT4 might be responsible for the elimination and detoxification of harmful anionic substances from the fetus...
  18. ncbi request reprint Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
    S H Cha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    Mol Pharmacol 59:1277-86. 2001
    ..3 by fluorescent in situ hybridization analysis. These results suggest an important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney...
  19. ncbi request reprint Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity
    J Nakauchi
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Neurosci Lett 287:231-5. 2000
    ....
  20. ncbi request reprint Human cystinuria-related transporter: localization and functional characterization
    K Mizoguchi
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Kidney Int 59:1821-33. 2001
    ..Although the mutations of the recently identified transporter BAT1/b(0,+)AT have been related to nontype I cystinuria, the function and localization of human BAT1 (hBAT1)/b(0,+)AT have not been well characterized...
  21. ncbi request reprint Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Mitaka, Japan
    Biochem Biophys Res Commun 251:586-91. 1998
    ..No CT1 expression was detected in the heart, spleen, or lung. The present study provides the molecular basis of carnitine transport in the body...
  22. ncbi request reprint Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells
    N Morita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 298:1179-84. 2001
    ..The present study shows that rOat2 is a multispecific transporter and suggests that it may be involved at least partly, in the hepatic uptake of IDM, salicylate and nucleoside derivatives...
  23. ncbi request reprint A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter
    Y Shigeta
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    Kidney Int 69:1198-206. 2006
    ..The results of the present study contribute toward understanding the distribution and frequency of cystinuria-related mutations of SLC7A9...
  24. ncbi request reprint Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein
    A Chairoungdua
    Department of Pharmacology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, USA
    J Biol Chem 274:28845-8. 1999
    ..The results from the present investigation were used to establish a family of amino acid transporters associated with type II membrane glycoproteins...
  25. ncbi request reprint Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 273:23629-32. 1998
    ..The cloning of LAT1 is expected to facilitate the research on the protein-protein interaction in the transporter field and to provide a clue to the search for still unidentified transporters...
  26. ncbi request reprint Tissue specific variants of glutamate transporter GLT-1
    N Utsunomiya-Tate
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    FEBS Lett 416:312-6. 1997
    ..These results suggest the tissue specific alternative splicing at 5'-ends of GLT-1 messages and the interesting association of spliced variants with different C-termini...
  27. ncbi request reprint Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    M Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Am J Physiol 276:F122-8. 1999
    ..1 by fluorescent in situ hybridization analysis. These results indicate that hOAT1 is a multispecific organic anion transporter on the basolateral membrane of the proximal tubule in human kidney...
  28. ncbi request reprint Expression of a system L neutral amino acid transporter at the blood-brain barrier
    H Matsuo
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo Japan
    Neuroreport 11:3507-11. 2000
    ..LAT1 is, thus, a blood-brain barrier system L transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA...
  29. ncbi request reprint Mouse Asc-1 (asc-type amino acid transporter 1) maps to chromosome 7, region B1-B5
    H Matsuo
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo
    Chromosome Res 8:456. 2000
  30. ncbi request reprint Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier
    D Sugiyama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 298:316-22. 2001
    ..Taking the selectivity of these inhibitors into consideration, the maximum contribution made by the Oatp2 and Oat family to the total efflux of E(2)17betaG from the brain appears to be about 40 and 20%, respectively...
  31. ncbi request reprint Expression cloning and characterization of a novel multispecific organic anion transporter
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 272:18526-9. 1997
    ..Isolation of OAT1 will facilitate elucidation of the molecular basis of drug kinetics and the development of new drugs lacking unwanted side effects...
  32. ncbi request reprint Characterization of ochratoxin A transport by human organic anion transporters
    K Y Jung
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Life Sci 69:2123-35. 2001
    ..These pharmacological characteristics of hOAT1 and hOAT3 may be significantly related with the events in the development of OTA-induced nephrotoxicity in the human kidney...
  33. ncbi request reprint Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    T Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, Mitaka, Tokyo, Japan
    FEBS Lett 429:179-82. 1998
    ..14C]Salicylate uptake via NLT was saturable (Km = 88.8 +/- 23.4 microM) and sodium-independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver >> kidney). We propose that NLT be renamed OAT2...
  34. ncbi request reprint Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Eur J Pharmacol 419:113-20. 2001
    ..In contrast, KW-3902 did not exert the effects of significance, whereas KW-3902 was the most potent...
  35. ncbi request reprint The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity
    R Noshiro
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Kidney Int 70:275-82. 2006
    ..These results indicate that the PEPT2-PDZK1 interaction thus plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the human kidney...
  36. ncbi request reprint [Amino acid transporter molecule as a drug target]
    H Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Yakurigaku Zasshi 114:11P-16P. 1999
    ..In addition, BCH also suppressed strongly T24 carcinoma cell growth. Moreover, LAT1 transports amino acid mimetic drugs. Thus, these results indicate that amino acid transporter molecule such as LAT1 can be a drug target...
  37. pmc Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis
    T Usui
    Department of Ophthalmology, Faculty of Medicine, Tokyo University, Bunkyo-ku, Tokyo, Japan
    J Clin Invest 108:107-15. 2001
    ..These results indicate that the normal transport activity of NBC-1 is indispensable not only for the maintenance of corneal and lenticular transparency but also for the regulation of aqueous humor outflow...
  38. ncbi request reprint Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Curr Drug Metab 2:339-54. 2001
    ....
  39. ncbi request reprint Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cells
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Biochem Mol Biol Int 42:113-21. 1997
    ..In conclusion, TXA2 appears to mediate cisplatin-induced apoptosis of S3 cells by inducing an increase in the level of c-fos mRNA expression...
  40. doi request reprint Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule
    P Jutabha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, 181 8611, Japan
    Nucleosides Nucleotides Nucleic Acids 30:1302-11. 2011
    ..Thus, we propose that hNPT4 is an important transepithelial proximal tubular transporter that transports diuretic drugs and operates functionally with basolateral organic anion transporters 1/3 (OAT1/OAT3)...
  41. ncbi request reprint [Micromethods for the determination of metabolic characteristics in individual nephron segments]
    H Endou
    Dept of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Yakurigaku Zasshi 103:11-7. 1994
    ..As an example of the modern techniques, microscopic fluorometry using Fura-2AM has been established to identify agonist-induced cytosolic free calcium transients...
  42. ncbi request reprint Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter
    N Utsunomiya-Tate
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 271:14883-90. 1996
    ....
  43. ncbi request reprint Molecular physiology of urate transport
    Matthias A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiology (Bethesda) 20:125-33. 2005
    ..The recently identified human urate transporters URAT1, MRP4, OAT1, and OAT3 are thought to play central roles in homeostasis and may prove interesting targets for future drug development...
  44. ncbi request reprint Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    J Pharmacol Exp Ther 315:534-44. 2005
    ....
  45. ncbi request reprint A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout
    Atsuo Taniguchi
    Tokyo Women s Medical University, Japan
    Arthritis Rheum 52:2576-7. 2005
  46. ncbi request reprint Integrated physiology of proximal tubular organic anion transport
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Japan
    Curr Opin Nephrol Hypertens 14:472-9. 2005
    ..This review focuses on the interpretation of the physiological integration of identified transport molecules in the renal proximal tubules...
  47. ncbi request reprint A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
    Harunobu Tahara
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Pharmacol Exp Ther 315:337-45. 2005
    ....
  48. ncbi request reprint Differential gene expression of organic anion transporters in male and female rats
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 290:482-7. 2002
    ..Our results provide information on the differential gene expression of OAT isoforms with sex hormone dependency...
  49. ncbi request reprint Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
    Sun Young Park
    Department of Pediatrics, Kwangju Christian Hospital, Gwangju 503 715, Korea
    Arch Pharm Res 28:421-32. 2005
    ....
  50. ncbi request reprint Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Pharmacol Exp Ther 300:746-53. 2002
    ..These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively...
  51. ncbi request reprint Nephrin and podocin expression around the onset of puromycin aminonucleoside nephrosis
    Makoto Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 97:234-41. 2005
    ..However, the first change induced by PA was the change of podocin localization from a linear pattern to a dot-like one prior to the onset of albuminuria...
  52. ncbi request reprint Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia
    Naoki Wakida
    Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
    J Clin Endocrinol Metab 90:2169-74. 2005
    ..Future studies are needed to identify a responsible gene for the postsecretory reabsorption defect-type familial renal hypouricemia...
  53. ncbi request reprint Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane
    Yukino Nishibori
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Kidney Int 66:1755-65. 2004
    ..In order to study a potential pathomechanism of massive proteinuria in patients with SRN, we have investigated the trafficking and subcellular localization of five common disease-causing missense mutants of human podocin...
  54. ncbi request reprint A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese
    Naoharu Iwai
    National Cardiovascular Center, Suita, Osaka, Japan
    Kidney Int 66:935-44. 2004
    ..Recently, SLC22A12 has been identified as a urate-anion exchanger in the human kidney...
  55. ncbi request reprint Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    Am J Nephrol 25:425-33. 2005
    ..The mechanism by which uric acid enters the VSMC is not known. We hypothesized that uric acid enters via transporters similar to that observed in the kidney...
  56. ncbi request reprint Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    Clin Exp Nephrol 9:195-205. 2005
    ..In this review, we introduce and discuss some novel aspects of OATs, with special emphasis on URAT1, in the context of their biological significance, functional regulation, and roles in human disease...
  57. doi request reprint Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct
    Hirokazu Yokoyama
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Cell Physiol Biochem 21:269-78. 2008
    ..Molecular identification of Oat8 in these cells indicates a possible novel role of OAT family in the renal secretion/reabsorption of OA and acids and bases via affecting the V-ATPase-dependent functions...
  58. doi request reprint Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid
    Hatsuki Nakagawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Basic Clin Pharmacol Toxicol 103:1-8. 2008
    ..Collectively, the difference between the perfluorooctanoic acid half-lives in human beings and rats is not likely to be attributable to differences in the affinities of these transporters for perfluorooctanoic acid...
  59. ncbi request reprint Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    J Am Soc Nephrol 18:1419-25. 2007
    ..These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters...
  60. ncbi request reprint L-type amino acid transporter-1 expressed in human astrocytomas, U343MGa
    Shinji Asano
    Department of Molecular Physiology, College of Information Science and Engineering, Ritsumeikan University, 1 1 1 Noji higashi, Kusatsu, Shiga 525 8577, Japan
    Biol Pharm Bull 30:415-22. 2007
    ....
  61. pmc Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation
    Daisuke Fukuhara
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Am J Pathol 170:888-98. 2007
    ....
  62. ncbi request reprint New insights into renal transport of urate
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka shi, Tokyo, Japan
    Curr Opin Rheumatol 19:151-7. 2007
    ..This review focuses on recent progress in the understanding of various aspects of renal transport of urate...
  63. ncbi request reprint Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway
    Sirinun Nilwarangkoon
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Pharmacol Sci 103:48-55. 2007
    ....
  64. ncbi request reprint Human vascular smooth muscle cells express a urate transporter
    Karen L Price
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 17:1791-5. 2006
    ..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease...
  65. ncbi request reprint Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics
    Suparat Khamdang
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka Tokyo 181, Japan
    Eur J Pharmacol 465:1-7. 2003
    ..The interaction of human-OAT2 with cephalosporins was the weakest among the basolateral human-OATs tested. In addition, it is suggested that human-OATs mediate cephaloridine-induced nephrotoxicity...
  66. ncbi request reprint Molecular physiology of renal organic anion transporters
    Takashi Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Am J Physiol Renal Physiol 290:F251-61. 2006
    ..We will also discuss the physiological roles of each organic anion transporter in the light of the transepithelial transport of organic anions in the kidneys...
  67. ncbi request reprint Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins
    Hiroki Miyazaki
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    J Am Soc Nephrol 16:3498-506. 2005
    ....
  68. ncbi request reprint The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    J Biol Chem 279:45942-50. 2004
    ..Taken together, the present study indicates the novel role of PDZK1 in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules...
  69. ncbi request reprint The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules
    Tomoki Imaoka
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Am Soc Nephrol 15:2012-22. 2004
    ..In addition to the kidney, mouse RST was detected in the brain capillaries and the choroid plexus, and it may also play a role in efflux transport of organic anions across the barriers of the central nervous system...
  70. ncbi request reprint Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes
    Masato Okubo
    Department of Therapeutics, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo, 105 8512, Japan
    Toxicol Appl Pharmacol 187:162-7. 2003
    ..1 microM Cd(2+) by human Nramp2 was inhibited by metallothionein (IC50 = 0.14 microM). Therefore, human Nramp2 is suggested to function as a pH-dependent cadmium absorption transporter on the luminal membrane of human intestinal cells...
  71. ncbi request reprint Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 305:1087-97. 2003
    ..These results suggest that the renal uptake of 2,4-D is mainly accounted for by rOat1 and the uptake of PCG and DHEAS by rOat3, and rOat3 is partly involved in the renal uptake of temocaprilat and estrone sulfate...
  72. ncbi request reprint Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
    Michio Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 300:918-24. 2002
    ..In addition, L-valyl ester appears to be important in differential substrate recognition between hOAT1 and hOAT3. hOAT1 may not be the molecule responsible for the drug interaction between ACV and probenecid...
  73. ncbi request reprint Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
    Hiroaki Kimura
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikeikai University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 301:293-8. 2002
    ....
  74. ncbi request reprint Isoform selectivity of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters
    Naoto Shikano
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan
    J Nucl Med 44:244-6. 2003
    ..We examined the isoform selectivity of (125)I-IMT transport of the 2 human L-type amino acid transporters, hLAT1 and hLAT2, with human 4F2hc-coexpressed Xenopus laevis oocytes...
  75. ncbi request reprint Urate transport via human PAH transporter hOAT1 and its gene structure
    Kimiyoshi Ichida
    Department of Internal Medicine, Jikei University School of Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 63:143-55. 2003
    ..Whether urate is transported by the PAH transporter in humans remains unclear. Familial juvenile gouty nephropathy (FJGN) is thought to develop as a result of an abnormality in the urate transporter...
  76. ncbi request reprint Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells
    Do Kyung Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Mitaka, Japan
    Biochim Biophys Acta 1565:112-21. 2002
    ..T24 cell is, therefore, proposed to be an excellent tool to examine the interaction of chemical compounds with LAT1...
  77. ncbi request reprint Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity
    Atsushi Enomoto
    Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 13:1711-20. 2002
    ..These results suggest that rOAT1 and rOAT3 play an important role in the transcellular transport of IS and the induction of its nephrotoxicity...
  78. ncbi request reprint Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University, School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 277:36262-71. 2002
    ..The identification of CT2 represents an interesting evolutionary link between OCT/OCTNs and OATs, as well as provides us with an important insight into the maturation of human spermatozoa...
  79. ncbi request reprint Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment
    Ken ichi Hosoya
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Exp Ther 302:225-31. 2002
    ..L-Cystine transport via system x(c)(-) at the BBB is likely to be induced under oxidative stress conditions following DEM treatment due to enhanced transcription of the xCT gene...
  80. ncbi request reprint Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution...
  81. ncbi request reprint Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    Atsushi Enomoto
    Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Pharmacol Exp Ther 301:797-802. 2002
    ..Comparing the K(i) values with the therapeutically relevant concentrations of unbound inhibitors in the plasma, probenecid alone was predicted to inhibit hOAT4-mediated organic anion transport in vivo...
  82. ncbi request reprint Interaction of human organic anion transporters with various cephalosporin antibiotics
    Michio Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Mitaka shi, Japan
    Eur J Pharmacol 438:137-42. 2002
    ....
  83. ncbi request reprint Interactions of human organic anion as well as cation transporters with indoxyl sulfate
    Atsushi Enomoto
    Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Eur J Pharmacol 466:13-20. 2003
    ..In addition, it was suggested that human-OAT1 and human-OAT3 are involved in the urinary excretion of indoxyl sulfate, the exacerbation of renal dysfunction and the induction of uremic encephalopathy by indoxyl sulfate...
  84. ncbi request reprint Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule
    Promsuk Jutabha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    J Biol Chem 278:27930-8. 2003
    ..Therefore, it is proposed that OATV1 plays an important role to excrete drugs, xenobiotics, and their metabolites driven by membrane voltage through the apical membrane of the tubular epithelial cells into the urine...
  85. ncbi request reprint Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis
    Jun Inatomi
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 112 8688, Tokyo, Japan
    Pflugers Arch 448:438-44. 2004
    ..Our results expand the spectrum of kNBC1 mutations in permanent isolated pRTA with ocular abnormalities and increase our understanding of the renal tubular mechanism that is essential for acid-base homeostasis...
  86. ncbi request reprint The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
    Fusako Komoda
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pediatr Nephrol 19:728-33. 2004
    ..The present study demonstrates that homozygous W258X mutation is the predominant genetic cause of idiopathic renal hypouricemia in Japanese patients...
  87. ncbi request reprint [Molecular biology of urate transporter]
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Seikagaku 76:101-10. 2004
  88. ncbi request reprint Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
    Marija Ljubojevic
    Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, HR 10001 Zagreb, Croatia
    Am J Physiol Renal Physiol 287:F124-38. 2004
    ....
  89. ncbi request reprint Function and localization of urate transporter 1 in mouse kidney
    Makoto Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:261-8. 2004
    ..RST mRNA and protein levels were higher in male kidneys than female. RST transported urate similar to hURAT1 and, therefore, appears to be mURAT1-the mouse homologue of hURAT1...
  90. ncbi request reprint Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier
    Yoshitane Nozaki
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku Tokyo, 13 0033 Japan
    J Pharmacol Exp Ther 309:226-34. 2004
    ..These results suggest that the renal uptake of MTX is not so greatly affected by NSAIDs as expected from the inhibition of rOat3-mediated transport...
  91. ncbi request reprint Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B
    Christoph Boehmer
    Department of Physiology I, University of Tubingen, Tubingen D 72076, Germany
    Biochem Biophys Res Commun 313:998-1003. 2004
    ..The action of the kinases and NHERF-2 may link urinary citrate excretion to proximal tubular H(+) secretion...
  92. ncbi request reprint Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions
    Takeshi Sakata
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Biochem Biophys Res Commun 313:789-93. 2004
    ..This study suggests that the newly found OCT1 variants will contribute to inter-individual variations leading to the differences in cationic drug disposition and perhaps certain disease processes...
  93. ncbi request reprint Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:164-73. 2004
    ..The findings indicate that SLC22A12 was responsible for most renal hypouricemia and that URAT1 is the primary reabsorptive urate transporter, targeted by pyrazinamide, benzbromarone, and probenecid in vivo...
  94. ncbi request reprint Two male siblings with hereditary renal hypouricemia and exercise-induced ARF
    Motoko Tanaka
    Department of Nephrology, Akebono Clinic, Kumamoto, Japan
    Am J Kidney Dis 42:1287-92. 2003
    ..This is the first report of the 2 male siblings of familial renal hypouricemia complicated with exercise-induced ARF, with definite demonstration of genetic abnormality in the responsible gene (URAT1)...
  95. ncbi request reprint [Urate transporter and renal hypouricemia]
    Atsushi Enomoto
    Nagoya University Hospital, Department of Clinical Preventive Medicine, Nagoya 466 8560
    Rinsho Byori 51:892-7. 2003
    ..Moreover, we demonstrated that patients with renal hypouricemia have mutational defects in SLC22A12...
  96. ncbi request reprint Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 278:43838-45. 2003
    ..Based on the substrate selectivity, affinity, and N-ethylmaleimide sensitivity, LAT3 is proposed to be a transporter subserving system L2. LAT3 should denote a new family of organic solute transporters...
  97. ncbi request reprint The SLC22 drug transporter family
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Bayerische Maximilians Universit├Ąt W├╝rzburg, Koellikerstr 6, 97070, Wurzburg, Germany
    Pflugers Arch 447:666-76. 2004
    ..Defect mutations of transporters of the SLC22 family may cause specific diseases such as "primary systemic carnitine deficiency" or "idiopathic renal hypouricemia" or change drug absorption or excretion...
  98. ncbi request reprint Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney
    Ryoji Kojima
    Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    J Am Soc Nephrol 13:848-57. 2002
    ..These results on the distribution of each OAT isoform will facilitate the understanding of the role of OATs in the renal processing of organic anions...