Hiroaki Miyoshi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. doi request reprint Comparison of CD20 expression in B-cell lymphoma between newly diagnosed, untreated cases and those after rituximab treatment
    Hiroaki Miyoshi
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Cancer Sci 103:1567-73. 2012
  2. doi request reprint Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders
    Hiroaki Miyoshi
    Department of Pathology, School of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Am J Clin Pathol 137:879-89. 2012
  3. doi request reprint Disseminated Mycobacterium genavense infection in a healthy boy
    Hiroaki Miyoshi
    Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata 990 2292, Japan
    Hum Pathol 41:1646-9. 2010
  4. doi request reprint Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression
    Ayako Ichikawa
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Eur J Haematol 91:20-8. 2013
  5. doi request reprint CD5-positive follicular lymphoma characterized by CD25, MUM1, low frequency of t(14;18) and poor prognosis
    Hiroaki Miyoshi
    Department of Pathology, Kurume University, Kurume, Japan
    Pathol Int 64:95-103. 2014
  6. doi request reprint Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Cancer Sci 102:1734-41. 2011
  7. doi request reprint The Wnt signaling pathway and mitotic regulators in the initiation and evolution of mantle cell lymphoma: Gene expression analysis
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan
    Int J Oncol 43:457-68. 2013
  8. doi request reprint A spindle cell variant of diffuse large B-cell lymphoma is characterized by T-cell/myofibrohistio-rich stromal alterations: analysis of 10 cases and a review of the literature
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Eur J Haematol 89:302-10. 2012
  9. doi request reprint Endothelin B receptor expression in malignant gliomas: the perivascular immune escape mechanism of gliomas
    Shinji Nakashima
    Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    J Neurooncol 127:23-32. 2016
  10. doi request reprint Clinicopathological features of double-hit B-cell lymphomas with MYC and BCL2, BCL6 or CCND1 rearrangements
    Maki Yoshida
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan
    Pathol Int 65:519-27. 2015

Collaborators

  • Koichi Ohshima
  • Yasuo Sugita
  • Yoshito Akagi
  • Mizuhiko Terasaki
  • Koji Nagafuji
  • Tetsushi Kinugasa
  • Ilseung Choi
  • Naoto Shiba
  • Ying Guo
  • Daisuke Niino
  • Shigeo Nakamura
  • Kennosuke Karube
  • Tadashi Yoshino
  • Ryuichi Wada
  • Yoshizo Kimura
  • Maki Yoshida
  • Fumiko Arakawa
  • Junichi Kiyasu
  • Ayako Ichikawa
  • Shinji Nakashima
  • Yukinao Ishibashi
  • Masanori Takeuchi
  • Noriaki Yoshida
  • Kensaku Sato
  • Takashi Okamura
  • Masao Seto
  • Naohiro Yoshida
  • Shintaro Yokoyama
  • Toshihiro Hashiguchi
  • Kaori Yasuda
  • Satoru Kuhara
  • Kosuke Tashiro
  • Atushi Doi
  • Yukihiko Nakamura
  • Nobuko Suefuji
  • Kei Shimizu-Kohno
  • Yutaka Imamura
  • Keisuke Kawamoto
  • Shinya Fujino
  • Hiroaki Taniguchi
  • Atae Utsunomiya
  • Masaharu Miyahara
  • Takeharu Kato
  • Joji Shimono
  • Tatsuya Nishi
  • Yukiyoshi Moriuchi
  • Mamiko Sakata-Yanagimoto
  • Kotaro Yuge
  • Takafumi Ohchi
  • Mitsuhiro Katagiri
  • Masahiro Mitsuoka
  • Motohiro Morioka
  • Daisuke Kurita
  • Hiroko Muta
  • Yuya Sasaki
  • Sachiko Shiraiwa
  • Kazutaka Nakajima
  • Yoshitaka Imaizumi
  • Shinzo Takamori
  • Tatsuyuki Kakuma
  • Koichi Akashi
  • Toshiaki Haraguchi
  • Akie Hirata
  • Koji Hiraoka
  • Takahiro Okawa
  • Takanori Shoda
  • Fujio Higuchi
  • Tetsuya Hamada
  • Yasunobu Abe
  • Ryoichi Takayanagi
  • Yuji Yufu
  • Motoaki Shiratsuchi
  • Naokuni Uike
  • Kensei Nagata
  • Osamu Miura
  • Masakazu Higuchi
  • Riko Ichikawa
  • Chisato Koike
  • Taizo Shimomura
  • Nobuo Kuwahara
  • Kazuhisa Fujikawa
  • Daisuke Nino
  • Yumi Takasaki
  • Ken Ishiyama
  • Toshiaki Morito
  • Koichi Higaki
  • Rituko Seki
  • Namiko Hashiguchi
  • Yuju Ohno

Detail Information

Publications23

  1. doi request reprint Comparison of CD20 expression in B-cell lymphoma between newly diagnosed, untreated cases and those after rituximab treatment
    Hiroaki Miyoshi
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Cancer Sci 103:1567-73. 2012
    ..These results suggest the influence of B-lymphoma subtype and a therapeutic effect before biopsy on CD20 expression at relapse and contribute to a better therapeutic approach for relapse cases after rituximab therapy...
  2. doi request reprint Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders
    Hiroaki Miyoshi
    Department of Pathology, School of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Am J Clin Pathol 137:879-89. 2012
    ..Our study confirmed the continuity between f-PTCL and AITL. Moreover, Bcl-6 expression in f-PTCL was statistically associated with the characteristics of AITL...
  3. doi request reprint Disseminated Mycobacterium genavense infection in a healthy boy
    Hiroaki Miyoshi
    Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata 990 2292, Japan
    Hum Pathol 41:1646-9. 2010
    ..M genavense DNA was identified by direct sequencing of 16S ribosomal DNA that had been amplified by polymerase chain reaction...
  4. doi request reprint Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression
    Ayako Ichikawa
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Eur J Haematol 91:20-8. 2013
    ..The objective of this study was to identify factors predictive of relapse and survival in patients with RA-LPD, and spontaneous regression in patients with RA-LPD treated with MTX (MTX-LPD)...
  5. doi request reprint CD5-positive follicular lymphoma characterized by CD25, MUM1, low frequency of t(14;18) and poor prognosis
    Hiroaki Miyoshi
    Department of Pathology, Kurume University, Kurume, Japan
    Pathol Int 64:95-103. 2014
    ..These results suggest that CD5-positive FL should be considered a different type of FL, and its clinicopathological management should be conducted differently. ..
  6. doi request reprint Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Cancer Sci 102:1734-41. 2011
    ..In addition, clinicians should be aware of the possible presence of small-MCL to avoid making a misdiagnosis of follicular hyperplasia or CLL/SLL...
  7. doi request reprint The Wnt signaling pathway and mitotic regulators in the initiation and evolution of mantle cell lymphoma: Gene expression analysis
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan
    Int J Oncol 43:457-68. 2013
    ..Thus, we observe that the Wnt signaling pathway may play an important role in initial lymphomagenesis in addition to t(11;14) translocations, and that specific mitotic regulators facilitate transformation into more aggressive forms...
  8. doi request reprint A spindle cell variant of diffuse large B-cell lymphoma is characterized by T-cell/myofibrohistio-rich stromal alterations: analysis of 10 cases and a review of the literature
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Eur J Haematol 89:302-10. 2012
    ..0017, respectively). Thus, T-cell/myofibrohistio-rich stromal alterations in Sp-DLBCL, especially those mediated by TGFβ1 and FGF2, may play a role in the transition of lymphoma cells into those with spindle-shaped features...
  9. doi request reprint Endothelin B receptor expression in malignant gliomas: the perivascular immune escape mechanism of gliomas
    Shinji Nakashima
    Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    J Neurooncol 127:23-32. 2016
    ..These results suggest that ETBR expression during neo-angiogenesis may interfere with the homing of CTLs around the tumor and be involved in the immune escape mechanism of gliomas. ..
  10. doi request reprint Clinicopathological features of double-hit B-cell lymphomas with MYC and BCL2, BCL6 or CCND1 rearrangements
    Maki Yoshida
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan
    Pathol Int 65:519-27. 2015
    ..5%. High dose chemotherapy did not improve the outcome. We suggest that screening of genetic variations to detect DH lymphomas is required in diagnosing all lymphomas, even those determined morphologically to be follicular lymphoma. ..
  11. doi request reprint Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas
    Nobuko Suefuji
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 62:690-8. 2012
    ..Using PCR analysis, clonal IgH and TCR rearrangements were detected in 7 of 8 and 7 of 7 Southern blot-negative cases, respectively. Our results suggested that PCR analysis was useful in diagnosing CTBL...
  12. doi request reprint Low incidence of MYC/BCL2 double-hit in Burkitt lymphoma
    Maki Yoshida
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 65:486-9. 2015
    ..In conclusion, BCL2 translocation is a rare cytogenetic abnormality in BL, and BL probably accounts for only a small fraction of MYC/BCL2 DH lymphomas. BCL2 expression in BL is probably not associated with BCL2 translocations. ..
  13. pmc Identification of miR-15b as a transformation-related factor in mantle cell lymphoma
    Fumiko Arakawa
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Int J Oncol 48:485-92. 2016
    ..However, the physiological significance of increased miR-15b in MCL is still unknown. Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the trans-formation of cMCL to aMCL. ..
  14. doi request reprint Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases
    Kei Shimizu-Kohno
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, School of Medicine, Yamagata University, Yamagata, Japan
    Pathol Int 62:577-82. 2012
    ..Most of the patients with SBL-U presented with thrombocytopenia, bone marrow involvement, and advanced stage. Our study revealed the frequency and clinical features of splenic malignant lymphoma in Japan...
  15. doi request reprint Composite T lymphoblastic leukemia/lymphoma and diffuse large B-cell lymphoma: case report
    Daisuke Niino
    Department of Pathology, School of Medicine, Kurume University, Fukuoka, Japan
    Pathol Int 61:363-8. 2011
    ..She has shown no signs of recurrence 20 months after the diagnosis. We describe here a very unusual and, to the best of our knowledge, an as yet never reported case of a primary composite lymphoma of T-LBL and DLBCL...
  16. pmc Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma
    Junichi Kiyasu
    Department of Pathology, Kurume University, School of Medicine, Kurume, Japan Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Hematology, Iizuka Hospital, Iizuka, Japan
    Blood 126:2193-201. 2015
    ..0323). This is the first report describing the clinicopathological features and outcomes of PD-L1(+) DLBCL. Immunotherapy targeting the PD-1/PD-L1 pathway should be considered in this distinct DLBCL subgroup. ..
  17. doi request reprint High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma
    Maki Yoshida
    Department of Pathology, School of Medicine, Kurume University, Kurume City, Fukuoka, Japan
    Pathol Int 62:518-24. 2012
    ..In conclusion, we assume the incidence of t(14;18) in HL associated with FL is higher than previously believed and BCL2 expression derived from t(14;18) may play a role in the pathogenesis of HL associated with FL...
  18. doi request reprint Clinicopathologic and Prognostic Implications of Programmed Death Ligand 1 Expression in Thymoma
    Shintaro Yokoyama
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Ann Thorac Surg 101:1361-9. 2016
    ..The aim of this study was to characterize PD-L1 expression in thymoma and determine statistical associations between this expression and clinical features...
  19. doi request reprint Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis
    Yukinao Ishibashi
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan
    Oncol Rep 33:1667-74. 2015
    ..Future research should focus on the oncogenic role and the efficacy of potential inhibitors of ALK. ..
  20. doi request reprint Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma
    Ying Guo
    Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
    Pathol Int 64:263-6. 2014
    ..It seems that phosphorylated JAK3 expression does not necessarily harbor exon 13 mutations. The mechanism responsible for activating expression of the gene will be a topic for further research. ..
  21. doi request reprint Case of polycythemia vera with unusual organizing pneumonia mimicking the clinical features of military tuberculosis and possibly caused by the involvement of neoplastic megakaryocytes
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume City, Fukuoka, Japan
    Pathol Int 61:486-90. 2011
    ..JAK2 mutation or the preleukemic phase of MPN may accelerate the activation of megakaryocytes and result in the proliferative process of fibrosis...
  22. doi request reprint CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis
    Noriaki Yoshida
    Department of Pathology, Kurume University School of Medicine, Japan
    J Pathol 238:621-6. 2016
    ..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  23. doi request reprint A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)
    Naohiro Yoshida
    Department of Surgery, Kurume University School of Medicine, Kurume shi, Fukuoka, Japan
    Ann Surg Oncol 23:919-27. 2016
    ..This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis...