T Hashimoto

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Treatment strategies for pemphigus vulgaris in Japan
    Takashi Hashimoto
    Kurume University School of Medicine, Department of Dermatology, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Expert Opin Pharmacother 9:1519-30. 2008
  2. doi request reprint Granular C3 Dermatosis
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 830 0011 Kurume, Japan
    Acta Derm Venereol 96:748-53. 2016
  3. doi request reprint Summary of results of serological tests and diagnoses for 4774 cases of various autoimmune bullous diseases consulted to Kurume University
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 175:953-965. 2016
  4. doi request reprint Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan
    Br J Dermatol . 2016
  5. pmc Distinct characteristics in Japanese dermatitis herpetiformis: a review of all 91 Japanese patients over the last 35 years
    Chika Ohata
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Clin Dev Immunol 2012:562168. 2012
  6. ncbi request reprint Bullous pemphigoid with prominent milium formation
    Daisuke Tsuruta
    Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Acta Dermatovenerol Croat 21:35-8. 2013
  7. doi request reprint Desmoglein 3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris
    Hiroshi Koga
    Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Department of Dermatology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Expert Opin Ther Targets 17:293-306. 2013
  8. doi request reprint Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
    Dermatol Ther 25:382-5. 2012
  9. doi request reprint Low-dose cyclosporin improves the health-related quality of life in Japanese psoriasis patients dissatisfied with topical corticosteroid monotherapy
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Fukuoka, Japan
    Australas J Dermatol 53:202-6. 2012
  10. doi request reprint Pathogenesis of epidermolysis bullosa acquisita, an autoimmune subepidermal bullous disease
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    J Pathol 228:1-7. 2012

Collaborators

Detail Information

Publications158 found, 100 shown here

  1. ncbi request reprint Treatment strategies for pemphigus vulgaris in Japan
    Takashi Hashimoto
    Kurume University School of Medicine, Department of Dermatology, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Expert Opin Pharmacother 9:1519-30. 2008
    ..Pemphigus vulgaris is a severe and possibly fatal skin disease with blisters and erosions on the oral mucosae and the skin...
  2. doi request reprint Granular C3 Dermatosis
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 830 0011 Kurume, Japan
    Acta Derm Venereol 96:748-53. 2016
    ..The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes. ..
  3. doi request reprint Summary of results of serological tests and diagnoses for 4774 cases of various autoimmune bullous diseases consulted to Kurume University
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 175:953-965. 2016
    ..Although many new disease entities of autoimmune bullous disease (AIBD) have recently been recognized, satisfactory immunological diagnostic methods and comprehensive classifications for various AIBDs have not been established...
  4. doi request reprint Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan
    Br J Dermatol . 2016
    ..IgE autoantibodies are considered to be involved in pathogenesis of bullous pemphigoid (BP), particularly inflammatory and erythematous phenotypes...
  5. pmc Distinct characteristics in Japanese dermatitis herpetiformis: a review of all 91 Japanese patients over the last 35 years
    Chika Ohata
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Clin Dev Immunol 2012:562168. 2012
    ....
  6. ncbi request reprint Bullous pemphigoid with prominent milium formation
    Daisuke Tsuruta
    Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Acta Dermatovenerol Croat 21:35-8. 2013
    ..We diagnosed the patient as BP with milia. Since milia are occasionally found in BP, they are not a definite differential criterion from epidermolysis bullosa acquisita...
  7. doi request reprint Desmoglein 3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris
    Hiroshi Koga
    Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Department of Dermatology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Expert Opin Ther Targets 17:293-306. 2013
    ..Other types of pemphigus also show anti-Dsg3 antibodies. Genetic disease of Dsg3 has not been reported...
  8. doi request reprint Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
    Dermatol Ther 25:382-5. 2012
    ..0 μg/mL 2 hours after administration. Patients who were not improved by the additional mizoribine might require a continuously higher dose of mizoribine to achieve effective therapy...
  9. doi request reprint Low-dose cyclosporin improves the health-related quality of life in Japanese psoriasis patients dissatisfied with topical corticosteroid monotherapy
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Fukuoka, Japan
    Australas J Dermatol 53:202-6. 2012
    ..Low-dose oral cyclosporin could be effective in patients who are dissatisfied with topical corticosteroid treatment alone...
  10. doi request reprint Pathogenesis of epidermolysis bullosa acquisita, an autoimmune subepidermal bullous disease
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    J Pathol 228:1-7. 2012
    ..The expression equilibrium of the activating and inhibitory FcgRs can be modulated towards the inhibitory FcgRIIB by IVIG therapy, resulting in beneficial clinical effects of IVIG in EBA and other autoimmune skin-blistering diseases...
  11. pmc Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
    Emilia Licarete
    Department of Dermatology, University of Freiburg, Hauptstr, 7, Freiburg 79104, Germany
    BMC Immunol 13:16. 2012
    ..The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors...
  12. ncbi request reprint Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Arch Dermatol 137:735-8. 2001
    ..To examine the frequency of antidesmoglein 1 (Dsg1) and antidesmoglein 3 (Dsg3) IgA autoantibodies in IgA pemphigus...
  13. ncbi request reprint Recent advances in the study of the pathophysiology of pemphigus
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, 830 0011 Kurume, Fukuoka, Japan
    Arch Dermatol Res 295:S2-11. 2003
    ..Therefore, studies of the pathophysiology of pemphigus are extremely important as a paradigm for research into various types of autoimmune diseases in other fields...
  14. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
    ....
  15. ncbi request reprint Paraneoplastic pemphigus sera react strongly with multiple epitopes on the various regions of envoplakin and periplakin, except for the c-terminal homologous domain of periplakin
    Y Nagata
    Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Invest Dermatol 116:556-63. 2001
    ....
  16. ncbi request reprint Bullous pemphigoid sera react specifically with various domains of BP230, most frequently with C-terminal domain, by immunoblot analyses using bacterial recombinant proteins covering the entire molecule
    T Hamada
    Department of Dermatology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
    Exp Dermatol 10:256-63. 2001
    ..These results indicate that the BP230 is specifically reacted by bullous pemphigoid sera, and that the immunoblotting using the BP230 recombinant proteins should be a useful tool for the diagnosis of bullous pemphigoid...
  17. ncbi request reprint Application of confocal laser scanning microscopy to differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita
    T Kazama
    Department of Dermatology, Niigata University School of Medicine, Japan
    Br J Dermatol 138:593-601. 1998
    ..These spatial relationships are compatible with their previously described ultrastructural locations. Thus, this method appears to be useful in the differential diagnosis of BP and EBA...
  18. doi request reprint Five Japanese cases of antidesmoglein 1 antibody-positive and antidesmoglein 3 antibody-negative pemphigus with oral lesions
    H Koga
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    Br J Dermatol 166:976-80. 2012
    ....
  19. ncbi request reprint IgG reactive to CTL-directed epitopes of self-antigens is either lacking or unbalanced in atopic dermatitis patients
    N Kawamoto
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume, Japan
    Tissue Antigens 61:352-61. 2003
    ..This information may provide new insight into the immune-mechanisms of elevated auto-reactivity of AD patients...
  20. ncbi request reprint Development of pemphigus vulgaris in a patient with pemphigus foliaceus: antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay
    K Ishii
    Department of Dermatology, Keio University School of Medicine, Saiseikai Central Hospital, Tokyo, Japan
    J Am Acad Dermatol 42:859-61. 2000
    ..Antidesmoglein (Dsg) 1 antibodies alone were detected in the PF stage, whereas both anti-Dsg3 and anti-Dsg1 antibodies were detected in the PV stage...
  21. doi request reprint A severe and refractory case of anti-p200 pemphigoid resulting in multiple skin ulcers and scar formation
    Y Goto-Ohguchi
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Dermatology 218:265-71. 2009
    ..In the present case, methylprednisolone pulse therapy was effective enough to reduce the disease activity...
  22. doi request reprint Immunoglobulin G deposition to nonhemidesmosomal lamina lucida and early neutrophil involvement are characteristic features in a case of anti-p200 pemphigoid
    A Shimizu
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Br J Dermatol 168:647-55. 2013
    ....
  23. ncbi request reprint Immunoreactivity against intracellular domains of desmogleins in pemphigus
    Y Ohata
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160-8582, Tokyo, Japan
    J Dermatol Sci 25:64-71. 2001
    ..Although the frequency was low, some sera did react with the intracellular domain of Dsgs...
  24. ncbi request reprint The clinical transition between pemphigus foliaceus and pemphigus vulgaris correlates well with the changes in autoantibody profile assessed by an enzyme-linked immunosorbent assay
    A Komai
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan
    Br J Dermatol 144:1177-82. 2001
    ..In addition, ELISA using recombinant baculoproteins was particularly useful in distinguishing PF and PV...
  25. ncbi request reprint The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus
    Y Hisamatsu
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Br J Dermatol 151:73-83. 2004
    ..However, the presence of IgG anti-Dsc autoantibodies is still controversial, and antibodies to Dsc2 and Dsc3 have not been clearly identified...
  26. ncbi request reprint Bullous pemphigoid positive for anti-BP180 and anti-laminin 5 antibodies in a patient with graft-vs-host disease
    Rieko Izumi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Am Acad Dermatol 56:S94-7. 2007
    ..Immune disturbance as well as destruction of basal epidermal cells and base membrane by GVHD may result in the induction of autoimmune blistering diseases with unusual clinical and laboratory manifestations...
  27. doi request reprint Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus
    P T Chan
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Br J Dermatol 162:1242-50. 2010
    ..The two major subtypes are nonendemic and endemic PF. A previous study in endemic PF demonstrated that changes in antibody epitope could modulate disease relapse and remission...
  28. ncbi request reprint IgG/IgA pemphigus with IgG and IgA antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay
    N Oiso
    Department of Dermatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Br J Dermatol 147:1012-7. 2002
    ..This is the second case of IgG/IgA pemphigus in which the human target antigens for both IgG and IgA antibodies have been unequivocally identified. This study provides further evidence that IgG/IgA pemphigus is a distinct disease entity...
  29. ncbi request reprint Epidermolysis bullosa acquisita sera react with distinct epitopes on the NC1 and NC2 domains of type VII collagen: study using immunoblotting of domain-specific recombinant proteins and postembedding immunoelectron microscopy
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Br J Dermatol 150:843-51. 2004
    ..The sera of epidermolysis bullosa acquisita (EBA) react with type VII collagen, a major component of anchoring fibrils, in which the major epitopes have been considered to be present in the N-terminal noncollagenous (NC) 1 domain...
  30. ncbi request reprint Pemphigus foliaceus with prominent neutrophilic pustules
    K Matsuo
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan
    Br J Dermatol 145:132-6. 2001
    ..This study indicates that pemphigus foliaceus may show prominent neutrophilic pustular skin lesions...
  31. doi request reprint Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Dermatol 162:513-7. 2010
    ..IgG autoantibodies against laminin-332 in patients with MMP are well documented; however, IgA and IgE autoantibodies against laminin-332 have not yet been described...
  32. doi request reprint A clinical study of patients with pemphigus vulgaris and pemphigus foliaceous: an 11-year retrospective study (1996-2006)
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
    Clin Exp Dermatol 33:641-3. 2008
    ..Dapsone was the mainstay of treatment for the patients with PF. The patients were investigated for any association with an underlying malignancy; in patients with PV, lung, stomach and uterine cancers (one patient each) were seen...
  33. doi request reprint Clinical and immunological findings in 104 cases of paraneoplastic pemphigus
    A Ohzono
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 173:1447-52. 2015
    ..Although there are many reports of sporadic patients with paraneoplastic pemphigus (PNP), only a few systematic studies on large cohorts of patients with PNP have been reported...
  34. doi request reprint IgA pemphigus with paraneoplastic pemphigus-like clinical features showing IgA antibodies to desmoglein 1/3 and desmocollin 3, and IgG and IgA antibodies to the basement membrane zone
    A Ueda
    Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
    Clin Exp Dermatol 38:370-3. 2013
    ..Despite extensive investigations and postmortem examination, no underlying neoplasms were found. The complex immunopathological findings probably played an important role in the development of the patient's unusual clinical features...
  35. doi request reprint Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features
    J Mitsuya
    Department of Dermatology, Nihon University School of Medicine, 30 1 Oyaguchi kamicho, Itabashi ku, Tokyo 173 8610, Japan
    Br J Dermatol 158:1354-7. 2008
    ..This is the first report in which an immunoblot analysis revealed the unusual combination of autoantibodies to both the p200 antigen and the gamma 2 subunit of laminin 5...
  36. pmc Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice
    M Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 102:775-82. 1998
    ....
  37. ncbi request reprint Bullous pemphigoid associated with silicosis
    H Ueki
    Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan
    Dermatology 201:265-7. 2000
    ..Clinical symptoms improved after treatment with systemic steroids. To the best of our knowledge, this is the first reported case of BP associated with silicosis...
  38. ncbi request reprint Clinical phenotype and anti-desmoglein autoantibody profile in paraneoplastic pemphigus
    M Ohyama
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Am Acad Dermatol 44:593-8. 2001
    ..This finding suggests that besides anti-Dsg IgG other pathologic mechanisms such as lichenoid reaction or interface dermatitis may be involved in the blister formation in PNP...
  39. ncbi request reprint Autoimmune vesicles on the face and neck. A variant of Brunsting-Perry type localized bullous pemphigoid?
    Y Sugita
    Department of Dermatology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Eur J Dermatol 11:557-9. 2001
    ..This case might be a variant of Brunsting-Perry type of localized BP or localized epidermolysis bullosa acquisita, presenting the clinical heterogeneity of subepidermal blistering diseases...
  40. ncbi request reprint Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen: case report and review of the literature
    M Mayuzumi
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    Br J Dermatol 155:1048-52. 2006
    ....
  41. ncbi request reprint Antidesmoglein autoantibodies in silicosis patients with no bullous diseases
    H Ueki
    Department of Dermatology, Kawasaki Medical School, Okayama, Japan
    Dermatology 202:16-21. 2001
    ..It is well known that during long-term silicosis, some autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus or rheumatoid arthritis, can occur...
  42. ncbi request reprint Exacerbation of paraneoplastic pemphigus by cyclophosphamide treatment: detection of novel autoantigens and bronchial autoantibodies
    K Preisz
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 150:1018-24. 2004
    ..In this case, which was characterized by a mixed IgA/IgG antibody panel displaying known and unique antigenicity, the serious episodes of paraneoplastic pemphigus flared after cyclophosphamide treatment...
  43. doi request reprint Some epidermolysis bullosa acquisita sera react with epitopes within the triple-helical collagenous domain as indicated by immunoelectron microscopy
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Br J Dermatol 160:1090-3. 2009
    ..Recently, some EBA cases with reactivity to other domains, i.e. the triple-helical (T-H) collagenous domain and the NC-2 domain, have been reported...
  44. ncbi request reprint A case of bullous pemphigoid successfully treated by plasmapheresis: assessment of the change in titers of circulating antibodies by immunoblotting and enzyme-linked immunosorbent assay
    Jee Bum Lee
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    J Dermatol 30:326-31. 2003
    ..The reduction of titers of circulating autoantibodies in the sera correlated well with the decrease in the disease activity in both the first and second rounds of plasmapheresis treatment in this case...
  45. doi request reprint Epidermolysis bullosa acquisita: what's new?
    Norito Ishii
    Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Dermatol 37:220-30. 2010
    ..v. immunoglobulin. In this review, we will focus on recent progress in our understanding of the clinical manifestations, the etiopathogenesis as well as the management of EBA...
  46. ncbi request reprint A case of bullous pemphigoid associated with autoantibodies targeting antigenic sites other than the NC16a domain of BP180
    Y Shinojima
    Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan
    Clin Exp Dermatol 30:503-5. 2005
    ..We conclude that it is difficult to differentiate their clinical features from those associated with autoantibodies targeting the NC16a domain of BP180...
  47. doi request reprint Anti-desmocollin autoantibodies in nonclassical pemphigus
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 173:59-68. 2015
    ..No consistent immunoassay for immunoglobulin (Ig) G autoantibodies to Dscs has been developed...
  48. doi request reprint Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University
    K Yoshimura
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 171:544-53. 2014
    ..Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about immunological profiles in DIP...
  49. ncbi request reprint 97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane
    A Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 106:739-43. 1996
    ..These results indicate that the 97-kDa LAD antigen is a component of the lamina lucida...
  50. ncbi request reprint Clinical significance of enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid
    Y Amo
    Department of Dermatology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555, Kanagawa, Japan
    J Dermatol Sci 26:14-8. 2001
    ..The result suggests that this NC16A-ELISA is a useful method for evaluating the clinical course and efficacy of the therapy in patients with BP...
  51. ncbi request reprint A case of nonscarring subepidermal blistering disease associated with autoantibodies reactive with both type VII collagen and laminin 5
    Naoka Umemoto
    Department of Dermatology, Jichi Medical School Omiya Medical Center, Omiya, Saitama, Japan
    Dermatology 207:61-4. 2003
    ..We regarded our case as a nonscarring subepidermal blistering disease with autoantibodies to both type VII collagen and two different subunits of laminin 5. Such a case has not been previously reported...
  52. ncbi request reprint Plectin deficient epidermolysis bullosa simplex with 27-year-history of muscular dystrophy
    Yoshie Takahashi
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 37:87-93. 2005
    ..Epidermolysis bullosa simplex associated with muscular dystrophy is caused by plectin deficiency...
  53. ncbi request reprint Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit
    Teruki Dainichi
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Dermatol 15:189-93. 2005
    ..Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled...
  54. pmc Anti-laminin gamma-1 pemphigoid
    Teruki Dainichi
    Department of Dermatology, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 106:2800-5. 2009
    ..The epitope is localized to the 246 C-terminal amino acids within the coiled-coil domain. The 9 C-terminal residues are known to be critically involved in laminin recognition by integrins...
  55. doi request reprint Two cases of childhood bullous pemphigoid
    Tomoko Toyama
    Department of Dermatology, Saitama Medical University, 38 Morohongo, Moroyamamachi, Iruma gun, Saitama, Japan, 350 0495
    Eur J Dermatol 19:368-71. 2009
    ..Both patients received vaccinations within two weeks before the appearance of the eruption. These cases were considered to be childhood BP presenting both IgG and IgA autoantibodies against the NC16A domains of BP180...
  56. doi request reprint Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies
    Hiroko Nakashima
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Dermatol 37:264-8. 2010
    ..This case suggests that non-desmoglein antigen on keratinocyte cell surface can be targeted in some patients with this unusual variant of pemphigus...
  57. doi request reprint Tetracycline and niacinamide control bullous pemphigoid but not pemphigus foliaceus when these conditions coexist
    Junko Shiohara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    J Dermatol 37:657-61. 2010
    ..This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions...
  58. ncbi request reprint Immunolocalization of target autoantigens in IgA pemphigus
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Clin Exp Dermatol 29:62-6. 2004
    ..IEN-type IgA pemphigus may be the first member of the pemphigus group of autoimmune bullous dermatoses that reacts with a nondesmosomal transmembranous protein...
  59. ncbi request reprint Paraneoplastic pemphigus associated with bronchiolitis obliterans
    M Takahashi
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    Chest 117:603-7. 2000
    ..Furthermore, prevention of the initial autoantibody-mediated injury to the respiratory epithelium should be an important treatment goal...
  60. ncbi request reprint Clinical, histopathological and immunological distinction in two cases of IgA pemphigus
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Clin Exp Dermatol 27:636-40. 2002
    ..These results confirm that the autoantigen in SPD-type IgA pemphigus is Dsc1, whereas the antigen in most cases of IEN-type IgA pemphigus is unknown...
  61. ncbi request reprint A case of antiepiligrin cicatricial pemphigoid with nephrotic syndrome
    Yuri Uchino
    Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima, Japan
    J Dermatol 31:228-31. 2004
    ..To our knowledge, the association of antiepiligrin cicatricial pemphigoid with nephrotic syndrome has not been reported previously...
  62. ncbi request reprint A case of anti-p200 pemphigoid with autoantibodies against both a novel 200-kD dermal antigen and the 290-kD epidermolysis bullosa acquisita antigen
    Hirotoshi Furukawa
    Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Dermatology 209:145-8. 2004
    ..Anti-p200 pemphigoid with autoantibodies against the 200-kD dermal antigen has recently been identified...
  63. ncbi request reprint Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid
    Mariko Yoshida
    Department of Dermatology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 41:21-30. 2006
    ..We produced different recombinant glutathione-S-transferase-fusion proteins, which roughly presented N-terminal domain, central rod domain and C-terminal domain of human BP230...
  64. ncbi request reprint Partial cDNA cloning of the 230-kD mouse bullous pemphigoid antigen by use of a human monoclonal anti-basement membrane zone antibody
    M Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 95:252-9. 1990
    ..g., enzyme-linked immunosorbent assay using recombinant proteins or synthetic peptides as antigens, but also for pathophysiologic study in which mouse models of BP might be used...
  65. doi request reprint Clinical and immunological profiles of 25 patients with pemphigoid gestationis
    N Tani
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Br J Dermatol 172:120-9. 2015
    ..Systematic study of pemphigoid gestationis (PG) has not been performed owing to its rarity...
  66. doi request reprint Efficacy and safety of rituximab treatment in Indian pemphigus patients
    A J Kanwar
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Eur Acad Dermatol Venereol 27:e17-23. 2013
    ..Various treatment modalities have been described to treat pemphigus. In cases where the disease fails to respond to conventional therapy, rituximab has been shown to be effective...
  67. ncbi request reprint [A case of pemphigus foliaceus associated with bullous impetigo successfully treated with tetracycline and nicotinamide]
    K Izu
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan, Yahatanishi-ku, Kitakyushu 807-8555, Japan
    J UOEH 23:59-67. 2001
    ..To our knowledge, however, there is no reported pemphigus case which has been successfully treated only with tetracycline and nicotinamide...
  68. doi request reprint Simultaneous occurrence of anti-BP180 mucous membrane pemphigoid and mucosal-dominant pemphigus vulgaris
    K Kobayashi
    Department of Dermatology, Tokyo Women s Medical University Medical Center East, Tokyo, Japan
    Clin Exp Dermatol 34:e785-8. 2009
    ..To our knowledge, the simultaneous initial occurrence of MMP and PV has never been reported previously. We present a rare case of concurrent PV and anti-BP180 MMP, the diagnosis of which was confirmed by ELISA and immunoblotting assays...
  69. ncbi request reprint Nevus lipomatosus cutaneus superficialis with follicular papules and hypertrophic pilo-sebaceous units
    Mitsuse Inoue
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Int J Dermatol 41:241-3. 2002
  70. ncbi request reprint Aggressive digital papillary adenocarcinoma arising on the right great toe
    Osamu Mori
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830 0011, Japan
    Eur J Dermatol 12:491-4. 2002
    ..Intraluminal contents, however, showed positive reactivity with CEA and EMA. On the basis of their histologic and immunohistochemical features, the tumor was diagnosed as aggressive digital papillary adenocarcinoma...
  71. ncbi request reprint BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid
    Masakazu Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 30:224-32. 2002
    ..These findings indicate that NC16a ELISA will be a valuable tool not only for the diagnosis of patients with BP but also for the monitoring of the disease activity...
  72. ncbi request reprint Antiepiligrin cicatricial pemphigoid of the larynx successfully treated with a combination of tetracycline and niacinamide
    Kikuo Sakamoto
    Department of Otolaryngology, Head and Neck Surgery, Kurume University School of Medicine, Asahi machi 67, Kurume, 830 0011, Japan
    Arch Otolaryngol Head Neck Surg 128:1420-3. 2002
    ..The patient showed no respiratory difficulty during the 2-year follow-up period. The combined therapy of tetracycline and niacinamide is thus considered to be an effective treatment for various types of cicatricial pemphigoid...
  73. ncbi request reprint Peptide vaccination for patients with melanoma and other types of cancer based on pre-existing peptide-specific ctotoxic T-lymphocyte precursors in the periphery
    Shoko Tanaka
    Department of Dermatology, Kurume University of School of Medicine, Fukuoka, Japan
    J Immunother 26:357-66. 2003
    ..These results indicate that peptide vaccination of patients showing evidence of pre-existing peptide-specific CTL precursors can be applied in further clinical trials aimed at the treatment of melanoma and other types of cancer...
  74. ncbi request reprint Immunofluorescence studies using skin sections of recessive dystrophic epidermolysis bullosa patients indicated that the antigen of anti-p200 pemphigoid is not a fragment of type VII collagen
    Yuanlin Liu
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, 830 0011, Fukuoka, Kurume, Japan
    J Dermatol Sci 32:125-9. 2003
    ..However, the nature of this 200 kDa antigen has not been well characterized...
  75. ncbi request reprint Immunofluorescence analysis of the basement membrane zone components in human anagen hair follicles
    Sohaila Joubeh
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
    Exp Dermatol 12:365-70. 2003
    ....
  76. ncbi request reprint Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides based on pre-existing, peptide-specific cellular responses
    Takashi Mine
    Department of Immunology, Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Fukuoka, Kurume 830 0011, Japan
    Clin Cancer Res 10:929-37. 2004
    ..The aim of this study is to find a laboratory marker for overall survival in advanced cancer patients who were vaccinated with peptides based on pre-existing, peptide-specific CTL precursors in the circulation...
  77. ncbi request reprint Novel keratin 5 and 14 gene mutations in patients with epidermolysis bullosa simplex from Poland
    Takahiro Hamada
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Arch Dermatol Res 296:577-9. 2005
    ..However, no genotype-phenotype correlation was identified in families with EBS-WC. The present study demonstrates the first series of molecular genetic data in EBS from Poland...
  78. ncbi request reprint Pemphigoid nodularis: two case studies and analysis of autoantibodies before and after the development of generalized blistering
    Hirotsugu Tashiro
    Department of Dermatology, Nippon Medical School, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 72:60-5. 2005
    ..It is possible that different factors from the changes in serum reactivity with BP antigens may be involved in initiating generalized blistering...
  79. ncbi request reprint Paraneoplastic pemphigus mimicking erosive mucosal lichen planus associated with primary hepatocellular carcinoma
    Hideto Yokokura
    Department of Dermatology, Jichi Medical University Omiya Medical Center, Saitama, Japan
    J Dermatol 33:842-5. 2006
    ..The results of negative Dsg1 and positive Dsg3 were consistent with clinical features showing severe mucosal involvement without cutaneous erosion. In PNP, the association with non-hematological solid tumor is extremely rare...
  80. ncbi request reprint By the grace of peeling: the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis
    Teruki Dainichi
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Arch Dermatol Res 300:S31-8. 2008
    ..This review discusses basic information about chemical peeling with SA-PEG, looks at its action on photo-induced tumor suppression, and proposes a new function for the stratum corneum in keratinocyte proliferation/differentiation...
  81. ncbi request reprint Efficacy of interferon-gamma in patients with refractory bullous pemphigoid
    Takekuni Nakama
    Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Dermatol 34:737-45. 2007
    ..These results suggest that, in severe BP patients refractory to conventional therapies, interferon-gamma in addition to oral corticosteroids is effective and thus should be considered for further clinical use...
  82. doi request reprint Molecular and clinical characterization in Japanese and Korean patients with Hailey-Hailey disease: six new mutations in the ATP2C1 gene
    Takahiro Hamada
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
    J Dermatol Sci 51:31-6. 2008
    ..To date, over 90 pathological mutations scattered throughout ATP2C1 have been described with no indication of mutational hotspots or clustering of mutations. No paradigm for genotype-phenotype correlation has emerged...
  83. doi request reprint Clavus detected incidentally by positron emission tomography with computed tomography
    Teruki Dainichi
    Department of Dermatology, School of Medicine, Kurume University, 67 Asahi Machi, Kurume, Fukuoka, Japan
    J Dermatol 35:242-3. 2008
    ..There had been a clavus in exactly the same region. Every dermatologist, radiologist and oncologist needs to know about this finding for making an accurate diagnosis...
  84. doi request reprint Skin tightening effect using fractional laser treatment: I. A randomized half-side pilot study on faces of patients with acne
    Teruki Dainichi
    Department of Dermatology, Kurume University, School of Medicine, Fukuoka, Japan
    Dermatol Surg 36:66-70. 2010
    ..Fractional laser resurfacing is a new procedure for skin rejuvenation...
  85. doi request reprint How does intramolecular epitope spreading occur in BPAG2 (BP180)?
    Takashi Hashimoto
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    J Invest Dermatol 130:924-6. 2010
    ..In this issue, using a transgenic mouse model, Di Zenzo et al. report that intramolecular epitope spreading does occur for human BPAG2...
  86. doi request reprint Skin tightening effect using fractional laser treatment II: A pilot animal study on skin remodeling
    Teruki Dainichi
    Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan
    Dermatol Surg 36:71-5. 2010
    ..Fractional laser resurfacing is a new procedure for skin rejuvenation. We have found that it has a skin tightening effect in humans...
  87. doi request reprint From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid
    Teruki Dainichi
    Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Dermatol 37:231-8. 2010
    ..Unveiling the pathogenicity and development of a useful diagnostic method is necessary for appropriate management of this new disease...
  88. doi request reprint Juvenile myelomonocytic leukemia characterized by cutaneous lesion containing Langerhans cell histiocytosis-like cells
    Shuichi Ozono
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Int J Hematol 93:389-93. 2011
    ..In the current case, molecular biological analysis enabled us to develop a precise diagnosis...
  89. pmc Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing
    Daisuke Tsuruta
    Department of Dermatology, Kurume University School of Medicine, Japan
    J Dermatol Sci 62:1-7. 2011
    ..We also discuss recent publications which indicate, contrary to expectation, that certain focal contact proteins retard keratinocyte migration while hemidesmosomal proteins regulate directed keratinocyte motility during wound healing...
  90. ncbi request reprint Recurrent p.N767S mutation in the ATP2A2 gene in a Japanese family with haemorrhagic Darier disease clinically mimicking epidermolysis bullosa simplex with mottled pigmentation
    T Hamada
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume 830 0011, Japan
    Br J Dermatol 157:605-8. 2007
  91. doi request reprint A case of lichen planus pemphigoides with autoantibodies to the NC16a and C-terminal domains of BP180 and to desmoglein-1
    A Sekiya
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Syouwa ku, Nagoya, Aichi, 4668550, Japan
    Br J Dermatol 171:1230-5. 2014
    ..This is the first case in which autoantibodies to the C-terminal domain of BP180 were detected. The oral mucosal symptoms in this case may have been caused by autoantibodies to the BP180 C-terminal domain. ..
  92. doi request reprint Pigmentary demarcation lines associated with pregnancy
    T Nakama
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
    Clin Exp Dermatol 34:e573-6. 2009
    ..Pigmentary demarcation lines are mainly a cosmetic problem. Two of our three cases presented to obstetricians initially. We suggest that dermatologists should be aware that pigmentary demarcation lines may be associated with pregnancy...
  93. ncbi request reprint Brief report: incidence of and risk factors for autistic disorder in neonatal intensive care unit survivors
    T Matsuishi
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan
    J Autism Dev Disord 29:161-6. 1999
    ..Children with AD had a significantly higher history of the meconium aspiration syndrome (p = .0010) than the controls. Autistic patients had different risk factors than CP...
  94. ncbi request reprint Vesiculobullous systemic lupus erythematosus: a case with circulating IgG and IgA autoantibodies to type VII collagen
    Yukiko Nitta
    Department of Dermatology, Kurume Medical University, Fukuoka Ken, Japan
    J Am Acad Dermatol 47:S283-6. 2002
    ..To our knowledge, this is the first report of vesiculobullous systemic lupus erythematosus with circulating IgG and IgA autoantibodies to type VII collagen...
  95. ncbi request reprint Comparative study of autoantigen profile between Colombian and Brazilian types of endemic pemphigus foliaceus by various biochemical and molecular biological techniques
    Yoshiko Hisamatsu
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 32:33-41. 2003
    ..Our previous study suggested that Colombian EPF seemed to react various plakin family proteins, such as envoplakin, periplakin and BP230...
  96. ncbi request reprint Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus
    Yuko Futei
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Am Acad Dermatol 49:1023-8. 2003
    ..It has been demonstrated that in PV, dominant epitopes reside in N-terminal adhesive regions of Dsg3 and that the dominant IgG subclass against Dsg3 is IgG4...
  97. ncbi request reprint IgG/IgA pemphigus with dyskeratotic acantholysis and intraepidermal neutrophilic microabscesses
    Kimiko Nakajima
    Department of Dermatology, Kochi Medical School, Nankoku, Kochi, Japan
    J Dermatol 34:757-60. 2007
    ..Skin lesions improved within 1 month and remission has continued for 9 years under oral administration of dapsone...
  98. doi request reprint Brunsting-Perry type localized bullous pemphigoid, possibly induced by furosemide administration and sun exposure
    Sachiko Takeichi
    Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima, 770 8503, Japan
    Eur J Dermatol 19:500-3. 2009
    ..Furthermore, photosensitivity caused by furosemide administration may contribute to the induction and exacerbation of the lesions...
  99. doi request reprint Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid
    Fumi Yamaki
    Department of Dermatology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Dermatol 37:255-8. 2010
    ..These clinical and immunological changes in a patient are a rare event, suggesting an epitope-spreading phenomenon...