Mitsuharu Ueda

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint [Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)]
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Rinsho Byori 57:242-51. 2009
  2. doi request reprint SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Chem 55:1223-7. 2009
  3. doi request reprint Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 24:1533-44. 2011
  4. ncbi request reprint Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma
    Kazutoshi Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Int J Oncol 37:797-804. 2010
  5. ncbi request reprint FK506 inhibits murine AA amyloidosis: possible involvement of T cells in amyloidogenesis
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    J Rheumatol 33:2260-70. 2006
  6. doi request reprint Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
    Konen Obayashi
    Diagnostic Unit for Amyloidosis, Department of Laboratory Medicine, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Clin Chim Acta 419:127-31. 2013
  7. doi request reprint Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma
    Satoru Shinriki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    J Oral Pathol Med 39:41-7. 2010
  8. doi request reprint Potential use of glucuronylglucosyl-β-cyclodextrin as a novel therapeutic tool for familial amyloidotic polyneuropathy
    Hirofumi Jono
    Department of Diagnostic Medicine, Kumamoto University, Kumamoto, Japan
    Amyloid 19:50-2. 2012
  9. doi request reprint Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Hum Pathol 43:96-104. 2012
  10. doi request reprint Transthyretin forms amyloid fibrils at physiological pH with ultrasonication
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 15:234-9. 2008

Detail Information

Publications66

  1. ncbi request reprint [Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)]
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Rinsho Byori 57:242-51. 2009
    ..Recently, Notch3 immunostaining of skin biopsy specimens has been introduced as a simplified supportive test for the diagnosis of CADASIL...
  2. doi request reprint SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Chem 55:1223-7. 2009
    ..However, those methods require an immunoprecipitation step with an anti-TTR antibody and are not suitable for quantitative detection. We investigated the usefulness of SELDI-TOF mass spectrometry (MS) without an immunoprecipitation step...
  3. doi request reprint Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 24:1533-44. 2011
    ..As myocardial biopsy may be dangerous for elderly people, the use of a combination of gastrointestinal tract and subcutaneous tissue biopsies may make diagnosis of senile systemic amyloidosis easier...
  4. ncbi request reprint Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma
    Kazutoshi Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Int J Oncol 37:797-804. 2010
    ..Thus, MK expression may affect prognosis via the p53 status and mutation of the p53 gene, and MK may be an attractive target for therapeutic intervention in patients with cancer cells with mutant p53...
  5. ncbi request reprint FK506 inhibits murine AA amyloidosis: possible involvement of T cells in amyloidogenesis
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    J Rheumatol 33:2260-70. 2006
    ..To determine the possibility that T cells represent a potential target for therapy in AA amyloidosis...
  6. doi request reprint Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
    Konen Obayashi
    Diagnostic Unit for Amyloidosis, Department of Laboratory Medicine, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Clin Chim Acta 419:127-31. 2013
    ..This study investigated whether a relationship exists between the presence of de novo antibodies and the clinical manifestations of familial amyloidotic polyneuropathy (FAP)...
  7. doi request reprint Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma
    Satoru Shinriki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    J Oral Pathol Med 39:41-7. 2010
    ..An inhibitor of STAT3 activation, AG490, significantly reduced SAA1 expression in SAS cells. These data demonstrated that SAA was up-regulated in HNSCC through the Janus kinase-STAT3 pathway...
  8. doi request reprint Potential use of glucuronylglucosyl-β-cyclodextrin as a novel therapeutic tool for familial amyloidotic polyneuropathy
    Hirofumi Jono
    Department of Diagnostic Medicine, Kumamoto University, Kumamoto, Japan
    Amyloid 19:50-2. 2012
    ..Collectively, these data indicate that GUG-β-CyD may inhibit TTR misfolding by stabilizing its conformation, which, in turn, suppresses TTR amyloid formation...
  9. doi request reprint Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Hum Pathol 43:96-104. 2012
    ..However, cellular metabolic disturbances caused by cells' being physically confined by amyloid deposits may induce cell degeneration...
  10. doi request reprint Transthyretin forms amyloid fibrils at physiological pH with ultrasonication
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 15:234-9. 2008
    ..In addition, this method allows analysis of accelerator factors or inhibitory agents in TTR amyloid fibril formation at neutral pH...
  11. doi request reprint Role of conformational change in the C-terminus of beta2-microglobulin in dialysis-related amyloidosis
    Jaemi Kim
    Department of Molecular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Ann Clin Biochem 45:489-95. 2008
    ..However, no direct experiments have previously been performed to address whether unfolded beta(2)m in the C-terminus may be prone to form amyloid fibrils...
  12. doi request reprint Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma
    Satoru Shinriki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    J Pathol 225:142-50. 2011
    ..Together, these data suggest that tocilizumab acted as expected: it inhibited lymph node metastasis in OSCC by reducing tumour lymphangiogenesis...
  13. doi request reprint Spinal multifocal amyloidosis derived from wild-type transthyretin
    Takanao Sueyoshi
    Department of Orthopaedic and Neuro Musculoskeletal Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Amyloid 18:165-8. 2011
    ..Clinical manifestations of TTR-related amyloidosis may vary more than we previously thought. In spinal amyloidosis, WT TTR is one of the candidate precursor proteins for the disease...
  14. doi request reprint Effect of recipient-derived cells on the progression of familial amyloidotic polyneuropathy after liver transplantation: a retrospective study
    Yuki Ohya
    Department of Transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Ann Clin Biochem 47:529-34. 2010
    ....
  15. doi request reprint Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation
    Toshinori Oshima
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan
    J Neurol Neurosurg Psychiatry 85:740-6. 2014
    ..To elucidate the long-term effects of liver transplantation (LT) on familial amyloid polyneuropathy (FAP)...
  16. doi request reprint Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts
    Hirohisa Okabe
    Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 131:2234-41. 2012
    ..0001). These data suggest that CXCL5 is important for the interaction between cholangiocarcinoma and CAFs, and inhibition of tumor-stromal interactions may be a useful therapeutic approach for cholangiocarcinoma...
  17. doi request reprint Manifestations of transthyretin-related familial amyloidotic polyneuropathy: long-term follow-up of Japanese patients after liver transplantation
    Yuki Ohya
    Department of Transplantation and Pediatric Surgery, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Surg Today 41:1211-8. 2011
    ..To observe which symptoms of transthyretin-related familial amyloidotic polyneuropathy (FAP) progressed in the long term after liver transplantation (LT), focusing on cardiac, kidney, and ocular symptoms...
  18. ncbi request reprint Evaluation of myocardial changes in familial amyloid polyneuropathy after liver transplantation
    Sadahisa Okamoto
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Honjo
    Intern Med 47:2133-7. 2008
    ..The aim of this study was to assess myocardial changes in FAP amyloidgenic transthyretin (ATTR) Val30Met after LT...
  19. ncbi request reprint Aging and transthyretin-related amyloidosis: pathologic examinations in pulmonary amyloidosis
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Amyloid 13:24-30. 2006
    ..55 +/- 8.75 vs. 39.75 +/- 4.17 years old, p < 0.005), similar to the finding in one SSA patient. These results suggest that aging could play an important role in the progression of pulmonary amyloid formation in FAP ATTR V30M...
  20. doi request reprint A rapid and sensitive prenatal diagnosis of familial amyloidotic polyneuropathy ATTR Val30Met by mass spectrometry
    Taro Yamashita
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Prenat Diagn 29:930-3. 2009
    ..To make a prenatal diagnosis of familial amyloidotic polyneuropathy (FAP) by mass spectrometry with the amniotic fluid...
  21. doi request reprint Rapid detection of wild-type and mutated transthyretins
    Masayoshi Tasaki
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan
    Ann Clin Biochem 53:508-10. 2016
    ..The aim of this study was to evaluate the clinical usefulness of SELDI-TOF MS for diagnosis of transthyretin-related amyloidosis...
  22. doi request reprint Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach
    Masayoshi Tasaki
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan Department of Immunology and Hematology, Division of Informative Clinical Science, Graduate School of Medical Sciences, Kumamoto University, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Int J Cardiol 170:69-74. 2013
    ..To elucidate age and sex differences in FAP, we investigated biochemical characteristics of amyloid deposits in different tissue sites of FAP by proteomic analysis...
  23. doi request reprint Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 63:260-5. 2013
    ..GR is a nuclear transcription factor that leads to myocardial hypertrophy, and cumulative prednisolone doses may promote marked cardiomegaly and severe cardiac amyloidosis...
  24. doi request reprint Novel function of transthyretin in pancreatic alpha cells
    Yu Su
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto, Japan
    FEBS Lett 586:4215-22. 2012
    ..These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon...
  25. doi request reprint Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Lett 316:23-30. 2012
    ..Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model. Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma...
  26. doi request reprint Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma
    Tomoko Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Oncol Rep 27:1674-80. 2012
    ..These data suggest that MK may play important roles in cisplatin resistance in OSCC by modulating both cell growth and intracellular cisplatin accumulation...
  27. doi request reprint Interaction between amyloid fibril formation and extracellular matrix in the proceedings of VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 19:8-10. 2012
    ..To know the precise mechanism of this up-regulation may lead to deeper understanding of FAP pathogenesis...
  28. doi request reprint Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis
    Tomoko Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Oral Oncol 46:657-61. 2010
    ..001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs...
  29. doi request reprint Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy
    Tomoe Kugimiya
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Lab Invest 91:1219-28. 2011
    ..Taken together, these results indicate that albumin may have an inhibitory role in the TTR amyloid-formation process...
  30. doi request reprint Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 081, Japan
    J Pathol 219:481-90. 2009
    ..This chain reaction may have important implications for FAP pathogenesis...
  31. doi request reprint Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation
    Yohei Misumi
    Departments of Neurology, Kumamoto University, Kumamoto, Japan
    Liver Transpl 22:656-64. 2016
    ..Because acquired amyloidosis will likely increase, careful follow-up for early amyloidosis detection and new treatments, including TTR stabilizers and gene-silencing therapies, are required. Liver Transplantation 22 656-664 2016 AASLD. ..
  32. doi request reprint Antibody therapy for familial amyloidotic polyneuropathy
    Yu Su
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 19:45-6. 2012
    ..MAb ATTR may have a potential to suppress TTR amyloid deposition and become a candidate for the antibody therapy for FAP...
  33. ncbi request reprint A transgenic rat with the human ATTR V30M: a novel tool for analyses of ATTR metabolisms
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 352:299-304. 2007
    ..These results thus suggest that this transgenic rat may be a useful animal model which analyzes the metabolism of human ATTR V30M including liver transplantation studies...
  34. doi request reprint Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism
    Masayoshi Tasaki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 400:559-62. 2010
    ..These novel findings should provide insights into the transmission mechanism of systemic amyloidoses...
  35. doi request reprint Inhibition of insulin amyloid fibril formation by cyclodextrins
    Keisuke Kitagawa
    a Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 22:181-6. 2015
    ..These findings have significant implications for the mechanism underlying insulin amyloid fibril formation and for developing optimal additives to prevent this subcutaneous adverse effect. ..
  36. pmc Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells
    Takuya Nakamura
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Oncotarget 6:1008-19. 2015
    ..These data suggest that the intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance dependent on a slow-cycling state in BM-DTCs. ..
  37. doi request reprint Osteopontin-integrin α(v)β(3) axis is crucial for 5-fluorouracil resistance in oral squamous cell carcinoma
    Takuya Nakamura
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Japan
    FEBS Lett 589:231-9. 2015
    ..Targeting integrin αvβ3 reversed the resistance in a 5-FU-resistant clone highly expressing OPN. Our data suggest that the OPN-integrin αvβ3 axis is crucial for 5-FU resistance in OSCC. ..
  38. doi request reprint Stromal expression of neutrophil gelatinase-associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma
    Satoru Shinriki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Histopathology 64:356-64. 2014
    ..This study aimed to elucidate the clinical significance of NGAL in OSCC...
  39. doi request reprint Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Lab Invest 92:474-84. 2012
    ..Those findings may be valuable for understanding the genotype-phenotype correlation in this inherited human disease...
  40. ncbi request reprint Muscular amyloid angiopathy with amyloidgenic transthyretin Ser50Ile and Tyr114Cys
    Taro Yamashita
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Muscle Nerve 31:41-5. 2005
    ..Muscular amyloid angiopathy may contribute to motor nerve injury that, in turn, may lead to amyotropic changes in patients with FAP Ser50Ile and Tyr114Cys...
  41. ncbi request reprint Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis
    Shiori Saito
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    Biochemistry 44:11122-9. 2005
    ..These results suggest that the nitric oxide-mediated modification of transthyretin, especially variant transthyretin, may play an important role in amyloid formation in senile systemic amyloidosis and familial amyloidotic polyneuropathy...
  42. doi request reprint Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis
    Hirofumi Jono
    Department of Diagnostic Medicine, Graduate School of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem J 437:35-42. 2011
    ..Collectively, these results indicate that GUG-β-CyD may inhibit TTR misfolding by stabilizing its conformation, which, in turn, suppresses TTR amyloid formation...
  43. doi request reprint Antitumor effect of humanized anti-interleukin-6 receptor antibody (tocilizumab) on glioma cell proliferation. Laboratory investigation
    Mareina Kudo
    Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurosurg 111:219-25. 2009
    ..The aim of this study was to evaluate the involvement of IL-6 signaling in glioma and the inhibitory effect of IL-6 signaling on glioma tumor proliferation...
  44. doi request reprint Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis
    Akihiro Yanagisawa
    1 Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan 2 Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 28:201-7. 2015
    ..In conclusion, transthyretin amyloid deposits in the ligamentum flavum may be related to the pathogenesis of lumbar spinal canal stenosis in elderly patients. ..
  45. pmc Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy
    Jianying Guo
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Oncotarget 5:6353-64. 2014
    ..These data suggest that CYLD down-regulation is crucial for hypoxia-mediated inflammation in GBM, which may affect the long-term efficacy of anti-VEGF therapy. ..
  46. ncbi request reprint Effect of tacrolimus and partial hepatectomy on transthyretin metabolism in rats
    Manuel E Zeledon R
    Department of Pediatric Surgery and Transplantation, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Transpl Int 19:233-8. 2006
    ..This finding -- that TTR, the source of FAP-inducing amyloid, did not increase after transplantation -- may help post-transplantation treatment of patients who have FAP and other liver diseases...
  47. doi request reprint Wild-type transthyretin-derived amyloidosis in various ligaments and tendons
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 42:1259-64. 2011
    ..In the future, such amyloid deposits may aid determination of the pathogenesis of ligament and tendon disorders in older patients...
  48. doi request reprint Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurol Sci 362:266-71. 2016
    ..The efficacy and safety of tafamidis in transthyretin (TTR) familial amyloid polyneuropathy (TTR-FAP) were evaluated in this open-label study...
  49. doi request reprint Clinicopathological and biochemical findings of thyroid amyloid in hereditary transthyretin amyloidosis with and without liver transplantation
    Guannan Huang
    a Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Chuo Ku, Kumamoto, Japan and
    Amyloid . 2017
    ..Thyroid hormone functions may diminish according to the disease progression. LT could prevent thyroid dysfunction in hereditary TTR amyloidosis...
  50. doi request reprint Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid
    Akihiro Yanagisawa
    a Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuo Ku, Kumamoto, Japan
    Amyloid 23:26-32. 2016
    ..Also, aging may induce ATTR formation in the knee joint in elderly patients with knee OA, whereas AApo A-I formation may be inversely correlated with age. ..
  51. doi request reprint Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma
    Satoru Shinriki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 15:5426-34. 2009
    ..The aim of this study was to investigate the effects of inhibition of IL-6R-mediated signaling on OSCC progression and to evaluate the availability of tocilizumab, a humanized antihuman IL-6R antibody, as a therapeutic agent for OSCC...
  52. pmc Involvement of Macrophages in the Pathogenesis of Familial Amyloid Polyneuropathy and Efficacy of Human iPS Cell-Derived Macrophages in Its Treatment
    Genki Suenaga
    Department of Neurology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    PLoS ONE 11:e0163944. 2016
    ..To improve this situation, clinical application of pluripotent stem cell-derived MLs may be useful as an approach for FAP therapy...
  53. doi request reprint Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism
    Hirofumi Jono
    Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan Electronic address
    Clin Chim Acta 458:5-11. 2016
    ..We investigated the sources of variation of serum TTR concentrations in healthy subjects...
  54. ncbi request reprint Role of extracellular superoxide dismutase in patients under maintenance hemodialysis
    Masaaki Nakamura
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nephron Clin Pract 101:c109-15. 2005
    ..Although EC-SOD Arg213Gly, which cannot bind on endothelial cells, has been considered a polymorphism, the effect of EC-SOD on hemodialysis patients has not been well examined...
  55. ncbi request reprint Novel methods for detecting amyloidogenic proteins in transthyretin related amyloidosis
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Front Biosci 13:5548-58. 2008
    ..We present here a new diagnostic procedure for the disease using current methods of molecular genetics and protein chemistry...
  56. ncbi request reprint Analysis of amyloid fibrils in the cheetah (Acinonyx jubatus)
    Joakim Bergström
    Department of Diagnostic Medicine, Kumamoto University, Japan
    Amyloid 13:93-8. 2006
    ..Our finding of a 12-kDa protein AA component provides evidence that the cheetah SAA sequence is longer than the previously reported 90 amino acid residues (approximately 10 kDa), and hence SAA is part of the amyloid fibril...
  57. ncbi request reprint A different amyloid formation mechanism: de novo oculoleptomeningeal amyloid deposits after liver transplantation
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Transplantation 77:345-9. 2004
    ..However, the effect on amyloid formation of TTR that is synthesised by the retina and the choroid plexus remains to be elucidated in FAP patients with liver transplants...
  58. doi request reprint Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients
    Konen Obayashi
    Department of Medicine, Umea University Hospital, S 901 85 Umea, Sweden
    Clin Chim Acta 398:10-4. 2008
    ....
  59. doi request reprint Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells
    Kaori Isono
    Department of Neurology, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan Department of Transplantation and Pediatric Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    Stem Cell Res 12:574-83. 2014
    ..FAP-specific iPS cells demonstrated the possibility of serving as a pathological tool that will contribute to understanding the pathogenesis of FAP and development of FAP treatments. ..
  60. ncbi request reprint [Practical application of nutritional assessment protein and inflammatory marker in the nutrition support team (NST)]
    Takiko Tateishi
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556
    Rinsho Byori 53:825-31. 2005
    ..As for this index, it is expected to be used by NST while further alternation may be needed...
  61. ncbi request reprint [Application to transthyretin analysis]
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University
    Rinsho Byori 54:601-8. 2006
    ..In addition, we analyzed TTR modifications and protein profiles in serum samples of Japanese and Swedish patients using SELDI-TOF-MS to look for a key protein(s) as a trigger of FAP...
  62. doi request reprint Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells
    Hirohisa Okabe
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ann Surg Oncol 18:1175-84. 2011
    ..The aim of this study is to investigate the effect of HS cells on CC cell progression in vitro and in vivo...
  63. doi request reprint Genotypic and phenotypic spectrum of CADASIL in Japan: the experience at a referral center in Kumamoto University from 1997 to 2014
    Akihiko Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 0811, Japan
    J Neurol 262:1828-36. 2015
    ..Fresh frozen skin biopsy specimens may aid detection of Notch3 deposits on vascular walls for an improved diagnosis of CADASIL. ..
  64. pmc Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells
    Naoko Wada
    Department of Hematology, Kumamoto University Hospital, Kumamoto, Japan
    Int J Oncol 46:963-72. 2015
    ..These findings together support the use of SHK as a potential therapeutic agent for MM...
  65. doi request reprint Excessive fibrinolysis in AL-amyloidosis is induced by urokinae-type plasminogen activator from bone marrow plasma cells
    Mitsuhiro Uchiba
    Department of Blood Transfusion and Cell Therapy, Kumamoto University Hospital, Kumamoto, Japan
    Amyloid 16:89-93. 2009
    ..The present data suggested that uPA expressed in plasma cells may have contributed to the pathogenesis of excessive fibrinolysis...
  66. doi request reprint Midkine in plasma as a novel breast cancer marker
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 100:1735-9. 2009
    ..Midkine may be a useful novel tumor marker for detection of breast cancer, superior to conventional tumor markers...