Sachiko Tsukamoto

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
  2. doi Halenaquinone inhibits RANKL-induced osteoclastogenesis
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan Electronic address
    Bioorg Med Chem Lett 24:5315-7. 2014
  3. doi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
  4. doi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
  5. doi Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem 21:3831-8. 2013
  6. doi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
  7. doi Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids from the Indonesian marine sponge Acanthostrongylophora ingens
    Ahmed H El-Desoky
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    J Nat Prod 77:1536-40. 2014
  8. doi Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis
    Eriko Sakai
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862 0973, Japan
    J Nat Med 68:215-9. 2014
  9. doi Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor
    Michitaka Yamaguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 23:3884-6. 2013
  10. doi Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Kumamoto, Japan
    Bioorg Med Chem Lett 25:5389-92. 2015

Collaborators

  • Tsuyoshi Ikeda
  • Jens C Frisvad
  • David H Sherman
  • Benjamin Nicholson
  • Yasushi Saeki
  • Masahiro Fujimuro
  • Ryoji Nagai
  • Masateru Ono
  • Hitoshi Yoshimitsu
  • Naomi Sakashita
  • Hikaru Kato
  • Remy E P Mangindaan
  • Fitje Losung
  • Nicole J de Voogd
  • Hideyoshi Yokosawa
  • Yukio Fujiwara
  • Keisuke Eguchi
  • Motohiro Takeya
  • Henki Rotinsulu
  • Ippei Kagiyama
  • Robert M Williams
  • Eriko Sakai
  • Tetsuro Kawabata
  • Toshiyuki Kuwana
  • Mitsue Miyazaki
  • Rumi Yamanokuchi
  • Tatsuo Nehira
  • Masaki Gushiken
  • Haruka Takamoto
  • Ai Noda
  • Akane Furusato
  • Ahmed H El-Desoky
  • Yuichi Nakamura
  • Michitaka Yamaguchi
  • James D Sunderhaus
  • Hiroshi Morioka
  • Yoshiaki Suwa
  • Noriyuki Iwasaki
  • Shuntaro Ushiyama
  • Akinori Hayashida
  • Michio Namikoshi
  • Yumiko Nagasawa
  • Mona El-Aasr
  • Kayo Sugimoto
  • Kanae Matsuo
  • Takashi Nakahara
  • Timothy J McAfoos
  • Tadateru Nishikawa
  • Jennifer M Finefield
  • Wilmar Maarisit
  • Shengying Li
  • Hasita Horlad
  • Matthew P Kodrasov
  • Fije Losung
  • Tadashi Watanabe
  • Kumiko Imada
  • Hiroaki Terasawa
  • Sosuke Yoshinaga
  • Hideharu Umaoka
  • Kazuyo Ukai
  • Makiko Yoshitomi
  • Reiko Ueoka
  • Keiichiro Tsurushima
  • Hisayoshi Kobayashi
  • Norika Daiguji
  • Hiroshi Hirota
  • Naoki Horiuchi
  • Toshihiro Nohara
  • Daisuke Nakano
  • Junei Kinjo
  • Masafumi Okawa

Detail Information

Publications24

  1. doi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
    ..Here, we review natural products targeting the ubiquitin-proteasome system as well as synthetic compounds with potent inhibitory effects...
  2. doi Halenaquinone inhibits RANKL-induced osteoclastogenesis
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan Electronic address
    Bioorg Med Chem Lett 24:5315-7. 2014
    ..Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways. ..
  3. doi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
    ....
  4. doi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
    ..The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway...
  5. doi Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem 21:3831-8. 2013
    ..Although manzamine A has been reported to show several biological activities, this is the first report of a suppressive effect of manzamine A on atherosclerosis in vivo...
  6. doi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
    ..They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge...
  7. doi Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids from the Indonesian marine sponge Acanthostrongylophora ingens
    Ahmed H El-Desoky
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    J Nat Prod 77:1536-40. 2014
    ..Compound 4 was converted to the dimer 2 during storage, suggesting nonenzymatic dimer formation. Among the four isolated compounds, 1, 2, and 4 showed proteasome inhibitory activity. ..
  8. doi Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis
    Eriko Sakai
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862 0973, Japan
    J Nat Med 68:215-9. 2014
    ..Compound 2 inhibited chymotrypsin-like activity of the proteasome and Ubc13 (E2)-Uev1A interaction with IC50 values of 4 and 5 μg/mL, respectively, whereas 1 had little effect on the activity or interaction...
  9. doi Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor
    Michitaka Yamaguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 23:3884-6. 2013
    ..We isolated spongiacidin C from the marine sponge Stylissa massa as the first USP7 inhibitor from a natural source. This compound inhibited USP7 most strongly with an IC50 of 3.8 μM among several USP family members tested...
  10. doi Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Kumamoto, Japan
    Bioorg Med Chem Lett 25:5389-92. 2015
    ..Bastadin 6 was the strongest inhibitor of foam cell formation due to its suppression of acyl-coenzyme A:cholesterol acyltransferase. ..
  11. doi Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens
    Akane Furusato
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 16:3888-91. 2014
    ..Acanthomanzamines D and E have an additional oxazolidine and 2-methyloxazolidine rings, respectively, which fuse to the manzamine skeleton. ..
  12. doi Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors
    Ai Noda
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 25:2650-3. 2015
    ..Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1μM. ..
  13. doi Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
    Masaki Gushiken
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862 0973, Japan
    J Nat Med 69:595-600. 2015
    ..Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 μg/disk, while its oxo congener, manadodioxan D, was inactive. ..
  14. pmc Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404)
    Ippei Kagiyama
    Graduated School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, 862 0973, Japan
    Angew Chem Int Ed Engl 55:1128-32. 2016
    ..protuberus and A. amoenus produced congeners with a syn-bicyclo[2.2.2]diazaoctane core. Plausible biosynthetic pathways to access these cores within the three species likely arise from an intramolecular hetero Diels-Alder reaction. ..
  15. doi Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
    Yuichi Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 15:322-5. 2013
    ..They inhibited p53-Hdm2 interaction with IC(50) values of 2.0-55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC(50) value of 2.0 μM...
  16. ncbi Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
    Yumiko Nagasawa
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chem Pharm Bull (Tokyo) 59:287-90. 2011
    ..Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC(50) values of 50 and 32 µg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 µg/ml...
  17. doi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
    ..These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis...
  18. doi Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage
    Haruka Takamoto
    a Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Biotechnol Biochem 79:1315-9. 2015
    ..The results of the present study suggest that the chlorophyll derivatives contained in edible plants may be useful for the prevention and treatment of atherosclerosis. ..
  19. doi Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
    Rumi Yamanokuchi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Bioorg Med Chem 20:4437-42. 2012
    ..So far, only five E1 inhibitors, panapophenanthrine, himeic acid A, largazole, and hyrtioreticulins A and B (1 and 2), have been isolated from natural sources and, among them, 1 is the most potent E1 inhibitor...
  20. ncbi Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp
    Toshiyuki Kuwana
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Chem Pharm Bull (Tokyo) 61:105-7. 2013
    ..and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not...
  21. ncbi [Study on natural products for drug development]
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe Honmachi, Kumamoto, Japan
    Yakugaku Zasshi 130:1273-81. 2010
    ..Recently, the isolation of the antipodes of notoamides from the terrestrial Aspergillus has been reported. We propose that each enantiomer is generated by a distinct face-selective IMDA...
  22. pmc Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications
    Hikaru Kato
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 17:700-3. 2015
    ..The presence of (+)-versicolamide B suggests that the fungus possesses only the oxidase, which converts (+)-6-epi-stephacidin A into (+)-Versicolamide B, but not for (-)-6-epi-Stephacidin A. ..
  23. pmc Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B
    James D Sunderhaus
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Org Lett 15:22-5. 2013
    ..Furthermore, [(13)C](2)-notoamide T was synthesized and provided to Aspergillus versicolor and Aspergillus sp. MF297-2, in which significant incorporation was observed in the advanced metabolite, notoamide B...
  24. doi Onionin A from Allium cepa inhibits macrophage activation
    Mona El-Aasr
    Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    J Nat Prod 73:1306-8. 2010
    ..This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages...