Seigo Sugiyama

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. pmc A pilot study of ezetimibe vs. atorvastatin for improving peripheral microvascular endothelial function in stable patients with type 2 diabetes mellitus
    Seigo Sugiyama
    Diabetes Care Center, Jinnouchi Hospital, 6 2 3 Kuhonji, Chuo Ku, Kumamoto, 862 0976, Japan
    Lipids Health Dis 14:37. 2015
  2. ncbi request reprint Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease
    Seigo Sugiyama
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, Kumamoto 860 8556, Japan
    Atherosclerosis 194:e43-51. 2007
  3. doi request reprint Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure
    Seiji Takashio
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 62:632-40. 2013
  4. doi request reprint Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris
    Yasuhiro Izumiya
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Atherosclerosis 214:415-21. 2011
  5. ncbi request reprint High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome
    Takashi Fukunaga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 73:1914-9. 2009
  6. pmc Peripheral endothelial function and cardiovascular events in high-risk patients
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 2:e000426. 2013
  7. ncbi request reprint Increased plasma levels of thioredoxin in patients with glucose intolerance
    Shinzo Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 44:1127-32. 2005
  8. doi request reprint Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease
    Toshimitsu Nozaki
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 54:601-8. 2009
  9. pmc Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease
    Keisuke Ohba
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 1:e002485. 2012
  10. pmc Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years
    Koji Sato
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 2:e000227. 2013

Detail Information

Publications103 found, 100 shown here

  1. pmc A pilot study of ezetimibe vs. atorvastatin for improving peripheral microvascular endothelial function in stable patients with type 2 diabetes mellitus
    Seigo Sugiyama
    Diabetes Care Center, Jinnouchi Hospital, 6 2 3 Kuhonji, Chuo Ku, Kumamoto, 862 0976, Japan
    Lipids Health Dis 14:37. 2015
    ..Different cardiovascular actions between treatments for the inhibition of cholesterol absorption and the suppression of cholesterol synthesis for achieving improvement in endothelial function are unknown in DM...
  2. ncbi request reprint Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease
    Seigo Sugiyama
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, Kumamoto 860 8556, Japan
    Atherosclerosis 194:e43-51. 2007
    ..03). Pravastatin exhibits beneficial effects on glucose metabolism especially in the postprandial state associated with increasing plasma adiponectin levels in CAD patients with IGT...
  3. doi request reprint Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure
    Seiji Takashio
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 62:632-40. 2013
    ..This study investigated factors associated with cardiac troponin T (cTnT) release from failing myocardium...
  4. doi request reprint Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris
    Yasuhiro Izumiya
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Atherosclerosis 214:415-21. 2011
    ..We hypothesized that nicorandil has beneficial effects on coronary arterial plaque characteristics and atherosclerogenesis...
  5. ncbi request reprint High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome
    Takashi Fukunaga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 73:1914-9. 2009
    ..The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated...
  6. pmc Peripheral endothelial function and cardiovascular events in high-risk patients
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 2:e000426. 2013
    ....
  7. ncbi request reprint Increased plasma levels of thioredoxin in patients with glucose intolerance
    Shinzo Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 44:1127-32. 2005
    ..The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD)...
  8. doi request reprint Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease
    Toshimitsu Nozaki
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 54:601-8. 2009
    ....
  9. pmc Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease
    Keisuke Ohba
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 1:e002485. 2012
    ..Microvascular coronary artery spasm (microvascular CAS) can cause nonobstructive coronary artery disease. We investigated the clinical features of microvascular CAS and the therapeutic efficacy of calcium channel blockers...
  10. pmc Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years
    Koji Sato
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Heart Assoc 2:e000227. 2013
    ..The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA)...
  11. ncbi request reprint Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes
    Junichi Matsubara
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, and Department of Cardiovascular Clinical and Translational Research, Kumamoto University Hospital, Kumamoto, Japan
    Circ J 77:1337-44. 2013
    ..Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial dysfunction in DM patients with coronary artery disease (CAD)...
  12. ncbi request reprint Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men
    Fumiyuki Otsuka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 71:1703-9. 2007
    ..The hypothesis investigated in the present study was that plasma adiponectin levels correlate with IGT and coronary artery disease (CAD) in non-diabetic men...
  13. doi request reprint Digital assessment of endothelial function and ischemic heart disease in women
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 55:1688-96. 2010
    ....
  14. doi request reprint Effects of endothelial dysfunction on residual platelet aggregability after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease
    Koichiro Fujisue
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences
    Circ Cardiovasc Interv 6:452-9. 2013
    ..Endothelial function could affect platelet reactivity in vivo. We hypothesized that endothelial dysfunction could be associated with high RPR after dual antiplatelet therapy in patients with stable coronary artery disease...
  15. doi request reprint Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina
    Shunichiro Fuchigami
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Thromb Res 122:618-23. 2008
    ..However, there is no information as to whether ADAMTS13 affects the pathogenesis of unstable angina (UA). Thus, the purpose of this study was to examine changes in plasma VWF and ADAMTS13 levels in UA patients...
  16. ncbi request reprint Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease
    Hidenobu Koga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 45:1622-30. 2005
    ....
  17. doi request reprint Determination of cut-off levels for on-clopidogrel platelet aggregation based on functional CYP2C19 gene variants in patients undergoing elective percutaneous coronary intervention
    Takamichi Ono
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Thromb Res 128:e130-6. 2011
    ....
  18. ncbi request reprint Relation between CD4+ T-cell activation and severity of chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Takashi Fukunaga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Cardiol 100:483-8. 2007
    ..019). In conclusion, we demonstrated pronounced type 1 T-helper cell activation in patients with HF in proportion to severity of HF and that the specificity of T-cell activation differs between patients with IC and those with IDC...
  19. doi request reprint Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction
    Eiichi Akiyama
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 60:1778-86. 2012
    ..The purpose of this study was to investigate whether peripheral endothelial dysfunction could predict the occurrence of cardiovascular events in patients with heart failure (HF) with normal left ventricular ejection fraction (HFNEF)...
  20. ncbi request reprint Osteopontin expression of circulating T cells and plasma osteopontin levels are increased in relation to severity of heart failure
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Circ J 71:1879-84. 2007
    ..In a rat model of HF, osteopontin is dramatically increased in the left ventricular myocardium, so the association between osteopontin and HF was examined in the present study...
  21. doi request reprint Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome
    Hirofumi Ueno
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Cardiol 138:174-81. 2010
    ..In order to use RAAS inhibitors more safely and effectively in heart failure, it is necessary to understand the factors affecting serum potassium concentration in the clinical setting...
  22. pmc Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease
    Kensuke Toyama
    Life Science, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 7:e41369. 2012
    ..However, there is no information on the vascular effects of the combination of statins and exercise on arterial wall stiffness in CAD patients...
  23. pmc Basal and ischemia-induced transcardiac troponin release into the coronary circulation in patients with suspected coronary artery disease
    Masaaki Konishi
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e60163. 2013
    ..Troponin release from the coronary circulation remains to be determined because of the lower sensitivity of the conventional assay. We sought to determine basal and angina-induced troponin release using a highly sensitive troponin assay...
  24. doi request reprint Neointimal tissue component assessed by tissue characterization with 40 MHz intravascular ultrasound imaging: comparison of drug-eluting stents and bare-metal stents
    Kenichi Tsujita
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Catheter Cardiovasc Interv 82:1068-74. 2013
    ..The present study used iMap IVUS system to compare neointimal tissue components between DES and bare-metal stents (BMSs)...
  25. ncbi request reprint Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease
    Keisuke Watanabe
    Depatment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 46:2022-30. 2005
    ....
  26. ncbi request reprint Prognostic value of remnant-like lipoprotein particle levels in patients with coronary artery disease and type II diabetes mellitus
    Hironobu Fukushima
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    J Am Coll Cardiol 43:2219-24. 2004
    ....
  27. ncbi request reprint Plasma thioredoxin levels in patients with unstable angina
    Jun Hokamaki
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Int J Cardiol 99:225-31. 2005
    ..Thioredoxin levels were associated with recurrent myocardial ischemia in patients with unstable angina...
  28. doi request reprint Prognostic value of endothelial microparticles in patients with heart failure
    Toshimitsu Nozaki
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, Japan
    Eur J Heart Fail 12:1223-8. 2010
    ..Endothelium-derived microparticles (EMPs) are a novel quantitative plasma marker of endothelial dysfunction. We investigated whether plasma levels of EMPs can predict future cardiovascular events in patients with HF...
  29. doi request reprint Pump failure death and sudden cardiac death in patients with cardiac dysfunction: a search for prognostic predictive factors--a long-term follow-up study
    Hiroki Usuku
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    J Cardiol 55:55-64. 2010
    ..There have been few reports that have analyzed the predictive factors for heart failure death, which is sub-divided into pump failure death and sudden cardiac death, in the long term...
  30. ncbi request reprint The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm
    Tsunenori Nishijima
    The Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacogenet Genomics 17:581-7. 2007
    ..In this study, we examined whether the polymorphism is a prognostic marker in coronary spasm patients...
  31. doi request reprint The synergistic combined effect of anemia with high plasma levels of B-type natriuretic peptide significantly predicts an enhanced risk for major adverse cardiac events
    Hirofumi Ueno
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Heart Vessels 23:243-8. 2008
    ....
  32. doi request reprint Aspirin possibly reduces cerebrovascular events in type 2 diabetic patients with higher C-reactive protein level: subanalysis from the JPAD trial
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan Health Care Center, Kumamoto University, Kumamoto, Japan Electronic address
    J Cardiol 62:165-70. 2013
    ....
  33. doi request reprint Accumulation of pericardial fat correlates with left ventricular diastolic dysfunction in patients with normal ejection fraction
    Masaaki Konishi
    Department of Cardiovascular Medicine, Kumamoto University, Kumamoto, Japan
    J Cardiol 59:344-51. 2012
    ..Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary circulation and myocardial function...
  34. ncbi request reprint Aspirin reduces cerebrovascular events in type 2 diabetic patients with poorly controlled blood pressure. Subanalysis from the JPAD trial
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 76:1526-32. 2012
    ....
  35. ncbi request reprint Relation between platelet microaggregates and ankle brachial index in patients with peripheral arterial disease
    Takashi Kudoh
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Thromb Res 117:263-9. 2006
    ..While platelet microaggregates are a significant predictor of adverse clinical outcome in coronary artery disease, the significance of platelet aggregability in peripheral arterial disease has not been elucidated...
  36. doi request reprint Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction
    Junichi Matsubara
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 57:861-9. 2011
    ..This study investigated the clinical significance of plasma pentraxin 3 (PTX3) levels in patients with heart failure with normal ejection fraction (HFNEF) and whether PTX3 is produced from coronary circulation...
  37. ncbi request reprint Echolucent carotid plaques predict future coronary events in patients with coronary artery disease
    Osamu Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 43:1177-84. 2004
    ..The purpose of this study was to examine whether echolucent carotid plaques predict future coronary events in patients with clinically stable coronary artery disease (CAD)...
  38. ncbi request reprint Cannabinoid 1 receptor blockade reduces atherosclerosis with enhances reverse cholesterol transport
    Koichi Sugamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Atheroscler Thromb 17:141-7. 2010
    ..The reverse cholesterol transport (RCT) system plays important roles in atherogenesis. We investigated whether CB1 receptor blockade could modulate atherogenesis in mice...
  39. doi request reprint Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure
    Seiji Takashio
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Cardiol 113:1697-704. 2014
    ..These results suggested that ongoing myocardial damage correlates with the presence and extent of myocardial fibrosis...
  40. ncbi request reprint Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction
    Sunao Kojima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Atherosclerosis 194:204-13. 2007
    ..05). Patterns of serial changes in plasma adiponectin concentrations are different between men and women and plasma adiponectin concentrations can be used to predict future adverse cardiac events in AMI patients...
  41. doi request reprint Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders
    Tsuyoshi Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Mol Cell Cardiol 44:915-26. 2008
    ..These findings suggest that metabolic disorders exacerbate ischemia-reperfusion injury as a result of overexpression of inflammatory mediators, and this effect might be improved, in part by the anti-inflammatory effects of pioglitazone...
  42. ncbi request reprint Successful diet and exercise therapy as evaluated on self-assessment score significantly improves endothelial function in metabolic syndrome patients
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
    Circ J 77:2807-15. 2013
    ..The utility of the lifestyle modification self-assessment score (Self-AS) in the improvement of endothelial function by office-based counseling for patients with MetS was investigated...
  43. ncbi request reprint Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease
    Hidenobu Koga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, Kumamoto City, Japan
    Eur Heart J 27:817-23. 2006
    ..Dyslipidaemia is a common feature of diabetes. We investigated the association between certain lipid fractions and plasma platelet-derived microparticle (PMP) levels in patients with type-2 DM...
  44. ncbi request reprint Plasma thioredoxin levels and platelet aggregability in patients with acute myocardial infarction
    Shinzo Miyamoto
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Am Heart J 146:465-71. 2003
    ..A platelet aggregometer that uses laser-light scattering enables minimal changes in platelet aggregability to be monitored; however, the relationship between oxidative stress and platelet aggregability in vivo is not well understood...
  45. ncbi request reprint Urinary biopyrrins levels are elevated in relation to severity of heart failure
    Jun Hokamaki
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    J Am Coll Cardiol 43:1880-5. 2004
    ..We investigated the relationship between the urinary levels of biopyrrins and the severity of heart failure (HF)...
  46. ncbi request reprint Coronary spastic angina in patients with connective tissue disease
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Circ J 68:367-70. 2004
    ....
  47. ncbi request reprint Expression levels of Toll-like receptor genes in coronary atherosclerotic lesions of patients with acute coronary syndrome or stable angina pectoris
    Ryuichiro Fukushima
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    Circ J 73:1479-84. 2009
    ..TLR gene expression levels were examined, not only in peripheral blood mononuclear cells (PBMCs), but also in coronary plaques in ACS and SAP patients...
  48. doi request reprint Premenopausal woman with acute myocardial infarction caused by spontaneous coronary artery dissection and potential association with coronary vasospasm
    Kenichi Tsujita
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cardiovasc Interv Ther 27:121-6. 2012
    ..The current case suggests the significance of the IVUS in detecting etiology of MI in younger patients and the potential association between SCAD and coronary vasospasm...
  49. ncbi request reprint Significance of coronary vasospasm in the perioperative management of non-cardiac surgery
    Yasuhiro Nagayoshi
    Department of Cardiovascular Medicine, National Health Insurance Central Hospital Aso, Kumamoto, Japan
    Circ J 76:1965-71. 2012
    ..The prevalence of Japanese patients with coronary vasospasm is higher as compared with Western countries. The present study reported the role of coronary vasospasm in the perioperative period in a Japanese university hospital...
  50. doi request reprint Hypercholesterolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque
    Shinobu Kojima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cardiol 147:371-6. 2011
    ..The purpose of this study was to verify the effects of low-density lipoprotein (LDL) cholesterol level on plaque morphology, and test the hypothesis that adiponectin influences coronary plaque volume and composition...
  51. doi request reprint Pericardial fat inflammation correlates with coronary artery disease
    Masaaki Konishi
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Atherosclerosis 213:649-55. 2010
    ..We sought to assess the association between inflammation in pericardial fat (PF) and coronary artery disease (CAD) by pathological examination and clinical evaluation with cardiac computed tomography (CT)...
  52. ncbi request reprint Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma
    Sunao Kojima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Thromb Res 115:483-90. 2005
    ..Adiponectin has potential antiatherosclerotic properties. We hypothesized that adiponectin was associated with atherosclerotic vascular changes involved in inflammation...
  53. doi request reprint Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages
    Koichi Sugamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan
    Circulation 119:28-36. 2009
    ..We sought to determine whether the endocannabinoid system could be involved in human atherosclerosis and whether CB1 receptor blockade could modulate proinflammatory activity in macrophages...
  54. doi request reprint Significant association between score of periodontal disease and coronary artery disease
    Yoko Oe
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Heart Vessels 24:103-7. 2009
    ..Composite periodontal risk scores were independent and significant predictive factors for CAD...
  55. doi request reprint Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease
    Kensuke Toyama
    Department of Cardiovascular Medicine, Faculty of Life Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Atherosclerosis 217:158-64. 2011
    ..We compared the effects of two statins (rosuvastatin and atorvastatin) combined with exercise on coenzyme Q10 and HDL-C levels in CAD patients...
  56. ncbi request reprint Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 72:1346-50. 2008
    ..In the present study, an investigation took place to see whether aldosterone regulates the expression of ACE2 as well as that of ACE in cultured neonatal rat cardiomyocytes...
  57. ncbi request reprint Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction
    Shun ichi Koide
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    J Am Coll Cardiol 41:539-45. 2003
    ....
  58. ncbi request reprint Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis
    Hidetomo Maruyoshi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 74:1251-6. 2010
    ..It was hypothesized that the Doppler waveform indices of OA correlate with severity of systemic atherosclerosis...
  59. ncbi request reprint Impact of CYP2C19 polymorphism on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing percutaneous coronary intervention
    Koichi Kaikita
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    J Atheroscler Thromb 21:64-76. 2014
    ..The purpose of this study was to investigate the effects of CYP2C19 gene variants on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing elective percutaneous coronary intervention (PCI)...
  60. doi request reprint A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice
    Junichi Matsubara
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 59:265-76. 2012
    ..The aim of this study was to investigate the antiatherogenic effects of the dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin (DFS)...
  61. ncbi request reprint Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure
    Makoto Shono
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 71:1040-6. 2007
    ....
  62. ncbi request reprint Catheter ablation of a polymorphic ventricular tachycardia inducing monofocal premature ventricular complex
    Takashi Uemura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 47:1799-802. 2008
    ..Radiofrequency catheter ablation was performed to eradicate this PVC. No polymorphic ventricular tachycardia has developed after the procedure, and the patient has had no recurrence of syncope...
  63. doi request reprint Differences in oxidative stress markers based on the aetiology of heart failure: comparison of oxidative stress in patients with and without coronary artery disease
    Yasuhiro Nagayoshi
    Department of Community Medicine, Kumamoto University Hospital, Kumamoto City, Japan
    Free Radic Res 43:1159-66. 2009
    ..In the CAD group, 8-OHdG levels reflected the severity of atherosclerosis. These results indicate that the properties of oxidative stress markers should be carefully taken into consideration for the assessment of HF status...
  64. ncbi request reprint Effects of a fixed combination of losartan with hydrochlorothiazide on glucose tolerance in hypertensive patients uncontrolled with angiotensin ii receptor blockers alone
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Atheroscler Thromb 20:238-44. 2013
    ..Recently, it has been reported that ARB/ HCTZ did not worsen fasting blood sugar levels; however, the detailed glucose tolerance change effect with combination therapy of ARB/HCTZ compared to ARB alone therapy remains to be investigated...
  65. doi request reprint Usefulness of SUM of ST-segment elevation on electrocardiograms (limb leads) for predicting in-hospital complications in patients with stress (takotsubo) cardiomyopathy
    Seiji Takashio
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Cardiol 109:1651-6. 2012
    ..72 to 0.90, p <0.001). The results suggest that the extent and magnitude of ST-segment elevation on the electrocardiogram are potentially useful predictors of in-hospital complications in patients with stress cardiomyopathy...
  66. doi request reprint Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy
    Koichiro Yamamoto
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Cardiol 57:194-201. 2011
    ..The aim was to examine the impact of CYP2C19 genotype on the residual platelet reactivity in Japanese patients with coronary heart disease (CHD) during antiplatelet therapy...
  67. ncbi request reprint Impact of delta-sarcoglycan gene polymorphism on the occurrence of coronary spastic angina in Japanese patients with hypertrophic cardiomyopathy
    Tsuyoshi Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Circ J 71:1263-7. 2007
    ..Coronary spasm might cause myocardial ischemia in HCM patients. Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model...
  68. doi request reprint Effects of gastric medicines on gastroduodenal injury in patients with stable angina during antiplatelet therapy
    Seiji Hokimoto
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1, Honjo, Kumamoto 860 8556, Japan
    J Cardiol 54:71-5. 2009
    ..The aim of this study was to examine the effects of gastric medicines on gastroduodenal injury during antiplatelet therapy after coronary intervention...
  69. ncbi request reprint Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease
    Fumiyuki Otsuka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan
    J Am Coll Cardiol 48:1155-62. 2006
    ..We sought to assess whether plasma adiponectin levels correlate with angiographic coronary lesion complexity in patients with coronary artery disease (CAD)...
  70. doi request reprint Association of pericardial fat accumulation rather than abdominal obesity with coronary atherosclerotic plaque formation in patients with suspected coronary artery disease
    Masaaki Konishi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Atherosclerosis 209:573-8. 2010
    ..The purpose of this study was to examine the association of pericardial fat with the presence of coronary plaques...
  71. doi request reprint Smoking cessation is associated with increased plasma adiponectin levels in men
    Fumiyuki Otsuka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, Kumamoto 860 8556, Japan
    J Cardiol 53:219-25. 2009
    ..However, the influence of smoking cessation on adiponectin levels remains unknown. We sought to assess whether smoking cessation is associated with increased plasma adiponectin levels in men...
  72. doi request reprint Analysis of atrioventricular nodal reentrant tachycardia with variable ventriculoatrial block: characteristics of the upper common pathway
    Kenji Morihisa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pacing Clin Electrophysiol 32:484-93. 2009
    ..The precise nature of the upper turnaround part of atrioventricular nodal reentrant tachycardia (AVNRT) is not entirely understood...
  73. ncbi request reprint Multidisciplinary mechanical supports improve outcome in a shock patient with cardiac amyloidosis: a case report
    Yoshiro Onoue
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Intern Med 51:1215-9. 2012
    ..It is reasonable to initiate IABP and hemofiltration dialysis during the early stages for the appropriate control of hemodynamics and fluid in shock patients with cardiac amyloidosis...
  74. ncbi request reprint Total coronary artery plaque burden measured by cardiac computed tomography is associated with metabolic syndrome
    Masaaki Konishi
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Atheroscler Thromb 18:939-45. 2011
    ..The purpose of this study was to quantify coronary plaque volume using 64-slice computed tomography (CT)...
  75. doi request reprint Improvement effect on endothelial function in patients with congestive heart failure treated with cardiac resynchronization therapy
    Koji Enomoto
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Cardiol 58:69-73. 2011
    ..However the precise mechanisms of the relationship between CRT and vascular endothelial function have not been well discussed...
  76. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008
    ..Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes...
  77. ncbi request reprint Acute myocardial infarction induced by cisplatin-based combination chemotherapy for malignant melanoma: a case report
    Takashi Fukunaga
    Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    J Cardiol 47:191-5. 2006
    ..Chemotherapy should be used cautiously in patients with coronary risk factors before treatment is begun...
  78. doi request reprint Prognostic value of plasma von Willebrand factor-cleaving protease (ADAMTS13) antigen levels in patients with coronary artery disease
    Mitsutoshi Miura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Thromb Haemost 103:623-9. 2010
    ..Our findings suggest that low plasma ADAMTS13 as well as high VWF level is a useful predictor of cardiac and cerebrovascular events in CAD patients...
  79. ncbi request reprint Serial changes in von Willebrand factor-cleaving protease (ADAMTS13) and prognosis after acute myocardial infarction
    Masakazu Matsukawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Cardiol 100:758-63. 2007
    ..In conclusion, these findings suggest that monitoring the changes of VWF and ADAMTS13 antigen levels in the early phase might be valuable for predicting and preventing thrombosis during 1-year follow-up in patients with AMI...
  80. doi request reprint A Q312X mutation in the hemojuvelin gene is associated with cardiomyopathy due to juvenile haemochromatosis
    Yasuhiro Nagayoshi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan
    Eur J Heart Fail 10:1001-6. 2008
    ..The candidate modifier genes are hemojuvelin (HJV) and hepcidin antimicrobial peptide (HAMP). In the Japanese population, the prevalence of JH is quite low. The influence of HJV mutation on the JH phenotype is still unclear...
  81. ncbi request reprint Hypoadiponectinemia is associated with coronary artery spasm in men
    Hidetomo Maruyoshi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 69:1154-6. 2005
    ..The relationship between adiponectin and coronary spastic angina (CSA), both of which are closely involved in coronary endothelial dysfunction, has not been elucidated...
  82. ncbi request reprint Formation of platelet microaggregates correlates with adverse clinical outcome in patients with coronary artery disease
    Shinzo Miyamoto
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Thromb Haemost 89:681-6. 2003
    ..In patients with CAD, an increase in small platelet aggregates is closely correlated with the future occurrence of cardiovascular events..
  83. ncbi request reprint Effects of nicorandil on endogenous fibrinolytic capacity in patients with coronary artery disease
    Tomohiro Sakamoto
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Circ J 68:232-5. 2004
    ..Nicorandil is a hybrid-type anti-anginal drug that combines a K(ATP) channel opener and a nitric oxide donor. Recently the IONA study reported that nicorandil improves the prognosis of patients with stable angina pectoris...
  84. ncbi request reprint [Acute coronary syndrome-initiating factors]
    Kenichi Tsujita
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    Nihon Rinsho 68:607-14. 2010
    ..On the other hand, coronary spasm plays an important role in the pathogenesis of ACS especially in Japan. In this article, we review related factors leading to plaque rupture and erosion in the basic aspect...
  85. ncbi request reprint Fulminant myocarditis survivor after 56 hours of non-responsive cardiac arrest successfully returned to normal life by cardiac resynchronization therapy: a case report
    Koichi Sugamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto, Kumamoto 860 8556
    J Cardiol 48:345-52. 2006
    ..She presented with paradoxical ventricular motion with a low cardiac output, so CRT was performed. After the initiation of CRT, her heart failure symptoms improved and she could return home...
  86. ncbi request reprint Floating coronary artery thrombus prior to the onset of acute myocardial infarction
    Hidetomo Maruyoshi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 45:173-4. 2006
  87. ncbi request reprint Clinical characteristics and outcomes of Japanese women undergoing coronary revascularization therapy
    Shunsuke Funakoshi
    Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe 650 0046, Japan
    Circ J 75:1358-67. 2011
    ..This study aimed to identify gender-based differences in risk factor profiles and outcomes among Japanese patients undergoing coronary revascularization...
  88. ncbi request reprint Increased serum matrix metalloproteinase-1 concentration predicts advanced left ventricular remodeling in patients with acute myocardial infarction
    Hirofumi Soejima
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Circ J 67:301-4. 2003
    ..01), 7 days (p<0.01) and 2 weeks (p<0.05) were lower in the high LVEF group than in low LVEF group. A high concentration of MMP-1 at the subacute phase after AMI predicts advanced left ventricular remodeling...
  89. doi request reprint Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease
    Kensuke Toyama
    Department of Cardiovascular Medicine, Faculty of Life Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Cardiol 56:142-6. 2010
    ..Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated...
  90. ncbi request reprint B-type natriuretic peptide as a marker of the effects of enalapril in patients with heart failure
    Michihiro Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Med 112:716-20. 2002
    ..It is not known how plasma levels of these hormones respond to changes in cardiac function that occur as a result of treatment with angiotensin-converting enzyme (ACE) inhibitors...
  91. ncbi request reprint Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease
    Koichi Sugamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan
    Circ J 72:1193-7. 2008
    ..Pioglitazone added to successful statin therapy may be beneficial for coronary artery disease (CAD) patients without diabetes mellitus...
  92. ncbi request reprint Successful coronary stenting of the left anterior descending artery at the branching site of the targeted septal perforator immediately after percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy
    Tsuyoshi Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Intern Med 44:722-6. 2005
    ..A coil stent was selected due to possibility of repeat septal ablation in the future. Simultaneous treatment of HOCM and LAD stenosis is considered safe and effective using a coil stent...
  93. ncbi request reprint Cardiac displacement with a congenital complete left-sided pericardial defect in a patient with exertional angina pectoris--a case report
    Sunao Kojima
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Honjo, Kumamoto City, Japan
    Angiology 55:445-9. 2004
    ..The congenital complete left-sided pericardial defect could not be diagnosed preoperatively, but it was confirmed by thoracotomy...
  94. ncbi request reprint Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque
    Keishi Miyata
    Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 365:207-13. 2008
    ....
  95. ncbi request reprint Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction
    Shin ichi Nakamura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan
    Circulation 105:2968-73. 2002
    ..This study examined the hypothesis that variation in the GCL genes may be associated with coronary artery disease in which oxidative stress plays a pathogenetic role...
  96. doi request reprint Changes in plasma von Willebrand factor and ADAMTS13 levels associated with left atrial remodeling in atrial fibrillation
    Takashi Uemura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Thromb Res 124:28-32. 2009
    ..The aim of this study was to examine the relationship between changes in plasma VWF and ADAMTS13 levels, and left atrial remodeling in AF patients...
  97. ncbi request reprint [Acute coronary syndrome related factors]
    Hidenobu Koga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University
    Nihon Rinsho 64:642-6. 2006
    ..A basic approach to atherosclerotic diseases is important and helpful for physicians in clinical situation. In this article, we review related factors leading to plaque rupture and erosion in the basic aspect...
  98. ncbi request reprint Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function
    Shin ichi Nakamura
    2nd Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Nakakoma gun, Yamanashi, 409 3898 Japan
    Circulation 108:1425-7. 2003
    ....
  99. ncbi request reprint Increased plasma levels of thioredoxin in patients with coronary spastic angina
    Shinzo Miyamoto
    Antioxid Redox Signal 6:75-80. 2004
    ..The plasma levels of thioredoxin and current smoking were risk factors for coronary spastic angina, and they were independent from other traditional risk factors...
  100. ncbi request reprint Plasminogen activator inhibitor contributes to the coronary wall thickening in patients with angiographically normal coronary
    Yuji Miyao
    Division of Cardiovascular Center, Kumamoto National Hospital, Ninomaru 1 5, Kumamoto 860 0008, Kumamoto, Japan
    Thromb Res 112:123-9. 2003
    ..The aim of this study was to evaluate if the PAI activity contributes to the extent of atherosclerotic changes in angiographically normal coronary arteries using IVUS technique...
  101. ncbi request reprint Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma
    Masanori Aikawa
    Leducq Center for Cardiovascular Research, Department of Medicine, University of California, San Diego, La Jolla, Calif, USA
    Circulation 106:1390-6. 2002
    ..This study tested the hypothesis that lipid lowering decreases oxidative stress and improves EC functions related to inflammatory cell accumulation...