Takafumi Senokuchi

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. pmc Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes
    Takeshi Matsumura
    Department of Metabolic Medicine, Kumamoto University, Kumamoto, Japan
    Cardiovasc Diabetol 12:177. 2013
  2. pmc Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress
    Takafumi Senokuchi
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 57:2967-76. 2008
  3. pmc Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
    Seongah Han
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, New York 10032, USA
    J Clin Invest 119:1029-41. 2009
  4. pmc Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice
    Tracie A Seimon
    Department of Medicine, Division of Molecular Medicine, Columbia University, PH 9 405, 630 W 168th Street, New York, New York 10032, USA
    J Clin Invest 119:886-98. 2009
  5. ncbi request reprint SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
  6. doi request reprint Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line
    Kazuya Yamagata
    Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 407:620-5. 2011
  7. doi request reprint Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γ in macrophages
    Takeshi Matsumura
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Arterioscler Thromb Vasc Biol 31:1268-75. 2011
  8. ncbi request reprint The macrophage at the crossroads of insulin resistance and atherosclerosis
    Chien Ping Liang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 100:1546-55. 2007

Collaborators

Detail Information

Publications8

  1. pmc Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes
    Takeshi Matsumura
    Department of Metabolic Medicine, Kumamoto University, Kumamoto, Japan
    Cardiovasc Diabetol 12:177. 2013
    ..We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects with type 2 diabetes...
  2. pmc Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress
    Takafumi Senokuchi
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 57:2967-76. 2008
    ..However, the molecular mechanisms of increased apoptosis in insulin-resistant macrophages remain unclear...
  3. pmc Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
    Seongah Han
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, New York 10032, USA
    J Clin Invest 119:1029-41. 2009
    ..These findings suggest a dual action of hepatic IR on lipoprotein levels, in which the ability to increase VLDL apoB and lipid secretion via AKT/GSK is offset by upregulation of Ldlr...
  4. pmc Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice
    Tracie A Seimon
    Department of Medicine, Division of Molecular Medicine, Columbia University, PH 9 405, 630 W 168th Street, New York, New York 10032, USA
    J Clin Invest 119:886-98. 2009
    ..Our results demonstrate that p38alpha MAPK may play a critical role in suppressing ER stress-induced macrophage apoptosis in vitro and advanced lesional macrophage apoptosis in vivo...
  5. ncbi request reprint SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
    ..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
  6. doi request reprint Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line
    Kazuya Yamagata
    Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 407:620-5. 2011
    ..These results suggest that increased KCNQ1 protein expression limits insulin secretion from pancreatic β-cells by regulating the potassium channel current...
  7. doi request reprint Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γ in macrophages
    Takeshi Matsumura
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Arterioscler Thromb Vasc Biol 31:1268-75. 2011
    ..Here, we investigated the molecular basis of the antiatherosclerotic effects of telmisartan in macrophages and apolipoprotein E-deficient mice...
  8. ncbi request reprint The macrophage at the crossroads of insulin resistance and atherosclerosis
    Chien Ping Liang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 100:1546-55. 2007
    ....