Hironobu Ihn

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis
    Hironobu Ihn
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol Sci 49:103-13. 2008
  2. ncbi request reprint [Treatment of skin ulcers in collagen vascular diseases]
    Hironobu Ihn
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceuticals Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nihon Hansenbyo Gakkai Zasshi 77:211-3. 2008
  3. doi request reprint TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts
    Noritoshi Honda
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Immunol 188:3323-31. 2012
  4. doi request reprint Hair miR-29a levels are decreased in patients with scleroderma
    Risa Takemoto
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 22:832-3. 2013
  5. doi request reprint Down-regulation of miR-223 contributes to the formation of Gottron's papules in dermatomyositis via the induction of PKCɛ
    Kuniko Inoue
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Eur J Dermatol 23:160-7. 2013
  6. doi request reprint Decreased miR-7 expression in the skin and sera of patients with dermatomyositis
    Yuka Oshikawa
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Acta Derm Venereol 93:273-6. 2013
  7. doi request reprint miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3
    Noritoshi Honda
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Am J Pathol 182:206-16. 2013
  8. doi request reprint Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts
    Taiji Nakashima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8555, Japan
    J Immunol 188:3573-83. 2012
  9. pmc Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis
    Hideo Kudo
    Kumamoto University, Kumamoto, Japan
    Arthritis Rheumatol 66:1636-47. 2014
  10. doi request reprint Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions
    Asako Ichihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Allergy Clin Immunol 133:1065-74. 2014

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis
    Hironobu Ihn
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol Sci 49:103-13. 2008
    ..This review focuses on the possible role of autocrine TGF-beta signaling in the pathogenesis of SSc...
  2. ncbi request reprint [Treatment of skin ulcers in collagen vascular diseases]
    Hironobu Ihn
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceuticals Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nihon Hansenbyo Gakkai Zasshi 77:211-3. 2008
    ..This review shows skin manifestations of various collagen vascular diseases and the causes of skin ulcers in these diseases...
  3. doi request reprint TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts
    Noritoshi Honda
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Immunol 188:3323-31. 2012
    ..miR-196a may play some roles in the pathogenesis of SSc. Investigation of the regulatory mechanisms of type I collagen expression by miR-196a may lead to new treatments using miRNA...
  4. doi request reprint Hair miR-29a levels are decreased in patients with scleroderma
    Risa Takemoto
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 22:832-3. 2013
    ..To confirm the clinical usefulness of hair microRNAs, large-scale researches are needed in the future. ..
  5. doi request reprint Down-regulation of miR-223 contributes to the formation of Gottron's papules in dermatomyositis via the induction of PKCɛ
    Kuniko Inoue
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Eur J Dermatol 23:160-7. 2013
    ..Gottron's papules, one of the skin manifestations, are of great diagnostic value because they are specific to DM. However, the pathogenesis of Gottron's papules remains unclear...
  6. doi request reprint Decreased miR-7 expression in the skin and sera of patients with dermatomyositis
    Yuka Oshikawa
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Acta Derm Venereol 93:273-6. 2013
    ..Clarifying the up- or down-stream events of down-regulated miR-7 in patients with dermatomyositis may lead to further understanding of the disease and a new therapeutic approach...
  7. doi request reprint miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3
    Noritoshi Honda
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Am J Pathol 182:206-16. 2013
    ..Investigation of the regulatory mechanisms of tissue fibrosis by miR-150 could lead to development of new diagnostic tools and new treatments using miRNA...
  8. doi request reprint Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts
    Taiji Nakashima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8555, Japan
    J Immunol 188:3573-83. 2012
    ..Clarifying the novel regulatory mechanisms of fibrosis by the cytokine network consisting of TGF-β and IL-17A may lead to a new therapeutic approach for this disease...
  9. pmc Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis
    Hideo Kudo
    Kumamoto University, Kumamoto, Japan
    Arthritis Rheumatol 66:1636-47. 2014
    ..To clarify the role of interleukin-20 (IL-20) in the regulatory mechanism of extracellular matrix expression and to determine the contribution of IL-20 to the phenotype of systemic sclerosis (SSc)...
  10. doi request reprint Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions
    Asako Ichihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Allergy Clin Immunol 133:1065-74. 2014
    ..Toxic epidermal necrolysis (TEN) is a severe drug-induced cutaneous reaction. Although one of the primary histologic features of TEN is keratinocyte apoptosis, its exact mechanism remains unknown...
  11. doi request reprint Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor β signaling
    Ikko Kajihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Japan
    Mod Rheumatol 23:516-24. 2013
    ..Our study was undertaken to evaluate whether dermal fibroblasts function as one of the sources of the increased VEGF in SSc, and to clarify its mechanism...
  12. doi request reprint Discoidin domain receptor 2-microRNA 196a-mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts
    Katsunari Makino
    Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 133:110-9. 2013
    ..DDR2-microRNA-196a pathway may be a previously unreported negative feedback system, and its impairment may be involved in the pathogenesis of SSc...
  13. doi request reprint microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma
    Mitsuhiko Etoh
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Arch Dermatol Res 305:9-15. 2013
    ..Investigation of the regulatory mechanisms of LSc by miRNA may lead to new treatments by the transfection into the lesional skin of this disease...
  14. doi request reprint microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma
    Takaomi Sing
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Rheumatology (Oxford) 51:1550-6. 2012
    ..However, the role of miRNA in SSc is not fully understood. This study investigated the expression and role of miR-92a in SSc patients and evaluated the possibility that miR-92a is involved in the pathogenesis of this disease...
  15. doi request reprint Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts
    Ikko Kajihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Am J Pathol 180:703-14. 2012
    ..Thus, TSP-2 may play an important role in the maintenance of fibrosis and angiopathy in patients with SSc...
  16. doi request reprint Detection of hair-microRNAs as the novel potent biomarker: evaluation of the usefulness for the diagnosis of scleroderma
    Zhongzhi Wang
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Dermatol Sci 72:134-41. 2013
    ..Serum microRNA levels are known as useful biomarkers for various diseases. Recent publication has indicated the existence of microRNAs in hair roots and hair shafts...
  17. doi request reprint Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK
    Keitaro Yamane
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    J Mol Med (Berl) 91:69-81. 2013
    ..On the other hand, miR-214 was not detected in the serum. Investigation of the regulatory mechanisms of keratinocyte proliferation by microRNA may lead to develop new biomarkers and treatments using microRNA...
  18. doi request reprint The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis
    Aki Ogata
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 418:494-9. 2012
    ..We propose that keratinocyte-derived Angptl2 functions in DM pathogenesis by inducing chronic inflammation in skin tissue...
  19. doi request reprint Kinesin family member 20A is a novel melanoma-associated antigen
    Junji Yamashita
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Acta Derm Venereol 92:593-7. 2012
    ..These results suggest that immunotherapy with KIF20A may be a novel treatment option for advanced melanoma...
  20. doi request reprint The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma
    Junji Yamashita
    Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan
    Melanoma Res 23:13-20. 2013
    ..In conclusion, miR-146a may be involved in the pathogenesis of MM, and individuals with the CG genotype have an increased risk of developing MM...
  21. doi request reprint The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma
    Katsunari Makino
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Immunol 190:3905-15. 2013
    ..p. miRNA injection improved the skin fibrosis induced by bleomycin in mice. Investigation of more detailed mechanisms of miRNA-mediated regulation of collagen expression may lead to new therapeutic approaches against SSc and LSc...
  22. doi request reprint CD163 expression is increased in the involved skin and sera of patients with systemic lupus erythematosus
    Wakana Nakayama
    Department of Dermatology and Plastic Surgery, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Eur J Dermatol 22:512-7. 2012
    ..To investigate the relationship between M2 macrophages and disease activity in SLE...
  23. ncbi request reprint Angiogenin expression in the sera and skin of patients with rheumatic diseases
    Aki Kuwahara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 6:229-33. 2012
    ..Further studies with an increased number of patients may help to clarify the relationship between angiogenin and vascular abnormalities in rheumatic diseases and to develop new therapeutic strategies...
  24. doi request reprint Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-δ in normal human dermal fibroblasts
    Chikako Moriya
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 131:655-61. 2011
    ..Taken together, these findings indicate that IL-13 may induce the formation of thickened dermis in AD by decreasing collagen degradation. Blockade of IL-13 signaling cascades in AD patients may be a new therapeutic approach...
  25. pmc Suppression of melanin production by expression of HSP70
    Tatsuya Hoshino
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Biol Chem 285:13254-63. 2010
    ..This study provides the first evidence of an inhibitory effect of HSP70 on melanin production both in vitro and in vivo. This effect seems to be mediated by modulation of MITF activity through a direct interaction between HSP70 and MITF...
  26. ncbi request reprint Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers
    Zhongzhi Wang
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Eur J Dermatol . 2016
    ..The diagnosis of nail diseases is sometimes difficult, and nail psoriasis without skin lesions is indistinguishable from nail changes caused by other diseases...
  27. doi request reprint AT-rich Interaction Domain-containing Protein 3B is a New Tumour Marker for Melanoma
    Satoshi Nakahara
    Department of Dermatology and Plastic Surgery, Faculty of Life Science, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, Japan
    Acta Derm Venereol . 2016
    ..is missing (Short communication)...
  28. doi request reprint Cell division cycle-associated protein 1 as a new melanoma-associated antigen
    Aki Tokuzumi
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 43:1399-1405. 2016
    ..CDCA1-specific siRNA inhibited the cell proliferation of SKMEL2 and WM115 cells, but did not reduce the migration or invasion activity. These results suggest that CDCA1 may be a new therapeutic target of melanoma...
  29. doi request reprint Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts
    Kayo Nakamura
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Dermatol Sci 84:30-39. 2016
    ..Exosomes are small vesicles shed from various cells. They contain proteins, lipids, and nucleic acids, and are regarded as a tool of cell-cell communication...
  30. ncbi request reprint Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression
    Wakana Nakayama
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Chuo ku Kumamoto, Japan
    Rheumatology (Oxford) . 2016
    ..The aim of this study was to investigate the regulation of extracellular matrix expression by IL-23 and its contribution to the phenotype of SSc...
  31. doi request reprint Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin
    Zhongzhi Wang
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Dermatol Sci 79:268-78. 2015
    ..Integrins, especially αv integrin (ITGAV), are thought to play central roles in tissue fibrosis and the pathogenesis of scleroderma. So far, skin phenotype of tissue-specific transgenic mice of ITGAV have not been investigated...
  32. doi request reprint EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin
    Hideo Kudo
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Immunol 195:3565-73. 2015
    ..Clarifying the mechanism regulating the extracellular matrix expression by EBI3 in SSc skin may lead to better understanding of this disease and new therapeutic strategies using ointment or microinjection of the subunit. ..
  33. doi request reprint Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress
    Jun Aoi
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Mol Cancer Res 12:239-49. 2014
    ..Overall, this study strongly suggests that the inflammatory mediator Angptl2 accelerates chemically induced carcinogenesis through increased oxidative stress and decreased Msh2 expression in skin tissue...
  34. doi request reprint The proportion of lymphocytic inflammation with CD123-positive cells in lupus erythematous profundus predict a clinical response to treatment
    Azusa Miyashita
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, Japan
    Acta Derm Venereol 94:563-7. 2014
    ..027). These results suggest that the clinical response to treatment of lupus erythematosus profundus could be predicted from the histological features. ..
  35. doi request reprint Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients
    Takamitsu Makino
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Eur J Dermatol 24:470-6. 2014
    ..Localized scleroderma (LSc) exhibits fibrosis of the skin and subcutaneous tissue. LSc shows an excessive deposition of type 1 collagen...
  36. doi request reprint miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation
    Ikko Kajihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Arch Dermatol Res 306:367-74. 2014
    ..Taken together, LRP-1 overexpression caused by the miR-205 down-regulation may play a role in the abnormal proliferation of DFSP cells via directly regulating ERK phosphorylation. ..
  37. doi request reprint Serum angiopoietin-like protein 3 concentrations in rheumatic diseases
    Yasuyo Hayashi
    Department of Dermatology and Plastic Surgery, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Eur J Dermatol 22:500-4. 2012
    ..Clarifying the role of Angptl3 in each rheumatic disease may lead to further understanding of the pathogenesis and new therapeutic approaches...
  38. doi request reprint Increased serum levels of miR-1266 in patients with psoriasis vulgaris
    Asako Ichihara
    Department of Dermatology and Plastic Surgery, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Eur J Dermatol 22:68-71. 2012
    ..Taken together, serum miR-1266 may have potential for a new disease marker. miR-1266 is not likely to regulate IL-17A expression directly, but may be involved in the pathogenesis of psoriasis by regulating other target molecules...
  39. ncbi request reprint Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus
    Yong Xie
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Japan
    Biosci Trends 5:83-8. 2011
    ..In conclusion, this study revealed that T lymphocytes, B lymphocytes, and natural killer cells may play some roles in the pathogenesis of DLE...
  40. doi request reprint microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma
    Minami Inoue
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Int J Dermatol 55:786-90. 2016
    ..The diagnosis of dermatomyositis is sometimes difficult. We tried to evaluate the possibility that levels of Homo sapiens microRNA-214 (hsa-miR-214) in hair roots or hair shafts can be a useful marker of the disease...
  41. doi request reprint Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons
    Azusa Miyashita
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Immunol Res 4:248-58. 2016
    ..The iPS-ML-IFNs could infiltrate into tumor tissue and exert anticancer effects in the local tumor tissue. In conclusion, this method will provide a new therapeutic modality for metastatic melanoma...
  42. doi request reprint Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization
    Zhongzhi Wang
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 25:131-6. 2016
    ..Further studies on the regulatory mechanism of tissue fibrosis by lncRNAs in SSc skin lead to a better understanding of the pathogenesis, new diagnostic methods by their serum levels and new therapeutic approaches using siRNAs. ..
  43. pmc Investigation of FOXM1 as a Potential New Target for Melanoma
    Azusa Miyashita
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, Japan
    PLoS ONE 10:e0144241. 2015
    ..In conclusion, FOXM1 is considered to be a new therapeutic target for melanoma. ..
  44. doi request reprint Detection of hair root miR-19a as a novel diagnostic marker for psoriasis
    Hiroki Hirao
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Eur J Dermatol 23:807-11. 2013
    ..Objective biomarkers that reflect the diagnosis and disease activity have not been in clinical use for psoriasis...
  45. doi request reprint Evaluation of sentinel node biopsy for cutaneous squamous cell carcinoma
    Satoshi Fukushima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto, Japan
    J Dermatol 41:539-41. 2014
    ..In conclusion, the efficacy of SLNB in SCC is comparable to that of melanoma in the positive rate. There are two kinds of benefit, avoidance of unnecessary complete lymph node dissection and early detection of metastasis. ..
  46. doi request reprint Serum levels of tenascin-C in collagen diseases
    Kuniko Inoue
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 40:715-9. 2013
    ..Clarifying the role of tenascin-C in the pathogenesis of collagen diseases may lead to a new therapeutic approach. ..
  47. doi request reprint Expression analysis of multiple microRNAs in each patient with scleroderma
    Shigeru Koba
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 22:489-91. 2013
    ..Our study is the first to demonstrate different expression profiles of multiple microRNAs in each patient with scleroderma and examine its clinical significance. ..
  48. doi request reprint Intravenous immunoglobulin treatment recovers the down-regulated levels of Th1 cytokines in the sera and skin of scleroderma patients
    Hideo Kudo
    Department of Dermatology and Plastic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    J Dermatol Sci 69:77-80. 2013
    ..Although intravenous immunoglobulin (IVIG) may be one of the promising treatments, the mechanisms by which IVIG improves the fibrosis of SSc remain unknown...
  49. doi request reprint Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts
    Toshikatsu Igata
    Department of Dermatology and Plastic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 393:101-5. 2010
    ..This study also suggests that controlling Rac1 signaling is a new therapeutic approach to chronic/untreatable ulcer...
  50. doi request reprint The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker
    Hisashi Kanemaru
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    J Dermatol Sci 61:187-93. 2011
    ..This suggests that the serum level of miR-221 might increase in patients with MM and thus could be used as a new tumor marker...
  51. ncbi request reprint Activation of the extracellular signal-regulated kinases signaling pathway in squamous cell carcinoma of the skin
    Xiaoyong Zhang
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 1:156-60. 2007
    ..These results suggest that ERK1/2 signal pathways play an important role in the proliferation of SCC and that the inhibition of this signal pathway may be effective in the treatment of cutaneous SCC...
  52. doi request reprint Enhanced CCR9 expression levels in psoriatic skin are associated with poor clinical outcome to infliximab treatment
    Aiko Koga
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 43:522-5. 2016
    ..Our results indicated that the expression levels of CCR9 in lesional skin may be a useful biologic marker of the clinical efficacy of infliximab therapy in psoriasis patients. ..
  53. doi request reprint Sensitive detection of melanoma metastasis using circulating microRNA expression profiles
    Rie Shiiyama
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Melanoma Res 23:366-72. 2013
    ..Clarifying the involvement of the microRNA network in the pathogenesis of melanoma may contribute to the development of new diagnostic tools and to advancing the understanding of this disease. ..
  54. doi request reprint miR-424 levels in hair shaft are increased in psoriatic patients
    Yasuo Tsuru
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 41:382-5. 2014
    ..Hair root miR-424 was not useful for evaluating both diagnosis and severity of the disease. Our results indicated hair shaft miR-424 levels may be useful as a diagnostic marker of psoriasis. ..
  55. doi request reprint Hair shaft miRNA-221 levels as a new tumor marker of malignant melanoma
    Taisuke Inada
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 42:198-201. 2015
    ..Our investigations offer new insight into the relationship between miR-221 and MM, and may provide a new, non-invasive way to screen for melanoma. ..
  56. doi request reprint A case of anaplastic large cell lymphoma of skeletal muscle
    Yosuke Kubo
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 41:999-1002. 2014
    ..Based on the histological examination, this patient was diagnosed to have ALK-negative ALCL of the skeletal muscle. Further studies are needed to clarify the biological behavior of primary skeletal muscle ALCL...
  57. doi request reprint Serum levels of leptin receptor in patients with malignant melanoma as a new tumor marker
    Hironori Mizutani
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 22:748-9. 2013
    ..To our knowledge, this is the first report investigating the serum levels of leptin receptor in MM, and serum leptin receptor levels may be used as a useful tumor marker of MM. ..
  58. doi request reprint Serum levels of soluble CD163 in patients with systemic sclerosis
    Wakana Nakayama
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Rheumatol Int 32:403-7. 2012
    ..Furthermore, serum sCD163 levels may be a marker of pulmonary hypertension at the early stage in patients with SSc...
  59. ncbi request reprint The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma
    Hazuki Nishi
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 4:86-9. 2010
    ..Our data showed that the staining intensity of HMW-MAA ALM lesions was weaker than that of SSM. Furthermore, the percentage of HMW-MAA positive staining in ALM lesions was higher than previously reported...
  60. doi request reprint The expression of SnoN in normal human skin and cutaneous keratinous neoplasms
    Xiaoyong Zhang
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Dermatol 48:579-83. 2009
    ..This study investigated the expression and significance of SnoN protein in normal human skin and in the development of seborrheic keratosis (SK), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) of the skin...
  61. doi request reprint Non-radioisotope method for diagnosing photosensitive genodermatoses and a new marker for xeroderma pigmentosum variant
    Satoru Hashimoto
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Dermatol 36:138-43. 2009
    ..Moreover, we discovered a new useful marker for XP variant based on checkpoint activity. The non-radioisotope method and the new marker described here comprise an easy way to diagnose XP and CS...
  62. doi request reprint Immunohistochemical characterization of the cellular infiltrate in localized scleroderma
    Yong Xie
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Dermatol 47:438-42. 2008
    ..This study was performed to determine the immunohistochemical features of the cellular infiltrate in localized scleroderma...
  63. pmc Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing
    Katsunari Makino
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 9:e97972. 2014
    ..The endothelial cell-derived ET-1 is the potent therapeutic target in fibrosis or wound healing, and investigations of the overall regulatory mechanisms of these pathological conditions by ET-1 may lead to a new therapeutic approach. ..
  64. pmc Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
    Nobuyo Higashi-Kuwata
    Department of Dermatology and Plastic and Reconstructive Surgery, Kumamoto University, Kumamoto, Japan
    Arthritis Res Ther 12:R128. 2010
    ....
  65. pmc Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy
    Taiji Nakashima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 5:e14334. 2010
    ..Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear...
  66. doi request reprint Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients
    Hiroki Arakawa
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Exp Dermatol 20:764-6. 2011
    ..Serum adiponectin levels may be a useful biomarker for fibrotic condition in patients with SSc. Clarifying the role of adiponectin in collagen diseases may lead to further understanding of the pathogenesis and new therapeutic approach...
  67. ncbi request reprint The growth of Vibrio vulnificus and the habitat of infected patients in Kumamoto
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 1:134-9. 2007
    ..vulnificus. Therefore, investigating these geographical and meteorological factors can help predict areas with a higher number of V. vulnificus infection outbreaks...
  68. doi request reprint NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma
    Naoki Shimozono
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Res 75:4458-65. 2015
    ..Collectively, our findings advance knowledge concerning the genetic causes of angiosarcoma, with potential implications for new diagnostic and therapeutic approaches...
  69. doi request reprint Expression pattern of VEGFR-1, -2, -3 and D2-40 protein in the skin of patients with systemic sclerosis
    Nobuyo Higashi-Kuwata
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Eur J Dermatol 21:490-4. 2011
    ..This study details the expression of VEGFR and D2-40 in the skin of patients with SSc, and highlights a possible role of microcirculatory dysfunction in the pathogenesis of systemic sclerosis...
  70. doi request reprint The prevalence of melanocytic nevi on the soles in the Japanese population
    Hazuki Kogushi-Nishi
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Am Acad Dermatol 60:767-71. 2009
    ..Acral lentiginous melanoma (ALM) is the most common type of melanoma in Japan. The association between ALM and acral nevus has not been elucidated...
  71. ncbi request reprint [Cancer immunotherapy by utilizing dedritic cells derived from pluripotent stem cells]
    Satoshi Fukushima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 34:113-20. 2011
    ..Here we describe the previous studies about cancer immunotherapy by utilizing dendritic cells derived from pluripotent stem cells...
  72. doi request reprint Multiple antigen-targeted immunotherapy with alpha-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells
    Satoshi Fukushima
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Immunother 32:219-31. 2009
    ..With the aid of advancing technologies related to pluripotent stem cells, induced pluripotent stem cells, and ES cells, clinical application of DC highly potent in eliciting anticancer immunity will be realized in the near future...
  73. doi request reprint Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node
    Hiroshi Kato
    Department of Dermatology and Plastic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 37:730-4. 2010
    ....
  74. doi request reprint Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis
    Asako Ichihara
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 41:414-7. 2014
    ..Repeated bacterial examinations are important and required for the diagnosis of rapidly growing mycobacteria. ..
  75. doi request reprint Case of neuro-Behçet's disease successfully maintained a remission using infliximab for 2 years
    Hisashi Kanemaru
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 40:632-4. 2013
    ..Here, we report a female case with NBD successfully treated by infliximab and corticosteroids for 2 years. Our report suggests treatment with infliximab may be effective for long-term remission of NBD. ..
  76. ncbi request reprint Evaluation of usefulness of 3D views for clinical photography
    Masatoshi Jinnin
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 5:211-6. 2011
    ..The wide use of the technique may revolutionize presentation of clinical pictures in meetings, educational lectures, or manuscripts...
  77. ncbi request reprint [Systemic sclerosis]
    Hironobu Ihn
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
    Nihon Rinsho 67:519-22. 2009
    ..This review discusses recent studies that investigated the cellular and molecular mechanisms in the pathogenesis of SSc...
  78. doi request reprint Submental perforator flap: location and number of submental perforating vessels
    Tsuyoshi Ishihara
    Department of Plastic and Reconstructive Surgery, Honjo, Kumamoto University, Kumamoto, Japan
    Scand J Plast Reconstr Surg Hand Surg 42:127-31. 2008
    ....
  79. pmc Geographical Flushing of the Children's Face: A New Clinical Entity?
    Masatoshi Jinnin
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Case Rep Dermatol Med 2013:802130. 2013
    ..Thus, it should be worth regarding such symptom as the benign new clinical entity, which may comfort patients with similar conditions and merit further attention in clinical practice...
  80. doi request reprint Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells
    Yumi Honda
    Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto, Japan
    J Cutan Pathol 40:503-8. 2013
    ..The derivation of pagetoid cells is unclear; however, the localized small region of pagetoid cells over the hidradenocarcinoma in the present case may suggest a common histogenesis of these two malignant neoplasms...
  81. doi request reprint Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis
    Jun Aoi
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Res 71:7502-12. 2011
    ..Overall, we propose that Angptl2 contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies...
  82. doi request reprint Cutaneous hyalohyphomycosis by Scedosporium apiospermum in an immunocompromised patient
    Koji Makino
    Mycoses 54:259-61. 2011
    ..apiospermum sensu stricto by sequencing of the internal transcribed spacer-1 region of ribosomal DNA genes. Resection of the eruption and oral itraconazole (100 mg day(-1)) therapy for 4 months was effective in curing the infection...
  83. ncbi request reprint Expression of CD1a and CD86 on scleroderma Langerhans cells
    Yong Xie
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Eur J Dermatol 18:50-4. 2008
    ..CD86 is predominantly expressed on dermal Langerhans cells in the lesional skin of localized scleroderma. Therefore, it might play an important role in the pathogenesis of localized scleroderma...
  84. doi request reprint Two cases of anti-epiligrin cicatricial pemphigoid with and without associated malignancy
    Satoshi Fukushima
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Acta Derm Venereol 88:484-7. 2008
    ..Patient 1 had prostate carcinoma and his blistering was resistant to therapy. Patient 2 had no detectable malignancy and treatment with doxycycline was successful...
  85. ncbi request reprint Quick detection of herpes viruses from skin vesicles and exudates without nucleic acid extraction using multiplex PCR
    Keisuke Sakai
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 2:164-8. 2008
    ..In conclusion, omission of the nucleic acid extraction step prior to real-time PCR does not negatively affect downstream reactions. Using multiplex PCR may allow more rapid qualitative analysis of HSV1, 2 and VZV...
  86. doi request reprint Differential expression of heat shock protein 105 in melanoma and melanocytic naevi
    Faith Chengetayi Muchemwa
    Department of Dermatology and Plastic and Reconstructive Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Melanoma Res 18:166-71. 2008
    ....
  87. doi request reprint Tsukushi controls the hair cycle by regulating TGF-β1 signaling
    Daisuke Niimori
    Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 372:81-7. 2012
    ..Biochemical analysis indicates that TSK directly binds to TGF-β1. Our data suggest that TSK controls the hair cycle by regulating TGF-β1 signaling...
  88. doi request reprint Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis
    Seiji Takashio
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Cardiol 110:1507-11. 2012
    ..Amyloid deposition in blood vessels suggests poor prognosis of these patients...
  89. pmc Photosensitivity and acute liver insufficiency in late-onset erythropoietic protoporphyria with a chromosome 18q abnormality
    Yuka Oshikawa
    Department of Dermatology, Kumamoto University, Kumamoto, Japan
    Case Rep Dermatol 4:144-9. 2012
    ..The results of this report suggest that plasmapheresis and red blood cell exchange transfusion are effective for treating liver insufficiency in patients with late-onset EPP...
  90. pmc Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70
    Minoru Matsuda
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Biol Chem 285:5848-58. 2010
    ..The findings here also suggest that the protective action of HSP70 is mediated by anti-apoptotic, anti-inflammatory, and anti-DNA damage effects...
  91. ncbi request reprint Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 126:1761-9. 2006
    ..Anti-alphavbeta5 antibody reversed the myofibroblastic features of LSc fibroblasts. These results indicate that upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in LSc fibroblasts...
  92. doi request reprint Fixed food eruption caused by cashew nut
    Satoshi Fukushima
    Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Allergol Int 57:285-7. 2008
    ..The diagnosis of fixed 'drug' eruption is not difficult for dermatologists, but it is difficult to identify the causative agent when the patient denies ingestion of any drugs. There have been some reported cases of fixed 'food' eruption...
  93. doi request reprint Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 35:129-39. 2008
    ..1%) suffered from liver cancer. The incidence of V. vulnificus infection was different according to districts. Geographic and climatic factors also contributed to the occurrence of V. vulnificus infection...
  94. doi request reprint Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma
    Yuichiro Yoshino
    Department of Dermatology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto, Japan
    J Dermatol 35:206-14. 2008
    ..These results suggest that increased serum levels of TIMP-1 and TIMP-2 reflected the extent of metastatic melanoma lesions, and that serum levels of TIMP-1 may be a new useful marker for melanoma progression...
  95. ncbi request reprint A new disorder in UV-induced skin cancer with defective DNA repair distinct from xeroderma pigmentosum or Cockayne syndrome
    Satoru Hashimoto
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 128:694-701. 2008
    ..These results indicate that KPSX7 cells are defective for some types of repair activity in UV-damaged DNA. In summary, the patient had a previously unknown disorder related to UV-induced carcinogenesis, with defective DNA repair...
  96. ncbi request reprint Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblast
    Kenichi Yamane
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 48:1652-66. 2003
    ..In the present study, we investigated the mechanism of up-regulation of TGFbetaR expression...
  97. ncbi request reprint Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts
    Hironobu Ihn
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Invest Dermatol 125:247-55. 2005
    ....
  98. pmc Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Pathol 166:1451-63. 2005
    ..These results indicate that the constitutive overexpression of TSP-1 may play an important role in autocrine TGF-beta signaling and accumulation of ECM in scleroderma fibroblasts...
  99. pmc Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 113:253-64. 2004
    ..To our knowledge, this is the first report of a disturbed negative regulation of TGF-beta signaling in fibrotic disorders...
  100. ncbi request reprint Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 124:886-92. 2005
    ..These results indicate that the constitutive phosphorylation of FAK, which is possibly because of the autocrine TGF-beta signaling, may play an important role in alphaSMA expression in scleroderma fibroblasts...
  101. ncbi request reprint Antagonistic effects of TNF-alpha on TGF-beta signaling through down-regulation of TGF-beta receptor type II in human dermal fibroblasts
    Kenichi Yamane
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 171:3855-62. 2003
    ..These results indicated that TNF-alpha impaired the response of the cells to TGF-beta by regulating the turnover of TbetaRII...