Yukio Ando

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurol Sci 362:266-71. 2016
  2. pmc Midkine as a prognostic biomarker in oral squamous cell carcinoma
    K Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Br J Cancer 99:655-62. 2008
  3. pmc Midkine: a novel prognostic biomarker for cancer
    Hirofumi Jono
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Cancers (Basel) 2:624-41. 2010
  4. ncbi request reprint [Chairmen's introductory remarks]
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Rinsho Byori 61:583-4. 2013
  5. pmc Guideline of transthyretin-related hereditary amyloidosis for clinicians
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    Orphanet J Rare Dis 8:31. 2013
  6. ncbi request reprint Diagnosis and therapeutic approaches to transthyretin amyloidosis
    Y Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan
    Curr Med Chem 19:2312-23. 2012
  7. ncbi request reprint Novel methods for detecting amyloidogenic proteins in transthyretin related amyloidosis
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Front Biosci 13:5548-58. 2008
  8. ncbi request reprint [Transthyretin: it's miracle function and pathogenesis]
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Rinsho Byori 57:228-35. 2009
  9. doi request reprint Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy
    Haruki Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Sci 287:178-84. 2009
  10. doi request reprint Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 24:1533-44. 2011

Detail Information

Publications135 found, 100 shown here

  1. doi request reprint Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurol Sci 362:266-71. 2016
    ..The efficacy and safety of tafamidis in transthyretin (TTR) familial amyloid polyneuropathy (TTR-FAP) were evaluated in this open-label study...
  2. pmc Midkine as a prognostic biomarker in oral squamous cell carcinoma
    K Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Br J Cancer 99:655-62. 2008
    ..The increased S-MK concentrations in early-stage OSCC were strongly associated with poor survival. Serum midkine concentrations may thus be a useful marker not only for cancer screening but also for predicting prognosis of OSCC patients...
  3. pmc Midkine: a novel prognostic biomarker for cancer
    Hirofumi Jono
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Cancers (Basel) 2:624-41. 2010
    ..Here, we review and discuss the possibility and usefulness of MK as a novel tumor marker. ..
  4. ncbi request reprint [Chairmen's introductory remarks]
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Rinsho Byori 61:583-4. 2013
    ..5% corresponded to HbA1c (JDS) 6.1%. In this symposium, we presented the viewpoint of the Japanese Society of Diabetes Mellitus for standardization of HbAlc and the issue of using NGSP instead of JDS...
  5. pmc Guideline of transthyretin-related hereditary amyloidosis for clinicians
    Yukio Ando
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    Orphanet J Rare Dis 8:31. 2013
    ....
  6. ncbi request reprint Diagnosis and therapeutic approaches to transthyretin amyloidosis
    Y Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan
    Curr Med Chem 19:2312-23. 2012
    ..We present here the current diagnostic procedure and therapeutic approaches for the disease...
  7. ncbi request reprint Novel methods for detecting amyloidogenic proteins in transthyretin related amyloidosis
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Front Biosci 13:5548-58. 2008
    ..We present here a new diagnostic procedure for the disease using current methods of molecular genetics and protein chemistry...
  8. ncbi request reprint [Transthyretin: it's miracle function and pathogenesis]
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Rinsho Byori 57:228-35. 2009
    ..Moreover, TTR plays important roles in various CNS disorders, diabetes melitus, and lipid metabolism...
  9. doi request reprint Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy
    Haruki Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Sci 287:178-84. 2009
    ..Amyloid deposition in late-onset cases may be similar to that observed in senile systemic amyloidosis with wild-type TTR deposition, suggesting that aging may play an important role in these cases...
  10. doi request reprint Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 24:1533-44. 2011
    ..As myocardial biopsy may be dangerous for elderly people, the use of a combination of gastrointestinal tract and subcutaneous tissue biopsies may make diagnosis of senile systemic amyloidosis easier...
  11. ncbi request reprint A different amyloid formation mechanism: de novo oculoleptomeningeal amyloid deposits after liver transplantation
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Transplantation 77:345-9. 2004
    ..However, the effect on amyloid formation of TTR that is synthesised by the retina and the choroid plexus remains to be elucidated in FAP patients with liver transplants...
  12. doi request reprint Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
    Konen Obayashi
    Diagnostic Unit for Amyloidosis, Department of Laboratory Medicine, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Clin Chim Acta 419:127-31. 2013
    ..This study investigated whether a relationship exists between the presence of de novo antibodies and the clinical manifestations of familial amyloidotic polyneuropathy (FAP)...
  13. ncbi request reprint Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma
    Kazutoshi Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Int J Oncol 37:797-804. 2010
    ..Thus, MK expression may affect prognosis via the p53 status and mutation of the p53 gene, and MK may be an attractive target for therapeutic intervention in patients with cancer cells with mutant p53...
  14. doi request reprint Peritransplant gastrointestinal symptoms in familial amyloidotic polyneuropathy
    Yuki Ohya
    Department of Transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Exp Clin Transplant 11:327-31. 2013
    ....
  15. doi request reprint Role of conformational change in the C-terminus of beta2-microglobulin in dialysis-related amyloidosis
    Jaemi Kim
    Department of Molecular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Ann Clin Biochem 45:489-95. 2008
    ..However, no direct experiments have previously been performed to address whether unfolded beta(2)m in the C-terminus may be prone to form amyloid fibrils...
  16. pmc The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells
    Seiko Susuki
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Global Centers of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Biol Chem 284:8312-21. 2009
    ..These findings suggest that the affinity to the ER-resident protein BiP regulates the fate of TTR variants in the ER...
  17. doi request reprint The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy
    Haruki Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Aichi, Japan
    Amyloid 16:142-8. 2009
    ..The electrophysiological abnormality at the distal portion of the median nerve may be a consequence of polyneuropathy rather than an entrapment injury...
  18. ncbi request reprint FK506 inhibits murine AA amyloidosis: possible involvement of T cells in amyloidogenesis
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    J Rheumatol 33:2260-70. 2006
    ..To determine the possibility that T cells represent a potential target for therapy in AA amyloidosis...
  19. doi request reprint Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma
    Satoru Shinriki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    J Oral Pathol Med 39:41-7. 2010
    ..An inhibitor of STAT3 activation, AG490, significantly reduced SAA1 expression in SAS cells. These data demonstrated that SAA was up-regulated in HNSCC through the Janus kinase-STAT3 pathway...
  20. ncbi request reprint Muscular amyloid angiopathy with amyloidgenic transthyretin Ser50Ile and Tyr114Cys
    Taro Yamashita
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Muscle Nerve 31:41-5. 2005
    ..Muscular amyloid angiopathy may contribute to motor nerve injury that, in turn, may lead to amyotropic changes in patients with FAP Ser50Ile and Tyr114Cys...
  21. doi request reprint Impact of liver transplantation on transthyretin-related ocular amyloidosis in Japanese patients
    Ryuhei Hara
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Arch Ophthalmol 128:206-10. 2010
    ..To evaluate the long-term impact of liver transplantation on ocular manifestations of familial amyloid polyneuropathy (FAP) in Japanese patients...
  22. doi request reprint Manifestations of transthyretin-related familial amyloidotic polyneuropathy: long-term follow-up of Japanese patients after liver transplantation
    Yuki Ohya
    Department of Transplantation and Pediatric Surgery, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Surg Today 41:1211-8. 2011
    ..To observe which symptoms of transthyretin-related familial amyloidotic polyneuropathy (FAP) progressed in the long term after liver transplantation (LT), focusing on cardiac, kidney, and ocular symptoms...
  23. doi request reprint A rapid and sensitive prenatal diagnosis of familial amyloidotic polyneuropathy ATTR Val30Met by mass spectrometry
    Taro Yamashita
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Prenat Diagn 29:930-3. 2009
    ..To make a prenatal diagnosis of familial amyloidotic polyneuropathy (FAP) by mass spectrometry with the amniotic fluid...
  24. doi request reprint Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation
    Toshinori Oshima
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan
    J Neurol Neurosurg Psychiatry 85:740-6. 2014
    ..To elucidate the long-term effects of liver transplantation (LT) on familial amyloid polyneuropathy (FAP)...
  25. ncbi request reprint Clinicopathologic and genetic features of early- and late-onset FAP type I (FAP ATTR Val30Met) in Japan
    Gen Sobue
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Amyloid 10:32-8. 2003
    ..Unmyelinated fibers in the biopsied sural nerve specimens of late-onset cases seemed to be relatively well preserved compared to those of previously reported early-onset cases...
  26. ncbi request reprint Ocular amyloid angiopathy associated with familial amyloidotic polyneuropathy caused by amyloidogenic transthyretin Y114C
    Takahiro Kawaji
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ophthalmology 112:2212. 2005
    ..To report the clinicopathological findings for a unique ocular amyloid angiopathy in patients with familial amyloidotic polyneuropathy (FAP) caused by amyloidogenic transthyretin Y114C...
  27. doi request reprint Potential use of lactosylated dendrimer (G3)/α-cyclodextrin conjugates as hepatocyte-specific siRNA carriers for the treatment of familial amyloidotic polyneuropathy
    Yuya Hayashi
    Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Mol Pharm 9:1645-53. 2012
    ..Taken together, these results suggest that Lac-α-CDE (G3, DSL 1.2) has the potential for a novel hepatocyte-selective siRNA carrier in vitro and in vivo, and has a possibility as a therapeutic tool for FAP to the liver transplantation...
  28. doi request reprint Potential use of glucuronylglucosyl-β-cyclodextrin as a novel therapeutic tool for familial amyloidotic polyneuropathy
    Hirofumi Jono
    Department of Diagnostic Medicine, Kumamoto University, Kumamoto, Japan
    Amyloid 19:50-2. 2012
    ..Collectively, these data indicate that GUG-β-CyD may inhibit TTR misfolding by stabilizing its conformation, which, in turn, suppresses TTR amyloid formation...
  29. doi request reprint Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Hum Pathol 43:96-104. 2012
    ..However, cellular metabolic disturbances caused by cells' being physically confined by amyloid deposits may induce cell degeneration...
  30. doi request reprint Transthyretin forms amyloid fibrils at physiological pH with ultrasonication
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 15:234-9. 2008
    ..In addition, this method allows analysis of accelerator factors or inhibitory agents in TTR amyloid fibril formation at neutral pH...
  31. doi request reprint Effect of recipient-derived cells on the progression of familial amyloidotic polyneuropathy after liver transplantation: a retrospective study
    Yuki Ohya
    Department of Transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Ann Clin Biochem 47:529-34. 2010
    ....
  32. doi request reprint Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid
    Akihiro Yanagisawa
    a Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuo Ku, Kumamoto, Japan
    Amyloid 23:26-32. 2016
    ..Also, aging may induce ATTR formation in the knee joint in elderly patients with knee OA, whereas AApo A-I formation may be inversely correlated with age. ..
  33. doi request reprint SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Chem 55:1223-7. 2009
    ..However, those methods require an immunoprecipitation step with an anti-TTR antibody and are not suitable for quantitative detection. We investigated the usefulness of SELDI-TOF mass spectrometry (MS) without an immunoprecipitation step...
  34. doi request reprint Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 63:260-5. 2013
    ..GR is a nuclear transcription factor that leads to myocardial hypertrophy, and cumulative prednisolone doses may promote marked cardiomegaly and severe cardiac amyloidosis...
  35. doi request reprint Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts
    Hirohisa Okabe
    Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 131:2234-41. 2012
    ..0001). These data suggest that CXCL5 is important for the interaction between cholangiocarcinoma and CAFs, and inhibition of tumor-stromal interactions may be a useful therapeutic approach for cholangiocarcinoma...
  36. doi request reprint Multi-elemental analysis of serum and amyloid fibrils in familial amyloid polyneuropathy patients
    Seiko Susuki
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    Amyloid 15:108-16. 2008
    ..2; duration of disease 6.5 +/- 1.3 years) compared with other metals. These findings firstly suggest that the mineral status could be a candidate factor, which participates in the wide spectrum of clinical pictures of FAP patients...
  37. doi request reprint Spinal multifocal amyloidosis derived from wild-type transthyretin
    Takanao Sueyoshi
    Department of Orthopaedic and Neuro Musculoskeletal Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Amyloid 18:165-8. 2011
    ..Clinical manifestations of TTR-related amyloidosis may vary more than we previously thought. In spinal amyloidosis, WT TTR is one of the candidate precursor proteins for the disease...
  38. doi request reprint Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma
    Satoru Shinriki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    J Pathol 225:142-50. 2011
    ..Together, these data suggest that tocilizumab acted as expected: it inhibited lymph node metastasis in OSCC by reducing tumour lymphangiogenesis...
  39. ncbi request reprint Amyloid formation in rat transthyretin: effect of oxidative stress
    Takahiro Tajiri
    Department of Pharmacology and Therapeutics, Graduate School of Clinical Pharmacy, Kumamoto University, 5 1 Oe honmachi, 860 0973, Kumamoto, Japan
    Clin Chim Acta 323:129-37. 2002
    ..Transgenic mice carrying a human mutant transthyretin (TTR) gene are too small for in vivo experiments. It is necessary to have rat TTR protein and its antibody to overcome this problem...
  40. doi request reprint Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach
    Masayoshi Tasaki
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan Department of Immunology and Hematology, Division of Informative Clinical Science, Graduate School of Medical Sciences, Kumamoto University, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Int J Cardiol 170:69-74. 2013
    ..To elucidate age and sex differences in FAP, we investigated biochemical characteristics of amyloid deposits in different tissue sites of FAP by proteomic analysis...
  41. doi request reprint Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo
    Yuya Hayashi
    Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe Honmachi, Chuo Ku, Kumamoto 862 0973, Japan
    J Drug Target 21:487-96. 2013
    ..1) showed selective gene transfer activity to hepatic parenchymal cells rather than hepatic non-parenchymal cells. These results suggest that PEG-LαC (G3, DSP2.1) is useful as a hepatocyte-selective gene carrier in vitro and in vivo...
  42. ncbi request reprint Presence of variant transthyretin in aqueous humor of a patient with familial amyloidotic polyneuropathy after liver transplantation
    Katsuki Haraoka
    First Department of Internal Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Amyloid 9:247-51. 2002
    ..In conclusion, TTR metabolism may occur in its own ocular cycle and variant TTR produced by the retina may play an important role in amyloid formation in the ocular tissues of FAP patients...
  43. ncbi request reprint A novel tool for detecting amyloid deposits in systemic amyloidosis in vitro and in vivo
    Yukio Ando
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Lab Invest 83:1751-9. 2003
    ..These results suggest that BSB may become a valuable tool for detection of amyloid deposits in amyloidosis and of the mechanism of amyloid formation...
  44. doi request reprint Novel function of transthyretin in pancreatic alpha cells
    Yu Su
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto, Japan
    FEBS Lett 586:4215-22. 2012
    ..These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon...
  45. ncbi request reprint Secondary glaucoma in patients with familial amyloidotic polyneuropathy
    Akira Kimura
    Department of Ophthalmology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Arch Ophthalmol 121:351-6. 2003
    ..To elucidate the clinical features and surgical outcomes of the treatment of secondary glaucoma associated with transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP)...
  46. ncbi request reprint Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP)
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 0811, Japan
    Med Mol Morphol 38:142-54. 2005
    ..On the basis of results achieved so far, SSO is a promising tool for gene therapy...
  47. doi request reprint Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci
    Haruki Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    J Neurol 255:1526-33. 2008
    ..Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed...
  48. doi request reprint Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation
    Haruki Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 82:1287-90. 2011
    ..This case allows for the characterisation of amyloid deposition during the asymptomatic stage of FAP. Widespread amyloid deposition may occur before tissue damage in this disease...
  49. ncbi request reprint Effect of tacrolimus and partial hepatectomy on transthyretin metabolism in rats
    Manuel E Zeledon R
    Department of Pediatric Surgery and Transplantation, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Transpl Int 19:233-8. 2006
    ..This finding -- that TTR, the source of FAP-inducing amyloid, did not increase after transplantation -- may help post-transplantation treatment of patients who have FAP and other liver diseases...
  50. ncbi request reprint Aging and transthyretin-related amyloidosis: pathologic examinations in pulmonary amyloidosis
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Amyloid 13:24-30. 2006
    ..55 +/- 8.75 vs. 39.75 +/- 4.17 years old, p < 0.005), similar to the finding in one SSA patient. These results suggest that aging could play an important role in the progression of pulmonary amyloid formation in FAP ATTR V30M...
  51. ncbi request reprint Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 56:408-12. 2006
    ....
  52. ncbi request reprint Evaluation of myocardial changes in familial amyloid polyneuropathy after liver transplantation
    Sadahisa Okamoto
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Honjo
    Intern Med 47:2133-7. 2008
    ..The aim of this study was to assess myocardial changes in FAP amyloidgenic transthyretin (ATTR) Val30Met after LT...
  53. doi request reprint Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis
    Hirofumi Jono
    Department of Diagnostic Medicine, Graduate School of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem J 437:35-42. 2011
    ..Collectively, these results indicate that GUG-β-CyD may inhibit TTR misfolding by stabilizing its conformation, which, in turn, suppresses TTR amyloid formation...
  54. doi request reprint Rapid detection of wild-type and mutated transthyretins
    Masayoshi Tasaki
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan
    Ann Clin Biochem 53:508-10. 2016
    ..The aim of this study was to evaluate the clinical usefulness of SELDI-TOF MS for diagnosis of transthyretin-related amyloidosis...
  55. doi request reprint Inhibition of insulin amyloid fibril formation by cyclodextrins
    Keisuke Kitagawa
    a Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 22:181-6. 2015
    ..These findings have significant implications for the mechanism underlying insulin amyloid fibril formation and for developing optimal additives to prevent this subcutaneous adverse effect. ..
  56. ncbi request reprint Role of VLDL/chylomicron in amyloid formation in familial amyloidotic polyneuropathy
    Xuguo Sun
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 311:344-50. 2003
    ..These results suggest that TTR should be highly associated especially with VLDL/CM and amyloidogenicity of TTR should be enhanced around the adipocytes...
  57. ncbi request reprint Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis
    Shiori Saito
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    Biochemistry 44:11122-9. 2005
    ..These results suggest that the nitric oxide-mediated modification of transthyretin, especially variant transthyretin, may play an important role in amyloid formation in senile systemic amyloidosis and familial amyloidotic polyneuropathy...
  58. ncbi request reprint A transgenic rat with the human ATTR V30M: a novel tool for analyses of ATTR metabolisms
    Mitsuharu Ueda
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 352:299-304. 2007
    ..These results thus suggest that this transgenic rat may be a useful animal model which analyzes the metabolism of human ATTR V30M including liver transplantation studies...
  59. doi request reprint Novel therapy for transthyretin-related ocular amyloidosis: a pilot study of retinal laser photocoagulation
    Takahiro Kawaji
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ophthalmology 117:552-5. 2010
    ..This study investigated a new strategy to prevent ocular involvements...
  60. doi request reprint Wild-type transthyretin-derived amyloidosis in various ligaments and tendons
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 42:1259-64. 2011
    ..In the future, such amyloid deposits may aid determination of the pathogenesis of ligament and tendon disorders in older patients...
  61. doi request reprint Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Lett 316:23-30. 2012
    ..Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model. Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma...
  62. doi request reprint Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma
    Tomoko Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Oncol Rep 27:1674-80. 2012
    ..These data suggest that MK may play important roles in cisplatin resistance in OSCC by modulating both cell growth and intracellular cisplatin accumulation...
  63. doi request reprint Antibody therapy for familial amyloidotic polyneuropathy
    Yu Su
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 19:45-6. 2012
    ..MAb ATTR may have a potential to suppress TTR amyloid deposition and become a candidate for the antibody therapy for FAP...
  64. doi request reprint Interaction between amyloid fibril formation and extracellular matrix in the proceedings of VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 19:8-10. 2012
    ..To know the precise mechanism of this up-regulation may lead to deeper understanding of FAP pathogenesis...
  65. pmc Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
    Takashi Sato
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    EMBO J 26:2501-12. 2007
    ..These findings suggest that unlike for wild-type TTR, the ER quality control system may differentially regulate the fate of the TTR variants and their monomeric counterparts...
  66. doi request reprint Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 081, Japan
    J Pathol 219:481-90. 2009
    ..This chain reaction may have important implications for FAP pathogenesis...
  67. doi request reprint Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding
    Masanori Miyata
    Department of Molecular Medicine, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochemistry 49:114-23. 2010
    ..These findings indicate that structural modification by Glu54 point mutation may sufficiently alter tetramer stability and T(4) binding...
  68. doi request reprint Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis
    Tomoko Ota
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Oral Oncol 46:657-61. 2010
    ..001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs...
  69. doi request reprint Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism
    Masayoshi Tasaki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 400:559-62. 2010
    ..These novel findings should provide insights into the transmission mechanism of systemic amyloidoses...
  70. doi request reprint Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy
    Tomoe Kugimiya
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Lab Invest 91:1219-28. 2011
    ..Taken together, these results indicate that albumin may have an inhibitory role in the TTR amyloid-formation process...
  71. ncbi request reprint A case of vitreous amyloidosis without systemic symptoms in familial amyloidotic polyneuropathy
    Takahiro Kawaji
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Amyloid 11:257-9. 2004
    ..FAP should be suspected as the cause in cases of vitreous opacities in patients from areas with endemic foci of FAP...
  72. doi request reprint Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/α-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy
    Yuya Hayashi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
    Amyloid 19:47-9. 2012
    ....
  73. doi request reprint Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease
    Mitsuharu Ueda
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Lab Invest 92:474-84. 2012
    ..Those findings may be valuable for understanding the genotype-phenotype correlation in this inherited human disease...
  74. ncbi request reprint [Immunological and serological laboratory tests: transthyretin]
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811
    Rinsho Byori 53:554-7. 2005
    ..To elucidate the pathogenesis of those disorders, an accurate measurement of TTR concentrations in plasma and cerebrospinal fluids is of vital importance...
  75. ncbi request reprint Chromium(III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation
    Takashi Sato
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    FEBS Lett 580:491-6. 2006
    ..Moreover, we demonstrate that Cr(3+) and T(4) cooperatively suppressed in vitro fibril formation due to the stabilization of WT-TTR and V30M-TTR...
  76. doi request reprint Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma
    Satoru Shinriki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 15:5426-34. 2009
    ..The aim of this study was to investigate the effects of inhibition of IL-6R-mediated signaling on OSCC progression and to evaluate the availability of tocilizumab, a humanized antihuman IL-6R antibody, as a therapeutic agent for OSCC...
  77. ncbi request reprint A novel type of familial transthyretin amyloidosis, ATTR Asn124Ser, with co-localization of kappa light chains
    Joakim Bergström
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Amyloid 14:141-5. 2007
    ..In this study, we report a patient having a novel TTR variant, ATTR Asn124Ser, with co-localization of kappa light chains in the amyloid deposits in the thyroid tissue...
  78. ncbi request reprint Transthyretin synthesis in rabbit ciliary pigment epithelium
    Takahiro Kawaji
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Exp Eye Res 81:306-12. 2005
    ..These results suggest that TTR synthesized in the CPE may lead to ocular manifestations, especially glaucoma, in FAP. TTR mRNA also acts as an anti-acute phase reactant in ocular tissues...
  79. doi request reprint Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus
    Gang Zhao
    Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    Genes Cells 13:1257-68. 2008
    ..However, the serum human TTR levels in the Val30/Val30 mice were much less than those in the +/Val30 mice. This contradictory expression was due to unstable Val30 tetramers caused by low binding affinity to mouse retinol binding protein...
  80. doi request reprint Antitumor effect of humanized anti-interleukin-6 receptor antibody (tocilizumab) on glioma cell proliferation. Laboratory investigation
    Mareina Kudo
    Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurosurg 111:219-25. 2009
    ..The aim of this study was to evaluate the involvement of IL-6 signaling in glioma and the inhibitory effect of IL-6 signaling on glioma tumor proliferation...
  81. doi request reprint Transthyretin-related vitreous amyloidosis in different endemic areas
    Takahiro Kawaji
    Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Amyloid 17:105-8. 2010
    ..to investigate the vitreous opacity in patients with familial amyloidotic polyneuropathy (FAP) in two major endemic areas, Japan and Sweden...
  82. doi request reprint Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 102:439-45. 2011
    ..In breast cancer, reduced FBXW7 mRNA expression may have independent prognostic potential through the enhanced function of cell cycle regulatory proteins...
  83. ncbi request reprint Role of extracellular superoxide dismutase in patients under maintenance hemodialysis
    Masaaki Nakamura
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nephron Clin Pract 101:c109-15. 2005
    ..Although EC-SOD Arg213Gly, which cannot bind on endothelial cells, has been considered a polymorphism, the effect of EC-SOD on hemodialysis patients has not been well examined...
  84. ncbi request reprint Analysis of amyloid fibrils in the cheetah (Acinonyx jubatus)
    Joakim Bergström
    Department of Diagnostic Medicine, Kumamoto University, Japan
    Amyloid 13:93-8. 2006
    ..Our finding of a 12-kDa protein AA component provides evidence that the cheetah SAA sequence is longer than the previously reported 90 amino acid residues (approximately 10 kDa), and hence SAA is part of the amyloid fibril...
  85. ncbi request reprint [Pathogenesis and therapy for transthyretin related amyloidosis]
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto
    Rinsho Byori 56:114-20. 2008
    ..As we expected, amyloid deposition was significantly reduced by the injection of ATTR Y78P to the mice. These therapies may become novel strategies for essential FAP therapy instead of liver transplantation...
  86. ncbi request reprint Applications of gene therapy for familial amyloidotic polyneuropathy
    Masaaki Nakamura
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Expert Opin Biol Ther 4:1621-7. 2004
    ..This article summarises the general concept of gene therapy and reviews the recent data on gene therapy for FAP...
  87. ncbi request reprint Transthyretin-related familial amyloidotic polyneuropathy
    Yukio Ando
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Arch Neurol 62:1057-62. 2005
    ..We present herein the current clinicopathological, biochemical, molecular genetic, and epidemiological aspects of transthyretin-related FAP, and we introduce a new diagnostic procedure for the disease...
  88. ncbi request reprint [Practical application of nutritional assessment protein and inflammatory marker in the nutrition support team (NST)]
    Takiko Tateishi
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556
    Rinsho Byori 53:825-31. 2005
    ..As for this index, it is expected to be used by NST while further alternation may be needed...
  89. ncbi request reprint [Novel tool for diagnosis of amyloidosis]
    Konen Obayashi
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    Rinsho Byori 56:986-93. 2008
    ..These results suggest that BSB and FSB may become valuable tools for detection of amyloid deposits in amyloidosis and of the mechanism of amyloid formation...
  90. ncbi request reprint [Gene therapy in familial amyloidotic polyneuropathy by single-stranded oligonucleotides (SSOs)]
    Masaaki Nakamura
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 0811
    Rinsho Byori 52:804-12. 2004
    ..Therefore, gene therapy via this method may be a promising alternative to liver transplantation for treatment of FAP...
  91. doi request reprint Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients
    Shuji Goto
    Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Pharm Pharmacol 60:267-72. 2008
    ..These results support the initial hypothesis, while also helping to clarify the mechanism of severe idiosyncratic hepatotoxicity with VPA...
  92. doi request reprint Midkine in plasma as a novel breast cancer marker
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 100:1735-9. 2009
    ..Midkine may be a useful novel tumor marker for detection of breast cancer, superior to conventional tumor markers...
  93. doi request reprint In vitro and in vivo gene delivery mediated by Lactosylated dendrimer/alpha-cyclodextrin conjugates (G2) into hepatocytes
    Hidetoshi Arima
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Control Release 146:106-17. 2010
    ..These results suggest the potential use of Lac-alpha-CDE (DSL 2.6) as a non-viral vector for gene delivery toward hepatocytes...
  94. ncbi request reprint Presence of autoantibody against ATTR Val30Met after sequential liver transplantation
    Yukio Ando
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Transplantation 73:751-5. 2002
    ....
  95. ncbi request reprint A novel localized amyloidosis associated with lactoferrin in the cornea
    Yukio Ando
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Lab Invest 82:757-66. 2002
    ..8% of healthy Japanese volunteers, suggesting that the mutation may not be an essential mutation for amyloid formation (p = 0.104). Results thus suggest that lactoferrin is this precursor protein...
  96. ncbi request reprint Vitreous opacities and outcome of vitreous surgery in patients with familial amyloidotic polyneuropathy
    Takahisa Koga
    Department of Ophthalmology, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Ophthalmol 135:188-93. 2003
    ..To report the prevalence of vitreous opacities and the outcome of vitreous surgery in patients with familial amyloidotic polyneuropathy (FAP)...
  97. ncbi request reprint New therapeutic approaches for familial amyloidotic polyneuropathy (FAP)
    Yukio Ando
    Department of Laboratory Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Amyloid 10:55-66. 2003
    ..On the basis of results achieved so far, SSOs are a promising tool for gene therapy...
  98. doi request reprint Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients
    Konen Obayashi
    Department of Medicine, Umea University Hospital, S 901 85 Umea, Sweden
    Clin Chim Acta 398:10-4. 2008
    ....
  99. ncbi request reprint Salivary chromogranin A: useful and quantitative biochemical marker of affective state in patients with amyotrophic lateral sclerosis
    Konen Obayashi
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University
    Intern Med 47:1875-9. 2008
    ..To evaluate the affective state biochemically and quantitatively in amyotrophic lateral sclerosis (ALS) patients using salivary chromogranin A (CgA) measurement...
  100. ncbi request reprint [Accreditation of ISO 15189 in the Department of Laboratory Medicine, Kumamoto University Hospital: successful cases]
    Konen Obayashi
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Rinsho Byori 57:156-60. 2009
    ..A laboratory cafe, which we are preparing in our hospital now, may be a new unique trial of how to apply ISO 15189. In conclusion, ISO 15189 may become an effective tool to develop and advance medical laboratories...