Affiliation: Kochi University
- Bacteriophage therapy: a revitalized therapy against bacterial infectious diseasesShigenobu Matsuzaki
Department of Molecular Microbiology and Infections, Kochi Medical School, Kohasu, Nankoku, Japan
J Infect Chemother 11:211-9. 2005..Phage therapy will compensate for unavoidable complications of chemotherapy such as the appearance of multidrug resistance or substituted microbism...
- Isolation and characterization of a novel Staphylococcus aureus bacteriophage, phiMR25, and its therapeutic potentialHiroshi Hoshiba
Department of Pediatrics, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Arch Virol 155:545-52. 2010..aureus, as was the case for phiMR11. These results suggest that phiMR25 could be another candidate phage to treat S. aureus infection...
- Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10Jumpei Uchiyama
Department of Microbiology and Infection, Faculty of Medicine, Kochi University, Kohasu, Oko cho, Nankoku, Kochi, 783 8505, Japan
Arch Virol 157:733-8. 2012..aeruginosa. Phage KPP10 is considered to be suitable for therapeutic purposes because it is a lytic phage without ORF-encoded pathogenicity or a lysogenization factors...
- Morphological and genetic analysis of three bacteriophages of Serratia marcescens isolated from environmental waterKenshi Matsushita
Department of Pediatrics, Kochi Medical School, Nankoku, Kochi, Japan
FEMS Microbiol Lett 291:201-8. 2009..Both Smp14 and phiEco32 have been reported as potential therapeutic phages. These results suggest that KSP90 and KSP100 may be candidate therapeutic phages to control S. marcescens infection...
- Tail-associated structural protein gp61 of Staphylococcus aureus phage phi MR11 has bifunctional lytic activityMohammad Rashel
Department of Microbiology and Infection, Kochi Medical School, Nankoku, Kochi, Japan
FEMS Microbiol Lett 284:9-16. 2008..This is the first report of the presence of a tail-associated virion protein that acts as a lysin, in an S. aureus phage...
- Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11Mohammad Rashel
Department of Biochemistry, Kochi Medical School, Nankoku 783 8505, Japan
J Infect Dis 196:1237-47. 2007..These results indicate that MV-L might be useful as a powerful therapeutic agent against multidrug-resistant S. aureus infections...
- A novel site-specific recombination system derived from bacteriophage phiMR11Mohammad Rashel
Department of Microbiology and Infection, Kochi Medical School, Kohasu Oko cho, Nankoku, Kochi 783 8505, Japan
Biochem Biophys Res Commun 368:192-8. 2008..In in vitro assays using crude or purified integrase, only buffer and substrate DNAs were required for the recombination reaction, indicating that other bacterially encoded factors are not essential for activity...
- Characterization of lytic enzyme open reading frame 9 (ORF9) derived from Enterococcus faecalis bacteriophage phiEF24CJumpei Uchiyama
Department of Microbiology and Infection, Faculty of Medicine, Kochi University, Nankoku City, Kochi, Japan
Appl Environ Microbiol 77:580-5. 2011..These results suggested that ORF9 is an endolysin of phage φEF24C and can be a therapeutic alternative to antibiotics...
- Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinomaMasanao Murakami
Department of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
J Clin Virol 50:37-41. 2011..Merkel cell polyomavirus (MCPyV) was first identified in Merkel cell carcinoma (MCC) as a new tumor virus. Studies have also reported differing frequencies of MCPyV detection in other skin cancers in western countries...
- High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac musclesTakuma Higuchi
Laboratory of Molecular Biology, Science Research Center, Kochi Medical School, Kochi, Japan
PLoS ONE 7:e43340. 2012....
- Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11Shigenobu Matsuzaki
Department of Microbiology, Kochi Medical School, Kochi, Japan
J Infect Dis 187:613-24. 2003..These results uphold the efficacy of phage therapy against pernicious S. aureus infections in humans and suggest that phi MR11 may be a potential prototype for gene-modified, advanced therapeutic S. aureus phages...