Wataru Ogawa

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. doi request reprint Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene
    Wataru Ogawa
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 83:e75-7. 2009
  2. ncbi request reprint Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007
  3. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
  4. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
  5. ncbi request reprint Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
  6. pmc Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
  7. doi request reprint Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes
    Yoko Okuno
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Metabolism 62:1470-6. 2013
  8. pmc PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 115:138-45. 2005
  9. doi request reprint The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
    Tomoki Nagare
    Department of Internal Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 379:98-103. 2009
  10. ncbi request reprint Role of Krüppel-like factor 15 in PEPCK gene expression in the liver
    Kiyoshi Teshigawara
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 327:920-6. 2005

Detail Information

Publications52

  1. doi request reprint Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene
    Wataru Ogawa
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 83:e75-7. 2009
    ..The cases highlight the diversity of clinical phenotypes associated with mutations of the insulin receptor gene...
  2. ncbi request reprint Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007
    ....
  3. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  4. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms...
  5. ncbi request reprint Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
    ..Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus...
  6. pmc Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
    ....
  7. doi request reprint Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes
    Yoko Okuno
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Metabolism 62:1470-6. 2013
    ..The difference in the physiological features reflected by the index measured under fasting (F-CPI) or postprandial (PP-CPI) conditions has remained unclear, however...
  8. pmc PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 115:138-45. 2005
    ..These results indicate that PKClambda plays a prominent role in regulation of glucose-induced insulin secretion by modulating the expression of genes important for beta cell function...
  9. doi request reprint The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
    Tomoki Nagare
    Department of Internal Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 379:98-103. 2009
    ..These results thus implicate KLF15 in the regulation of adrenomedullin expression in adipose tissue...
  10. ncbi request reprint Role of Krüppel-like factor 15 in PEPCK gene expression in the liver
    Kiyoshi Teshigawara
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 327:920-6. 2005
    ..These results suggest that insulin and its counteracting hormones regulate the hepatic expression of KLF15, and that this transcription factor contributes to the regulation of PEPCK gene expression in the liver...
  11. doi request reprint Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation
    Tetsuya Hosooka
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Nat Med 14:188-93. 2008
    ..These results indicate that Dok1 promotes adipocyte hypertrophy by counteracting the inhibitory effect of ERK on PPAR-gamma and may thus confer predisposition to diet-induced obesity...
  12. ncbi request reprint Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis
    Toshiyuki Mori
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 280:12867-75. 2005
    ..Our observations thus demonstrate that KLF15 plays an essential role in adipogenesis in 3T3-L1 cells through its regulation of PPAR gamma expression...
  13. doi request reprint PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
  14. ncbi request reprint Role of hepatic STAT3 in the regulation of lipid metabolism
    Shinichi Kinoshita
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E200-8. 2008
    ..Furthermore, these alterations in hepatic gene expression likely occurred through a mechanism independent of sterol regulatory element-binding proteins...
  15. doi request reprint Identification and characterization of an alternative promoter of the human PGC-1alpha gene
    Toyo Yoshioka
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Japan
    Biochem Biophys Res Commun 381:537-43. 2009
    ..Our results thus reveal a potential molecular basis for isoform-specific regulation of PGC-1alpha expression in contracting muscle...
  16. pmc Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
    Kazuaki Miyake
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:1483-91. 2002
    ..PI 3-K activity in the liver is thus essential for normal carbohydrate and lipid metabolism in living animals...
  17. ncbi request reprint Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes
    Hiroshi Sakaue
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:38870-4. 2003
    ..These results indicate that PDK-1 is essential for insulin-induced glucose uptake in adipocytes...
  18. ncbi request reprint [Insulin signaling and pathophysiology of type 2 diabetes mellitus]
    Wataru Ogawa
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Nihon Rinsho 64:1381-9. 2006
    ....
  19. pmc Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis
    Kazuhito Tawaramoto
    Division of Diabetes, Endocrinology, and Metabolism, Kawasaki Medical School, Okayama 701 0192, Japan
    Mol Endocrinol 26:95-109. 2012
    ..This demonstrates an unexpected role of PDK1 signaling in endothelial cells on the maintenance of proper glucose homeostasis through the regulation of adipocyte development...
  20. doi request reprint Role of S6K1 in regulation of SREBP1c expression in the liver
    Shuying Li
    Department of Medicine, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 412:197-202. 2011
    ....
  21. doi request reprint PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
    Kyoko Nakamura
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 283:17702-11. 2008
    ..These data indicate that PDK1 plays an important role in cell proliferation and cell cycle progression by controlling the expression of both cyclin D1 and p27(Kip1)...
  22. pmc PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
    Michihiro Matsumoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Clin Invest 112:935-44. 2003
    ..Hepatic PKClambda is thus a determinant of hepatic lipid content and whole-body insulin sensitivity...
  23. ncbi request reprint Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
    ..These results suggest that PDK1 is important in maintenance of pancreatic cell mass and glucose homeostasis...
  24. pmc Evaluation of a minimally invasive system for measuring glucose area under the curve during oral glucose tolerance tests: usefulness of sweat monitoring for precise measurement
    Kazuhiko Sakaguchi
    Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Japan
    J Diabetes Sci Technol 7:678-88. 2013
    ..Therefore, we developed a sweat monitoring patch to reduce this effect and investigated its efficacy in volunteers undergoing oral glucose tolerance tests (OGTTs)...
  25. ncbi request reprint [Mechanism of insulin action and diabetes mellitus]
    Wataru Ogawa
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Seikagaku 75:1332-44. 2003
  26. ncbi request reprint Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation
    Hiroshi Sakaue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 279:39951-7. 2004
    ..These results suggest that MKP-1 plays an essential role in adipocyte differentiation through down-regulation of p42/p44 MAPK activity...
  27. doi request reprint Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease
    Takuo Emoto
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    J Atheroscler Thromb 23:908-21. 2016
    ..The association between atherosclerosis and gut microbiota has also been attracting increased attention. Our aim was to specify a characteristic trend of gut microbiota in coronary artery disease (CAD)...
  28. doi request reprint Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver
    Sachie Nakamichi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Mol Endocrinol 42:161-9. 2009
    ..Our results thus demonstrate that GRAIL in the liver is essential for maintenance of normal glucose and lipid metabolism in living animals...
  29. ncbi request reprint Correlation of serum CPR to plasma glucose ratio with various indices of insulin secretion and diseases duration in type 2 diabetes
    Yoko Okuno
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 59:E44-53. 2013
    ..Our data clearly shows that the CPR index is a useful parameter to reflect the degree of impaired glucose tolerance...
  30. ncbi request reprint Regulation of SREBP1c expression by mTOR signaling in hepatocytes
    Mototsugu Takashima
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 55:E45-52. 2009
    ..These results thus suggest that mTOR signaling plays a major role in Akt-mediated up-regulation of SREBP1c expression but that it plays only a minor role in insulin-induced expression of this transcription factor...
  31. ncbi request reprint [Energy metabolism and glycemic metabolism in elderly people]
    Tomoaki Nakamura
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 71:1932-5. 2013
    ..Moreover, the dysfunction of mitochondria and the decline in the activity of certain hormones also appear to contribute to the pathogenesis of glucose intolerance in the elderly...
  32. doi request reprint C-peptide response to glucagon challenge is correlated with improvement of early insulin secretion by liraglutide treatment
    Michinori Takabe
    Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 98:e32-5. 2012
    ..The serum C-peptide response to glucagon challenge strongly correlated with the improvement of the early insulin-response. The C-peptide response to glucagon challenge would be useful to predict therapeutic response to liraglutide...
  33. pmc Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre, randomised, crossover study
    Tomoaki Nakamura
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Diabetologia 58:2013-9. 2015
    ....
  34. doi request reprint A minimally invasive system for glucose area under the curve measurement using interstitial fluid extraction technology: evaluation of the accuracy and usefulness with oral glucose tolerance tests in subjects with and without diabetes
    Kazuhiko Sakaguchi
    Division of Diabetes, Metabolism and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes Technol Ther 14:485-91. 2012
    ..This study aimed to evaluate the usefulness of this system by comparing data with the findings of oral glucose tolerance tests (OGTTs) in subjects with and without diabetes...
  35. pmc The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:2473-83. 2006
    ..In conclusion, the LXXLL motif of FoxO1 may have an important role for its transcriptional activity and Sirt1 binding and should be a target site for regulation of gene expression of FoxO1 target genes and glucose metabolism in vivo...
  36. ncbi request reprint Alpha-lipoic acid and insulin autoimmune syndrome
    Yoshihiko Ishida
    Ishida Clinic, Kobe, Japan
    Diabetes Care 30:2240-1. 2007
  37. pmc Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway
    Lin Deng
    Division of Microbiology, Center for Infectious Disease, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Virol 85:8556-68. 2011
    ..Taken together, these observations suggest that HCV promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway...
  38. ncbi request reprint Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells
    Yoshihiro Yutsudo
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Pancreas 30:50-3. 2005
    ..We showed previously that cholecystokinin (CCK)-induced 70-kd S6 kinase activation is partly mediated by protein kinase C (PKC) in pancreatic acinar AR42J cells. Here, we examined which isoform of PKC is involved in this process...
  39. pmc Tissue glycogen content and glucose intolerance
    Masato Kasuga
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 111:1282-4. 2003
  40. ncbi request reprint Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1
    Toshiyuki Takada
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 277:34359-66. 2002
    ..These results suggest that SAP-1 induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway...
  41. doi request reprint Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets
    Ayumi Kanno
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan Electronic address
    Biochem Biophys Res Commun 458:681-6. 2015
    ..Our data showed that not only increased pancreatic β-cell mass and insulin secretion but also elevated insulin translation is the major compensatory mechanism of pancreatic β-cells. ..
  42. ncbi request reprint [Insulin receptor gene]
    Wataru Ogawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 64:368-72. 2006
  43. ncbi request reprint Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis
    Yoshiyuki Rikitake
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:108-14. 2002
    ..Thus, our results demonstrate the crucial role of NO in S1P-induced angiogenesis in vivo and in vitro and suggest the divergent roles of NO in the S1P-induced angiogenic response...
  44. ncbi request reprint [Insulin action: its variety and diversity]
    Wataru Ogawa
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Nihon Rinsho 60:228-33. 2002
  45. pmc Thrombospondin 1 Suppresses Insulin Signaling in C2C12 Myotubes
    Kaku Matsugi
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Kobe J Med Sci 62:E13-8. 2016
    ..Thus, TSP-1 could be a potential target for the treatment of insulin resistance and metabolic disease related to insulin resistance. ..
  46. ncbi request reprint Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes
    Michihiro Matsumoto
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 51:1672-80. 2002
    ..These results suggest that the IRS-1-PI 3-kinase pathway is essential for insulin-induced expression of SREBP-1c and glucokinase genes...
  47. pmc Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography
    Masaru Kuroda
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo, 650 0017, Japan
    Cardiovasc Diabetol 15:79. 2016
    ..We aimed to investigate the effects of glucose fluctuations on neointimal growth after everolimus-eluting stent (EES) implantation...
  48. doi request reprint Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease
    Takuo Emoto
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Heart Vessels 32:39-46. 2017
    ..We classified the gut microbiota profiles in coronary artery disease patients using data mining analysis of T-RFLP data and demonstrated the possibility that gut microbiota is a diagnostic marker of suffering from CAD...
  49. doi request reprint Impaired Mechanics of Left Ventriculo-Atrial Coupling in Patients With Diabetic Nephropathy
    Yasuhide Mochizuki
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Circ J 80:1957-64. 2016
    ..However, the effect of diabetic nephropathy on left atrial (LA) function remains unknown...
  50. doi request reprint Negatively-charged residues in the polar carboxy-terminal region in FSP27 are indispensable for expanding lipid droplets
    Yoshikazu Tamori
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Chibune General Hospital, Osaka, Japan
    FEBS Lett 590:750-9. 2016
    ..We propose that the carboxy-terminal domain of FSP27 has a crucial role in LD expansion, whereas the amino-terminal domain only has a supportive role. ..
  51. pmc Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity
    Tomokazu Matsuda
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 10:e0130757. 2015
    ..Enhanced C/EBPβ expression and decreased AMPK activity act synergistically to induce ER stress-associated pancreatic beta cell failure. ..
  52. pmc Requirement of fibroblast growth factor 10 in development of white adipose tissue
    Hiroshi Sakaue
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Genes Dev 16:908-12. 2002
    ..Therefore, FGF10 plays an important role in adipogenesis, at least partly by contributing to the expression of C/EBPbeta through an autocrine/paracrine mechanism...