Genomes and Genes
Affiliation: Kobe University
- Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditureJun Nakae
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Diabetes 57:563-76. 2008..Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear...
- The FoxO transcription factors and metabolic regulationJun Nakae
21st Century COE Program for Signal Transduction Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
FEBS Lett 582:54-67. 2008..The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome...
- The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activityJun Nakae
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
J Clin Invest 116:2473-83. 2006..In conclusion, the LXXLL motif of FoxO1 may have an important role for its transcriptional activity and Sirt1 binding and should be a target site for regulation of gene expression of FoxO1 target genes and glucose metabolism in vivo...
- PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditureYongheng Cao
Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
PLoS ONE 6:e18324. 2011..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms...
- PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intakeKristy Iskandar
International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
Am J Physiol Endocrinol Metab 298:E787-98. 2010..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
- Novel repressor regulates insulin sensitivity through interaction with Foxo1Jun Nakae
Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
EMBO J 31:2275-95. 2012..Taken together, these data suggest that FCoR is a novel repressor that regulates insulin sensitivity and energy metabolism in adipose tissue by acting to fine-tune Foxo1 activity...
- Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivityYasuhide Fukatsu
Department of Clinical Molecular Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
Endocrinology 150:2683-91. 2009..Our results suggest that HB-EGF produced by contracting muscle acts as an insulin sensitizer that facilitates peripheral glucose disposal...
- Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathwayYongheng Cao
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
J Biol Chem 281:40242-51. 2006..These data suggest a novel mechanism by which FoxO1 regulates the insulin signaling pathway through negative regulation of TSC2 function...
- Transgenic rescue of insulin receptor-deficient miceHaruka Okamoto
Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 114:214-23. 2004..These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes...
- Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivityAtsushi Tsuchida
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Biol Chem 279:30817-22. 2004....
- Mosaic analysis of insulin receptor functionTadahiro Kitamura
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Clin Invest 113:209-19. 2004..These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action...
- The forkhead transcription factor Foxo1 regulates adipocyte differentiationJun Nakae
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Dev Cell 4:119-29. 2003..We propose that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation...
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthTadahiro Kitamura
Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
J Clin Invest 110:1839-47. 2002..We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts...
- Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1Jun Nakae
Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nat Genet 32:245-53. 2002..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
- Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factorsMarta L Hribal
Russ Berrie Research Pavilion, Rm 238, 1150 St Nicholas Avenue, New York, NY 10032, USA
J Cell Biol 162:535-41. 2003..Inhibition of Foxo expression by siRNA resulted in more efficient differentiation, associated with increased myosin expression. These observations indicate that Foxo proteins are key effectors of Akt-dependent myogenesis...
- Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic miceJennifer Altomonte
Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Am J Physiol Endocrinol Metab 285:E718-28. 2003..These results demonstrated that functional inhibition of Foxo1, caused by hepatic expression of its mutant, is associated with reduced hepatic gluconeogenic activity and improved fasting glycemia in diabetic mice...
- Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptorShouhong Xuan
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 110:1011-9. 2002..These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion...
- Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceYoshiaki Kido
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 277:36740-7. 2002..We conclude that Igf1r and Insr are required for embryonic development of the exocrine but not of the endocrine pancreas and that defects of Igf1r do not alter glucose homeostasis as long as the insulin receptor system remains intact...