Y Mizushina

Summary

Affiliation: Kobe Gakuin University
Country: Japan

Publications

  1. ncbi request reprint Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation
    Isoko Kuriyama
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    J Nutr Biochem 16:594-601. 2005
  2. ncbi request reprint In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach
    Yoshiyuki Mizushina
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Oncol Rep 28:821-8. 2012
  3. ncbi request reprint Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Mini Rev Med Chem 12:1135-43. 2012
  4. pmc Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180
    Exp Ther Med 5:17-22. 2013
  5. pmc Effects of intermediates between vitamins K(2) and K(3) on mammalian DNA polymerase inhibition and anti-inflammatory activity
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Int J Mol Sci 12:1115-32. 2011
  6. pmc Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities
    Tsukasa Ishida
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    Evid Based Complement Alternat Med 2012:650514. 2012
  7. ncbi request reprint Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Food Funct 5:696-704. 2014
  8. ncbi request reprint Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chuo Ku, Kobe, Hyogo 651 8586, Japan Electronic address
    Bioorg Med Chem 22:1070-6. 2014
  9. ncbi request reprint Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Food Chem Toxicol 59:793-800. 2013
  10. ncbi request reprint Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Food Chem 141:1000-7. 2013

Detail Information

Publications93

  1. ncbi request reprint Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation
    Isoko Kuriyama
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    J Nutr Biochem 16:594-601. 2005
    ..Based on these results, the glycolipids fraction from spinach is potentially a source of food material for a novel anticancer activity...
  2. ncbi request reprint In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach
    Yoshiyuki Mizushina
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Oncol Rep 28:821-8. 2012
    ....
  3. ncbi request reprint Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Mini Rev Med Chem 12:1135-43. 2012
    ..e., the binding site of the primer and dNTP substrate) might have a "pocket" that could "join" these compounds. These results appear to suggest a potential structure for the development of more potent inhibitors of human telomerase...
  4. pmc Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180
    Exp Ther Med 5:17-22. 2013
    ..These results suggest that MGDG has the potential for cancer prevention and health promotion...
  5. pmc Effects of intermediates between vitamins K(2) and K(3) on mammalian DNA polymerase inhibition and anti-inflammatory activity
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Int J Mol Sci 12:1115-32. 2011
    ..In conclusion, this study has identified VK(2) and VK(3) intermediates, such as MK-2, that are promising anti-inflammatory candidates...
  6. pmc Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities
    Tsukasa Ishida
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    Evid Based Complement Alternat Med 2012:650514. 2012
    ..In conclusion, this study has identified compound 3, which is the aglycone of compounds 1 and 2, as a promising anti-inflammatory candidate based on mammalian pol inhibition...
  7. ncbi request reprint Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Food Funct 5:696-704. 2014
    ..These results suggest that steamed germinated soybeans, especially the glucosyl compound components, may be useful for their anti-inflammatory properties...
  8. ncbi request reprint Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chuo Ku, Kobe, Hyogo 651 8586, Japan Electronic address
    Bioorg Med Chem 22:1070-6. 2014
    ..On the basis of these results, the relationship between the three-dimensional structure and pol β inhibitory mechanism of compound 2 is discussed. ..
  9. ncbi request reprint Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Food Chem Toxicol 59:793-800. 2013
    ..These results suggest that decreased proliferation by α-mangostin may be a result of the inhibition of cellular topos rather than pols, and α-mangostin might be an anticancer chemotherapeutic agent...
  10. ncbi request reprint Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Food Chem 141:1000-7. 2013
    ..These results suggest that this byproduct formed during the sake-brewing process is useful as an anti-inflammatory agent. ..
  11. ncbi request reprint Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review)
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Int J Oncol 42:793-802. 2013
    ..The promising anti-inflammatory candidates based on the inhibition of DNA repair-related pols, such as pol λ, by VKs quinone derivatives, such as NQ, are discussed...
  12. ncbi request reprint Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochimie 89:581-90. 2007
    ..Based on these results, the IMPDH-inhibitory mechanism of fatty acids is discussed...
  13. ncbi request reprint 5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Arch Biochem Biophys 446:69-76. 2006
    ..On the basis of these results, HMF was suggested to bind to the pol beta-like region of pol lambda and TdT...
  14. ncbi request reprint Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Biophys Res Commun 339:949-55. 2006
    ..These results indicated that tocotrienols targeted both pol lambda and angiogenesis as anti-cancer agents. The relationship between the inhibition of pol lambda and anti-angiogenesis by delta-tocotrienol was discussed...
  15. ncbi request reprint Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Curr Med Chem Anticancer Agents 5:613-25. 2005
    ..Based on these results, the molecular actions of SQAGs and drug design strategies for developing new anti-neoplastic agents were discussed...
  16. ncbi request reprint Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase lambda and a new ligand for inhibitor-affinity chromatography
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Biophys Res Commun 337:1288-95. 2005
    ..We then made a monoacetylcurcumin-conjugated column with epoxy-activated Sepharose 6B. In the column, pol lambda of full length was selectively adsorbed and eluted...
  17. ncbi request reprint Inhibitory effect of mispyric acid on mammalian DNA polymerases
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo, Japan
    Biosci Biotechnol Biochem 69:1534-8. 2005
    ..The moiety of two carboxylic acids in mispyric acid was important for the inhibition of pols, and the stereoisomers of mispyric acid had no inhibitory effect...
  18. ncbi request reprint Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Hyogo, Japan
    Biochem Biophys Res Commun 333:101-9. 2005
    ..EGCg at 250 microg was the strongest suppressor of inflammation (65.6% inhibition) among the compounds tested. The relationship between the structure of tea catechins and the inhibition of mammalian pols and inflammation was discussed...
  19. ncbi request reprint Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Life Sci 77:2127-40. 2005
    ..0%). The relationship between the structure of stevioside-based compounds and these activities were discussed...
  20. ncbi request reprint Beta-sitosterol-3-O-beta-D-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    J Steroid Biochem Mol Biol 99:100-7. 2006
    ..On the basis of these results, the pol lambda inhibitory mechanism of compound 1 is discussed...
  21. ncbi request reprint Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochim Biophys Acta 1780:203-13. 2008
    ..The application of inhibitors for the formation of Cdt1-geminin complex is discussed...
  22. ncbi request reprint Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Hyogo 651 2180, Japan
    Int J Mol Med 21:281-90. 2008
    ..These results suggested that, at least in vitro, oleic acid-containing cell membranes of the lipid bilayer inhibit Cdt1-geminin complex formation by binding to Cdt1 and thereby liberating Cdt1 from inhibition by geminin...
  23. ncbi request reprint Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α
    Yoshiyuki Mizushina
    Kobe Gakuin University, Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe, Hyogo, Japan
    Expert Opin Investig Drugs 20:1523-34. 2011
    ..We carried out a screen for small molecule selective inhibitors of eukaryotic DNA polymerases (pols). Dehydroaltenusin, isolated from a fungus (Alternaria tenuis), was found to be a specific inhibitor of pol α...
  24. ncbi request reprint Acylated catechin derivatives: inhibitors of DNA polymerase and angiogenesis
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Front Biosci (Elite Ed) 3:1337-48. 2011
    ..Moreover, the results suggest that acylation of catechin is an effective chemical modification to improve the anti-cancer activity of catechin...
  25. pmc A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem J 370:299-305. 2003
    ..SQDG should, therefore, be called a mammalian pol epsilon-specific inhibitor or animal polymerase-specific inhibitor. To our knowledge, this represents the first report about an inhibitor specific to mammalian pol epsilon...
  26. ncbi request reprint Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Int J Oncol 37:993-1000. 2010
    ..These results suggest that the effect of p53-dependent cell cycle arrest may be effective for topo inhibition by com-pound 5. From these findings, the action mode of alkyl p-coumarates as an anti-cancer agent is discussed...
  27. pmc 3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Mar Drugs 7:624-39. 2009
    ....
  28. ncbi request reprint Specific inhibitors of mammalian DNA polymerase species
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo, Japan
    Biosci Biotechnol Biochem 73:1239-51. 2009
    ..These compounds might be useful not only as "molecular probes" for pol research, but also as biomedical and chemotherapeutic drugs for anti-cancer or anti-inflammation...
  29. ncbi request reprint The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Molecules 14:102-21. 2009
    ..The relationship between the three-dimensional molecular structures of KA-A-related compounds and these inhibitory activities is discussed...
  30. ncbi request reprint The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochimie 90:947-56. 2008
    ..These data could help to further understanding of the structure and function of Cdt1. In addition, SQDG could be a clue to developing more appropriate inhibitors of Cdt1-geminin interactions...
  31. ncbi request reprint Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo 651 2180, Japan
    Int J Mol Med 15:785-93. 2005
    ..Based on these results, the relationship among the three-dimensional structure of epolactaene derivatives and the inhibition of polymerases and topo II, and anti-inflammation is discussed...
  32. ncbi request reprint Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Lipids 39:977-83. 2004
    ..The 3-D structure of the active site of both DNA polymerases and topoisomerases must have had a pocket to join alpha-eleostearic acid, and this pocket was 12.03 A long and 9.24 A wide...
  33. ncbi request reprint Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon
    Yoshiyuki Mizushina
    Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Biochem Biophys Res Commun 312:1025-32. 2003
    ....
  34. ncbi request reprint Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Lipids 38:1065-74. 2003
    ..From these results, the properties of lipid emulsions containing SQDG/SQMG and their possible use in in vivo experiments including clinical use are discussed...
  35. ncbi request reprint Petasiphenol: a DNA polymerase lambda inhibitor
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, and High Technology Research Center, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochemistry 41:14463-71. 2002
    ..On the basis of these results, the pol lambda inhibitory mechanism of petasiphenol is discussed...
  36. ncbi request reprint Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors
    Yoshiyuki Mizushina
    Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, 651 2180 Hyogo, Japan
    Biochem Pharmacol 66:1935-44. 2003
    ..Expectedly, petasiphenol also showed an anti-12-O-tetradecanoylphorbol-13-acetate-induced inflammatory effect in mice. This finding may provide clues to investigating the molecular mechanism of inflammation...
  37. ncbi request reprint Selective inhibition of mammalian DNA polymerase alpha by vitamin D2 and D3
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo, Japan
    J Pharmacol Sci 92:283-90. 2003
    ..The cells were halted at the G1 phase in the cell cycle by these compounds...
  38. ncbi request reprint Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase alpha and a new carrier for inhibitor-affinity chromatography
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science and High Tecnology Research Center, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Biophys Res Commun 301:480-7. 2003
    ..We then made a KAG-conjugated column such as the epoxy-activated Sepharose 6B. In the column, pol alpha was selectively adsorbed and eluted...
  39. ncbi request reprint The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases
    Yoshiyuki Mizushina
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Biochem Biophys Res Commun 304:78-85. 2003
    ..The relationship between the structure of DRB and the inhibition of eukaryotic DNA polymerases is discussed...
  40. ncbi request reprint Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Biophys Res Commun 305:365-73. 2003
    ..The triterpene frames could be used for screening new inhibitors of the enzymes, and computer-simulated drug design using the frame and pocket structure may in theory be a possible approach to develop new inhibitors...
  41. ncbi request reprint Kohamaic acid A, a novel sesterterpenic acid, inhibits activities of DNA polymerases from deuterostomes
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi, Hyogo 651 2180, Japan
    Biochim Biophys Acta 1648:55-61. 2003
    ..beta. KA-A is an inhibitor of replicative DNA polymerases from the deuterostome species, and subsequently, the inhibition of the first cleavage of fertilized sea urchin eggs might occur as a result of the suppression of DNA replication...
  42. ncbi request reprint A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science and High Technology Research Center, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Cancer Sci 95:354-60. 2004
    ..6 and 38.4 microM, respectively. The cells were halted at the G1 phase in the cell cycle. The relation between the structure of triterpene acids and their inhibitory activities is discussed...
  43. ncbi request reprint Molecular action mode of Hippospongic acid A, an inhibitor of gastrulation of starfish embryos
    Yoshiyuki Mizushina
    Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180
    J Biochem 133:541-52. 2003
    ..We also discussed the in vivo role of HA-A...
  44. ncbi request reprint Three-dimensional structural model analysis of the binding site of lithocholic acid, an inhibitor of DNA polymerase beta and DNA topoisomerase II
    Y Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    J Biochem 130:657-64. 2001
    ..In topo II, the three amino acid residues were Lys720, Leu760, and Thr791. These results suggested that the LCA binding domains of pol beta and topo II are three-dimensionally very similar...
  45. ncbi request reprint Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, and High Technology Research Center, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochemistry 43:10669-77. 2004
    ..From these results, the structure-function relationship among pol beta and its selective inhibitors was discussed...
  46. ncbi request reprint A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    J Biol Chem 277:630-8. 2002
    ..Based on these results, the inhibitory mechanism of solanapyrone A is discussed...
  47. ncbi request reprint [Structural homology between molecular probes binding site of DNA polymerase beta and DNA topoisomerase II]
    Yoshiyuki Mizushina
    Tanpakushitsu Kakusan Koso 47:708-14. 2002
  48. ncbi request reprint Selective inhibition of the activities of both eukaryotic DNA polymerases and DNA topoisomerases by elenic acid
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku Kobe, Hyogo, Japan
    Biochem Pharmacol 63:399-407. 2002
    ..EA could prevent the growth of NUGC-3 cancer cells, and the LD(50) value was 22.5 microM. The cells were halted at G1 and G2/M phase in the cell cycle. From these results, the action mode of EA is discussed...
  49. ncbi request reprint Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae
    Y Mizushina
    Department of Nutritional Science, and High Technology Research Center, Kobe Gakuin University, Hyogo, Japan
    Biol Pharm Bull 24:982-7. 2001
    ..In this study, we demonstrated the structure-function relationship in the selective inhibition of pol. alpha by the glycolipid group...
  50. ncbi request reprint Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    DNA Cell Biol 25:95-103. 2006
    ..These results suggest that acylation of catechin is an effective chemical modification to improve the anticancer activity of catechin...
  51. ncbi request reprint Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression
    Yuko Kumamoto-Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Biochim Biophys Acta 1790:339-46. 2009
    ....
  52. ncbi request reprint Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases
    Chikako Murakami
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo, Japan
    Biochim Biophys Acta 1574:85-92. 2002
    ..The cells were halted at G1 phase in the cell cycle by RAL...
  53. ncbi request reprint Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors
    Chikako Murakami
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Arch Biochem Biophys 403:229-36. 2002
    ..SQMG and GMG could halt the cell cycle at the G1 phase, but the cell cycle was not changed by MG. The relationship between the DNA polymerase inhibition and the cell growth effect by these compounds are discussed...
  54. ncbi request reprint Effects of DNA polymerase inhibitory and antitumor activities of lipase-hydrolyzed glycolipid fractions from spinach
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    J Nutr Biochem 16:121-8. 2005
    ..Spinach glycolipid fraction might be a potent antitumor compound if directly injected into a tumor-carrying body, and this fraction may be a healthy food material that has antitumor activity...
  55. ncbi request reprint Effects of glycolipids from spinach on mammalian DNA polymerases
    Chikako Murakami
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Pharmacol 65:259-67. 2003
    ..Both MGDG and MGMG could halt the cell cycle at the G1 phase, and subsequently induced severe apoptosis. The relationship between the DNA polymerase inhibition and the cell growth effect by these glycolipids is discussed...
  56. ncbi request reprint Anti-tumor effects of the glycolipids fraction from spinach which inhibited DNA polymerase activity
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Nutr Cancer 57:216-23. 2007
    ..The spinach glycolipids fraction might be a potent anti-tumor compound, and this fraction may be a healthy food substance with anti-tumor activity...
  57. ncbi request reprint Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53
    Hiroshi Iijima
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo 651 2180, Japan
    Int J Mol Med 19:41-8. 2007
    ....
  58. ncbi request reprint Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases
    Chikako Murakami
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Biochim Biophys Acta 1596:193-200. 2002
    ..The cells were halted at G1 phase in the cell cycle. The mode of action of the triterpenoids against anti-inflammatory activity and their relationships to the DNA polymerase inhibitory activity and cell growth inhibition were discussed...
  59. ncbi request reprint Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth
    Chisato Ishimaru
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Lipids 43:373-82. 2008
    ..These results suggested that the effect of cell cycle arrest might be effective on both pols and topos activities. From these findings, the action mode of cholesterol derivatives as anti-cancer compounds is discussed...
  60. ncbi request reprint A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid
    Chikako Murakami
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Nishi ku, Hyogo 651 2180, Kobe, Japan
    Biochim Biophys Acta 1645:72-80. 2003
    ..The arrest was correlated with an increased expression of p53 and cyclin E, indicating that alpha-SQMG-C(18) induced cell death through a p53-dependent apoptotic pathway...
  61. pmc Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Japan
    Biochem Pharmacol 80:1125-32. 2010
    ..These results support PGG as a novel inhibitor of select families of mammalian pols by distinct mechanisms, and suggest that the potent pol inhibition may contribute to its anti-cancer efficacy...
  62. ncbi request reprint Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth
    Yuki Matsui
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Cancer Lett 283:101-7. 2009
    ..In this study, we discussed the structure-function relationship in the selective inhibition of mammalian replicative pols and human cancer cell proliferation by MGDGs...
  63. ncbi request reprint Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase alpha
    Isoko Kuriyama
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Bioorg Med Chem 13:2187-96. 2005
    ..The relationships between the structures of dipeptide alcohols and the inhibition of eukaryotic DNA polymerases are discussed...
  64. ncbi request reprint Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases
    Yuko Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Hyogo 651 2180, Japan
    Int J Mol Med 18:583-8. 2006
    ..The three-dimensional structure of the active site of both DNA polymerases and topoisomerases must have a pocket to join C22:2, and this pocket was 19.41 Angstrom long and 9.58 Angstrom wide...
  65. ncbi request reprint Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, 518 Arise, Ikawadanicho, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Curr Med Chem 14:955-67. 2007
    ..The spinach Fraction-II containing SQDG might be a potent anti-tumor compound, and may be a healthy food substance with anti-tumor activity...
  66. ncbi request reprint Mechanism of cell cycle arrest and apoptosis induction by conjugated eicosapentaenoic acid, which is a mammalian DNA polymerase and topoisomerase inhibitor
    Yuko Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo, Japan
    Int J Oncol 30:1197-204. 2007
    ..These results suggested the therapeutic potential of cEPA as a leading anti-cancer compound that inhibited activities of pols and topos...
  67. ncbi request reprint The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression
    Chikako Murakami-Nakai
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe 651 2180, Hyogo, Japan
    Biochim Biophys Acta 1674:193-9. 2004
    ..Thus, the pharmacological abrogation of cell proliferation by dehydroaltenusin may prove to be an effective chemotherapeutic agent against tumors...
  68. ncbi request reprint Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Biochem Biophys Res Commun 352:390-6. 2007
    ..Therefore, dehydroaltenusin could be of interest as not only a mammalian pol alpha-specific inhibitor, but also as a candidate drug for anti-cancer treatment...
  69. ncbi request reprint Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line
    Yuko Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180
    Cancer Sci 97:716-23. 2006
    ..The cells were halted at S phase and G1 phase in the cell cycle, and suppressed mitochondrial proliferation. From these results, the relationship between the inhibition of pol gamma/topo II and cancer cell growth by CoQ is discussed...
  70. ncbi request reprint Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds
    Katsumi Nishimura
    Kobe Pharmaceutical University, Kobe, Japan
    Chem Pharm Bull (Tokyo) 57:476-80. 2009
    ..Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta...
  71. ncbi request reprint Inhibitory effect of conjugated eicosapentaenoic acid on mammalian DNA polymerase and topoisomerase activities and human cancer cell proliferation
    Yuko Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Biochem Pharmacol 70:453-60. 2005
    ..This compound also induced apoptosis of the cells. These results suggested the therapeutic potential of cEPA as a leading anti-cancer compound that poisons pols...
  72. ncbi request reprint Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Life Sci 80:1578-85. 2007
    ..These results suggest that acylation of epicatechin is an effective chemical modification to improve the anti-cancer activity of epicatechin...
  73. ncbi request reprint Anti-tumor effect of orally administered spinach glycolipid fraction on implanted cancer cells, colon-26, in mice
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo, 651 2180, Japan
    Lipids 43:741-8. 2008
    ..These results suggest that the orally administered glycolipid fraction from spinach could suppress colon tumor growth in mice by inhibiting the activities of neovascularization and cancer cellular proliferation in tumor tissue...
  74. ncbi request reprint Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp
    Masayuki Nishida
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Bioorg Med Chem 16:5115-22. 2008
    ..On the basis of these results, the pol lambda inhibitory mechanism of compound 1 is discussed...
  75. ncbi request reprint The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase alpha
    Isoko Kuriyama
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Hyogo 651 2180, Japan
    Int J Mol Med 22:793-9. 2008
    ..Therefore, demethoxydehydroaltenusin is of interest as a mammalian pol alpha-selective inhibitor as a 'chemical knockout agent' in vitro and in vivo...
  76. ncbi request reprint Inhibitory effect of monogalactosyldiacylglycerol, extracted from spinach using supercritical CO2, on mammalian DNA polymerase activity
    Hiroshi Iijima
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    J Agric Food Chem 54:1627-32. 2006
    ..The extract of Ujyou, which was the optimal subspecies for the extraction of MGDG, inhibited the activity of calf DNA polymerase alpha with IC(50) values of 145 microg/mL but was not effective against DNA polymerase beta...
  77. ncbi request reprint Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors based on the selective inhibition of DNA polymerase activity
    N Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Mini Rev Med Chem 11:32-8. 2011
    ..On the basis of these findings, we discuss the mode of action of plant chloroplast glycoglycerolipids as anti-cancer therapeutic agents...
  78. ncbi request reprint Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells
    Isoko Kuriyama
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Kobe, Hyogo, Japan
    Molecules 13:2948-61. 2008
    ..These findings suggest that C12 could be more interesting as a molecule probe or anticancer agent than aphidicolin. C12 might provide novel markers for the development of antiproliferative drugs...
  79. ncbi request reprint Inhibitory effect of somatostatin Peptide analogues on DNA polymerase activity and human cancer cell proliferation
    Isoko Kuriyama
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Anticancer Res 30:4841-9. 2010
    ..It was previously reported that ten small peptides derived from TT-232, somatostatin structural analogue (compounds 1-10), synthesised by a solution-phase method, exhibited potent antitumour activity on human epithelial tumour (A431) cells...
  80. ncbi request reprint Biotinylated lithocholic acids for affinity chromatography of mammalian DNA polymerases alpha and beta
    Madoka Watanabe
    Department of Applied Biological Science, Frontier Research Center for Genomic Drug Discovery, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Bioorg Med Chem Lett 12:287-90. 2002
    ..The streptavidine columns conjugated with the synthetic biotinylated compounds chromatographed both two enzymes eluted by KCl solution at the different concentrations...
  81. ncbi request reprint Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta
    Nobuyuki Kasai
    Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan
    FEBS J 272:4349-61. 2005
    ..The models show a SQMG interaction interface that is consistent with the data...
  82. ncbi request reprint Inhibitory effect of dipeptide alcohol derivatives containing mercapto group on eukaryotic DNA polymerase alpha
    Ikuo Kato
    Yanaihara Institute Inc, Awakura, Fujinomiya, Shizuoka 418 0011, Japan
    Int J Mol Med 16:653-9. 2005
    ..The relationships between the structures of dipeptide alcohol and the inhibition of eukaryotic DNA polymerases are discussed...
  83. ncbi request reprint Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases
    Akiko Saito
    Biotechnology Center, Toyama Prefecture, Kosugi, Toyama 939 0398, Japan
    Bioorg Med Chem 13:2759-71. 2005
    ..3,3''-Di-O-gallate dimers acted as strong inhibitor against DNA polymerase alpha and beta, whereas the desgalloyl and monogalloyl compounds did not exhibit any appreciable inhibitory activity against the DNA polymerase beta...
  84. ncbi request reprint Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells
    Kouji Kuramochi
    Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Bioorg Med Chem 14:2151-61. 2006
    ..Compound 1e displayed the strongest activity among all the synthesized compounds with an IC50 value of 0.70 microM...
  85. pmc Inhibition of telomerase by linear-chain fatty acids: a structural analysis
    Masako Oda
    Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation, Toda shi, Saitama 335 8502, Japan
    Biochem J 367:329-34. 2002
    ..The three-dimensional structure of the telomerase active site (i.e. the substrate primer-binding site) appears to have a pocket that could bind oleic acid, with the pocket being 8.50 A long and 12.80 A wide...
  86. ncbi request reprint Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biosci Biotechnol Biochem 68:448-50. 2004
    ..Compounds 1 and 2 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with the 50% inhibition values of 45.5 microM (1) and 40.8 microM (2), and 86.5 microM (1) and 30.0 microM (2), respectively...
  87. ncbi request reprint Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase
    Nobuyuki Kasai
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba 278 8510
    J Biochem 132:819-28. 2002
    ..However, as the rhombus in HIV-1 RT was not present in the DNA binding site, the three-dimensional structure of the DNA binding site must be distorted, and subsequently the enzyme is inhibited non-competitively...
  88. ncbi request reprint Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors
    Kouji Kuramochi
    Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Bioorg Med Chem 12:1983-9. 2004
    ..N- and O-alkyl derivatives that had modified core moieties showed moderate inhibition...
  89. ncbi request reprint Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda
    Toshifumi Takeuchi
    Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan
    Genes Cells 11:223-35. 2006
    ..Based on these results, the pol lambda-inhibitory mechanism of compound 13 is discussed...
  90. ncbi request reprint Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta
    Shizuka Murakami
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba ken 278 8510, Japan
    Biochem Biophys Res Commun 350:7-16. 2006
    ..These findings confirm our previous biochemical and 3D structural proposals concerning inhibition by NA and LCA...
  91. ncbi request reprint Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases
    Ryoichi Nakamura
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Org Biomol Chem 5:3912-21. 2007
    ..Our results suggest that the inhibitory mode of action of PFOdA and PFOS is different from that mediated by the classic fatty acid inhibitors against DNA polymerase beta...
  92. ncbi request reprint Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp
    Shinji Kamisuki
    Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278 8510, Japan
    Bioorg Med Chem 15:3109-14. 2007
    ..The structure-activity relationships of isolated compounds such as novel tetralols, dihydroisocoumarins, and chromone are discussed...
  93. ncbi request reprint Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth
    Shunya Takahashi
    RIKEN The Institute of Physical and Chemical Research, Wako Shi, Saitama, Japan
    Int J Oncol 32:451-8. 2008
    ..This compound also induced apoptosis of the cells. Based on these results, the action mode of compound 5 is discussed...