Masato Kasuga

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. pmc Insulin resistance and pancreatic beta cell failure
    Masato Kasuga
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1756-60. 2006
  2. pmc Tissue glycogen content and glucose intolerance
    Masato Kasuga
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 111:1282-4. 2003
  3. doi request reprint Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity
    Yasuhide Fukatsu
    Department of Clinical Molecular Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Endocrinology 150:2683-91. 2009
  4. pmc Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
  5. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
  6. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
  7. ncbi request reprint Lack of association of CPT1A polymorphisms or haplotypes on hepatic lipid content or insulin resistance in Japanese individuals with type 2 diabetes mellitus
    Yushi Hirota
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Metabolism 56:656-61. 2007
  8. ncbi request reprint Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1
    Takeshi Ogura
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:13711-20. 2004
  9. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
  10. ncbi request reprint Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007

Detail Information

Publications109 found, 100 shown here

  1. pmc Insulin resistance and pancreatic beta cell failure
    Masato Kasuga
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1756-60. 2006
    ..Given that type 2 diabetes accounts for more than 90% of cases of diabetes worldwide, it is important that we understand the pathogenesis of this condition and develop new approaches to its prevention and treatment...
  2. pmc Tissue glycogen content and glucose intolerance
    Masato Kasuga
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 111:1282-4. 2003
  3. doi request reprint Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity
    Yasuhide Fukatsu
    Department of Clinical Molecular Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Endocrinology 150:2683-91. 2009
    ..Our results suggest that HB-EGF produced by contracting muscle acts as an insulin sensitizer that facilitates peripheral glucose disposal...
  4. pmc Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
    ....
  5. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  6. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
    ..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients...
  7. ncbi request reprint Lack of association of CPT1A polymorphisms or haplotypes on hepatic lipid content or insulin resistance in Japanese individuals with type 2 diabetes mellitus
    Yushi Hirota
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Metabolism 56:656-61. 2007
    ..Neither haplotypes nor SNPs of CPT1A were found to be associated either with susceptibility to type 2 diabetes mellitus or with HLC or insulin resistance in type 2 diabetic patients...
  8. ncbi request reprint Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1
    Takeshi Ogura
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:13711-20. 2004
    ..Resistance to this inhibitory mechanism may contribute to the highly metastatic potential of B16 melanoma...
  9. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms...
  10. ncbi request reprint Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007
    ....
  11. ncbi request reprint Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-alpha
    Bui Xuan Truong
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Kobe 650 0017, Japan
    Int J Mol Med 16:279-84. 2005
    ..The results of this long-term follow-up study showed that no benefit of IFN-alpha treatment was detectable during long-term follow-up in Japanese patients with chronic hepatitis B...
  12. pmc FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
    Naonobu Nishino
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 118:2808-21. 2008
    ..In addition, we found that the nature of lipid accumulation in WAT appears to be associated with maintenance of energy balance and insulin sensitivity...
  13. ncbi request reprint Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 21:2108-12. 2007
    ..The present study is the first linking GI hormones to the leading cause of infant mortality and provides a novel insight for neurogenesis in which materno-fetal communication through GI hormones appears to be important...
  14. ncbi request reprint Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
    Tohru Uchida
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Nat Med 11:175-82. 2005
    ..Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2(-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition...
  15. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Lett 207:139-47. 2004
    ..These results suggest that E-NPP3 is involved in the infiltration of neoplastic BDC and is possible to be a tumor marker...
  16. doi request reprint CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis
    Mashito Sakai
    Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Nat Med 18:612-7. 2012
    ..We also found that loss of hepatic CITED2 function suppresses gluconeogenesis in diabetic mice, suggesting it as a therapeutic target for hyperglycemia...
  17. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
    ..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
  18. doi request reprint PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
  19. doi request reprint Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation
    Tetsuya Hosooka
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Nat Med 14:188-93. 2008
    ..These results indicate that Dok1 promotes adipocyte hypertrophy by counteracting the inhibitory effect of ERK on PPAR-gamma and may thus confer predisposition to diet-induced obesity...
  20. ncbi request reprint Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    Akihiro Asakawa
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Meidicine, Japan
    Gastroenterology 124:1325-36. 2003
    ..Pancreatic polypeptide (PP) belongs to a family of peptides including neuropeptide Y and peptide YY. We examined the role of PP in the regulation of body weight as well as the therapeutic potential of PP...
  21. doi request reprint The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
    Tomoki Nagare
    Department of Internal Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 379:98-103. 2009
    ..These results thus implicate KLF15 in the regulation of adrenomedullin expression in adipose tissue...
  22. pmc Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
    Yutaka Shigeyama
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 28:2971-9. 2008
    ..These results thus indicate that TSC2 regulates pancreatic beta-cell mass in a biphasic manner...
  23. ncbi request reprint Role of Krüppel-like factor 15 in PEPCK gene expression in the liver
    Kiyoshi Teshigawara
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 327:920-6. 2005
    ..These results suggest that insulin and its counteracting hormones regulate the hepatic expression of KLF15, and that this transcription factor contributes to the regulation of PEPCK gene expression in the liver...
  24. ncbi request reprint Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis
    Toshiyuki Mori
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 280:12867-75. 2005
    ..Our observations thus demonstrate that KLF15 plays an essential role in adipogenesis in 3T3-L1 cells through its regulation of PPAR gamma expression...
  25. ncbi request reprint Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
    ..Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus...
  26. doi request reprint Skp2 promotes adipocyte differentiation via a p27Kip1-independent mechanism in primary mouse embryonic fibroblasts
    Mitsuru Okada
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 379:249-54. 2009
    ..Our data suggest that Skp2 plays an essential role in adipogenesis in MEFs in a manner that is at least in part independent of regulation of p27(Kip1) expression...
  27. doi request reprint Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
    Kazuaki Miyake
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Hum Genet 54:236-41. 2009
    ..72, thereby indicating that our prediction model for type 2 diabetes may not be so useful but has some value. Incorporation of data from additional risk loci is most likely to increase the predictive power...
  28. pmc PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 115:138-45. 2005
    ..These results indicate that PKClambda plays a prominent role in regulation of glucose-induced insulin secretion by modulating the expression of genes important for beta cell function...
  29. pmc Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1
    Maki Koyanagi
    Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 6:e23238. 2011
    ..The present study examines the effects of TSC2 ablation on insulin secretion from pancreatic beta cells...
  30. ncbi request reprint Skp2 controls adipocyte proliferation during the development of obesity
    Tamon Sakai
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, USA
    J Biol Chem 282:2038-46. 2007
    ..Our observations thus indicate that Skp2 controls adipocyte proliferation during the development of obesity...
  31. ncbi request reprint MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese
    Tatsuya Koyama
    Division of Clinical Pharmacokinetics, Department of General Therapeutics, Kobe University Graduate School of Medicine, Japan
    Biol Pharm Bull 29:1449-53. 2006
    ..Further investigations with relatively large number of patients should be undertaken to confirm these preliminary results...
  32. ncbi request reprint The relationship between gastric emptying determined by the breath test and H. pylori
    Shigeyuki Ebara
    Division of Diabetes, Digestive, and Kidney Disease, Kobe University School of Medicine, Kobe, Japan
    Hepatogastroenterology 54:613-6. 2007
    ..Helicobacter pylori infection has been implicated in atrophic gastritis and gastric ulcer disease. However, the relationship between gastric emptying and Helicobacter pylori infection is still unclear...
  33. pmc Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice
    Tomokazu Matsuda
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 120:115-26. 2010
    ..Our results thus indicate that the accumulation of C/EBPbeta in pancreatic beta cells contributes to beta cell failure in mice by enhancing susceptibility to ER stress...
  34. ncbi request reprint Relationship of BRAF mutation, morphology, and apoptosis in early colorectal cancer
    Shiei Yoshida
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Colorectal Dis 23:7-13. 2008
    ..However, the relationship among BRAF mutations, morphology and apoptosis in early colorectal cancer has not been clear. Therefore, gene alternation, morphology, and apoptosis in early colorectal cancer were investigated...
  35. doi request reprint PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
    Kyoko Nakamura
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 283:17702-11. 2008
    ..These data indicate that PDK1 plays an important role in cell proliferation and cell cycle progression by controlling the expression of both cyclin D1 and p27(Kip1)...
  36. ncbi request reprint Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes
    Kunichi Kouyama
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:345-54. 2008
    ....
  37. pmc Chemerin regulates β-cell function in mice
    Michiko Takahashi
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Sci Rep 1:123. 2011
    ..These results indicate that chemerin regulates β-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner...
  38. ncbi request reprint Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy
    Toshifumi Mitani
    Departments of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Gastroenterol Hepatol 23:e334-9. 2008
    ..This study investigates the role of MT in H. pylori-induced gastritis with or without early gastric cancer (ECG) and evaluates the effect on MT expression after eradication therapy...
  39. doi request reprint The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are indispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte
    Takayuki Kawaguchi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 391:1336-41. 2010
    ....
  40. ncbi request reprint High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases
    Hirotaka Kato
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Cancer Res 10:7318-28. 2004
    ..Overexpression of PRL-3 has been implicated in colorectal cancer metastases. We investigated the significance of PRL-3 expression in the progression and development of colorectal cancer...
  41. ncbi request reprint Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes
    Atsushi Fukunaga
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Immunol 172:4091-9. 2004
    ..These observations show that the ligation of SHPS-1 with the SHPS-1 mAb or with CD47-Fc abrogates the migration of LCs in vivo and in vitro, which suggests that the SHPS-1-CD47 interaction may negatively regulate LC migration...
  42. ncbi request reprint Primary levofloxacin resistance and gyrA/B mutations among Helicobacter pylori in Japan
    Hideyuki Miyachi
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Helicobacter 11:243-9. 2006
    ..Nevertheless, there is a little information concerning the prevalence of levofloxacin resistance and this resistance mechanism...
  43. doi request reprint Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma
    Shinya Satake
    Division of Pathology, Department of Pathology and Microbiology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathol Int 58:156-63. 2008
    ..8-fold), whereas no induction of the other claudins was detected. These findings suggest that Cdx2 plays an important role in the regulation of intestinal claudin expression not only in gastric mucosa with IM but also GC...
  44. ncbi request reprint Role of hepatic STAT3 in the regulation of lipid metabolism
    Shinichi Kinoshita
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E200-8. 2008
    ..Furthermore, these alterations in hepatic gene expression likely occurred through a mechanism independent of sterol regulatory element-binding proteins...
  45. doi request reprint Identification and characterization of an alternative promoter of the human PGC-1alpha gene
    Toyo Yoshioka
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Japan
    Biochem Biophys Res Commun 381:537-43. 2009
    ..Our results thus reveal a potential molecular basis for isoform-specific regulation of PGC-1alpha expression in contracting muscle...
  46. ncbi request reprint [Insulin signaling and pathophysiology of type 2 diabetes mellitus]
    Wataru Ogawa
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Nihon Rinsho 64:1381-9. 2006
    ....
  47. doi request reprint Role of S6K1 in regulation of SREBP1c expression in the liver
    Shuying Li
    Department of Medicine, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 412:197-202. 2011
    ....
  48. doi request reprint Phase I and pharmacokinetic study of tegafur-uracil/leucovorin combined with 5-fluorouracil/leucovorin and irinotecan in patients with advanced colorectal cancer
    Naoko Chayahara
    Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Clin Oncol 32:56-60. 2009
    ....
  49. ncbi request reprint Development of pancreatic islets in pancreatic polypeptide-overexpressing mice
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Int J Mol Med 14:201-5. 2004
    ....
  50. ncbi request reprint Response to interferon-alpha in chronic hepatitis B with and without precore mutant strain detected by mutation site-specific assay
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Gastroenterol 38:460-4. 2004
    ..We investigated whether the presence of precore mutant (stop codon mutation at codon 28) affects the response to interferon-alpha in patients with chronic hepatitis B...
  51. doi request reprint An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice
    Sanshiro Tateya
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Endocrinology 151:971-9. 2010
    ..These data indicate that an increase in the concentration of MCP-1 in the circulation is sufficient to induce systemic insulin resistance irrespective of adipose tissue inflammation...
  52. ncbi request reprint Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population
    Masako Zenibayashi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Endocr J 55:699-707. 2008
    ..The aim of the present study was to examine whether common variants of LRP5 and LRP6 are associated with Type 2 DM or dyslipidemia in Japanese individuals...
  53. ncbi request reprint Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma
    Hidenobu Nagano
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Oncogene 22:4656-63. 2003
    ..In conclusion, these results indicate that SAP-1 expression is downregulated during the dedifferentiation of human HCC, and that this downregulation may play a causal role in disease progression...
  54. ncbi request reprint Insulin-stimulated fusion of GLUT4 vesicles to plasma membrane is dependent on wortmannin-sensitive insulin signaling pathway in 3T3-L1 adipocytes
    Takayuki Kawaguchi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E209-16. 2008
    ..These results suggest that wortmannin-sensitive insulin signaling pathway plays a crucial role in the fusion step of GLUT4 vesicles to the plasma membrane in 3T3-L1 adipocytes...
  55. pmc Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 115:291-301. 2005
    ....
  56. ncbi request reprint Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation
    Hiroshi Sakaue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 279:39951-7. 2004
    ..These results suggest that MKP-1 plays an essential role in adipocyte differentiation through down-regulation of p42/p44 MAPK activity...
  57. ncbi request reprint [Mechanism of insulin action and diabetes mellitus]
    Wataru Ogawa
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Seikagaku 75:1332-44. 2003
  58. ncbi request reprint Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese
    Tatsuya Okuno
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Clin Oncol 30:252-7. 2007
    ....
  59. ncbi request reprint Melanin-concentrating hormone enhances sucrose intake
    Ruka Sakamaki
    International Center for Medical Research, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1033-9. 2005
    ..These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals...
  60. ncbi request reprint Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats
    Satomi Higo
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 54:E35-45. 2008
    ....
  61. doi request reprint Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes
    Kazutoshi Tobimatsu
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 378:399-403. 2009
    ..These results suggest that the gain of Cited2 function counteracts glucocorticoid-induced muscle atrophy through inhibition of proteolysis mediated by p300-dependent gene transcription...
  62. ncbi request reprint Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
    Kazuaki Miyake
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Hum Genet 53:174-80. 2008
    ..However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population...
  63. ncbi request reprint Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population
    Masaki Mita
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E192-9. 2008
    ....
  64. ncbi request reprint Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation
    Yuko Okada
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E241-9. 2009
    ..Our results indicate that the diet-induced up-regulation of leptin, Mest/Peg1, and sFRP5 gene expression in WAT during the development of obesity in mice is not mediated directly by changes in DNA methylation...
  65. doi request reprint Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes
    Michiko Takahashi
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FEBS Lett 582:573-8. 2008
    ..Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function...
  66. ncbi request reprint Methylglyoxal induces prostaglandin E2 production in rat mesangial cells
    Atsuko Uriuhara
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:305-15. 2007
    ..Our results suggest a potential role of MG in the development of diabetic nephropathy through PGE2 production, and may serve as a novel insight into the therapeutic strategies for diabetic nephropathy...
  67. ncbi request reprint Diagnostic significance of gently sloping depression and irregular margin in superficial elevated colorectal tumors
    Takako Nakahara
    Division of Diabetes, Digestive, and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Colorectal Dis 22:25-31. 2007
    ..The aim of this study is to clarify the characteristics of superficial elevated tumors in endoscopic examination for the evaluation of malignant potential...
  68. ncbi request reprint Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction
    Naonobu Nishino
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:99-106. 2007
    ..These results suggest the possibility that insulin efficiently stores triglyceride in adipocytes by decreasing lipolysis and repressing energy expenditure...
  69. ncbi request reprint Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes
    Keiko Fukuyama
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 339:1212-6. 2006
    ..These results suggest that insulin resistance caused by the -112C allele influences the susceptibility to type 2 diabetes...
  70. ncbi request reprint Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects
    Norihide Yokoi
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 55:2379-86. 2006
    ..This is the largest association study so far conducted on these genes in Japanese and provides valuable information for comparison with other ethnic groups...
  71. doi request reprint Analysis of factors affecting increase in bone mineral density at lumbar spine by bisphosphonate treatment in postmenopausal osteoporosis
    Hiroshi Kaji
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Bone Miner Metab 27:76-82. 2009
    ....
  72. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Int J Mol Med 12:763-6. 2003
    ..Our results suggested that E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma...
  73. doi request reprint Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene
    Wataru Ogawa
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 83:e75-7. 2009
    ..The cases highlight the diversity of clinical phenotypes associated with mutations of the insulin receptor gene...
  74. ncbi request reprint A case of well-differentiated hepatocellular carcinoma arising in primary biliary cirrhosis
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Kobe J Med Sci 49:39-43. 2003
    ..It was interesting that such large well-differentiated hepatocellular carcinomas were generated in PBC...
  75. ncbi request reprint Early response to interferon alpha treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection
    Yasushi Seo
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan yseo med kobe u ac jp
    Int J Mol Med 13:75-9. 2004
    ..Early responsiveness to IFN alpha therapy in Japanese patients with chronic active HBV genotype C infection improves the long-term clinical outcome...
  76. ncbi request reprint Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes
    Yoshikazu Tamori
    Division of Diabetes, Digestive, and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetes 51:2045-55. 2002
    ..These results suggest that PPAR-gamma plays an important role in mature 3T3-L1 adipocytes at least in part by maintaining the expression of genes that confer the characteristics of mature adipocytes...
  77. ncbi request reprint Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes
    Hiroshi Sakaue
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:38870-4. 2003
    ..These results indicate that PDK-1 is essential for insulin-induced glucose uptake in adipocytes...
  78. ncbi request reprint Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus
    Tetsuya Teranishi
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Metabolism 56:1418-24. 2007
    ....
  79. ncbi request reprint Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam
    Bui Xuan Truong
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 751 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Int J Mol Med 19:293-9. 2007
    ..In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases...
  80. ncbi request reprint Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands
    Takako Utsumi
    Department of International and Environmental Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 79:229-35. 2007
    ..HBeAg appears to clear from the serum in young adulthood in HBV/D infection, which may be influenced by genotype-dependent features in relation to viral mutations...
  81. ncbi request reprint Serum hepatitis B virus DNA levels differentiating inactive carriers from patients with chronic hepatitis B
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, International Center for Medical Research ICMR, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Gastroenterol Hepatol 17:753-7. 2005
    ....
  82. ncbi request reprint [Search for type 2 diabetes susceptibility genes]
    Yushi Hirota
    Tanpakushitsu Kakusan Koso 50:2084-9. 2005
  83. pmc PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
    Michihiro Matsumoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Clin Invest 112:935-44. 2003
    ..Hepatic PKClambda is thus a determinant of hepatic lipid content and whole-body insulin sensitivity...
  84. ncbi request reprint HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection
    Yoshinori Watanabe
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University School of Medicine, Kobe, Japan
    J Gastroenterol Hepatol 21:420-4. 2006
    ..pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development...
  85. ncbi request reprint IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat
    Miyuki Nakaji
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu ku Kobe 650 0017, Japan
    Carcinogenesis 25:389-97. 2004
    ....
  86. ncbi request reprint [Molecular basis for the development of type 2 diabetes mellitus]
    Masato Kasuga
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 60:468-76. 2002
  87. ncbi request reprint Hepatitis B virus DNA in anti-HBe-positive asymptomatic carriers
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Intervirology 46:43-9. 2003
    ..We examined the level of hepatitis B virus (HBV) DNA and the mutations in the precore, core and polymerase regions of HBV in sera from anti-HBe-positive asymptomatic carriers (ASC)...
  88. ncbi request reprint Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes
    Michihiro Matsumoto
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 51:1672-80. 2002
    ..These results suggest that the IRS-1-PI 3-kinase pathway is essential for insulin-induced expression of SREBP-1c and glucokinase genes...
  89. ncbi request reprint Histological grading and staging in chronic hepatitis: its practical correlation
    Miyuki Nakaji
    Division of Surgical Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathol Int 52:683-90. 2002
    ..To know the distribution of inflammation using the modified HAI scoring system may be helpful and convenient in evaluating patients with chronic inflammatory liver disease...
  90. ncbi request reprint In vivo administration of glucosamine inhibited phosphatidylinositol 3-kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin receptor substrate in rat adipocytes
    Takeshi Miki
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Kobe J Med Sci 48:105-14. 2002
    ..These results suggest that glucosamine infusion contributes to the development of insulin resistance by mainly modulating the PI 3-kinase molecules...
  91. ncbi request reprint MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese
    Tatsuya Osuga
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Biol Pharm Bull 29:324-9. 2006
    ....
  92. ncbi request reprint Different apoptotic regulation of TRAIL-caspase pathway in HBV- and HCV-related hepatocellular carcinoma
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe Asahi Hospital, Kobe, Japan
    Int J Mol Med 11:499-504. 2003
    ..HBV-related HCC demonstrated significantly suppressed caspase-3 activity, signifying apoptosis. Both TRAIL-R1 and -R2 showed coefficient correlation with caspase-3 activity, and were strongly associated with apoptosis in human HCC...
  93. doi request reprint Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver
    Sachie Nakamichi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Mol Endocrinol 42:161-9. 2009
    ..Our results thus demonstrate that GRAIL in the liver is essential for maintenance of normal glucose and lipid metabolism in living animals...
  94. ncbi request reprint Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1
    Toshiyuki Takada
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 277:34359-66. 2002
    ..These results suggest that SAP-1 induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway...
  95. ncbi request reprint [Etiologies of impaired glucose tolerance and impaired fasting glycemia]
    Takeshi Ohara
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 63:89-94. 2005
  96. pmc Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
    Kazuaki Miyake
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:1483-91. 2002
    ..PI 3-K activity in the liver is thus essential for normal carbohydrate and lipid metabolism in living animals...
  97. ncbi request reprint A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program
    Maki Inoue
    Mouse Functional Genomics Research Group, RIKEN Genomic Sciences Center, Kanagawa, Japan
    Hum Mol Genet 13:1147-57. 2004
    ..This collection of Gk mutants will be valuable for understanding GK gene function, for dissecting the function of the enzyme and as models of human MODY2 and PNDM...
  98. ncbi request reprint [Insulin action: its variety and diversity]
    Wataru Ogawa
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Nihon Rinsho 60:228-33. 2002
  99. ncbi request reprint Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
    Atsushi Tsuchida
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:30817-22. 2004
    ....
  100. ncbi request reprint A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population
    Momoko Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 55:919-23. 2006
    ..002; and joint replication control subjects [n = 552], P = 0.037). We speculate that the PRKAA2 gene influences insulin resistance and susceptibility to type 2 diabetes in the Japanese population...
  101. ncbi request reprint MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer
    Chiho Komoto
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
    Drug Metab Pharmacokinet 21:126-32. 2006
    ..There was a tendency for higher frequencies of the T(-129)/C-(129)-C1236-A2677-C3435 haplotype in Japanese CRC patients and T(-129)-T1236-T2677-T3435 haplotype in Japanese ESCC patients, compared with that in healthy Japanese subjects...