Hideyuki Yamawaki

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint Visfatin causes endothelium-dependent relaxation in isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628 Japan
    Biochem Biophys Res Commun 383:503-8. 2009
  2. doi request reprint Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada City, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 393:668-72. 2010
  3. doi request reprint Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    Hypertension 63:397-403. 2014
  4. doi request reprint A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 423:152-7. 2012
  5. doi request reprint A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 418:676-81. 2012
  6. doi request reprint Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 408:339-43. 2011
  7. ncbi request reprint Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biol Pharm Bull 34:307-10. 2011
  8. doi request reprint Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells
    Hideyuki Yamawaki
    Dept of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034 8628, Japan
    Am J Physiol Cell Physiol 295:C1510-7. 2008
  9. doi request reprint Mechanisms underlying impairment of endothelium-dependent relaxation by fetal bovine serum in organ-cultured rat mesenteric artery
    Tomoka Morita
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Eur J Pharmacol 668:401-6. 2011
  10. doi request reprint Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Pharmacol Res 65:91-9. 2012

Collaborators

Detail Information

Publications62

  1. doi request reprint Visfatin causes endothelium-dependent relaxation in isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628 Japan
    Biochem Biophys Res Commun 383:503-8. 2009
    ..Present study revealed for the first time that visfatin has a vasodilating effect on isolated blood vessels, which is mediated via endothelium-derived NO...
  2. doi request reprint Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada City, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 393:668-72. 2010
    ..Omentin (1-300 ng/ml) also relaxed NA pre-contracted mesenteric artery. Present study for the first time demonstrated that omentin has a vasodilating effect on isolated blood vessels, which is mediated through endothelium-derived NO...
  3. doi request reprint Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    Hypertension 63:397-403. 2014
    ....
  4. doi request reprint A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 423:152-7. 2012
    ..The effect is mediated via inhibiting activation of NF-κB and p38 through stimulation of Akt/eNOS signaling and NO production...
  5. doi request reprint A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 418:676-81. 2012
    ..The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance...
  6. doi request reprint Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 408:339-43. 2011
    ..Omentin inhibits COX-2 induction via preventing the JNK activation presumably through activation of AMPK/eNOS/NO pathways...
  7. ncbi request reprint Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biol Pharm Bull 34:307-10. 2011
    ..These novel adipocytokines may be important future targets for the development of drugs and therapy for treating metabolic vascular disorders...
  8. doi request reprint Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells
    Hideyuki Yamawaki
    Dept of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034 8628, Japan
    Am J Physiol Cell Physiol 295:C1510-7. 2008
    ..On the other hand, MGO-induced morphological cell damage seems unlikely to be associated with COX-2-PGE(2)...
  9. doi request reprint Mechanisms underlying impairment of endothelium-dependent relaxation by fetal bovine serum in organ-cultured rat mesenteric artery
    Tomoka Morita
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Eur J Pharmacol 668:401-6. 2011
    ..These data suggest that FBS impairs endothelium-dependent relaxation by inhibiting events upstream of phospholipase C activation including phospholipase C, G-protein, and receptors in endothelium...
  10. doi request reprint Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Pharmacol Res 65:91-9. 2012
    ..Present results indicate that long-term MGO treatment has an inhibitory effect on contractility of isolated blood vessel, which is likely mediated via increased NOX1-derived superoxide production and subsequent apoptosis...
  11. ncbi request reprint Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    J Pharmacol Sci 120:26-35. 2012
    ....
  12. ncbi request reprint Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel
    Hidemi Nomura
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Pharmacol Sci 108:258-65. 2008
    ..While endothelium-dependent relaxation is mediated via nitric oxide, the endothelium-independent one is responsible for smooth muscle K+ (K(V), K(IR))-channel opening...
  13. ncbi request reprint Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    J Pharmacol Sci 111:193-200. 2009
    ..These results suggest that telmisartan could attenuate the monocrotaline-induced RV remodeling through improvements of RV hypertrophy, fibrosis, dysfunction, and inhibition of MMPs...
  14. ncbi request reprint Angiotensin II enhances interleukin-1 beta-induced MMP-9 secretion in adult rat cardiac fibroblasts
    Muneyoshi Okada
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi, Towada, Aomori, Japan
    J Vet Med Sci 72:735-9. 2010
    ..These results suggest that angiotensin II enhances IL-1beta-induced MMP-9 secretion through the augmentation of ERK phosphorylation via AT1R in adult rat cardiac fibroblasts...
  15. ncbi request reprint CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Pharmacol Sci 113:182-91. 2010
    ..It is suggested that CV-159 prevents activation of JNK and p38 through inhibition of ROS, while it prevents activation of NF-kappaB via a ROS-independent manner...
  16. doi request reprint HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Physiol Heart Circ Physiol 302:H1894-904. 2012
    ..It is also suggested in cultured vascular SMCs that TNF-induced HDAC4 mediates vascular inflammation likely via VCAM-1 induction through ROS-dependent NF-κB activation...
  17. doi request reprint Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Atherosclerosis 214:288-94. 2011
    ..In this study, we examined the synergistic effects of the two potent pathogenic factors, platelet-derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) to induce vascular hyperplasia using ex vivo organ-culture system...
  18. doi request reprint Addition of adult serum improves endothelium-dependent relaxation of organ-cultured rat mesenteric artery via inhibiting mitochondrial reactive oxygen species
    Tomoka Morita
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Vascul Pharmacol 58:105-11. 2013
    ..Addition of adult serum normalized the impaired EDR in part through inhibiting the increased mitochondrial ROS but not the membrane potential...
  19. doi request reprint Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells
    Kyosuke Kazama
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    Eur J Pharmacol 686:116-23. 2012
    ..It is suggested that omentin inhibits TNF-α-induced VCAM-1 expression via preventing the activation of p38 and JNK at least in part through inhibition of superoxide production...
  20. ncbi request reprint Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
    J Pharmacol Sci 112:176-83. 2010
    ..The present study revealed that MGO enhanced SNP-induced relaxation in a ROS-independent manner via in part opening smooth muscle BK(Ca) channels...
  21. doi request reprint A novel adipocytokine, vaspin inhibits platelet-derived growth factor-BB-induced migration of vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 423:844-9. 2012
    ..The present study for the first time revealed that vaspin inhibits PDGF-BB-induced SMCs migration through inhibiting p38/HSP27 signals via preventing the ROS generation...
  22. ncbi request reprint Long-term methylglyoxal treatment causes endothelial dysfunction of rat isolated mesenteric artery
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 75:151-7. 2013
    ..The present results demonstrated that long-term MGO treatment impairs endothelium-dependent relaxation through NOX-derived increased superoxide-mediated endothelial apoptosis...
  23. doi request reprint Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    Hypertension 60:1031-9. 2012
    ..It is also suggested that DAPK3 mediates the development of hypertension in spontaneously hypertensive rats likely via ROS-dependent inflammation, hypertrophy, and hypercontractility...
  24. ncbi request reprint Benzodiazepines inhibit the acetylcholine receptor-operated potassium current (IK.ACh) by different mechanisms in guinea-pig atrial myocytes
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 74:879-84. 2012
    ..ACh), it would act on the muscarinic receptor. In summary, benzodiazepines had the anticholinergic effects on atrial myocytes through inhibiting I(K).(ACh) by different molecular mechanisms...
  25. ncbi request reprint Mechanisms underlying the anti-inflammatory effects of the Ca2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Pharmacol Sci 113:214-23. 2010
    ..CV-159 prevents NF-kappaB phosphorylation by inhibiting ROS, while it prevents Akt phosphorylation by inhibiting both ROS and CaM...
  26. ncbi request reprint A novel adipocytokine, omentin, inhibits agonists-induced increases of blood pressure in rats
    Kyosuke Kazama
    Laboratory of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 75:1029-34. 2013
    ..In summary, we for the first time demonstrated that omentin inhibited agonists-induced increases in BP. The effect of omentin was suggested to be mediated likely via NO-dependent mechanism. ..
  27. ncbi request reprint Negative inotropic effect of carbachol and interaction between acetylcholine receptor-operated potassium channel (K.ACh channel) and GTP binding protein in mouse isolated atrium--a novel methodological trial
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    J Vet Med Sci 75:377-80. 2013
    ..1. The data indicate that immunoprecipitation with Kir3.1 and Western blotting of Gβ system is a useful method for assessing interaction between K.ACh channel and GTP binding protein in mouse atrium...
  28. ncbi request reprint Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Pharmacol Sci 118:303-10. 2012
    ..These findings may provide further mechanistic insights into the pathogenesis of diabetes-related macrovascular complications including hypertension...
  29. ncbi request reprint Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
    J Pharmacol Sci 109:305-10. 2009
    ..The present results indicate that MGO has an inhibitory effect on contractility of isolated blood vessel, which is mediated via opening smooth muscle BK(Ca) channel...
  30. doi request reprint Levosimendan inhibits interleukin-1β-induced cell migration and MMP-9 secretion in rat cardiac fibroblasts
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori 034 8628, Japan Electronic address
    Eur J Pharmacol 718:332-9. 2013
    ..The present study for the first time demonstrated in adult rat cardiac fibroblasts that levosimendan inhibits IL-1β-induced migration at least partly through the inhibition of MMP-9 secretion via suppressing ERK phosphorylation...
  31. doi request reprint Exploring calmodulin-related proteins, which mediate development of hypertension, in vascular tissues of spontaneous hypertensive rats
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Biochem Biophys Res Commun 405:47-51. 2011
    ....
  32. pmc Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Physiol Heart Circ Physiol 305:H756-68. 2013
    ..The present results for the first time demonstrate that eEF2K mediates TNF-α-induced vascular inflammation via ROS-dependent mechanism, which is at least partly responsible for the development of hypertension in SHR...
  33. ncbi request reprint Inhibitory effects of psychotropic drugs on the acetylcholine receptor-operated potassium current (IK.ACh) in guinea-pig atrial myocytes
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 75:743-7. 2013
    ..ACh. Chlorpromazine, clozapine, thioridazine, amitriptyline, imipramine, maprotiline and sulpiride are preferentially acting on muscarinic receptor. Fluphenazine and haloperidol may act on G protein and/or potassium channel. ..
  34. doi request reprint Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Pharmacol Res 64:493-500. 2011
    ..Consequently, vaspin could play inhibitory roles on inflammatory states of vascular SMCs...
  35. ncbi request reprint Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8675, Japan
    Eur J Pharmacol 515:134-41. 2005
    ....
  36. ncbi request reprint Contractile characteristics of rat mesenteric artery after organ culture
    Tomoka Morita
    School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Vet Med Sci 72:1621-7. 2010
    ..In FBS, maximal contractions by NA and ET-1 increased in E (+) and decreased in E (-) from control, while those by 5-HT increased in both E (+) and E (-)...
  37. ncbi request reprint Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
    J Pharmacol Sci 108:487-94. 2008
    ..These findings indicate that captopril attenuates the development of monocrotaline-induced right ventricular hypertrophy in association with inhibition of MMP-2 and MMP-9 in rats...
  38. doi request reprint Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium
    Tatsuya Baden
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 373:253-7. 2008
    ..These results indicate that telmisartan prevents MGO-induced apoptosis by inhibiting caspase-3 activation, which might explain at least in part the beneficial effects of telimisartan against diabetes-related cardiovascular diseases...
  39. ncbi request reprint Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    Biol Pharm Bull 33:1517-21. 2010
    ..Furthermore, captopril may enhance LV fibrosis through promoting isoprenaline-induced MMP-9 expression in cardiac interstitial cells...
  40. doi request reprint Death-associated protein kinase 3 mediates vascular structural remodelling via stimulating smooth muscle cell proliferation and migration
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Japan
    Clin Sci (Lond) 127:539-48. 2014
    ..The present study suggests DAPK3 as a novel pharmaceutical target for the prevention of hypertensive cardiovascular diseases. ..
  41. ncbi request reprint Influences of organic solvents on CYPMPO-electron spin resonance spectra in in vitro radical generating systems
    Masashi Mukohda
    School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Vet Med Sci 72:1547-50. 2010
    ..Any of the solvents used in the present study can be used in a hypoxanthine/xanthine oxidase superoxide generation system...
  42. ncbi request reprint Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    J Pharmacol Sci 114:390-8. 2010
    ..The present study revealed that MGO augments Ang II-induced contraction by increasing AT1R-mediated NADPH oxidase-derived superoxide and hydrogen peroxide production in endothelium of rat carotid artery...
  43. ncbi request reprint Vaspin can not inhibit TNF-alpha-induced inflammation of human umbilical vein endothelial cells
    Ben Dong Fu
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    J Vet Med Sci 71:1201-7. 2009
    ..The present results indicate that vaspin has no effects on normal ECs, and can not prevent TNF-alpha-induced inflammatory injury...
  44. doi request reprint Glyoxal causes inflammatory injury in human vascular endothelial cells
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 369:1155-9. 2008
    ..The present results indicate that glyoxal, a metabolite of glucose might be a more powerful inducer for vascular ECs inflammatory injury. Nitric oxide but not anti-oxidant is preventive against GO-mediated inflammatory injury...
  45. doi request reprint Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure
    Hidemizu Kunimoto
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Physiol Heart Circ Physiol 309:H1017-28. 2015
    ....
  46. doi request reprint Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling
    Satoshi Kameshima
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Physiol Heart Circ Physiol 308:H1298-305. 2015
    ..In conclusion, the present results suggest that eEF2K at least partly mediates MCT-induced PAH via stimulation of vascular structural remodeling perhaps through NADPH oxidase-1/ROS/matrix metalloproteinase-2 pathway. ..
  47. doi request reprint Involvement of cyclooxygenase-2 in carbachol-induced positive inotropic response in mouse isolated left atrium
    Yukio Hara
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    J Pharmacol Exp Ther 331:808-15. 2009
    ..Furthermore, for the first time, we demonstrated that the production of PGs depended in part on COX-2 in endocardial endothelium through the muscarinic M(3) receptor stimulation...
  48. doi request reprint Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling
    Satoru Kake
    Laboratory of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Oncol Rep . 2017
    ..These findings indicate that DAPK3 may be a novel target for the treatment of NSCLC...
  49. doi request reprint Expression pattern and function of tyrosine receptor kinase B isoforms in rat mesenteric arterial smooth muscle cells
    Kosuke Otani
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 467:683-9. 2015
    ..This study firstly defined expression level of TrkB isoforms and partly revealed their functions in peripheral vascular cells. ..
  50. doi request reprint Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats
    Satoshi Kameshima
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 469:654-8. 2016
    ..The present results indicate that the increased HDAC4 in brain and increased eEF2K in LV might be at least in part related to the development of hypertension. ..
  51. pmc Mechanisms underlying a decrease in KCl-induced contraction after long-term serum-free organ culture of rat isolated mesenteric artery
    Tomoka Morita
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    J Vet Med Sci 76:963-9. 2014
    ....
  52. doi request reprint A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats
    Kyosuke Kazama
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 452:142-6. 2014
    ..In conclusion, we for the first time demonstrate that chronic omentin treatment inhibits MCT-induced PAH in rats via inhibiting vascular structural remodeling and abnormal contractile reactivity...
  53. doi request reprint Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species
    Kyosuke Kazama
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 457:602-7. 2015
    ..These results indicate omentin as an attractive pharmaco-therapeautic target against DOX-induced cardiac side effect...
  54. doi request reprint A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism
    Kyosuke Kazama
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Physiol Heart Circ Physiol 306:H1714-9. 2014
    ..Our data suggest that omentin may be protective against hypertension development by inhibiting vascular structural remodeling...
  55. doi request reprint Zipper interacting protein kinase (ZIPK): function and signaling
    Tatsuya Usui
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori, 034 8628, Japan
    Apoptosis 19:387-91. 2014
    ..We propose that ZIPK is a potential future target for the development of pharmaceutical therapy for cancer as well as cardiovascular diseases. ..
  56. doi request reprint Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca(2+) channel
    Keisuke Imoto
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori, 034 8628, Japan
    Pflugers Arch 468:1259-70. 2016
    ..ES gene knockdown deteriorates MCT-induced right heart disease. ES is thus cardioprotective possibly through inhibiting T-type Ca(2+) channel activity. ..
  57. doi request reprint Canstatin inhibits isoproterenol-induced apoptosis through preserving mitochondrial morphology in differentiated H9c2 cardiomyoblasts
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori, 034 8628, Japan
    Apoptosis 21:887-95. 2016
    ..In conclusion, canstatin inhibits isoproterenol-induced apoptosis through the inhibition of mitochondrial fission via the suppression of dephosphorylation of Drp1 at Ser637 in differentiated H9c2 cardiomyoblasts. ..
  58. pmc Endostatin inhibits T-type Ca2+ channel current in guinea pig ventricular myocyte
    Jumpei Yasuda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada shi, Aomori 034 8628, Japan
    J Vet Med Sci 77:1289-91. 2015
    ..These data indicate that endostatin can be an endogenous inhibitor of T-type Ca(2+) channels in the cardiac myocytes. ..
  59. doi request reprint Levosimendan inhibits interleukin-1β-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan Electronic address
    Eur J Pharmacol 769:86-92. 2015
    ..The present study for the first time demonstrated that levosimendan inhibits IL-1β-induced apoptosis via the activation of PI3K/Akt pathway and the inhibition of iNOS expression in adult rat cardiac fibroblasts. ..
  60. pmc Endostatin inhibits bradykinin-induced cardiac contraction
    Jumpei Yasuda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada City, Aomori 034 8628, Japan
    J Vet Med Sci 77:1391-5. 2015
    ..These data suggest that endostatin may decrease bradykinin-induced cardiac contraction perhaps through the inhibition of voltage-dependent calcium channel. ..
  61. doi request reprint Endostatin stimulates proliferation and migration of adult rat cardiac fibroblasts through PI3K/Akt pathway
    Muneyoshi Okada
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35 1, Towada, Aomori 034 8628, Japan Electronic address
    Eur J Pharmacol 750:20-6. 2015
    ..Our findings suggest a novel function of endostatin except for an anti-angiogenic activity during the wound-healing process following myocardial infarction. ..
  62. ncbi request reprint Anticholinergic effects of artemisinin, an antimalarial drug, in isolated guinea pig heart preparations
    Yukio Hara
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 69:697-702. 2007
    ..In conclusion, we suggest that the anticholinergic action of artemisinin is mediated through inhibition of IK.ACh via inhibition of the muscarinic potassium channel and/or associated GTP-binding proteins...