Takao Satou

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
  2. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
  3. pmc Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
    Masashi Yanae
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    J Exp Clin Cancer Res 30:74. 2011
  4. pmc Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 29:127. 2010
  5. ncbi request reprint Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation
    T Satou
    Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Diagn Cytopathol 22:364-9. 2000
  6. ncbi request reprint Case of adrenal lymphangioma with atypical lymphocytes in aspirate cytology
    Takao Satou
    Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Diagn Cytopathol 29:87-90. 2003
  7. ncbi request reprint Repetitive administration of tetrabenazine induces irreversible changes in locomotion and morphology of the substantia nigra in rats
    T Satou
    2nd Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Exp Toxicol Pathol 53:303-8. 2001
  8. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:767-83. 2013
  9. doi request reprint The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Neurotox Res 16:378-89. 2009
  10. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013

Detail Information

Publications46

  1. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
    ..In this study, we investigated whether RANKL induces EMT in normal breast mammary epithelial cells and breast cancer cells, and the mechanism underlying such induction...
  2. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
    ..In the present study, we investigated the inhibitory effect of minodronate and alendronate on the osteoclast formation and clarified the mechanism involved in a mouse macrophage-like cell lines C7 and RAW264.7...
  3. pmc Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
    Masashi Yanae
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    J Exp Clin Cancer Res 30:74. 2011
    ..However, the molecular mechanism of apoptosis induction by statins is not well understood in glioblastoma. In the present study, we attempted to elucidate the mechanism by which statins induce apoptosis in C6 glioma cells...
  4. pmc Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 29:127. 2010
    ..In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line...
  5. ncbi request reprint Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation
    T Satou
    Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Diagn Cytopathol 22:364-9. 2000
    ....
  6. ncbi request reprint Case of adrenal lymphangioma with atypical lymphocytes in aspirate cytology
    Takao Satou
    Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Diagn Cytopathol 29:87-90. 2003
    ..This case provided important cytological findings that may assist in the prevention of cytological overdiagnosis...
  7. ncbi request reprint Repetitive administration of tetrabenazine induces irreversible changes in locomotion and morphology of the substantia nigra in rats
    T Satou
    2nd Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Exp Toxicol Pathol 53:303-8. 2001
    ....
  8. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:767-83. 2013
    ..Importantly, continuous and post-TBI access to EGCG improved cerebral function following TBI. In summary, consumption of green tea may be an effective therapy for TBI patients...
  9. doi request reprint The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Neurotox Res 16:378-89. 2009
    ....
  10. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013
    ..05). These results indicate that following TBI, high levels of free radicals are produced in the aged rat brain, which induces neuronal degeneration and apoptotic cell death around the damaged area, resulting in cognitive impairment...
  11. doi request reprint Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:361-74. 2013
    ..These results indicate that, although there were fewer NSCs that have the potential to differentiate into neurons and glia, these NSCs escaped free radical-induced degeneration around the damaged area after TBI in the aged rat brain...
  12. ncbi request reprint Cultured rat astrocytes give rise to neural stem cells
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurochem Res 31:1381-7. 2006
    ..These results indicate that isolated neurospheres from brain cortex astrocytes can differentiate into neurons and glia and might contribute to neurogenesis and neuroplasticity...
  13. ncbi request reprint Immature and mature neurons coexist among glial scars after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 29:734-42. 2007
    ..However, the generation, differentiation and maturation of neural stem cells (NSCs) among glial scars after brain injury have not yet been reported...
  14. doi request reprint Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis
    Motohiro Imano
    Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastrointest Surg 16:2190-6. 2012
    ....
  15. ncbi request reprint A preliminary study of single intraperitoneal administration of paclitaxel followed by sequential systemic chemotherapy with S-1 plus paclitaxel for advanced gastric cancer with peritoneal metastasis
    Motohiro Imano
    Kinki University Faculty of Medicine, Osaka, Japan
    Anticancer Res 32:4071-5. 2012
    ....
  16. doi request reprint (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Neural Transm (Vienna) 119:877-90. 2012
    ....
  17. doi request reprint (-)-Epigallocatechin-3-gallate protects against neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama City, Osaka, 589 8511, Japan
    Neuromolecular Med 13:300-9. 2011
    ..In summary, consumption of green tea may be an effective therapy for TBI patients...
  18. doi request reprint Neural stem cells and new neurons in the cerebral cortex of stroke-prone spontaneously hypertensive rats after stroke
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Mol Neurosci 41:55-65. 2010
    ..Immature cells and new neurons from the ipsilateral SVZ might migrate into the penumbra after cerebral stroke, and this is the first report of their observation after a spontaneous cerebral stroke...
  19. doi request reprint Safety of intraperitoneal administration of paclitaxel after gastrectomy with en-bloc D2 lymph node dissection
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    J Surg Oncol 105:43-7. 2012
    ....
  20. doi request reprint Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama shi, Osaka, 589 8511, Japan
    Mol Cell Biochem 324:191-9. 2009
    ....
  21. doi request reprint Expression of amyloid precursor protein after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Okasayyama City, Osaka, Japan
    Neurol Res 31:103-9. 2009
    ..However, the chronologic changes in APP expression have not been evaluated after traumatic brain injury (TBI)...
  22. doi request reprint Peritoneal metastatic lesions of gastric cancer exhibit low expression of human epidermal growth factor receptor 2
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Target Oncol 7:213-6. 2012
    ..Consequently, other therapeutic approaches for these patients must be developed...
  23. doi request reprint Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:1263-72. 2011
    ..Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction...
  24. ncbi request reprint Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Ohno Higashi Osaka Sayama, Osaka, Japan
    Am Surg 77:1515-20. 2011
    ..31, m-LV 28.2 ± 3.18, P < 0.05). These results suggest that the risk of metachronous liver metastasis could be well predicted by immunohistochemical staining of OPN in the central areas, and CD68 in the invasive margins of tumors...
  25. doi request reprint The relationship between SDF-1alpha/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 31:90-102. 2009
    ..In the present study, the temporal relationship between neural stem cells (NSCs) and SDF-1alpha/CXCR4 around a damaged area was investigated using a rat traumatic brain injury (TBI) model...
  26. doi request reprint Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:193-202. 2011
    ..Exercise increases the proliferation of NSCs around the damaged area following TBI. Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction induced by TBI...
  27. doi request reprint Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  28. doi request reprint High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan, 589 8511
    Target Oncol 8:231-5. 2013
    ..05). The intraperitoneally administrated EpCAM antibody might have a anti-cancer effect in PM lesions of GC. Additionally, it can be assumed that only GC cells which express a high level of EpCAM might metastasize to the peritoneum...
  29. ncbi request reprint Establishment of a novel model of peritoneal carcinomatosis of the peritoneal extension type
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 33:1439-46. 2013
    ..We developed a novel animal model, suitable for testing treatments for PET...
  30. ncbi request reprint Isolation of neural stem cells from damaged rat cerebral cortex after traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neuroreport 16:1687-91. 2005
    ..These results indicate that isolated and cultured neurospheres can differentiate into neurons and glia. An increase in nestin-positive cells around a cerebral cortical damaged area might contribute to neurogenesis and neuroplasticity...
  31. pmc Immunohistochemical analysis of brain lesions using S100B and glial fibrillary acidic protein antibodies in arundic acid- (ONO-2506) treated stroke-prone spontaneously hypertensive rats
    Hideaki Higashino
    Department of Pharmacology, Kinki University School of Medicine, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 116:1209-19. 2009
    ..These data indicate that arundic acid can prevent hypertension-induced stroke, and may inhibit the enlargement of the stroke lesion by preventing the inflammatory changes caused by overproduction of the S100B protein in the astrocytes...
  32. doi request reprint Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 6511, Japan
    World J Surg 34:1930-6. 2010
    ..The aim of the present study was to investigate differences in OPN-positive TAMs between cases of colorectal cancer with synchronous liver metastasis and those without liver metastasis...
  33. doi request reprint Neuroprotective effects of an extract from the inflamed skin of rabbits inoculated with vaccinia virus on glutamate-induced neurotoxicity in cultured neuronal cell line
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 30:430-4. 2008
    ..However, the pharmacologic mechanisms of Rosemorgen and Neurotropin remain unclear...
  34. ncbi request reprint An immunohistochemical study of osteopontin in pigment gallstone formation
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Am Surg 76:91-5. 2010
    ..Our results indicate that Opn, an acidic glycoprotein from the gallbladder epithelium, seems to be involved in lithiasis. Opn from macrophages and/or the epithelium seems to help form the matrix protein...
  35. ncbi request reprint Effect of basic fibroblast growth factor on cultured rat neural stem cell in three-dimensional collagen gel
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 27:429-32. 2005
    ..The effect of growth factors on the three-dimensional culture of neural stem cells has not been reported. We studied the effect of basic fibroblast growth factor (bFGF) on cultured rat neural stem cells in a three-dimensional culture...
  36. doi request reprint Immunohistochemical expression of osteopontin in gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastrointest Surg 13:1577-82. 2009
    ..Thus, the aim of this study was to determine the relationship between the degree of OPN expression, the proliferative activity of cancer cells, and the clinicopathological findings for surgically resected gastric cancer...
  37. ncbi request reprint Multifocal subcutaneous phaeohyphomycosis caused by Phialophora verrucosa
    Masatomo Kimura
    Second Department of Pathology, Kinki University School of Medicine, Osaka Sayama, Japan
    Arch Pathol Lab Med 127:91-3. 2003
    ..To our knowledge, this is the first report of multifocal subcutaneous phaeohyphomycosis caused by P verrucosa. The disease responded to oral itraconazole administration...
  38. doi request reprint Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
    Tomoya Takeda
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi, Osaka, Japan
    Toxicol Appl Pharmacol 306:105-12. 2016
    ..Taken together, our data suggest that mangiferin may be a potential therapeutic agent with a new mechanism of targeting NIK for the treatment of metastatic melanoma. ..
  39. pmc In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke
    Naoto Hayasaka
    Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    PLoS ONE 7:e32342. 2012
    ..However, soft tissue contrast resolution, particularly in the brain, is insufficient for detailed analysis, unlike the current applications of CT in the clinical arena. We address the soft tissue contrast resolution issue in this report...
  40. doi request reprint Macrophage inflammatory protein-1α induces osteoclast formation by activation of the MEK/ERK/c-Fos pathway and inhibition of the p38MAPK/IRF-3/IFN-β pathway
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Higashi Osaka, Osaka, Japan
    J Cell Biochem 111:1661-72. 2010
    ..These findings may be useful in the development of an OC inhibitor that targets intracellular signaling factors...
  41. doi request reprint Evaluation of parametrial spread in endometrial carcinoma
    Yoh Watanabe
    Department of Obstetrics and Gynecology and Pathology, Kinki University School of Medicine, Osaka, Japan
    Obstet Gynecol 116:1027-34. 2010
    ..To evaluate the detailed clinicopathologic characteristics of parametrial spread in uterine endometrial cancer...
  42. pmc Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels
    Takao Inoue
    Department of Pathology, Faculty of Medicine, Kinki University, Osaka, Japan
    PLoS ONE 9:e100988. 2014
    ..Thus, this study has identified a molecular alteration shared by pulmonary emphysema and T2DM. ..
  43. doi request reprint Osteoplastic ameloblastoma: a case report and literature review
    Yuko Itoh
    Department of Pathology, Kinki University, Osaka, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 113:e23-8. 2012
    ..The distinction between new bone formation and invasion of the bone marrow poses a problem. A thin rim of fibrous bone that can be accentuated by Masson-trichrome staining suggests the former...
  44. ncbi request reprint Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation
    Ryotaro Morinaga
    Department of Medical Oncology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Lung Cancer 58:411-3. 2007
    ..This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC...
  45. ncbi request reprint Type IV collagen, type IV collagenase activity and ability of cell proliferation in human thyroid tumours
    Takeshi Kusunoki
    Department of Otolaryngology, Kinki University School of Medicine, Osaka, Japan
    Asian J Surg 25:304-8. 2002
    ..It has been suggested that type IV collagenase degrades type IV collagen, a main component of the basement membrane...
  46. ncbi request reprint Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, 3 4 1, Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Mol Cell Biochem 304:53-60. 2007
    ..This finding may be useful in the development of an osteoclastic inhibitor that targets intracellular signaling factors...