Shozo Nishida

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi request reprint A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK
    Shozo Nishida
    Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Life Sci 73:2655-64. 2003
  2. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
  3. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
  4. ncbi request reprint Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells
    Shozo Nishida
    Department of Pharmacotheraphy, Kinki University, School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Life Sci 74:781-92. 2003
  5. ncbi request reprint Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK
    Shozo Nishida
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Mol Cell Biochem 269:109-14. 2005
  6. ncbi request reprint Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2
    Shozo Nishida
    Division of Pharmacotherapy, Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Biochem Biophys Res Commun 328:91-7. 2005
  7. ncbi request reprint Induction of apoptosis in HL-60 cells treated with medicinal herbs
    S Nishida
    Kinki University School of Pharmaceutical Sciences 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Am J Chin Med 31:551-62. 2003
  8. ncbi request reprint Apoptosis-inducing effect of a new bisphosphonate, YM529, on various hematopoietic tumor cell lines
    Shozo Nishida
    Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Biol Pharm Bull 26:96-100. 2003
  9. ncbi request reprint Change of Cu,Zn-superoxide dismutase activity of guinea pig lung in experimental asthma
    Shozo Nishida
    Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Kinki University School, 3 4 1 Kowakae, Higashiosaka, Osaka, 577 8502, Japan
    Free Radic Res 36:601-6. 2002
  10. doi request reprint By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Leuk Res 38:121-30. 2014

Collaborators

Detail Information

Publications67

  1. ncbi request reprint A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK
    Shozo Nishida
    Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Life Sci 73:2655-64. 2003
    ..The results of this study also suggest that YM529 can be used as an anticancer agent, in addition to its use as a therapeutic agent to treat osteoporosis...
  2. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
    ..In the present study, we investigated the inhibitory effect of minodronate and alendronate on the osteoclast formation and clarified the mechanism involved in a mouse macrophage-like cell lines C7 and RAW264.7...
  3. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
    ..In this study, we investigated whether RANKL induces EMT in normal breast mammary epithelial cells and breast cancer cells, and the mechanism underlying such induction...
  4. ncbi request reprint Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells
    Shozo Nishida
    Department of Pharmacotheraphy, Kinki University, School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Life Sci 74:781-92. 2003
    ..These results suggest the possibility of development of a new anticancer drug treatment...
  5. ncbi request reprint Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK
    Shozo Nishida
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Mol Cell Biochem 269:109-14. 2005
    ..The results of this study also suggested that mevastatin could be used as an anticancer agent...
  6. ncbi request reprint Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2
    Shozo Nishida
    Division of Pharmacotherapy, Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Biochem Biophys Res Commun 328:91-7. 2005
    ..These results suggest a newly elucidated action of bisphosphonates in the inhibition of bone resorption...
  7. ncbi request reprint Induction of apoptosis in HL-60 cells treated with medicinal herbs
    S Nishida
    Kinki University School of Pharmaceutical Sciences 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Am J Chin Med 31:551-62. 2003
    ....
  8. ncbi request reprint Apoptosis-inducing effect of a new bisphosphonate, YM529, on various hematopoietic tumor cell lines
    Shozo Nishida
    Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Biol Pharm Bull 26:96-100. 2003
    ..Therefore, it is concluded that further utilization of YM529 can be expected against hematopoietic tumor cells in the future...
  9. ncbi request reprint Change of Cu,Zn-superoxide dismutase activity of guinea pig lung in experimental asthma
    Shozo Nishida
    Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Kinki University School, 3 4 1 Kowakae, Higashiosaka, Osaka, 577 8502, Japan
    Free Radic Res 36:601-6. 2002
    ..These results were indicated that Cu, Zn-SOD was closely involved in the asthma process, particularly in the scavenging of oxygen radicals secreted from BAL cells...
  10. doi request reprint By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Leuk Res 38:121-30. 2014
    ..Furthermore, dasatinib reversed the drug-resistance of the drug-resistant cell lines. These findings suggest that Src inhibitors are potentially useful as an anti-MDR agent for the treatment of malignant tumor cells. ..
  11. doi request reprint Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Mol Cell Endocrinol 361:219-31. 2012
    ..Accordingly, we believe that its clinical applications will be investigated in the future for the development of osteoporosis therapy...
  12. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:767-83. 2013
    ..Importantly, continuous and post-TBI access to EGCG improved cerebral function following TBI. In summary, consumption of green tea may be an effective therapy for TBI patients...
  13. pmc Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 29:127. 2010
    ..In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line...
  14. doi request reprint Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways
    Hiroshi Matsuoka
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    Exp Cell Res 315:2022-32. 2009
    ..Moreover, tamoxifen markedly inhibited not only developing but also clinically evident metastasis. These findings suggest that tamoxifen has potential clinical applications for the treatment of tumor cell metastasis...
  15. ncbi request reprint Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    Cancer Sci 99:152-8. 2008
    ..Accordingly, YM529/ONO-5920 appears to have promise for use in effective future therapy for osteolysis and myeloma cell growth that depends on MIP-1 alpha...
  16. doi request reprint Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway
    Yoshihiro Tanimori
    Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Clin Exp Metastasis 27:529-38. 2010
    ..These findings suggest that YM529/ONO-5920 has potential clinical applications for the treatment of tumour cell metastasis...
  17. doi request reprint Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    Biochem Pharmacol 85:163-72. 2013
    ..The accumulation of N-BPs in bones suggests that they may act more effectively on tumors that have spread to bones or on Ras-variable tumors. This is the first study to show that the specific molecular pathways of N-BP-induced apoptosis...
  18. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013
    ..05). These results indicate that following TBI, high levels of free radicals are produced in the aged rat brain, which induces neuronal degeneration and apoptotic cell death around the damaged area, resulting in cognitive impairment...
  19. doi request reprint Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    Toxicol Appl Pharmacol 259:402-10. 2012
    ..These findings suggest that YM529/ONO-5920 has potential clinical applications for the treatment of tumor cell metastasis in osteosarcoma...
  20. ncbi request reprint Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, 3 4 1, Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Mol Cell Biochem 304:53-60. 2007
    ..This finding may be useful in the development of an osteoclastic inhibitor that targets intracellular signaling factors...
  21. doi request reprint Macrophage inflammatory protein-1α induces osteoclast formation by activation of the MEK/ERK/c-Fos pathway and inhibition of the p38MAPK/IRF-3/IFN-β pathway
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Higashi Osaka, Osaka, Japan
    J Cell Biochem 111:1661-72. 2010
    ..These findings may be useful in the development of an OC inhibitor that targets intracellular signaling factors...
  22. doi request reprint Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:361-74. 2013
    ..These results indicate that, although there were fewer NSCs that have the potential to differentiate into neurons and glia, these NSCs escaped free radical-induced degeneration around the damaged area after TBI in the aged rat brain...
  23. ncbi request reprint The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmaceutical Sciences, Kowakae, Higashi Osaka 577 8502, Japan
    Clin Exp Metastasis 24:431-8. 2007
    ..These results suggest that PKC inhibitors have potential clinical applications in the treatment of tumor cell metastasis...
  24. ncbi request reprint Immature and mature neurons coexist among glial scars after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 29:734-42. 2007
    ..However, the generation, differentiation and maturation of neural stem cells (NSCs) among glial scars after brain injury have not yet been reported...
  25. doi request reprint Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Eur J Cancer 49:3708-17. 2013
    ..The inhibition of TNF-α may thus provide a new therapeutic approach to control tumour progression and bone destruction in MM patients. ..
  26. doi request reprint Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis
    Motohiro Imano
    Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastrointest Surg 16:2190-6. 2012
    ....
  27. doi request reprint (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Neural Transm (Vienna) 119:877-90. 2012
    ....
  28. doi request reprint Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells
    Yuzuru Yamazoe
    Division of Pharmacotherapy, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Cell Biol Int 33:1087-94. 2009
    ..DMF also inhibited the nuclear entry of NF-kappaB/p65, thus inhibiting B16BL6 cell invasion and metastasis. These results suggest that DMF is potentially useful as an anti-metastatic agent for the treatment of malignant melanoma...
  29. pmc Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
    Masashi Yanae
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    J Exp Clin Cancer Res 30:74. 2011
    ..However, the molecular mechanism of apoptosis induction by statins is not well understood in glioblastoma. In the present study, we attempted to elucidate the mechanism by which statins induce apoptosis in C6 glioma cells...
  30. doi request reprint Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Cytokine 54:100-7. 2011
    ..These results suggest that statins are potentially useful as anti-angiogenic agents for the treatment of osteosarcoma...
  31. doi request reprint Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    Leuk Res 36:1315-22. 2012
    ..These results indicated that regulating these factors with inhibitors might be a viable approach to increasing the susceptibility of quiescent MM cells to chemotherapy...
  32. doi request reprint (-)-Epigallocatechin-3-gallate protects against neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama City, Osaka, 589 8511, Japan
    Neuromolecular Med 13:300-9. 2011
    ..In summary, consumption of green tea may be an effective therapy for TBI patients...
  33. doi request reprint Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama shi, Osaka, 589 8511, Japan
    Mol Cell Biochem 324:191-9. 2009
    ....
  34. doi request reprint The relationship between SDF-1alpha/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 31:90-102. 2009
    ..In the present study, the temporal relationship between neural stem cells (NSCs) and SDF-1alpha/CXCR4 around a damaged area was investigated using a rat traumatic brain injury (TBI) model...
  35. doi request reprint Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells
    Kaori Shoji
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Arch Pharm Res 34:469-75. 2011
    ..These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia...
  36. doi request reprint Expression of amyloid precursor protein after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Okasayyama City, Osaka, Japan
    Neurol Res 31:103-9. 2009
    ..However, the chronologic changes in APP expression have not been evaluated after traumatic brain injury (TBI)...
  37. doi request reprint Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashiosaka, Japan
    Leuk Res 39:445-52. 2015
    ..Our findings suggest that ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents for the treatment of vincristine-resistant MM. ..
  38. doi request reprint Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:1263-72. 2011
    ..Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction...
  39. doi request reprint The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kindai University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Clin Exp Pharmacol Physiol . 2016
    ..Therefore, our findings support the use of statins as potential anticancer agents. This article is protected by copyright. All rights reserved...
  40. doi request reprint A phase II trial of perioperative chemotherapy involving a single intraperitoneal administration of paclitaxel followed by sequential S-1 plus intravenous paclitaxel for serosa-positive gastric cancer
    Ying Feng Peng
    Department of Surgery, Kinki University, Faculty of Medicine, Osaka Sayama, Osaka, Japan
    J Surg Oncol 111:1041-6. 2015
    ....
  41. doi request reprint Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Biomed Pharmacother 68:999-1005. 2014
    ..These findings suggested that DMF might have potential as an anticancer agent that could be used in combination therapy with other anticancer drugs for the treatment of human hematopoietic tumors. ..
  42. doi request reprint Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:193-202. 2011
    ..Exercise increases the proliferation of NSCs around the damaged area following TBI. Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction induced by TBI...
  43. doi request reprint Peritoneal metastatic lesions of gastric cancer exhibit low expression of human epidermal growth factor receptor 2
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Target Oncol 7:213-6. 2012
    ..Consequently, other therapeutic approaches for these patients must be developed...
  44. doi request reprint Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase
    Tomoya Takeda
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Chem Biol Interact 251:26-33. 2016
    ..Importantly, since the number of reported NIK inhibitors is limited, mangiferin, which targets NIK, may be a potential anticancer agent for the treatment of MM. ..
  45. doi request reprint Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Biomed Pharmacother 78:23-9. 2016
    ..The net effect suppresses LPS-induced MIP-1α mRNA expression and protein secretion in MOPC-31C cells. Thus, statins hold great promise for developing effective therapies against myeloma-induced osteolysis. ..
  46. doi request reprint PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Int J Cancer 137:243-50. 2015
    ....
  47. doi request reprint High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan, 589 8511
    Target Oncol 8:231-5. 2013
    ..05). The intraperitoneally administrated EpCAM antibody might have a anti-cancer effect in PM lesions of GC. Additionally, it can be assumed that only GC cells which express a high level of EpCAM might metastasize to the peritoneum...
  48. ncbi request reprint Establishment of a novel model of peritoneal carcinomatosis of the peritoneal extension type
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 33:1439-46. 2013
    ..We developed a novel animal model, suitable for testing treatments for PET...
  49. doi request reprint Association between occupational exposure levels of antineoplastic drugs and work environment in five hospitals in Japan
    Jin Yoshida
    Department of Environmental Health, Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka, Japan
    J Oncol Pharm Pract 17:29-38. 2011
    ..We investigated the relationship between the contamination level of antineoplastic drugs and the conditions of their handling...
  50. doi request reprint Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
    Tomoya Takeda
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi, Osaka, Japan
    Toxicol Appl Pharmacol 306:105-12. 2016
    ..Taken together, our data suggest that mangiferin may be a potential therapeutic agent with a new mechanism of targeting NIK for the treatment of metastatic melanoma. ..
  51. doi request reprint Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway
    Tomoya Takeda
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    Int J Oncol 48:2704-12. 2016
    ..Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM. ..
  52. doi request reprint RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, 577 8502, Japan
    Tumour Biol 37:9099-110. 2016
    ..These findings may prove to be useful in the development of cell adhesion-mediated drug resistance inhibitors in RANK-positive MM cells. ..
  53. doi request reprint Neuroprotective effects of an extract from the inflamed skin of rabbits inoculated with vaccinia virus on glutamate-induced neurotoxicity in cultured neuronal cell line
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 30:430-4. 2008
    ..However, the pharmacologic mechanisms of Rosemorgen and Neurotropin remain unclear...
  54. ncbi request reprint [Clinical evaluation of calculating carboplatin dosage using Japanese equation for estimating GFR for gynecologic cancer]
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Japan
    Gan To Kagaku Ryoho 38:1143-8. 2011
    ..Thus, using eGFR in planning carboplatin dosage suggested clinical application to patients with Japanese gynecologic cancer...
  55. ncbi request reprint A preliminary study of single intraperitoneal administration of paclitaxel followed by sequential systemic chemotherapy with S-1 plus paclitaxel for advanced gastric cancer with peritoneal metastasis
    Motohiro Imano
    Kinki University Faculty of Medicine, Osaka, Japan
    Anticancer Res 32:4071-5. 2012
    ....
  56. doi request reprint Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  57. ncbi request reprint Histopathological findings of human thyroid tumors and dynamic MRI
    Takeshi Kusunoki
    Department of Otolaryngology, Kinki University School of Medicine, Osakasayama, Osaka 589 8511, Japan
    Auris Nasus Larynx 29:357-60. 2002
    ..Time intensity curves for gadolinium-diethylenetriaminepentaceticacid (Gd-DTPA) enhanced magnetic resonance imaging (MRI), namely dynamic MRI, were determined for thyroid diseases, and compared with findings of histopathologic examination...
  58. doi request reprint The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Neurotox Res 16:378-89. 2009
    ....
  59. ncbi request reprint Cultured rat astrocytes give rise to neural stem cells
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurochem Res 31:1381-7. 2006
    ..These results indicate that isolated neurospheres from brain cortex astrocytes can differentiate into neurons and glia and might contribute to neurogenesis and neuroplasticity...
  60. pmc Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University Faculty of Pharmacy, Higashi Osaka, Osaka, Japan Department of Pharmacy, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    PLoS ONE 9:e101902. 2014
    ..We retrospectively evaluated potential risk factors for cisplatin-induced nephrotoxicity as well as the potential impact of intravenous magnesium supplementation on such toxicity...
  61. ncbi request reprint Type IV collagen, type IV collagenase activity and ability of cell proliferation in human thyroid tumours
    Takeshi Kusunoki
    Department of Otolaryngology, Kinki University School of Medicine, Osaka, Japan
    Asian J Surg 25:304-8. 2002
    ..It has been suggested that type IV collagenase degrades type IV collagen, a main component of the basement membrane...
  62. ncbi request reprint Correlation between morphology of colonies formed by human thyroid tumor cells in collagen gel culture and invasive ability
    Takeshi Kusunoki
    Department of Otolaryngology, Faculty of Pharmaceutical Sciences, University School of Medicine, Osakasayama, Osaka, Japan
    Thyroid 12:281-6. 2002
    ..Our results indicate that collagen gel culture is a useful method for studying the heterogeneity of tumor cells as well as their invasive ability in vitro...
  63. ncbi request reprint Actual conditions of the mixing of antineoplastic drugs for injection in hospitals in Osaka Prefecture, Japan
    Jin Yoshida
    Department of Environmental Health, Osaka Prefectural Institute of Public Health, Osaka, Japan
    J Occup Health 50:86-91. 2008
    ..Because of the adverse effects of antineoplastic drugs, all hospitals in which the healthcare workers handle them should promote safety precautions...
  64. pmc Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion
    Naoyuki Kawao
    School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 135:1292-6. 2002
    ..5. Our study thus provides novel evidence that PAR-2 is localized in mucosal chief cells and facilitates gastric pepsin secretion in the rats, most probably by a direct mechanism...
  65. ncbi request reprint [Fluvastatin induces apoptosis on human tongue carcinoma cell line HSC-3]
    Kimiko Fujiwara
    Department of Pharmacy, Kinki University Hospital, Osakasayama City, Japan
    Yakugaku Zasshi 128:153-8. 2008
    ..The results of this study also indicate that fluvastatin may be used as an anticancer agent for tongue carcinoma...
  66. ncbi request reprint Diethyldithiocarbamate can induce two different type of death: apoptosis and necrosis mediating the differential MAP kinase activation and redox regulation in HL60 cells
    Saori Kimoto-Kinoshita
    Department of Biochemistry and Oncology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Mol Cell Biochem 265:123-32. 2004
    ..However, the mitochondrial transmembrane potential was remarkably decreased in the DDC-induced necrosis. Finally, duration of c-Jun N-terminal kinase (JNK) activation resulted in different types of cell death...
  67. ncbi request reprint Scanning electron microscope study of the rabbit anterior chamber angle
    Shozo Nishida
    Department of Ophthalmology, Aichi Medical University, Yazako, Nagakute cho, Japan
    Med Mol Morphol 38:54-62. 2005
    ..There is no shift between collagen bundles of the trabecular meshwork and the corneosclera, suggesting a frail connection between the two tissues...