Naoshi Nishida

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. doi request reprint Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    J Gastroenterol Hepatol 31:1646-53. 2016
  2. doi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
  3. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
  4. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
  5. doi request reprint Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:459-66. 2013
  6. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
  7. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
  8. doi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
  9. doi request reprint Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:440-6. 2013
  10. doi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013

Collaborators

Detail Information

Publications66

  1. doi request reprint Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    J Gastroenterol Hepatol 31:1646-53. 2016
    ..Here, we examine the associations between clinicopathological characteristics of NAFLD and advanced oxidative DNA damage that is associated with TSG methylation in the NAFLD liver...
  2. doi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
    ..Such analyses will clarify how this malignancy can be treated, diagnosed and prevented more effectively...
  3. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
    ..To determine the specific factors that contribute to a male predominance, we analyzed the clinicopathological factors, and genetic and epigenetic alterations of HCCs in male and female patients...
  4. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
    ..Although some putative oncogenes or tumor suppressor genes mapped in these SRO may be important, relative copy number changes of numerous other genes may affect pathogenesis of HCC...
  5. doi request reprint Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:459-66. 2013
    ..We conclude that oxidative stress alters the chromatin status, which leads to abnormal methylation of TSGs, and contributes to hepatocarcinogenesis in CHC patients...
  6. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
    ..32-p36.22, 5.1 Mb). Four known putative tumor-suppressor genes (TP73, RIZ1, NBL1/DAN, and CDKN2C) were outside the SRO, suggesting the presence of other candidate genes with critical roles in hepatocarcinogenesis...
  7. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
    ..0011, well-differentiated; p=0.0089, moderately/poorly-differentiated HCCs). We conclude that DNA hypomethylation is an important cause of CIN in the earliest step of HCC, especially in a background of non-cirrhotic liver...
  8. doi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
    ..Accurate diagnosis of tumor progression is critical for the appropriate management of HCC. Here, we established a sensitive assay to detect and quantify tumor-derived DNA in the serum of HCC patients...
  9. doi request reprint Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:440-6. 2013
    ..Although cold-inducible RNA-binding protein (CIRP) contributes to the protective effects of hypothermia through extracellular signal-regulated kinase activation in fibroblasts, the effects of hypothermia in the liver remain unclear...
  10. doi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013
    ..Local recurrence rate was used as the gold standard of evaluation...
  11. doi request reprint Expression of E-cadherin and vascular endothelial growth factor in noncancerous liver is associated with recurrence of hepatocellular carcinoma after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:88-92. 2013
    ..The purpose of this study was to examine how background liver affects postoperative recurrence of HCC that underwent curative resection using expression of cancer-related molecules in the adjacent noncancerous liver of HCC patients...
  12. ncbi request reprint Genotype stability and clonal evolution of hepatocellular carcinoma assessed by autopsy-based genome-wide microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 161:164-9. 2005
    ..In conclusion, clonal evolution of the HCC cells during metastatic progression seems rare, in contrast to many recurrent chromosomal aberrations that may have accumulated before the clinical manifestation...
  13. ncbi request reprint Outcome of Combination Therapy with Sofosbuvir and Ledipasvir for Chronic Type C Liver Disease
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama, Japan
    Oncology . 2016
    ..A phase III clinical study of combination therapy with sofosbuvir (SOF) and ledipasvir (LDV) was conducted in Japan, and the additive therapeutic effects were reported. In this study, we report the results of treatment in our hospital...
  14. doi request reprint Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka Sayama, Japan Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan and Kaifukuki Rehabilitation Ward, Biwako Chuo Hospital, Otsu, Japan
    Inflamm Bowel Dis 23:57-65. 2017
    ..RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear...
  15. ncbi request reprint Contrast-Enhanced Tissue Harmonic Imaging versus Phase Inversion Harmonic Sonographic Imaging for the Delineation of Hepatocellular Carcinomas
    Masashi Kono
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama, Japan
    Oncology . 2016
    ..To compare contrast tissue harmonic imaging (THI) with low mechanical index (MI) and conventional contrast harmonic imaging (CHI) with respect to lesion visibility of hepatocellular carcinoma (HCC)...
  16. doi request reprint Influence of Liver Inflammation on Liver Stiffness Measurement in Patients with Autoimmune Hepatitis Evaluation by Combinational Elastography
    Norihisa Yada
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama, Japan
    Oncology . 2017
    ....
  17. doi request reprint Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka Sayama, Japan Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan and Kaifukuki Rehabilitation Ward, Biwako Chuo Hospital, Otsu, Japan
    Inflamm Bowel Dis 23:66-74. 2017
    ..RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear...
  18. doi request reprint Real-Life Clinical Practice with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Center Experience Second Analysis
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:728-34. 2015
    ..We examined efficacy and adverse events (AEs) in patients treated with sorafenib over a 6-year period since approval in Japan...
  19. doi request reprint Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:745-50. 2015
    ..On the other hand, epigenetic alterations are reportedly responsible for HCC development. Here, we identified HCC risk factors that are associated with DNA methylation in the background liver tissue of NBNC-HCC patients...
  20. doi request reprint A Newly Developed Shear Wave Elastography Modality: With a Unique Reliability Index
    Norihisa Yada
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Osaka Sayama, Japan
    Oncology 89:53-9. 2015
    ..The aim of this study was to prospectively assess the usefulness of the reliability index, namely the percentage of the net amount of effective shear wave velocity (VsN)...
  21. doi request reprint Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Osaka Sayama, Japan
    Oncology 89:4-10. 2015
    ..We reevaluated the performance of ART in HCC patients treated in Japan, where selective TACE is commonly used...
  22. doi request reprint Validation of a Modified Substaging System (Kinki Criteria) for Patients with Intermediate-Stage Hepatocellular Carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Osaka Sayama, Japan
    Oncology 89:47-52. 2015
    ..In the present study, we examined the validity of the modified Bolondi classification (Kinki criteria) as a subclassification of patients with BCLC stage B HCC...
  23. pmc Cold-inducible RNA-binding protein promotes the development of liver cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Cancer Sci 106:352-8. 2015
    ..Intriguingly, the risk of human HCC recurrence is positively correlated with Cirp expression in liver. Cirp appears to play a critical carcinogenic function and its expression might be a useful biomarker for HCC risk prediction. ..
  24. doi request reprint Ultrasound elastography correlates treatment response by antiviral therapy in patients with chronic hepatitis C
    Norihisa Yada
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:118-23. 2014
    ..To investigate the relationship between tissue elasticity before and after antiviral therapy and shear wave as well as strain elastography...
  25. doi request reprint Validation of the criteria of transcatheter arterial chemoembolization failure or refractoriness in patients with advanced hepatocellular carcinoma proposed by the LCSGJ
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:32-6. 2014
    ..The study evaluated the validity of the definition of TACE failure or refractoriness as proposed by the Liver Cancer Study Group of Japan (LCSGJ) through a retrospective analysis of sorafenib treatment...
  26. doi request reprint Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:740-6. 2014
    ..This study identifies potential TSGs in HCCs using methylation profiling and pharmacological unmasking of methylated TSGs...
  27. doi request reprint Decreased blood flow after sorafenib administration is an imaging biomarker to predict overall survival in patients with advanced hepatocellular carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:733-9. 2014
    ..We retrospectively evaluated the association between decreased blood flow and the overall survival (OS) of HCC patients after the initiation of sorafenib therapy...
  28. ncbi request reprint Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 35:329-39. 2002
    ..On the other hand, deletions of 13q and 16q were infrequent and were seen only in the most aberrant cases, which suggested that these were late events...
  29. pmc Predictors of pain response in patients undergoing endoscopic ultrasound-guided neurolysis for abdominal pain caused by pancreatic cancer
    Kosuke Minaga
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Therap Adv Gastroenterol 9:483-94. 2016
    ..The aim of this study was to explore predictors of pain response in EUS-guided neurolysis for pancreatic cancer-associated pain...
  30. ncbi request reprint Malignant Transformation of Hepatocellular Adenoma
    Wing Yee Kwok
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama, Japan
    Oncology . 2016
    ..The lesion was diagnosed as malignant transformation of β-catenin-activated HCA. There are only few reports of cases with malignant transformation of HCA in Japan; it is necessary to accumulate cases to investigate it...
  31. doi request reprint Early Viral Response Predicts the Efficacy of Antiviral Triple Therapy with Simeprevir, Peg-Interferon and Ribavirin in Patients Infected with Hepatitis C Virus Genotype 1
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:708-14. 2015
    ..Here, we retrospectively analyzed the antiviral response associated with a triple regimen, in the context of early reduction of viral load during treatment...
  32. pmc Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastroenterol 49:1578-87. 2014
    ..1) and modified RECIST (mRECIST), provides for more accurate evaluation of response of patients with hepatocellular carcinoma (HCC) to treatment with sorafenib, a molecularly targeted agent, as assessed by overall survival (OS)...
  33. doi request reprint Radiofrequency ablation for hepatocellular carcinoma measuring 2 cm or smaller: results and risk factors for local recurrence
    Masashi Kono
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Dig Dis 32:670-7. 2014
    ..The purpose of this study was to evaluate the risk factors for local recurrence with radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) measuring ≤2 cm...
  34. doi request reprint Duration of stable disease is associated with overall survival in patients with advanced hepatocellular carcinoma treated with sorafenib
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:705-10. 2014
    ..This study aimed to clarify the correlation between SD periods and OS in patients with HCC treated with sorafenib...
  35. doi request reprint Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:561-7. 2012
    ..The aim of this study was to determine clinical characteristics on the risk of occurrence of HCC in CHC patients receiving maintenance IFN therapy...
  36. doi request reprint Combination guidance of contrast-enhanced US and fusion imaging in radiofrequency ablation for hepatocellular carcinoma with poor conspicuity on contrast-enhanced US/fusion imaging
    Tomohiro Minami
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:55-62. 2014
    ....
  37. doi request reprint Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Med Virol 85:987-95. 2013
    ..027). The combination regimen is a promising approach to treat chronic hepatitis B and may achieve significant reduction in serum HBV DNA and intrahepatic cccDNA. Wiley Periodicals, Inc...
  38. doi request reprint Heat shock protein A4 controls cell migration and gastric ulcer healing
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 60:850-7. 2015
    ..Here, we assessed the involvement of HSPA4 in gastric ulcer healing by using fibroblasts from wild-type and HSPA4-deficient mice, a murine gastric ulcer model, and samples from 65 patients with gastric cancer...
  39. ncbi request reprint Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
    Teruaki Ito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Gastroenterol 39:355-61. 2004
    ..Inactivation of RB/p16INK4a was frequently reported, but alterations of the p14ARF gene in hepatocellular carcinoma (HCC) in the Japanese population have been insufficiently analyzed...
  40. doi request reprint The prognostic value of vascular endothelial growth factor in hepatocellular carcinoma for predicting metastasis after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:75-81. 2013
    ..The purpose of this study was to identify factors predictive for postoperative recurrence of HCC in patients who underwent curative resection using immunohistochemistry...
  41. pmc Cases with Refractory Ascites and a Delayed Response to Tolvaptan
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    Intern Med 55:3273-3277. 2016
    ..5 mg/day) because the worsening of her subjective symptoms was mild and she wished to do so. The ascites was later found to have almost completely disappeared on computed tomography (CT) at 6 months...
  42. doi request reprint Characteristic pattern of reactivation of hepatitis B virus during chemotherapy for solid cancers
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 30:541-6. 2012
    ....
  43. doi request reprint Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Single-Center Experience
    Yasunori Minami
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Osaka Sayama, Japan
    Oncology 89:27-32. 2015
    ....
  44. doi request reprint Association of gankyrin and stemness factor expression in human colorectal cancer
    Hiromasa Mine
    Department of Gastroenterology and Hepatology, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:2337-44. 2013
    ..Although gankyrin is overexpressed in CRC tissues, its roles in the initiation step of colorectal carcinogenesis remain largely unexplored...
  45. pmc Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease
    Teppei Adachi
    Departments of Gastroenterology and Hepatology, and Biochemistry, Kinki University Faculty of Medicine, Osaka Sayama, Japan and Center for Innovation in Immunoregulative Technology and Therapeutics, and Department of Clinical Molecular Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Inflamm Bowel Dis 21:31-9. 2015
    ..Expression of heat shock protein A4 (HSPA4, also called Apg-2), a member of the HSP110 family, is induced by several forms of stress. The physiological and pathological functions of HSPA4 in the intestine remain to be elucidated...
  46. doi request reprint Genome-wide profiling of DNA methylation and tumor progression in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:658-63. 2014
    ..To clarify the progression pattern of abnormal DNA methylation during the development of hepatocellular carcinoma (HCC) using a comprehensive methylation assay...
  47. ncbi request reprint Transcatheter arterial embolization for tumor seeding in the chest wall after radiofrequency ablation for hepatocellular carcinoma
    Toshiya Shibata
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Japan
    Cardiovasc Intervent Radiol 29:479-81. 2006
    ..We conclude that transcatheter arterial embolization was effective for the control of tumor seeding after radiofrequency ablation for hepatocellular carcinoma...
  48. doi request reprint Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Cancer Res 74:6119-28. 2014
    ..Cirp promotes the development of intestinal inflammation and colorectal tumors through regulating apoptosis and production of TNFα and IL23 in inflammatory cells...
  49. doi request reprint Subclassification of BCLC B Stage Hepatocellular Carcinoma and Treatment Strategies: Proposal of Modified Bolondi's Subclassification (Kinki Criteria)
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:751-8. 2015
    ..These criteria should be further validated both retrospectively and prospectively. ..
  50. doi request reprint Cone-Beam CT Angiography for Hepatocellular Carcinoma: Current Status
    Yasunori Minami
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:759-64. 2015
    ..The purpose of this article is to provide a review of the principles, clinical applications and technique of CBCT angiography for HCC treatment. ..
  51. doi request reprint General Rules for the Clinical and Pathological Study of Primary Liver Cancer, Nationwide Follow-Up Survey and Clinical Practice Guidelines: The Outstanding Achievements of the Liver Cancer Study Group of Japan
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:765-70. 2015
    ..Both evidence-based and consensus-based treatment algorithms for HCC are used to complement each other in clinical practice in Japan. ..
  52. doi request reprint Molecular Mechanism and Prediction of Sorafenib Chemoresistance in Human Hepatocellular Carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:771-9. 2015
    ..Here, we review the recent reports and focus on the mechanism and prediction of chemoresistance to sorafenib in HCC. ..
  53. doi request reprint Challenges of Clinical Research on Hepatocellular Carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Dig Dis 33:780-90. 2015
    ..Further studies are warranted for the clinical practices of Japan to be adopted in the rest of the world. ..
  54. doi request reprint Oxidative stress and epigenetic instability in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:447-53. 2013
    ..The decrease of the level of methyl group donors also contributes to the alteration in the methylation status. These mechanisms should act in concert and induce epigenetic instability, leading to HCC...
  55. doi request reprint Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia
    Yoshiaki Nagata
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:381-8. 2013
    ..Intestinal-type gastric carcinomas progress through several sequential steps, including atrophic gastritis, intestinal metaplasia, dysplasia, and cancer...
  56. doi request reprint Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 56:994-1003. 2012
    ..0001), and number of methylated genes was an independent risk factor for HCC (hazard ratio = 5.21, 95% confidence interval = 2.25-11.76, P = 0.0002)...
  57. ncbi request reprint Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection
    Naoshi Nishida
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 62:141-8. 2002
    ..These findings indicate that accumulation of chromosomal changes is associated with metastatic behavior, and that LOH on 16q was the most useful prognostic indicator for metastasis after curative resection of HCC...
  58. pmc Survival Benefit of Locoregional Treatment for Hepatocellular Carcinoma with Advanced Liver Cirrhosis
    Satoshi Kitai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Liver Cancer 5:175-89. 2016
    ..However, the application of LT can be limited due to a shortage of donor livers. This study aimed to clarify the effect of non-surgical therapy on the survival of patients with HCC and decompensated LC...
  59. ncbi request reprint Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Histol Histopathol 25:647-54. 2010
    ..In addition, we proposed age should be taken into consideration for HCC development via epigenetic pathways. Further investigations are required to understand the mechanism of inducing epigenetic instability during hepatocarcinogenesis...
  60. doi request reprint Clinical and histological features of different types of Budd-Chiari syndrome: a comparison of 4 cases
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:408-14. 2013
    ..Pericellular fibrosis and hypervascular regenerative nodules were also reversible after obstruction removal. Therefore, it is very important to manage this rare disease before it progresses to liver cirrhosis...
  61. pmc Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI
    Yasunori Minami
    Yasunori Minami, Naoshi Nishida, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka 589 8511, Japan
    World J Gastroenterol 20:4160-6. 2014
    ..Therefore, we need to carefully address to these imaging findings given the fact that diagnostic difficulties of local recurrence of HCC. Here, we give an overview of the current status of the imaging assessment of HCC response to RFA. ..
  62. pmc Evaluation of anti-migration properties of biliary covered self-expandable metal stents
    Kosuke Minaga
    Kosuke Minaga, Masayuki Kitano, Hajime Imai, Yogesh Harwani, Kentaro Yamao, Ken Kamata, Takeshi Miyata, Shunsuke Omoto, Kumpei Kadosaka, Toshiharu Sakurai, Naoshi Nishida, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama 589 8511, Japan
    World J Gastroenterol 22:6917-24. 2016
    ..To assess anti-migration potential of six biliary covered self-expandable metal stents (C-SEMSs) by using a newly designed phantom model...
  63. ncbi request reprint Immunological Microenvironment of Hepatocellular Carcinoma and Its Clinical Implication
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka Sayama, Japan
    Oncology . 2016
    ....
  64. doi request reprint Clinical features of vascular disorders associated with chronic hepatitis virus infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:786-90. 2014
    ..New antiviral drugs for viral hepatitis could improve the prognosis of vascular and renal involvement...
  65. ncbi request reprint Regression of Hodgkin lymphoma in response to antiviral therapy for hepatitis C virus infection
    Ken Takahashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
    Intern Med 51:2745-7. 2012
    ....
  66. ncbi request reprint Benign hepatic nodules in Budd-Chiari syndrome: radiologic-pathologic correlation with emphasis on the central scar
    Yoji Maetani
    Department of Radiology, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    AJR Am J Roentgenol 178:869-75. 2002
    ..The purpose of this study was to determine the imaging features of benign hepatic nodules in patients with Budd-Chiari syndrome and to correlate them with pathologic findings, with special attention placed on the presence of a central scar...