Motohiro Imano

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. doi request reprint Immunohistochemical expression of osteopontin in gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastrointest Surg 13:1577-82. 2009
  2. ncbi request reprint An immunohistochemical study of osteopontin in pigment gallstone formation
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Am Surg 76:91-5. 2010
  3. doi request reprint Prospective randomized trial of short-term neoadjuvant chemotherapy for advanced gastric cancer
    M Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohnohigashi, Osaka Sayama, Osaka 589 8511, Japan
    Eur J Surg Oncol 36:963-8. 2010
  4. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
  5. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
  6. doi request reprint Treatment strategies for gastric cancer patients with peritoneal metastasis
    Motohiro Imano
    Surgery Department, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 44:399-404. 2014
  7. doi request reprint High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan, 589 8511
    Target Oncol 8:231-5. 2013
  8. ncbi request reprint Establishment of a novel model of peritoneal carcinomatosis of the peritoneal extension type
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 33:1439-46. 2013
  9. doi request reprint A Phase I/II trial of radiotherapy concurrent with TS-1 plus cisplatin in patients with clinically resectable type 4 or large type 3 gastric cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group OGSG1205
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Jpn J Clin Oncol 43:431-5. 2013
  10. doi request reprint Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis
    Motohiro Imano
    Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastrointest Surg 16:2190-6. 2012

Detail Information

Publications43

  1. doi request reprint Immunohistochemical expression of osteopontin in gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastrointest Surg 13:1577-82. 2009
    ..Thus, the aim of this study was to determine the relationship between the degree of OPN expression, the proliferative activity of cancer cells, and the clinicopathological findings for surgically resected gastric cancer...
  2. ncbi request reprint An immunohistochemical study of osteopontin in pigment gallstone formation
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Am Surg 76:91-5. 2010
    ..Our results indicate that Opn, an acidic glycoprotein from the gallbladder epithelium, seems to be involved in lithiasis. Opn from macrophages and/or the epithelium seems to help form the matrix protein...
  3. doi request reprint Prospective randomized trial of short-term neoadjuvant chemotherapy for advanced gastric cancer
    M Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohnohigashi, Osaka Sayama, Osaka 589 8511, Japan
    Eur J Surg Oncol 36:963-8. 2010
    ..We performed short-term neoadjuvant chemotherapy (s-NAC) to examine whether anticancer drugs can change the proliferative ability of cancer cells in gastric cancer patients...
  4. pmc Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 32:62. 2013
    ..In this study, we investigated whether RANKL induces EMT in normal breast mammary epithelial cells and breast cancer cells, and the mechanism underlying such induction...
  5. pmc Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Biomed Sci 21:10. 2014
    ..In the present study, we investigated the inhibitory effect of minodronate and alendronate on the osteoclast formation and clarified the mechanism involved in a mouse macrophage-like cell lines C7 and RAW264.7...
  6. doi request reprint Treatment strategies for gastric cancer patients with peritoneal metastasis
    Motohiro Imano
    Surgery Department, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 44:399-404. 2014
    ..Although catumaxomab and intraperitoneally administered paclitaxel are not generally used in Japan at present, these treatment strategies might therefore be effectively used in Japan in the near future. ..
  7. doi request reprint High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan, 589 8511
    Target Oncol 8:231-5. 2013
    ..05). The intraperitoneally administrated EpCAM antibody might have a anti-cancer effect in PM lesions of GC. Additionally, it can be assumed that only GC cells which express a high level of EpCAM might metastasize to the peritoneum...
  8. ncbi request reprint Establishment of a novel model of peritoneal carcinomatosis of the peritoneal extension type
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 33:1439-46. 2013
    ..We developed a novel animal model, suitable for testing treatments for PET...
  9. doi request reprint A Phase I/II trial of radiotherapy concurrent with TS-1 plus cisplatin in patients with clinically resectable type 4 or large type 3 gastric cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group OGSG1205
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Jpn J Clin Oncol 43:431-5. 2013
    ..In Phase II, a total of 30 patients will be enrolled in the Osaka Gastrointestinal Cancer Chemotherapy Study Group trial over a period of 6 years...
  10. doi request reprint Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis
    Motohiro Imano
    Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastrointest Surg 16:2190-6. 2012
    ....
  11. doi request reprint Peritoneal metastatic lesions of gastric cancer exhibit low expression of human epidermal growth factor receptor 2
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Target Oncol 7:213-6. 2012
    ..Consequently, other therapeutic approaches for these patients must be developed...
  12. ncbi request reprint A preliminary study of single intraperitoneal administration of paclitaxel followed by sequential systemic chemotherapy with S-1 plus paclitaxel for advanced gastric cancer with peritoneal metastasis
    Motohiro Imano
    Kinki University Faculty of Medicine, Osaka, Japan
    Anticancer Res 32:4071-5. 2012
    ....
  13. ncbi request reprint Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Ohno Higashi Osaka Sayama, Osaka, Japan
    Am Surg 77:1515-20. 2011
    ..31, m-LV 28.2 ± 3.18, P < 0.05). These results suggest that the risk of metachronous liver metastasis could be well predicted by immunohistochemical staining of OPN in the central areas, and CD68 in the invasive margins of tumors...
  14. pmc Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
    Masashi Yanae
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    J Exp Clin Cancer Res 30:74. 2011
    ..However, the molecular mechanism of apoptosis induction by statins is not well understood in glioblastoma. In the present study, we attempted to elucidate the mechanism by which statins induce apoptosis in C6 glioma cells...
  15. doi request reprint Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 6511, Japan
    World J Surg 34:1930-6. 2010
    ..The aim of the present study was to investigate differences in OPN-positive TAMs between cases of colorectal cancer with synchronous liver metastasis and those without liver metastasis...
  16. doi request reprint Safety of intraperitoneal administration of paclitaxel after gastrectomy with en-bloc D2 lymph node dissection
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    J Surg Oncol 105:43-7. 2012
    ....
  17. doi request reprint Impact of intraperitoneal chemotherapy after gastrectomy with positive cytological findings in peritoneal washings
    M Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Eur Surg Res 47:254-9. 2011
    ....
  18. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:767-83. 2013
    ..Importantly, continuous and post-TBI access to EGCG improved cerebral function following TBI. In summary, consumption of green tea may be an effective therapy for TBI patients...
  19. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013
    ..05). These results indicate that following TBI, high levels of free radicals are produced in the aged rat brain, which induces neuronal degeneration and apoptotic cell death around the damaged area, resulting in cognitive impairment...
  20. ncbi request reprint Randomized phase II trial of S-1 plus irinotecan versus S-1 plus paclitaxel as first-line treatment for advanced gastric cancer (OGSG0402)
    Naotoshi Sugimoto
    Department of Cancer Chemotherapy Center, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka, 569 0801, Japan
    Anticancer Res 34:851-7. 2014
    ..We performed this trial to evaluate the efficacy and safety of S-1 plus irinotecan (SIri) and S-1 plus paclitaxel (SPac) as first-line treatments for AGC in order to select the optimal regimen for a subsequent phase III trial...
  21. doi request reprint Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 120:361-74. 2013
    ..These results indicate that, although there were fewer NSCs that have the potential to differentiate into neurons and glia, these NSCs escaped free radical-induced degeneration around the damaged area after TBI in the aged rat brain...
  22. doi request reprint A phase I study of triplet combination chemotherapy of paclitaxel, cisplatin and S-1 in patients with advanced gastric cancer
    Yutaka Kimura
    Department of Surgery, NTT West Osaka Hospital, 2 6 40 Karasugatsuji, Tennojiku, Osaka 543 8922, Japan
    Jpn J Clin Oncol 43:125-31. 2013
    ..The primary objective of this study was to determine the maximum tolerated dose and dose-limiting toxicities of a triplet regimen adding paclitaxel to S-1 and cisplatin combination therapy...
  23. doi request reprint (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Neural Transm (Vienna) 119:877-90. 2012
    ....
  24. doi request reprint A newly modified esophagogastrostomy with a reliable angle of His by placing a gastric tube in the lower mediastinum in laparoscopy-assisted proximal gastrectomy
    Atsushi Yasuda
    Department of Surgery, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Gastric Cancer 18:850-8. 2015
    ..Jejunal interposition (JI) has a low rate of gastroesophageal reflux, but the procedure is more complicated, and delayed gastric emptying is a problem...
  25. doi request reprint A phase II trial of perioperative chemotherapy involving a single intraperitoneal administration of paclitaxel followed by sequential S-1 plus intravenous paclitaxel for serosa-positive gastric cancer
    Ying Feng Peng
    Department of Surgery, Kinki University, Faculty of Medicine, Osaka Sayama, Osaka, Japan
    J Surg Oncol 111:1041-6. 2015
    ....
  26. doi request reprint Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer
    Hajime Ishikawa
    Department of Surgery, Kinki University, 377 2 Ohno higasi, Osaka Sayama, Osaka, 589 8511, Japan
    Gastric Cancer 17:173-80. 2014
    ..The immunogenicity of LY6K-177 peptide vaccine therapy has been demonstrated in patients with advanced esophageal cancer. This study extends this treatment to gastric cancer...
  27. doi request reprint (-)-Epigallocatechin-3-gallate protects against neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama City, Osaka, 589 8511, Japan
    Neuromolecular Med 13:300-9. 2011
    ..In summary, consumption of green tea may be an effective therapy for TBI patients...
  28. doi request reprint Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:1263-72. 2011
    ..Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction...
  29. ncbi request reprint Phase II study of docetaxel, cisplatin and 5-fluorouracil (DCF) for metastatic esophageal cancer (OGSG 0403)
    Shigeyuki Tamura
    Department of Surgery, Kansai Rosai Hospital, Hyogo, Japan
    Anticancer Res 32:1403-8. 2012
    ....
  30. doi request reprint Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm (Vienna) 118:193-202. 2011
    ..Exercise increases the proliferation of NSCs around the damaged area following TBI. Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction induced by TBI...
  31. ncbi request reprint Multicenter phase II study of triplet combination chemotherapy with paclitaxel, cisplatin, and S-1 for advanced gastric cancer (OGSG 0703)
    Kazumasa Fujitani
    Osaka National Hospital, Osaka, Japan Department of Surgery, NTT West Osaka Hospital, Osaka, Japan Sakai Municipal Hospital, Osaka, Japan Osaka Medical College, Osaka, Japan Minoh City Hospital, Osaka, Japan Department of Surgery, Kitano Hospital, Osaka, Japan Kinki University Hospital, Osaka, Japan Osaka Police Hospital, Sakai, Japan Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan Yamanashi University, Kofu, Japan Cancer Chemotherapy Center, Osaka Medical College, Osaka, Japan Department of Surgery, Osaka National Hospital, Osaka, Japan Department of Surgery, Sakai Municipal Hospital, Sakai, Japan
    J Clin Oncol 30:124. 2012
    ..We conducted a multicenter phase II study of triplet combination using paclitaxel, cisplatin and S-1 (PCS) as first-line treatment for advanced gastric cancer...
  32. ncbi request reprint Phase II study of 2-week TS-1 administration followed by 1-week rest for gastric cancer
    Hiroshi Imamura
    Department of Surgery, Sakai Municipal Hospital, Osaka, Japan
    Hepatogastroenterology 54:2167-71. 2007
    ..Therefore, we conducted the phase II study of 2-weeks administration with TS-1 followed by a 1-week rest against metastatic gastric cancer, aiming for mitigation of adverse reactions without reduction of antitumor effect...
  33. doi request reprint Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  34. doi request reprint An immunohistochemical study of osteopontin in hepatolithiasis
    Akihiro Nakai
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Hepatobiliary Pancreat Surg 15:615-21. 2008
    ..To investigate the role of OPN in the genesis of hepatolithiasis, OPN was immunohistochemically studied in the intrahepatic bile ducts, intramural and extramural glands, and in stones...
  35. doi request reprint Involvement of osteopontin as a core protein in cholesterol gallstone formation
    Hideaki Ichikawa
    Department of Surgery, School of Medicine, Kinki University, Osaka Sayama, Osaka, Japan
    J Hepatobiliary Pancreat Surg 16:197-203. 2009
    ....
  36. ncbi request reprint [Minimally invasive esophagectomy with 10 cm thoracotomy assisted thoracoscopy for the thoracic esophageal cancer]
    Hitoshi Shiozaki
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Gan To Kagaku Ryoho 30:923-8. 2003
    ..Standard thoracotomy and laparotomy are significantly invasive procedures with potential complications and prolonged healing; minimally invasive esophagectomy has the potential to minimize morbidity and decrease healing time...
  37. ncbi request reprint [Treatment of oncogenic emergencies in esophageal disease]
    Hitoshi Shiozaki
    Department of Surgery, Kinki University Medical School, Osaka, Japan
    Nihon Geka Gakkai Zasshi 105:275-80. 2004
    ..Primary repair is appropriate for ruptures diagnosed early. Many are diagnosed late and T-tube drainage may be the simplest way to manage this difficult condition in this situation...
  38. pmc Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
    Hiroaki Kato
    Department of Surgery, Kinki University Faculty of Medicine, Osaka 589 8511, Japan
    Int J Oncol 42:1151-8. 2013
    ..In conclusion, the frequent gene amplification of EGFR, HER2 and FGFR2 and the presence of active EGFR mutations were observed in ESCC specimens. Our results strongly encourage the development of molecular targeted therapy for ESCC...
  39. ncbi request reprint Case of adrenal lymphangioma with atypical lymphocytes in aspirate cytology
    Takao Satou
    Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Diagn Cytopathol 29:87-90. 2003
    ..This case provided important cytological findings that may assist in the prevention of cytological overdiagnosis...
  40. ncbi request reprint Duodenogastric reflux after choledochoduodenostomy: evaluation by technetium-99m scintigraphy
    Naoki Hashimoto
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan
    Hepatogastroenterology 54:796-8. 2007
    ..Persistence of dyspeptic symptoms after choledochoduodenostomy (CDD) is common. There is evidence that at least some of these symptoms may be attributed to duodenogastric reflux (DGR). The aim of the study was to quantify DGR after CDD...
  41. pmc Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis
    Toru Aoyama
    Department of Surgery, Miura City Hospital, Miura, Japan
    Cancer Chemother Pharmacol 73:1047-54. 2014
    ..We conducted a randomized comparative trial to investigate whether TJ-14 prevents and controls COM in patients with gastric cancer...
  42. doi request reprint Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
    Tomoya Takeda
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi, Osaka, Japan
    Toxicol Appl Pharmacol 306:105-12. 2016
    ..Taken together, our data suggest that mangiferin may be a potential therapeutic agent with a new mechanism of targeting NIK for the treatment of metastatic melanoma. ..
  43. ncbi request reprint Expression of manganese superoxide disumutase influences chemosensitivity in esophageal and gastric cancers
    Ryo Izutani
    Department of Surgery II, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Cancer Detect Prev 26:213-21. 2002
    ..Thus, combined administration of TGFbeta1 and ADM might prove useful for treatment of malignant disease...