Yoshifumi Saisho

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Endocr Metab Immune Disord Drug Targets 15:196-205. 2015
  2. doi request reprint Relationships among different glycemic variability indices obtained by continuous glucose monitoring
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan Electronic address
    Prim Care Diabetes 9:290-6. 2015
  3. doi request reprint Relationship between body mass index and pancreas volume in Japanese people
    Kinsei Kou
    Department of Internal Medicine, Keio University School of Medicine Tokyo, Japan
    JOP 15:626-7. 2014
  4. pmc Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Int J Mol Sci 15:18381-406. 2014
  5. ncbi request reprint Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
  6. doi request reprint Dipeptidyl peptidase-4 inhibitors and angioedema: a class effect?
    Y Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabet Med 30:e149-50. 2013
  7. ncbi request reprint Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
  8. ncbi request reprint Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
  9. doi request reprint Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
  10. ncbi request reprint Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Endocr Metab Immune Disord Drug Targets 15:196-205. 2015
    ..This review summarizes the basic and clinical evidence of the anti-inflammatory action of metformin and discusses its clinical implication. ..
  2. doi request reprint Relationships among different glycemic variability indices obtained by continuous glucose monitoring
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan Electronic address
    Prim Care Diabetes 9:290-6. 2015
    ..Our results also underpin the importance of glycemic variability in relation to risk of hypoglycemia in patients with diabetes...
  3. doi request reprint Relationship between body mass index and pancreas volume in Japanese people
    Kinsei Kou
    Department of Internal Medicine, Keio University School of Medicine Tokyo, Japan
    JOP 15:626-7. 2014
    ..The volume of the pancreas increases with obesity...
  4. pmc Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Int J Mol Sci 15:18381-406. 2014
    ..This review summarizes the current knowledge on glycemic variability and oxidative stress, and discusses the clinical implications. ..
  5. ncbi request reprint Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
    ..Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021). In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes...
  6. doi request reprint Dipeptidyl peptidase-4 inhibitors and angioedema: a class effect?
    Y Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabet Med 30:e149-50. 2013
    ..Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to be generally well tolerated. However, angioedema has been reported as one of the rare adverse events of these drugs...
  7. ncbi request reprint Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
    ..Treatment of obesity may be an important strategy to preserve beta cell function in patients with type 2 diabetes...
  8. ncbi request reprint Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
    ..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy...
  9. doi request reprint Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  10. ncbi request reprint Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
    ..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM...
  11. ncbi request reprint Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:533-9. 2013
    ..05). Women with late-onset GDM showed significantly lower indices compared with NGT (each p < 0.05). The failure of beta cell to compensate for decreased insulin sensitivity could contribute to the development of the late-onset GDM...
  12. pmc C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e73430. 2013
    ..To clarify predictive values of C-reactive protein (CRP) and high-molecular-weight (HMW) adiponectin for development of metabolic syndrome...
  13. doi request reprint A Reduction of HbA1c after 3 Months Predicts 2-year Responsiveness to Sitagliptin Treatment
    Takeshi Nishimura
    Department of Internal Medicine, School of Medicine, Keio University, Japan
    Intern Med 54:2981-9. 2015
    ..Conclusion Sitagliptin has a long-term hypoglycemic effect in type 2 diabetes patients. A patient's ΔHbA1c at 3 months may be a predictor of their ΔHbA1c at 24 months. ..
  14. pmc Efficacy and safety of sitagliptin added to insulin in Japanese patients with type 2 diabetes: the EDIT randomized trial
    Seiji Sato
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0121988. 2015
    ..To clarify the efficacy and safety of adding sitagliptin to insulin therapy in Japanese patients with suboptimally controlled type 2 diabetes (T2DM)...
  15. ncbi request reprint Effects of mitiglinide, a short-acting insulin secretagogue, on daily glycemic variability and oxidative stress markers in Japanese patients with type 2 diabetes mellitus
    Noriko Kodani
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Drug Investig 33:563-70. 2013
    ....
  16. ncbi request reprint Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010
    ..We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome...
  17. doi request reprint Time-dependent changes in insulin requirement for maternal glycemic control during antenatal corticosteroid therapy in women with gestational diabetes: a retrospective study
    Arata Itoh
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 63:101-4. 2016
    ..When GDM is treated with ACS, levels of blood glucose should be carefully monitored, especially in patients treated with ritodrine hydrochloride. ..
  18. doi request reprint Effects of Liraglutide Monotherapy on Beta Cell Function and Pancreatic Enzymes Compared with Metformin in Japanese Overweight/Obese Patients with Type 2 Diabetes Mellitus: A Subpopulation Analysis of the KIND-LM Randomized Trial
    Kumiko Tanaka
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Clin Drug Investig 35:675-84. 2015
    ..This study was conducted as an exploratory analysis to clarify the effects of liraglutide, a GLP-1RA, on beta cell function, fat distribution and pancreas volume compared with metformin in Japanese overweight/obese patients with T2DM...
  19. ncbi request reprint Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: two year experience in a single institution in Japan
    Satoru Ikenoue
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 61:353-8. 2014
    ..Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists. ..
  20. doi request reprint Islet number rather than islet size is a major determinant of β- and α-cell mass in humans
    Kinsei Kou
    Departments of Internal Medicine K K, Y S, S S, H I and Pathology T Y, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 99:1733-40. 2014
    ..The objective of the study was to clarify the relative contribution of islet number and islet size to β- and α-cell mass in humans...
  21. ncbi request reprint Antenatal management of recurrent fetal goitrous hyperthyroidism associated with fetal cardiac failure in a pregnant woman with persistent high levels of thyroid-stimulating hormone receptor antibody after ablative therapy
    Tadashi Matsumoto
    Department of Obstetrics and Gynecology, Keio University, School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:1281-7. 2013
    ..This case report illustrates the impact of prenatal medication via the maternal circulation for fetal hyperthyroidism and cardiac failure. ..
  22. doi request reprint Efficacy and safety of liraglutide monotherapy compared with metformin in Japanese overweight/obese patients with type 2 diabetes
    Kumiko Tanaka
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 62:399-409. 2015
    ..In conclusion, liraglutide and metformin monotherapy showed similar reduction in HbA1c during 24 weeks, with no difference in weight gain or incidence of hypoglycemia in overweight or obese Japanese patients with T2DM. ..
  23. doi request reprint C-peptide immunoreactivity index is associated with improvement of HbA1c: 2-Year follow-up of sitagliptin use in patients with type 2 diabetes
    Takeshi Nishimura
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan Electronic address
    Diabetes Res Clin Pract 108:441-7. 2015
    ..This retrospective study aimed to determine the hypoglycaemic effect of 2 years of sitagliptin administration in terms of changes in HbA1c and C-peptide immunoreactivity (CPR) index (plasma CPR [ng/mL]/glucose [mg/dL]×100)...
  24. ncbi request reprint Prediction of recovery time from hypoglycemia in patients with insulin overdose
    Takako Ohyama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 58:607-11. 2011
    ..This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose...
  25. pmc Relationship between Stage of Diabetic Retinopathy and Pulse Wave Velocity in Japanese Patients with Type 2 Diabetes
    Kumiko Tanaka
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Diabetes Res 2013:193514. 2013
    ..Physicians should therefore pay attention to the value of PWV and macroangiopathy regardless of the stage of diabetic retinopathy...
  26. ncbi request reprint Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  27. doi request reprint Effects of Glucocorticoid Treatment on β- and α-Cell Mass in Japanese Adults With and Without Diabetes
    Seiji Sato
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes 64:2915-27. 2015
    ..The absence of apparent β-cell deficit in case subjects with GC-induced diabetes suggests that GC-induced diabetes is mainly caused by insulin resistance and/or β-cell dysfunction, but not necessarily a deficit of β-cell mass. ..
  28. ncbi request reprint Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 61:149-57. 2014
    ..In conclusion, our findings suggest that lower beta cell function is associated with sustained higher GA/HbA1c ratio in patients with type 2 diabetes. ..
  29. doi request reprint Change in β-cell mass in Japanese nondiabetic obese individuals
    Kinsei Kou
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 98:3724-30. 2013
    ..The aim of this study was to clarify the change in β-cell mass in Japanese obese individuals...
  30. doi request reprint Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
    ..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)...
  31. ncbi request reprint Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  32. ncbi request reprint Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 55:433-8. 2008
    ..In this study we tested this hypothesis by investigating the effects of dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, on tumor necrosis factor-alpha (TNF-alpha)-induced beta cell dysfunction...
  33. ncbi request reprint Study on the mechanism causing elevation of serum CA19-9 levels in diabetic patients
    Jun Murai
    Department of Internal Medicine, Kinki Central Hospital, Itami 664 8533, Japan
    Endocr J 60:885-91. 2013
    ..Taken all together, prolonged half-life of serum CA19-9 may contribute to the increase in serum CA19-9 levels in diabetic patients without obvious cancer. ..