Motoko Kawashima

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Tear lipid layer deficiency associated with incomplete blinking: a case report
    Motoko Kawashima
    MGD Clinic, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    BMC Ophthalmol 13:34. 2013
  2. pmc Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e33148. 2012
  3. doi request reprint Dry eye disease and work productivity loss in visual display users: the Osaka study
    Miki Uchino
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan Ryogoku Eye Clinic, Tokyo, Japan Electronic address
    Am J Ophthalmol 157:294-300. 2014
  4. doi request reprint Dry-eye screening by using a functional visual acuity measurement system: the Osaka Study
    Minako Kaido
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 55:3275-81. 2014
  5. doi request reprint Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 397:724-8. 2010
  6. pmc Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjögren syndrome and non-Sjögren syndrome dry eye patients
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 17:1397-404. 2011
  7. doi request reprint Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Gerontol 48:1096-100. 2013
  8. doi request reprint The antiaging approach for the treatment of dry eye
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 31:S3-8. 2012
  9. pmc Characterization of cultivated murine lacrimal gland epithelial cells
    Shinya Kobayashi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 18:1271-7. 2012
  10. doi request reprint The era of antiaging ophthalmology comes of age: antiaging approach for dry eye treatment
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmic Res 44:146-54. 2010

Collaborators

Detail Information

Publications45

  1. pmc Tear lipid layer deficiency associated with incomplete blinking: a case report
    Motoko Kawashima
    MGD Clinic, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    BMC Ophthalmol 13:34. 2013
    ..Unfortunately, the importance of blinking in meibomian gland dysfunction has been largely overlooked, and it is not known whether incomplete blinking causes tear lipid deficiency, even in the unobstructed meibomian glands...
  2. pmc Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e33148. 2012
    ..We investigated how oral administration of lactoferrin affects age-related lacrimal dysfunction...
  3. doi request reprint Dry eye disease and work productivity loss in visual display users: the Osaka study
    Miki Uchino
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan Ryogoku Eye Clinic, Tokyo, Japan Electronic address
    Am J Ophthalmol 157:294-300. 2014
    ..To estimate the impact of dry eye disease (DED) on work performance and productivity in office workers using visual display terminals (VDTs)...
  4. doi request reprint Dry-eye screening by using a functional visual acuity measurement system: the Osaka Study
    Minako Kaido
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 55:3275-81. 2014
    ..We determined whether functional visual acuity (VA) parameters and a dry eyes (DEs) symptoms questionnaire could predict DEs in a population of visual terminal display (VDT) users...
  5. doi request reprint Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 397:724-8. 2010
    ..Although molecular mechanism(s) by which CR maintains lacrimal gland function remains to be resolved, CR might provide a novel therapeutic strategy for treating dry eye syndrome...
  6. pmc Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjögren syndrome and non-Sjögren syndrome dry eye patients
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 17:1397-404. 2011
    ....
  7. doi request reprint Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Gerontol 48:1096-100. 2013
    ..Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions. ..
  8. doi request reprint The antiaging approach for the treatment of dry eye
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 31:S3-8. 2012
    ..In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye...
  9. pmc Characterization of cultivated murine lacrimal gland epithelial cells
    Shinya Kobayashi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 18:1271-7. 2012
    ..To date, mouse lacrimal gland epithelial cells have been cultured successfully but only in cases involving newborn mouse lacrimal glands. In this work, we attempted to cultivate and characterize adult mouse lacrimal gland epithelial cells...
  10. doi request reprint The era of antiaging ophthalmology comes of age: antiaging approach for dry eye treatment
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmic Res 44:146-54. 2010
    ..Finally, we share the preliminary results of our animal study on dry eye, and I report my personal experience as a dry eye patient, which has been alleviated by the antiaging approach...
  11. doi request reprint Advanced dry eye screening for visual display terminal workers using functional visual acuity measurement: the Moriguchi study
    Minako Kaido
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 99:1488-92. 2015
    ....
  12. pmc Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0123299. 2015
    ..Dry eye disease has become an important health problem. A lack of concordance between self-reported symptoms and the outcome of dry eye examinations has raised questions about dry eye disease...
  13. doi request reprint Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka Study
    Yuichi Uchino
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    JAMA Ophthalmol 132:985-92. 2014
    ..This investigation evaluated these relationships among patients with dry eye disease (DED) and individuals serving as controls...
  14. doi request reprint The anti-oxidative role of ABCG2 in corneal epithelial cells
    Miyuki Kubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5617-22. 2010
    ..The authors investigated whether ABCG2 functions in the homeostasis of corneal epithelial cells using abcg2 knockout (KO) mice and corneal epithelial cell lines...
  15. pmc Subepithelial corneal fibrosis partially due to epithelial-mesenchymal transition of ocular surface epithelium
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 16:2727-32. 2010
    ..To determine whether epithelial-mesenchymal transition is involved in the development of corneal subepithelial fibrosis (pannus)...
  16. ncbi request reprint How good is transplantation of corneal parts compared with penetrating keratoplasty?
    Seika Den
    From the Department of Ophthalmology, Tokyo Dental College, Ichikawa, Japan and Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 29:S48-51. 2010
    ..However, we encounter new complication such as graft dislocation. Surgical outcomes of our series and those of other institutes are discussed...
  17. pmc Nucleostemin as a possible progenitor marker of corneal epithelial cells
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 15:1162-8. 2009
    ..We examined the expression of nucleostemin as a marker of differentiation and senescence in corneal epithelial progenitor cells...
  18. doi request reprint Characteristics of traumatic globe rupture after keratoplasty
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 116:2072-6. 2009
    ..To analyze risk factors of traumatic wound rupture after penetrating keratoplasty (PKP) or deep anterior lamellar keratoplasty (DALK)...
  19. doi request reprint Ocular surface reconstruction by cultivated epithelial sheet transplantation
    Yoshiyuki Satake
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan and Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 33:S42-6. 2014
    ..In this review article, we also discuss our clinical experience in relation to these surgical procedures...
  20. doi request reprint Prevalence of dry eye disease and its risk factors in visual display terminal users: the Osaka study
    Miki Uchino
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan Ryogoku Eye Clinic, Tokyo, Japan Electronic address
    Am J Ophthalmol 156:759-66. 2013
    ..To investigate tear function and prevalence of dry eye disease (DED) in visual display terminal (VDT) users...
  21. doi request reprint Screening of dry eye disease in visual display terminal workers during occupational health examinations: The Moriguchi study
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine
    J Occup Health 57:253-8. 2015
    ..The aim of this study was to estimate the prevalence of dry eye disease (DED) in Japanese visual display terminal (VDT) workers and identify simple methods for screening DED during occupational health examinations...
  22. doi request reprint Porous silk fibroin film as a transparent carrier for cultivated corneal epithelial sheets
    Kazunari Higa
    a Department of Ophthalmology and Cornea Center, Tokyo Dental College, Sugano 5 11 13, Chiba 272 8513, Japan Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Biomater Sci Polym Ed 22:2261-76. 2011
    ..Porous silk fibroin film is a highly transparent, biocompatible material that may be useful as a carrier of cultivated epithelial sheets in the regeneration of corneal epithelium. ..
  23. ncbi request reprint Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial
    Tetsuya Kawakita
    Department of Ophthalmology, Keio University School of Medicine, Tokyo 160 8582
    Biomed Res 34:215-20. 2013
    ..These results suggest that fish oil supplementation added to usual care may be effective in the treatment of dry eye. ..
  24. ncbi request reprint Phenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Sugano 5 11 13, Ichikawa City, Chiba, Japan
    Arch Ophthalmol 125:1337-44. 2007
    ..To report phenotypic analysis of epithelia before and following cultivated limbal epithelial transplantation (CLET) for eyes with limbal stem cell deficiency...
  25. doi request reprint Effect of calorie restriction on change in lacrimal gland with age
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Cornea 30:S29-33. 2011
    ..Finally, suggestions are made for further prospective research that would elucidate the molecular mechanisms by which CR maintains lacrimal gland function...
  26. doi request reprint Aerobic exercise increases tear secretion in type 2 diabetic mice
    Kokoro Sano
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 55:4287-94. 2014
    ..To investigate the effects of exercise on tear secretion in type 2 diabetic mice, and to investigate the effect of the adenosine monophosphate-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)...
  27. pmc A field test of Web-based screening for dry eye disease to enhance awareness of eye problems among general Internet users: a latent strategy to promote health
    Motoko Kawashima
    Department of Ophthalomolgy, Keio University School of Medicine, Shinjuku ku, Japan
    J Med Internet Res 15:e209. 2013
    ..A Web-based self-check system including a brief questionnaire would seem to be a suitable tool for rapid disease screening...
  28. pmc Presumed stromal graft rejection after automated lamellar therapeutic keratoplasty: case report
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    J Med Case Reports 1:10. 2007
    ..To describe the development of presumed immune-mediated stromal rejection after automated lamellar therapeutic keratoplasty (ALTK) and its reversal after initiation of intensive topical corticosteroid therapy...
  29. ncbi request reprint Complete spontaneous crystalline lens dislocation into the anterior chamber with severe corneal endothelial cell loss
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Cornea 26:487-9. 2007
    ..To report an unusual case of a spontaneously dislocated crystalline lens into the anterior chamber that was successfully treated...
  30. ncbi request reprint Achievements and future problems with component surgery of the cornea
    Tetsuya Kawakita
    Department of Ophthalmology, Tokyo Dental College, 5 11 13 Sugano, Ichikawa, Chiba, Japan
    Cornea 26:S59-64. 2007
    ..Further refinements in surgical and biologic technology may take the limits of corneal regenerative medicine to new horizons...
  31. ncbi request reprint Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease
    Mizuka Kamoi
    Department of Ophthalmology, Keio University, School of Medicine, Tokyo, Japan
    Curr Eye Res 32:837-42. 2007
    ..To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT)...
  32. doi request reprint Relationship of Corneal Pain Sensitivity With Dry Eye Symptoms in Dry Eye With Short Tear Break-Up Time
    Minako Kaido
    Department of Ophthalmology Keio University School of Medicine, Tokyo, Japan 2Shinanozaka Clinic, Tokyo, Japan 3Wada Eye Clinic, Chiba, Japan
    Invest Ophthalmol Vis Sci 57:914-9. 2016
    ..The purpose of this prospective comparative study was to investigate corneal sensitivity in subjects with unstable tear film, with and without dry eye (DE) symptoms...
  33. doi request reprint Analysis of Meibum Before and After Intraductal Meibomian Gland Probing in Eyes With Obstructive Meibomian Gland Dysfunction
    Naohiko Nakayama
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 34:1206-8. 2015
    ..To evaluate whether the amount of meibum and its viscosity change after intraductal meibomian gland probing in patients with refractory obstructive meibomian gland dysfunction (o-MGD)...
  34. doi request reprint Association of serum lipids with macular thickness and volume in type 2 diabetes without diabetic macular edema
    Mariko Sasaki
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 55:1749-53. 2014
    ..To assess the relationship between macular thickness and volume as characterized by optical coherence tomography (OCT) and known risk factors for diabetic retinopathy (DR) or macular edema (DME) in type 2 diabetic patients with no DME...
  35. doi request reprint Deposition of lipid, protein, and secretory phospholipase A2 on hydrophilic contact lenses
    Hiroshi Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Eye Contact Lens 34:46-9. 2008
    ..This study was performed to determine the levels of sPLA2 from the deposition on two different frequent-replacement contact lens materials...
  36. ncbi request reprint Quantitative evaluation of tear meniscus height from fluorescein photographs
    Masataka Kawai
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 26:403-6. 2007
    ..To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye...
  37. pmc Endoscopy-guided vitreoretinal surgery following penetrating corneal injury: a case report
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Clin Ophthalmol 4:895-8. 2010
    ..This surgical technique offers a good option to vitrectomy with simultaneous keratoplasty in emergency cases where no graft is immediately available and there is the possibility of infection due to the presence of a foreign body...
  38. doi request reprint The disease burden of keratoconus in patients' lives: comparisons to a Japanese normative sample
    Yukako Tatematsu-Ogawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Eye Contact Lens 34:13-6. 2008
    ..The objective of this study was to evaluate vision-related quality of life (VR-QOL) in patients with keratoconus by using the Japanese version of the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25)...
  39. pmc Sleep and mood disorders in dry eye disease and allied irritating ocular diseases
    Masahiko Ayaki
    Department of Ophthalmology Keio University, School of Medicine, Tokyo, Japan
    Sci Rep 6:22480. 2016
    ..05). Our results demonstrate that sleep quality in patients with DED is significantly worse than in patients with other irritating ocular surface diseases and it is correlated with the severity of DED. ..
  40. doi request reprint Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study
    Reiko Arita
    Lid and Meibomian Gland Working Group, Japan Department of Ophthalmology, Itoh Clinic, Saitama, Japan Department of Ophthalmology, University of Tokyo, Tokyo, Japan Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan Electronic address
    Ophthalmology 122:925-33. 2015
    ....
  41. doi request reprint Abdominal breathing increases tear secretion in healthy women
    Kokoro Sano
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ocul Surf 13:82-7. 2015
    ..To determine the relationship between abdominal breathing and tear meniscus volume in healthy women, we investigated the change in tear meniscus volume in two groups: normal breathing and abdominal breathing...
  42. doi request reprint Endoscopy-guided vitreoretinal surgery
    Shinichi Kawashima
    Department of Ophthalmology, School of Medicine, Tsurumi University, 2 1 3 Tsurumi Tsurumi ku, Yokohama shi, Kanagawa, 2308501, Japan
    Expert Rev Med Devices 11:163-8. 2014
    ..Furthermore, there are no blind spots after surgery. We here discuss the advantages of intraocular endoscope use, the current state of endoscopy-guided vitreoretinal surgery, and its future prospects. ..
  43. ncbi request reprint Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Am J Ophthalmol 142:304-9. 2006
    ..To compare the therapeutic outcomes after deep lamellar keratoplasty (DLKP) and penetrating keratoplasty (PKP) in patients with lattice corneal dystrophy (LCD) and macular corneal dystrophy (MCD)...
  44. ncbi request reprint [Demodex-related marginal blepharitis in Japan]
    Tetsuya Kawakita
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Nippon Ganka Gakkai Zasshi 114:1025-9. 2010
    ..Some marginal blepharitis is related to demodex, but this has not yet been reported in Japan. In this study, patients with severe marginal blepharitis with cylindrical dandruff were studied to examine the number of demodex in their cilia...