Hiroshi Itoh

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Augmentation of neovascularization [corrected] in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 3:e1666. 2008
  2. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
  3. pmc MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Nephrol 13:32. 2012
  4. ncbi request reprint Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration
    Masakatsu Sone
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 27:2127-34. 2007
  5. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  6. doi request reprint Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
  7. doi request reprint Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
  8. doi request reprint Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
    Koichiro Homma
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Atherosclerosis 212:42-7. 2010
  9. pmc The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia
    Naofumi Oyamada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 149:3764-77. 2008
  10. pmc Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels
    Naoki Sawada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Mol Cell Biol 29:6018-32. 2009

Collaborators

Detail Information

Publications63

  1. pmc Augmentation of neovascularization [corrected] in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 3:e1666. 2008
    ..Here we investigated the therapeutic potential of human VPC-derived EC and MC for vascular regeneration...
  2. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
    ..Recent clinical studies have shown that plasma NP levels were lower in subjects with the metabolic syndrome. The present study was conducted to elucidate the roles for NP/cGK cascades in energy metabolism...
  3. pmc MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Nephrol 13:32. 2012
    ..ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes...
  4. ncbi request reprint Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration
    Masakatsu Sone
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 27:2127-34. 2007
    ..This time, we investigated kinetics of differentiation of human ES cells to vascular cells and examined their potential as a source for vascular regeneration...
  5. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  6. doi request reprint Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
    ..A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery...
  7. doi request reprint Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
    ....
  8. doi request reprint Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
    Koichiro Homma
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Atherosclerosis 212:42-7. 2010
    ..Here, we compared the functionality of human adult ECs (HAECs), human ES-derived ECs (ESECs) and human iPS-derived ECs (iPSECs)...
  9. pmc The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia
    Naofumi Oyamada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 149:3764-77. 2008
    ..By these beneficial effects, the infarct volume was significantly reduced in spironolactone-treated mice. Spironolactone may thus provide therapeutic neuroprotective effects in the ischemic brain after stroke...
  10. pmc Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels
    Naoki Sawada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Mol Cell Biol 29:6018-32. 2009
    ....
  11. ncbi request reprint Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration
    Tokuji Tanaka
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Pharmacol 508:255-65. 2005
    ..These results suggest that thiazolidinediones have therapeutic potential for the treatment of diabetic vascular complications...
  12. doi request reprint Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 23:575-80. 2010
    ..Because (P)RR is present in the podocytes, a central component of the glomerular filtration barrier, we hypothesized that aliskiren influences the (P)RR-induced two pathways in human podocytes...
  13. doi request reprint "Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertension 53:83-9. 2009
    ....
  14. ncbi request reprint Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK)
    Takatoshi Saito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Regul Pept 127:159-67. 2005
    ..The present results demonstrated the significance of regulation of Gax expression by redox-sensitive ERK1/2 activation...
  15. ncbi request reprint Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho Sakyo ku, Japan
    FEBS Lett 544:86-92. 2003
    ..The findings suggest that AM plays significant roles in vascular regeneration, associated with PKA- and PI3K-dependent activation of Akt in endothelial cells, and possesses therapeutic potential for vascular injury and tissue ischemia...
  16. ncbi request reprint Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2
    Kaori Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Kidney Int 78:69-78. 2010
    ..Our results suggest that transient high-dose angiotensin receptor blocker treatment effectively induced sustained regression of glomerulosclerosis by a mechanism mediated, in part, by changes in MMP-2 activity...
  17. doi request reprint Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla
    Kamon Iigaya
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo
    Hypertension 53:42-8. 2009
    ..The QTL on rat chromosome 1 was primarily related to the postsynaptic response of RVLM bulbospinal neurons to brain angiotensin II, whereas both the QTL and other genomic regions influenced the basal activity of RVLM neurons...
  18. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  19. ncbi request reprint (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1139-46. 2007
    ..The (pro)renin receptor-mediated ERK signal transduction is thus a possible new therapeutic target for preventing vascular complications...
  20. doi request reprint Feasibility of regression of hypertension using contemporary antihypertensive agents
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 26:1381-8. 2013
    ..In this study, we investigated whether treatment with candesartan or nifedipine controlled-release (CR) resulted in a sustained regression of hypertension in humans...
  21. ncbi request reprint Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
    Yasufumi Seki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Front Biosci (Elite Ed) 2:972-9. 2010
    ..Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp...
  22. doi request reprint Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells
    Daisuke Taura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 583:1029-33. 2009
    ..These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells...
  23. pmc Bile acid binding resin improves metabolic control through the induction of energy expenditure
    Mitsuhiro Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e38286. 2012
    ..However, the mechanisms by which BABR affects glucose homeostasis have not been established. We investigated how BABR affects glycemic control in diet-induced obesity models...
  24. pmc NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor
    Ayano Murai-Takeda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:8084-93. 2010
    ..These findings indicate that NF-YC functions as a new corepressor of agonist-bound MR via alteration of aldosterone-induced MR conformation...
  25. doi request reprint Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 33:304-12. 2010
    ..This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients...
  26. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010
    ..Candesartan may be a better antihypertensive drug than CCBs to improve subclinical atherosclerosis of patients with MetS...
  27. ncbi request reprint Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  28. doi request reprint The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    FASEB J 27:2301-15. 2013
    ..2- and 2.5-fold, respectively. DDAH2 overexpression improved GSIS in pancreas-specific Sirt1-deficient mice. In summary, the Sirt1/DDAH2/secretagogin pathway is a novel regulator of GSIS...
  29. ncbi request reprint Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  30. ncbi request reprint Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Circ Res 101:e2-10. 2007
    ..Collectively, the DDAH2/ADMA pathway can be a novel therapeutic target for vasculopathy in the ADMA or angiotensin II-induced pathophysiological conditions...
  31. doi request reprint Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling
    Hidehiro Kaneko
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Cardiovasc Res 91:546-55. 2011
    ..C-reactive protein (CRP) expression is increased with metabolic alterations. We sought to clarify the effect of CRP on the development of obesity-induced metabolic disorders using human CRP-overexpressing transgenic mice (CRPTG)...
  32. doi request reprint Add-on benefits of amlodipine and thiazide in nondiabetic chronic kidney disease stage 1/2 patients treated with valsartan
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:51-8. 2009
    ..These results suggest that 12 months of add-on treatment with either amlodipine or hydrochlorothiazide could have beneficial effects in nondiabetic chronic kidney disease stage 1/2 patients already being treated with valsartan...
  33. pmc Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:13045-56. 2010
    ..Renal Sirt1 can be a potential therapeutic target for the treatment of AKI...
  34. doi request reprint Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
    Masaki Ryuzaki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 34:301-7. 2011
    ..These results suggest that the ((P)RR)-dependent activation of prorenin contributes to the pathogenesis of slowly progressive nephropathy in the intact kidney in a rat model of renovascular hypertension...
  35. ncbi request reprint Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis
    Yusuke Sakamaki
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Nephron Exp Nephrol 115:e22-32. 2010
    ..To investigate the role of individual MMPs, we examined the course of Adriamycin-induced albuminuria and glomerulosclerosis in mice lacking either a gelatinase (MMP-9) or a collagenase (MMP-13)...
  36. doi request reprint Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
    Kenichiro Kinouchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:1143-7. 2009
    ..Thus, the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension...
  37. doi request reprint High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men
    Yoshie Seino
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Metabolism 58:355-60. 2009
    ..Furthermore, it was suggested longitudinally that measuring HMW adiponectin is efficient to predict the progression to metabolic syndrome compared with measuring total adiponectin or HMW-total adiponectin ratio...
  38. doi request reprint Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy
    Tatsuhiko Azegami
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 35:492-9. 2012
    ..These results suggest that transient AT1 vaccination is as effective as continuous treatment with ARB, not only for the attenuation of hypertension, but also for the prevention of L-NAME-induced nephropathy in SHR...
  39. ncbi request reprint Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 30:63-75. 2007
    ..Conversely, developmental exposure to Ang II during this "critical" period had the opposite effect, predisposing rats to higher blood pressure, renal injury, and oxidative stress after L-NAME administration...
  40. pmc Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice
    Naofumi Oyamada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Transl Med 6:54. 2008
    ..We examined the potential of vascular cells derived from human ES cells to contribute to vascular regeneration and to provide therapeutic benefit for the ischemic brain...
  41. doi request reprint The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells
    Shintaro Yamaguchi
    Division of Endocrinology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Atherosclerosis 219:468-74. 2011
    ..In the present study, we investigated the role of miR-145 in the differentiation process from human ESCs into ECs and SMCs...
  42. ncbi request reprint The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
    Endocrinology 147:1642-53. 2006
    ..In summary, this study suggests the neuroprotective and vasculo-neuro-regenerative roles of AM and provides basis for a new strategy to rescue ischemic brain through its multiple hormonal actions...
  43. ncbi request reprint Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases
    Kwijun Park
    Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Endocrinology 149:483-91. 2008
    ..In conclusion, this study showed a therapeutic potential of carperitide to treat peripheral arterial diseases refractory to conventional therapies...
  44. ncbi request reprint Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis
    Hidehiro Kaneko
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Circ J 75:2482-90. 2011
    ..The role of Tace in obesity-induced metabolic disorders was to be clarified in this study...
  45. pmc Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1
    Noriko Suda
    Department of Internal Medicine, School of Medicine, Keio University, Shinjujku ku, Tokyo 160 8582, Japan
    Endocrinology 152:2266-77. 2011
    ..These results showed the physiological roles of Ubc9 and PIAS1 as SF-1 coactivators beyond sumoylation enzymes in adrenocortical steroidogenesis and suggested their possible pathophysiological roles in human cortisol-producing adenomas...
  46. doi request reprint Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings
    Atsuhiro Ichihara
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Hypertens Res 33:177-80. 2010
    ....
  47. ncbi request reprint Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia
    Kazuhiko Doi
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Shogoin, Kyoto 606 8507, Japan
    Heart Vessels 22:104-8. 2007
    ..In conclusion, sustained release of bFGF using gelatin hydrogel augmented angiogenesis and improved tissue blood flow after excision of the femoral artery...
  48. ncbi request reprint Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
    ..Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021). In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes...
  49. pmc Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 19:1496-504. 2013
    ..These results suggest that Sirt1 in PTs protects against albuminuria in diabetes by maintaining NMN concentrations around glomeruli, thus influencing podocyte function. ..
  50. pmc Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:3404-9. 2003
    ....
  51. doi request reprint MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
    ..The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes...
  52. doi request reprint Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma
    Takuhiro Sonoyama
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 96:2771-8. 2011
    ..Meanwhile, an APA is reported to be generally more sensitive to ACTH than idiopathic hyperaldosteronism...
  53. doi request reprint Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrol Dial Transplant 26:2770-9. 2011
    ..The small G protein, Rho, and its downstream effector Rho-kinase have been shown to be involved in the tissue fibrosis process. This study was undertaken to investigate the role of Rho-kinase in the pathogenesis of these alterations...
  54. doi request reprint Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  55. ncbi request reprint [Current status and future prospects of C-type natriuretic peptide]
    Kwijun Park
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:151-6. 2004
  56. doi request reprint The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
    ..A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2...
  57. ncbi request reprint Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells
    Masakatsu Sone
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507 Japan
    Circulation 107:2085-8. 2003
    ..Here we examined whether VPCs occur in primate ES cells and investigated the differences in VPC differentiation kinetics between primate and mouse ES cells...
  58. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: characteristics and usefulness of the direct renin inhibitor aliskiren
    Atsuhiro Ichihara
    Department of Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 113:296-300. 2010
    ....
  59. ncbi request reprint [Clinical application of adrenomedullin to therapeutic angiogenesis]
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:307-13. 2004
  60. doi request reprint A new preventive strategy for hypoglycemia incorporating added food diet in patients with type 2 diabetes who received sitagliptin therapy
    Shu Meguro
    Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Endocr Res 37:175-81. 2012
    ..Further clinical studies will elucidate whether sitagliptin can decrease cardiovascular events as well as normalizing blood glucose and lowering the blood pressure...
  61. doi request reprint Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch
    Yoshikazu Hara
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Sci Signal 4:ra3. 2011
    ..Thus, inhibition of Rho-Rho-kinase signaling may provide a therapeutic strategy for disrupting a vicious cycle of adipocyte stretch, Rho-Rho-kinase signaling, and inflammation of adipose tissue that contributes to and aggravates obesity...
  62. doi request reprint Renal amyloidosis caused by apolipoprotein A-II without a genetic mutation in the coding sequence
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Exp Nephrol 15:774-9. 2011
    ..Here, we report a case of apoAII amyloidosis without a genetic mutation in the coding sequence and discuss the etiology of apoAII amyloidosis...
  63. ncbi request reprint Adrenomedullin promotes proliferation and migration of cultured endothelial cells
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Hypertens Res 26:S93-8. 2003
    ....