D Ito

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Notch3 gene polymorphism and ischaemic cerebrovascular disease
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 72:382-4. 2002
  2. ncbi Corneal endothelial degeneration in dentatorubral-pallidoluysian atrophy
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 59:289-91. 2002
  3. ncbi Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Stroke 32:1208-15. 2001
  4. ncbi Persistent CREB phosphorylation with protection of hippocampal CA1 pyramidal neurons following temporary occlusion of the middle cerebral artery in the rat
    K Tanaka
    Department of Neurology, Keio University, Tokyo, 160 8582, Japan
    Exp Neurol 161:462-71. 2000
  5. ncbi Activated phosphorylation of cyclic AMP response element binding protein is associated with preservation of striatal neurons after focal cerebral ischemia in the rat
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    Neuroscience 100:345-54. 2000
  6. ncbi Phosphorylation of cyclic adenosine monophosphate response element binding protein in oligodendrocytes in the corpus callosum after focal cerebral ischemia in the rat
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Cereb Blood Flow Metab 21:1177-88. 2001
  7. ncbi Immunohistochemical detection of leukemia inhibitory factor after focal cerebral ischemia in rats
    S Suzuki
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Cereb Blood Flow Metab 20:661-8. 2000
  8. ncbi Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Neuroreport 12:2169-74. 2001
  9. ncbi Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Stroke 31:2661-4. 2000
  10. ncbi Optimal continuous positive airway pressure in patients with obstructive sleep apnoea: role of craniofacial structure
    T Akashiba
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Respir Med 95:393-7. 2001

Collaborators

Detail Information

Publications46

  1. pmc Notch3 gene polymorphism and ischaemic cerebrovascular disease
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 72:382-4. 2002
    ..65, p=0.311). In conclusion, the results indicate that T6746C polymorphism in the intracellular domain of the Notch3 gene is not associated with an increased risk for CVD...
  2. ncbi Corneal endothelial degeneration in dentatorubral-pallidoluysian atrophy
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 59:289-91. 2002
    ..However, only a few reports have studied disturbances outside the central nervous system. We described 2 unrelated patients with DRPLA accompanied by corneal endothelial degeneration...
  3. ncbi Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Stroke 32:1208-15. 2001
    ..In the present study we examined time-dependent Iba1 expression after transient middle cerebral artery occlusion and characterized microglial activation in various brain regions...
  4. ncbi Persistent CREB phosphorylation with protection of hippocampal CA1 pyramidal neurons following temporary occlusion of the middle cerebral artery in the rat
    K Tanaka
    Department of Neurology, Keio University, Tokyo, 160 8582, Japan
    Exp Neurol 161:462-71. 2000
    ..These data suggest that CREB phosphorylation can be persistently activated in CA1 neurons after focal ischemia and that this phenomenon may be closely associated with protection of these neurons...
  5. ncbi Activated phosphorylation of cyclic AMP response element binding protein is associated with preservation of striatal neurons after focal cerebral ischemia in the rat
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    Neuroscience 100:345-54. 2000
    ....
  6. ncbi Phosphorylation of cyclic adenosine monophosphate response element binding protein in oligodendrocytes in the corpus callosum after focal cerebral ischemia in the rat
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Cereb Blood Flow Metab 21:1177-88. 2001
    ..These findings suggest that signal transduction through CREB phosphorylation may be closely associated with survival of OLGs and maintenance of myelination in the corpus callosum after cerebral ischemia...
  7. ncbi Immunohistochemical detection of leukemia inhibitory factor after focal cerebral ischemia in rats
    S Suzuki
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Cereb Blood Flow Metab 20:661-8. 2000
    ..These findings suggest that LIF expression in ischemically threatened neurons may reflect a repair or defense mechanism against the ischemic insult...
  8. ncbi Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain
    K Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Neuroreport 12:2169-74. 2001
    ..As such, this upregulation of NG2 expression may be an adaptive mechanism attempting to remyelinate rat brain tissue after ischemic insult. Only further study will elucidate this hypothesis...
  9. ncbi Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Stroke 31:2661-4. 2000
    ..In the present study we investigated a possible association between the C(-260)-->T polymorphism in the CD14 promoter and the occurrence of symptomatic ischemic cerebrovascular disease (CVD)...
  10. ncbi Optimal continuous positive airway pressure in patients with obstructive sleep apnoea: role of craniofacial structure
    T Akashiba
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Respir Med 95:393-7. 2001
    ..575, P<0.001). Optimal CPAP was closely correlated with oxygen desaturation during sleep. However, the craniofacial structure had additional effects such as an independent factor in determining the optimal CPAP level...
  11. ncbi Up-regulation of the Ire1-mediated signaling molecule, Bip, in ischemic rat brain
    D Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan
    Neuroreport 12:4023-8. 2001
    ..Immunofluorescence staining revealed Bip up-regulation in ischemic neurons, which were TUNEL positive. Our studies suggest that the Ire1-mediated signal might be associated with ischemic neuronal damage...
  12. ncbi [Targets of treatment in the acute phase of cerebral infarction]
    K Tanaka
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 41:1052-4. 2001
    ..Future targets of stroke treatment should include enhancement of intrinsic protection mechanisms such as CREB phosphorylation and activation of progenitors cells...
  13. ncbi A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene
    H Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurol 14:1288-91. 2007
    ..We report a novel pair of heterozygous mutations in the 3'-splicing site of exon 26 and the translation site of exon 28 of the dysferlin gene in two siblings, and effective treatment of their MM with dantrolene...
  14. ncbi A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    Y Imai
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    Biochem Biophys Res Commun 224:855-62. 1996
    ..Iba1 protein is therefore suggested to act as an adapter molecule, mediating calcium signals that may function in a monocytic lineage including microglia...
  15. pmc Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway
    K Takizawa
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan
    Br J Cancer 80:954-63. 1999
    ..These findings indicate that treatment with CDDP and 5-FU induces ICAM-1 expression by a NF-kappaB independent regulatory mechanism involving PTK...
  16. ncbi Craniofacial abnormalities in Japanese patients with severe obstructive sleep apnoea syndrome
    D Ito
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Respirology 6:157-61. 2001
    ..CONCLUSIONS: Japanese patients with severe OSAS have enlargement of the soft tissues and palate as well as craniofacial bony structural abnormalities. This is particularly apparent in non-obese patients...
  17. ncbi Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure
    K Ohsawa
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    J Neurochem 67:89-97. 1996
    ..These results suggest that XH2 and DMTase are candidates for annexin V-binding proteins and thus may mediate the biological activity of annexin V...
  18. ncbi B70 antigen is a second ligand for CTLA-4 and CD28
    M Azuma
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 366:76-9. 1993
    ..These findings indicate that B70 is a second ligand for CD28 and CTLA-4 and may play an important role for costimulation of T cells in a primary immune response...
  19. ncbi G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1121:246-9. 2006
    ..48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population...
  20. ncbi T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease
    Hidenori Hattori
    Departments of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosci Lett 374:132-5. 2005
    ..Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population...
  21. ncbi [Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]
    Keiko Ishii
    Department of Laboratory Medicine, Keio University, Shinjuku ku, Tokyo 160 8582
    Rinsho Byori 52:22-7. 2004
    ..05). Thus, GPIb alpha 145Met and p22phox 72 Tyr are the genetic factors associated with the risk of ischemic CVD in the Japanese. Carrying both of the two mutations might be associated with developing CVD at a younger age...
  22. ncbi A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Brain Res 1108:221-3. 2006
    ..7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia...
  23. ncbi [Study of genotype frequencies of ANP 664G/A polymorphism in normal subjects and CVD patients, and its association with plasma ANP levels]
    Atsumi Ohta
    Department of Laboratory Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 161 8582
    Rinsho Byori 50:296-300. 2002
    ..9708). These results suggest that there is a racial difference in the allele frequency of 664G/A, and that this polymorphism may not be a major risk factor for CVD in the Japanese, nor is it a major determinant of plasma ANP level...
  24. ncbi A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 924:98-108. 2002
    ..These data clearly indicate that NS-7 provides very efficient neuroprotection in the acute phase of cerebral ischemia, and sustains the normal function of PKA...
  25. ncbi Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants
    Gopal Thinakaran
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, IL, USA
    Methods Mol Biol 232:203-16. 2003
  26. ncbi Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003)
    Daisuke Ito
    Laboratories of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Am Vet Med Assoc 227:1454-60. 2005
    ..To determine whether magnetic resonance imaging findings in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion were predictive of clinical outcome...
  27. ncbi Clinical significance of focal adhesion kinase in resectable pancreatic cancer
    Kenichiro Furuyama
    Department of Surgery and Surgical Basic Science, Kyoto University, 54 Shogoinkawaracho, Sakyo, Kyoto, 606 8507, Japan
    World J Surg 30:219-26. 2006
    ..Focal adhesion kinase expression was not directly related to clinicopathological factors except tumor size in pancreatic carcinoma. Focal adhesion kinase expression may not be a prognostic marker for pancreatic cancer patients...
  28. ncbi Gene expression profiles of oral leukoplakia and carcinoma: genome-wide comparison analysis using oligonucleotide microarray technology
    Takeshi Odani
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Ohta ku, Tokyo 145 8515, Japan
    Int J Oncol 28:619-24. 2006
    ..Our data suggested that gene abnormalities in cytoskeleton network components might be responsible for the development and progression of oral leukoplakia...
  29. ncbi Genetic diagnosis of band 3 deficiency and sexing in bovine preimplantation embryos
    Soichi Kageyama
    Hokkaido Animal Research Center, Japan
    J Vet Med Sci 68:319-23. 2006
    ..Yamagata). These results demonstrate that our procedure is reliable and applicable to produce animals free from or homozygous for the mutant allele by breeding carrier animals...
  30. ncbi Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils
    Toru Kimura
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, 2 1 1, Kitasenzoku, Ota, Tokyo 145 8515, Japan
    Int Immunopharmacol 3:1519-28. 2003
    ..These results suggest that selective COX-2 inhibitors may contribute to resolution of acute inflammation through the reduction of inflammatory cytokine release in activated neutrophils...
  31. ncbi Ubiquitylation-independent ER-associated degradation of an AE1 mutant associated with dominant hereditary spherocytosis in cattle
    Daisuke Ito
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Cell Sci 119:3602-12. 2006
    ..These findings indicate that AE1 R664X protein, which is associated with dominant hereditary spherocytosis, has a dominant-negative effect on the expression of wild-type AE1...
  32. ncbi Thalidomide suppresses melanoma growth by activating natural killer cells in mice
    Ai Kawamata
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo 145 8515, Japan
    Oncol Rep 16:1231-6. 2006
    ..Production of the cytotoxic molecule perforin was also augmented. These data suggest that Thd strongly activates NK cell activity in mice, possibly resulting in enhanced tumor surveillance defense...
  33. ncbi [Ischemic brain and endoplasmic reticulum stress]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Nihon Rinsho 64:127-31. 2006
  34. ncbi Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by phosphatidylinositol 3-kinase inhibitors
    Gen Kondo
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, 2 1 1 Kitasenzoku, Ota ku, Tokyo 145 8515, Japan
    Oncol Rep 14:1215-22. 2005
    ..These results suggest that the PI 3-K/Akt signaling pathway may, in part, regulate Fas-mediated apoptosis in HL-60 cells through c-FLIP expression...
  35. ncbi Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44
    Yuriko Kinugasa
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan
    Clin Exp Metastasis 21:737-45. 2004
    ..Genetic or pharmacological inhibition of COX-2 may therefore be a beneficial strategy in the treatment of OSCC patients...
  36. ncbi Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma
    Shoichiro Tsuji
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cancer 106:17-25. 2003
    ..These results suggest that DcR3 is highly expressed in many pancreatic cancers and endogenous DcR3 blocks the growth inhibition signals mediated by mFasL. DcR3 can be a candidate target molecule for the therapeutic intervention...
  37. ncbi Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines
    Ming Heng Li
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo 145 8515, Japan
    Oral Oncol 40:63-70. 2004
    ..p21 was remarkably up-regulated, but it was speculated that its activity might be cancelled by an increased binding to CDK4...
  38. ncbi CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer
    Tomohiko Mori
    Department of Surgery and Surgical Basic Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Mol Cancer Ther 3:29-37. 2004
    ..Taken together, SDF-1/CXCR4 axis is involved in pancreatic cancer metastasis through migration and invasion. The small molecule antagonists against CXCR4 such as TN14003 might be an effective anti-metastatic agent for pancreatic cancer...
  39. ncbi Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo
    Koichiro Abe
    Laboratory of Molecular Immunoregulation, Center for Cancer Research and Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
    Blood 101:1477-83. 2003
    ..Second, the microenvironment in peripheral lymphoid organs associated with LTalpha/LTbeta-LTbetaR signaling and chemokine production is critical for recruitment efficiency of DCs, and this pathway is indispensable...
  40. ncbi Conditional transformation of mouse pancreatic epithelial cells: an in vitro model for analysis of genetic events in pancreatocarcinogenesis
    Masayuki Koizumi
    Department of Surgery and Basic Surgical Science, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 319:612-21. 2004
    ..These findings suggest that activation of ras and inactivation of p53 can cooperatively induce anchorage-independent growth of IMPE cells. This cell line might be useful for studying the processes involved in pancreatocarcinogenesis...
  41. ncbi N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    Sanae Nakajima
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 10:4125-33. 2004
    ..The purpose of the study presented here was to investigate whether a gain in N-cadherin in pancreatic cancer is involved in the process of metastasis via EMT and whether its expression is affected by growth factors...
  42. ncbi Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
    Hongyan Diao
    Division of Molecular Immunology, Hokkaido University, Sapporo 060 0815, Japan
    Immunity 21:539-50. 2004
    ..These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases...
  43. pmc Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties
    Daisuke Ito
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Knapp R212, 924 East 57th St, Chicago, IL 60637, USA
    Mol Cell Biol 24:9456-69. 2004
    ..Consequently, induced STC2 expression is an essential feature of survival component of the UPR...
  44. ncbi All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas
    Sidhartha Singh Tulachan
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Diabetes 52:76-84. 2003
    ....
  45. ncbi Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation
    Kenichi Miyaoka
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan
    J Surg Res 125:144-50. 2005
    ..This prospective study assessed the risk of SIRS and MODS after orthognathic surgery by measuring the circulating levels of inflammatory cytokines such as IL-6 and IL-10 as well as the neutrophil functions as a marker of organ failure...
  46. ncbi Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer
    Kozo Kataoka
    Department of Surgery and Basic Surgical Science, Kyoto University, Japan
    Surgery 138:450-5. 2005
    ..We hypothesized that tuberin might be involved in the proliferation and survival of pancreatic cancer cells...