A Ishiko

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis
    A Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 12:747-54. 2003
  2. ncbi request reprint Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Acta Neuropathol 112:333-9. 2006
  3. ncbi request reprint Does the position of the premature termination codon in COL7A1 correlate with the clinical severity in recessive dystrophic epidermolysis bullosa?
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 13:229-33. 2004
  4. ncbi request reprint Abnormal keratin expression in circumscribed palmar hypokeratosis
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Am Acad Dermatol 57:285-91. 2007
  5. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephaloapthy (CADASIL): a hereditary cerebrovascular disease, which can be diagnosed by skin biopsy electron microscopy
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Am J Dermatopathol 27:131-4. 2005
  6. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
  7. ncbi request reprint 97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen
    A Ishiko
    Department of Dermatology, Nippon Kokan Hospital, Kawasaki, Kanagawa, Japan
    J Invest Dermatol 111:93-6. 1998
  8. ncbi request reprint The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo
    S Nonaka
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:889-92. 2000
  9. ncbi request reprint Evaluation of immunoelectron microscopic techniques in the study of basement membrane antigens
    T Masunaga
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Histochem Cell Biol 110:107-11. 1998
  10. doi request reprint A Japanese-specific recurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa
    M Kouno
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Clin Exp Dermatol 36:386-92. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis
    A Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 12:747-54. 2003
    ....
  2. ncbi request reprint Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Acta Neuropathol 112:333-9. 2006
    ..Our results shed light on the relationship between Notch3 gene mutations and morphological deposition of GOM around the vascular smooth muscle cells...
  3. ncbi request reprint Does the position of the premature termination codon in COL7A1 correlate with the clinical severity in recessive dystrophic epidermolysis bullosa?
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 13:229-33. 2004
    ..Therefore, genotype-phenotype relationships in RDEB cannot be explained purely by the position of PTC...
  4. ncbi request reprint Abnormal keratin expression in circumscribed palmar hypokeratosis
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Am Acad Dermatol 57:285-91. 2007
    ..Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described...
  5. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephaloapthy (CADASIL): a hereditary cerebrovascular disease, which can be diagnosed by skin biopsy electron microscopy
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Am J Dermatopathol 27:131-4. 2005
    ..Dermatologists should be aware of these ultra-structural findings because this disease may occur sporadically and might be more common than initially thought...
  6. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
    ....
  7. ncbi request reprint 97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen
    A Ishiko
    Department of Dermatology, Nippon Kokan Hospital, Kawasaki, Kanagawa, Japan
    J Invest Dermatol 111:93-6. 1998
    ....
  8. ncbi request reprint The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo
    S Nonaka
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:889-92. 2000
    ..This unique structure of the antigen is thought to contribute to dermo- epidermal adhesion by intertwining with other basement membrane components...
  9. ncbi request reprint Evaluation of immunoelectron microscopic techniques in the study of basement membrane antigens
    T Masunaga
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Histochem Cell Biol 110:107-11. 1998
    ..These results confirm the advantages and limitations of these techniques of IEM and emphasize the importance of using different techniques of IEM in determining the precise ultrastructural distribution of basement membrane antigens...
  10. doi request reprint A Japanese-specific recurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa
    M Kouno
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Clin Exp Dermatol 36:386-92. 2011
    ..We report two unrelated Japanese patients with H-JEB. Genetic analyses detected a single nonsense mutation on the LAMC2 gene in these two patients...
  11. ncbi request reprint Compound heterozygosity for a point mutation and a deletion located at splice acceptor sites in the LAMB3 gene leads to generalized atrophic benign epidermolysis bullosa
    Y Takizawa
    Departments of Dermatology and Anatomy, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:312-6. 2000
    ....
  12. ncbi request reprint Glycine substitution mutations by different amino acids in the same codon of COL7A1 lead to heterogeneous clinical phenotypes of dominant dystrophic epidermolysis bullosa
    T Murata
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arch Dermatol Res 292:477-81. 2000
    ..These results further support the notion that different glycine substitution mutations in the same codon can lead to heterogeneous clinical phenotypes of DDEB, EB pruriginosa and classical type...
  13. doi request reprint Immunoglobulin G deposition to nonhemidesmosomal lamina lucida and early neutrophil involvement are characteristic features in a case of anti-p200 pemphigoid
    A Shimizu
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Br J Dermatol 168:647-55. 2013
    ....
  14. doi request reprint A novel de novo splice-site mutation in the COL7A1 gene in dominant dystrophic epidermolysis bullosa (DDEB): specific exon skipping could be a prognostic factor for DDEB pruriginosa
    M Saito
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Exp Dermatol 34:e934-6. 2009
    ..Our study should contribute to further refinement of the genotype-phenotype correlations in DEB, emphasizing the significance of mutation analysis for correct diagnosis and possibly for prediction of prognosis...
  15. ncbi request reprint Novel mutation of the Notch3 gene in a Japanese patient with CADASIL
    K Oki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurol 14:464-6. 2007
    ..Thus, the CADASIL in the present case may be a consequence of the mutation in exon 2 causing a structural change in the Notch3 protein...
  16. ncbi request reprint 97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane
    A Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 106:739-43. 1996
    ..These results indicate that the 97-kDa LAD antigen is a component of the lamina lucida...
  17. doi request reprint Novel mutation p.Gly59Arg in GJB6 encoding connexin 30 underlies palmoplantar keratoderma with pseudoainhum, knuckle pads and hearing loss
    I Nemoto-Hasebe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo, Japan
    Br J Dermatol 161:452-5. 2009
    ..Mutations in connexin genes including GJB2 (Cx26), GJB3 (Cx31), GJB4 (Cx30.3), GJB6 (Cx30) and GJA1 (Cx43) are responsible for various dermatological syndromes and/or inherited hearing loss, frequently showing overlapping phenotypes...
  18. doi request reprint Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases
    K Tanese
    Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
    Clin Exp Dermatol 35:51-5. 2010
    ..It is therefore important for treatment planning to evaluate the entire specimen histologically...
  19. ncbi request reprint Malignant chondroid syringoma with bone invasion: a case report and review of the literature
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Dermatopathol 26:403-6. 2004
    ..There have been no reports reporting effectiveness of chemotherapy and radiotherapy, and an early wide excision with a broad margin may be the most reliable treatment to date...
  20. ncbi request reprint Abnormal lamellar granules in a case of CHILD syndrome
    Masafumi Ishibashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Cutan Pathol 33:447-53. 2006
    ..Almost all area of her right-side body except the head and neck was covered by the erythematous lesion with yellow waxy scales, and the distal end of the rudimentary leg showed a verrucous appearance...
  21. ncbi request reprint Pyloric atresia-junctional epidermolysis bullosa syndrome showing novel 594insC/Q425P mutations in integrin beta4 gene (ITGB4)
    Takuji Masunaga
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Dermatol 13:61-4. 2004
    ..Our results contribute to further the accumulation of mutation data for better understanding of the genotype/phenotype correlation in PA-JEB, and may give profound insight into the role of integrins alpha6 and beta4...
  22. ncbi request reprint Prenatal exclusion of harlequin ichthyosis; potential pitfalls in the timing of the fetal skin biopsy
    A Shimizu
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Br J Dermatol 153:811-4. 2005
    ..However, prenatal testing must be done earlier than 21 weeks EGA in several countries including Japan where the present HI families live, because termination is legally allowed only until 22 weeks EGA...
  23. doi request reprint Acquired dermal melanocytosis of the face and extremities
    T Ouchi
    Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
    Clin Exp Dermatol 41:643-7. 2016
    ..One patient was treated with Q-switched ruby laser with excellent outcome. Increased awareness of ADMFE can lead to earlier diagnosis and potential treatment. ..
  24. doi request reprint Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation
    Masataka Saito
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Dermatol Sci 52:13-20. 2008
    ..General genotype-phenotype correlations have been delineated in recessive dystrophic epidermolysis bullosa (RDEB), but these remain complicated and it is still difficult to assess the clinical consequences of individual COL7A1 mutations...
  25. ncbi request reprint Ten novel mutations of the ADAR1 gene in Japanese patients with dyschromatosis symmetrica hereditaria
    Noriyuki Suzuki
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Invest Dermatol 127:309-11. 2007
    ..In this study, we report 10 novel mutations responsible for DSH: p.Q102fsX123, p.T369fsX374, p.S664fsX677, p.R892L, p.I913R, p.R916Q, p.P990fsX1016, p.C1081S, p.C1169F, and p.K1187X...
  26. ncbi request reprint Rapid growth of malignant melanoma in pregnancy
    Tomotaka Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dtsch Dermatol Ges 6:126-9. 2008
    ..There are no standarized guidelines for treatment; each case requires an individualized approach. We review the literature and present an algorithm to aid in approaching such patients...
  27. doi request reprint Inflammatory plaque with peripheral nodules: a new specific finding of cutaneous polyarteritis nodosa
    Po Tak Chan
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Am Acad Dermatol 60:320-5. 2009
    ..In conclusion, cutaneous polyarteritis nodosa can present as inflammatory plaques on the trunk and proximal extremities, and the presence of peripheral nodules around these plaques constitutes a useful clinical clue to its diagnosis...
  28. ncbi request reprint IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1145-53. 2004
    ..These findings indicate that anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in PV...
  29. ncbi request reprint Differences in recurrent COL7A1 mutations in dystrophic epidermolysis bullosa: ethnic-specific and worldwide recurrent mutations
    Takayuki Murata
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160 8582 Tokyo, Japan
    Arch Dermatol Res 295:442-7. 2004
    ..In conclusion, our results further support the notion that recurrent mutations can be classified into two types, ethnic-specific mutation and worldwide mutation...
  30. doi request reprint Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:308-16. 2010
    ..These results also clearly account for the majority of EBS-MD PLEC1 mutation restriction within the large exon 31 that encodes the plectin rod domain, whereas EBS-PA PLEC1 mutations are generally outside exon 31...
  31. doi request reprint Pretibial dystrophic epidermolysis bullosa with localized cutaneous amyloidosis: coincidental or secondary amyloidosis?
    Mikako Aoki
    Department of Dermatology, Nippon Medical School Musashikosugi Hospital, Kawasaki City, Kanagawa, Japan
    J Dermatol 37:259-63. 2010
    ..PDEB, in general, is often misdiagnosed as lichen amyloidosis; however, some PDEB cases could actually be associated with amyloid deposition...
  32. ncbi request reprint Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arch Dermatol Res 294:318-23. 2002
    ....
  33. ncbi request reprint In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 124:984-9. 2005
    ..These results indicate that the N-terminal regions of Dsg3 from opposing cells interact at the dense mid-line of desmosomes where EC1 overlaps...
  34. ncbi request reprint Neutrophils contact to plasma membrane of keratinocytes including desmosomal structures in canine pemphigus foliaceus
    Atsushi Yabuzoe
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    J Vet Med Sci 70:807-12. 2008
    ....
  35. ncbi request reprint Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice
    Cassian Sitaru
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Immunol 177:3461-8. 2006
    ..This robust experimental system should greatly facilitate further studies on the pathogenesis of EBA and the development of novel immunomodulatory therapies for this and other autoimmune diseases...
  36. pmc Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen
    Cassian Sitaru
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Clin Invest 115:870-8. 2005
    ..This animal model for EBA should facilitate further dissection of the pathogenesis of this disease and development of new therapeutic strategies...
  37. pmc Assessment of splice variant-specific functions of desmocollin 1 in the skin
    Xing Cheng
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 24:154-63. 2004
    ..However, a comparison of our mutants with dsc1-null mice suggests that the Dsc1 extracellular domain is necessary to maintain structural integrity of the skin...