Hiroshi Hirose

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Trends in blood pressure control in hypertensive patients with diabetes mellitus in Japan
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 26:717-22. 2003
  2. ncbi request reprint Insulin resistance and hypertension: seven-year follow-up study in middle-aged Japanese men (the KEIO study)
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 26:795-800. 2003
  3. ncbi request reprint Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
  4. doi request reprint Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
    Takashi Eguchi
    Department of Internal Medicine, School of Medicine, Keio University, Saitama Prefecture, Japan
    Hypertens Res 32:775-9. 2009
  5. ncbi request reprint Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 89:87-90. 2004
  6. ncbi request reprint Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
  7. doi request reprint MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
  8. ncbi request reprint An inverse association between serum gamma glutamyl transpeptidase activity and Breslow's Lifestyle Index; its practical application for screening of subjects with unhealthy lifestyles
    Hirokazu Yokoyama
    Health Center, Keio University, Japan
    J Occup Health 48:198-206. 2006
  9. doi request reprint A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer
    Norihisa Saeki
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:892-902. 2011
  10. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009

Detail Information

Publications73

  1. ncbi request reprint Trends in blood pressure control in hypertensive patients with diabetes mellitus in Japan
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 26:717-22. 2003
    ..ARBs and ACEIs became first-line medications, and CCBs became second-line medications to achieve the BP goal and prevent organ damage...
  2. ncbi request reprint Insulin resistance and hypertension: seven-year follow-up study in middle-aged Japanese men (the KEIO study)
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 26:795-800. 2003
    ..These findings suggest an important role of insulin resistance in predicting the future incidence of hypertension in middle-aged Japanese men...
  3. ncbi request reprint Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
    ....
  4. doi request reprint Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
    Takashi Eguchi
    Department of Internal Medicine, School of Medicine, Keio University, Saitama Prefecture, Japan
    Hypertens Res 32:775-9. 2009
    ..These results suggest that the TNFR2 gene locus has a potential effect on developing severe hypertension through the augmented TNF pathway and insulin resistance...
  5. ncbi request reprint Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 89:87-90. 2004
    ..162 and r = -0.140, respectively). These findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight...
  6. ncbi request reprint Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  7. doi request reprint MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
    ..The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes...
  8. ncbi request reprint An inverse association between serum gamma glutamyl transpeptidase activity and Breslow's Lifestyle Index; its practical application for screening of subjects with unhealthy lifestyles
    Hirokazu Yokoyama
    Health Center, Keio University, Japan
    J Occup Health 48:198-206. 2006
    ..Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues...
  9. doi request reprint A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer
    Norihisa Saeki
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:892-902. 2011
    ....
  10. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
    ..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...
  11. ncbi request reprint Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Sci (Lond) 103:137-42. 2002
    ..377). These findings suggest that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population...
  12. ncbi request reprint Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  13. doi request reprint Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents
    Hiroshi Nakatani
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 57:157-62. 2008
    ..The inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development...
  14. ncbi request reprint Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010
    ..We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome...
  15. ncbi request reprint Prevalence of metabolic syndrome in young men in Japan
    Ikuo Saito
    Health Center, Keio University, Japan
    J Atheroscler Thromb 14:27-30. 2007
    ....
  16. ncbi request reprint Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk
    Takashi Kohno
    Center for Medical Genomics, Tokyo, Japan
    Carcinogenesis 27:2448-54. 2006
    ..0 (95% CI: 1.2-3.2, P=0.002). The present results indicate that inter-individual differences in MTH1 activities due to SNPs are involved in susceptibility to SCLC...
  17. ncbi request reprint GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 54:296-9. 2005
    ..These results suggest that the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men...
  18. doi request reprint High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men
    Yoshie Seino
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Metabolism 58:355-60. 2009
    ..Furthermore, it was suggested longitudinally that measuring HMW adiponectin is efficient to predict the progression to metabolic syndrome compared with measuring total adiponectin or HMW-total adiponectin ratio...
  19. doi request reprint CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men
    Toshiyuki Morii
    Department of Internal Medicine, Keio University, School of Medicine, Shinjuku ku, Tokyo, Japan
    Biomarkers 14:207-12. 2009
    ..13, p <0.01). The difference in LDL-cholesterol concentrations was 10 mg dl(-1) between GG- and AA-genotype carriers (p <0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men...
  20. ncbi request reprint Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men
    Toshiyuki Morii
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 54:370-5. 2005
    ..The net increment in Glut-mediated glucose uptake by insulin in lymphoblasts may be a useful intermediate phenotype to study genetic aspects of the metabolic syndrome...
  21. ncbi request reprint Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice
    Ken Yajima
    Department of Internal Medicine, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Physiol Endocrinol Metab 284:E966-71. 2003
    ..GSIS was further increased by PPARgamma and -alpha agonists. We conclude that combination therapy with PPARgamma and PPARalpha agonists may be more useful with respect to body weight and pancreatic GSIS in type 2 diabetes with obesity...
  22. ncbi request reprint Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients
    Seiko Matsunaga-Irie
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Care 27:303-7. 2004
    ..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients...
  23. ncbi request reprint Inverse association between serum adiponectin level and transaminase activities in Japanese male workers
    Hirokazu Yokoyama
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    J Hepatol 41:19-24. 2004
    ..Since a novel polypeptide named adiponectin was shown to prevent the development of steatosis and steatohepatitis in animal models, we studied whether it was also possible in a clinical situation...
  24. ncbi request reprint Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 55:433-8. 2008
    ..In this study we tested this hypothesis by investigating the effects of dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, on tumor necrosis factor-alpha (TNF-alpha)-induced beta cell dysfunction...
  25. doi request reprint Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese
    Kouya Shiraishi
    Biology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    Carcinogenesis 30:65-70. 2009
    ..These results strongly indicate that CHRNA SNPs confer lung cancer susceptibility in a small subset of Japanese in a smoking-independent manner...
  26. ncbi request reprint Correlation between insulin resistance and gamma-glutamyl transpeptidase sensitivity in light drinkers
    Susumu Moriya
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Alcohol Clin Exp Res 27:52S-57S. 2003
    ..In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers...
  27. ncbi request reprint Characteristics of reference intervals of metabolic factors in healthy Japanese: a proposal to set generation- and gender-specific diagnostic criteria for metabolic syndrome
    Hirokazu Yokoyama
    Health Center, Keio University, Tokyo, Japan
    J Atheroscler Thromb 16:113-20. 2009
    ..To verify the clinical diagnostic criteria for metabolic syndrome (MetS-Criteria) for Japanese (Japanese-Criteria) from the viewpoint of reference intervals (RIs) of metabolic factors...
  28. ncbi request reprint Relation between blood pressure and rhinitis in a Japanese adolescent population
    Ikuo Saito
    Health Center, Keio University, Tokyo, Japan
    Hypertens Res 26:961-3. 2003
    ..These findings do not confirm a relation between allergic rhinitis and systolic BP...
  29. ncbi request reprint Associations among lifestyle status, serum adiponectin level and insulin resistance
    Hirokazu Yokoyama
    Health Center, Keio University, Yotsuya Office, 35 Shinanomachi, Shinjuku ku, Tokyo
    Intern Med 43:453-7. 2004
    ....
  30. doi request reprint Prediction of metabolic syndrome using artificial neural network system based on clinical data including insulin resistance index and serum adiponectin
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Comput Biol Med 41:1051-6. 2011
    ....
  31. doi request reprint Effects of losartan/hydrochlorothiazide treatment, after change from ARB at usual dosage, on blood pressure and various metabolic parameters including high-molecular weight adiponectin in Japanese male hypertensive subjects
    Hiroshi Hirose
    Health Center and Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Clin Exp Hypertens 33:41-6. 2011
    ..06 to 3.46 ± 1.28 μg/ml (P = 0.0105). In summary, changing treatment to losartan/HCTZ, when changed from a usual dosage of ARB, exerted good BP control, while the HMW-adiponectin level was unchanged in male hypertensive subjects...
  32. ncbi request reprint [How to use anti-hypertensive medication in management of diabetic patients]
    Hiroshi Hirose
    Health Center, Keio University
    Nihon Rinsho 61:1205-9. 2003
    ..However, Ca-channel blockers, alpha 1-blockers, beta-blockers and diuretics are often needed to achieve the goal: preventing organ damage which would be the most important issue for diabetic patients...
  33. ncbi request reprint Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gamma-GTP) activity in non-drinkers
    Hirokazu Yokoyama
    Health Center, Keio University, Tokyo, Japan
    Alcohol Clin Exp Res 26:91S-94S. 2002
    ..6% of subjects whose gamma-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum gamma-GTP activity in clinical subjects...
  34. ncbi request reprint Relations between serum reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 16:77-82. 2009
    ..We investigated the relations between reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population...
  35. ncbi request reprint Effects of leptin receptor gene 3'-untranslated region polymorphism on metabolic profiles in young Japanese men
    Kanako Nishikai
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Atheroscler Thromb 11:73-8. 2004
    ..42, p = 0.015). These findings suggest that serum HDL-cholesterol and apoA-I levels are influenced by the leptin receptor gene 3'-UTR polymorphism in young Japanese men...
  36. pmc C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e73430. 2013
    ..To clarify predictive values of C-reactive protein (CRP) and high-molecular-weight (HMW) adiponectin for development of metabolic syndrome...
  37. ncbi request reprint Trends in pharmacologic management of hypertension in Japan one year after the publication of the JSH 2000 guidelines. First Japanese Society of Hypertension
    Ikuo Saito
    Health Center, Keio University, Tokyo, Japan
    Hypertens Res 25:175-8. 2002
    ..Their first choice drug is shifting from calcium antagonists to AIIAs. These findings indicate the need for continued effort to evaluate the diversity of clinical practice and assess the appropriateness of continuing medical education...
  38. ncbi request reprint Associations between serum leptin levels and transaminase activities and the status of lifestyle in Japanese workers
    Hirokazu Yokoyama
    Health Center, Keio University, and Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Alcohol Clin Exp Res 28:159S-163S. 2004
    ..In this study, associations between serum leptin levels and serum transaminase activities and the statuses of various lifestyles, including that of ethanol consumption, were studied...
  39. ncbi request reprint Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders
    Hiroshi Hirose
    Health Center, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 17:1201-11. 2010
    ..It is suggested that HMW adiponectin is a useful marker for the evaluation and care of subjects with metabolic syndrome and related disorders...
  40. ncbi request reprint Relation between blood pressure control, body mass index, and intensity of medical treatment
    Ikuo Saito
    Health Center, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 26:711-5. 2003
    ..5% of cases. A higher intensity of medical treatment is needed to achieve BP control in obese hypertensive patients characterized by insulin resistance...
  41. ncbi request reprint Effect of valsartan, an angiotensin II receptor blocker, on markers of oxidation and glycation in Japanese type 2 diabetic subjects: blood pressure-independent effect of valsartan
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 74:201-3. 2006
    ..We therefore examined the effect of valsartan on markers of oxidation and glycation...
  42. doi request reprint Variability of home blood pressure measurements between first and second measurements on one occasion, and factors related to variability
    Hiroshi Kawabe
    Health Center, Keio University, Tokyo, Japan
    Clin Exp Hypertens 34:237-42. 2012
    ..Therefore, physicians should pay special attention to the above-mentioned fact in the future...
  43. ncbi request reprint Effects of telmisartan therapy on metabolic profiles and serum high molecular weight (HMW)-adiponectin level in Japanese male hypertensive subjects with abdominal obesity
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:137-42. 2009
    ..We investigated the effects of 3-month telmisartan therapy on various metabolic parameters, including serum HMW adiponectin and high-sensitivity C-reactive protein (hs-CRP) levels in male hypertensive subjects with abdominal obesity...
  44. doi request reprint A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    Toshimasa Yamauchi
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:864-8. 2010
    ..78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D...
  45. doi request reprint Elevated serum adiponectin level in patients with Mycobacterium avium-intracellulare complex pulmonary disease
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Respiration 79:383-7. 2010
    ..Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-alpha, and IL-6...
  46. pmc Genome-wide association study of pancreatic cancer in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, Department of Medical Genome Sciences, Graduate School of Frontier Scineces, The University of Tokyo, National Cancer Center Hospital, Tokyo, Japan
    PLoS ONE 5:e11824. 2010
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer...
  47. ncbi request reprint Two types of unsafe drinker judged to have metabolic syndrome: typical metabolic syndrome or alcohol-related syndrome?
    Hirokazu Yokoyama
    Health Center, Keio University, Tokyo, Japan
    Med Sci Monit 15:PH57-64. 2009
    ..Hypertension, hyperlipidemia, and hyperglycemia often occur in drinkers regardless of obesity. Thus, the diagnostic criteria of metabolic syndrome (MS) may judge some drinkers as having MS even when typical MS is absent...
  48. doi request reprint His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk
    Shumpei Ohnami
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:477-88. 2008
    ..This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis...
  49. ncbi request reprint Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 78:182-8. 2007
    ..Therefore, in the present study we investigated the relationship between the P/I ratio, glycation and oxidative stress markers in patients with T2DM, using newly developed intact chemiluminescent immunoassay for proinsulin...
  50. ncbi request reprint High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men
    Yoshie Seino
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 56:1493-9. 2007
    ....
  51. ncbi request reprint Relationship between waist circumferences measured at the umbilical level and midway between the ribs and iliac crest - a solution to the debate on optimal waist circumference standards in the diagnostic criteria of metabolic syndrome in Japan
    Hirokazu Yokoyama
    Health Center, Keio University, Yokohama, Japan
    J Atheroscler Thromb 18:735-43. 2011
    ....
  52. ncbi request reprint Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:328-31. 2003
    ..The SDF-1 gene polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 gene polymorphism affects the onset age in type 1 diabetes in general...
  53. ncbi request reprint Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 56:83-92. 2002
    ..These results suggest that insulin secretion from the rat insulinoma cell line, INS-1, is modulated by troglitazone, acting somewhere in the ATP-sensitive K(+) channel pathway, possibly through PPAR gamma...
  54. ncbi request reprint Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk
    Tokuki Sakiyama
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 114:730-7. 2005
    ..The present results suggest that these 4 SNPs function as genetic factors underlying lung cancer susceptibility by modulating activities to maintain the genome integrity of each individual...
  55. doi request reprint Palmitic acid-rich diet suppresses glucose-stimulated insulin secretion (GSIS) and induces endoplasmic reticulum (ER) stress in pancreatic islets in mice
    Takumi Hirata
    a Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Endocr Res 41:8-15. 2016
    ..05). TUNEL-positive β-cells were not detected in all groups. Dietary palmitic acid-supplementation for 2 weeks might suppress GSIS and induce ER stress in pancreatic islets in mice, in the early stage of lipotoxicity. ..
  56. doi request reprint Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery
    Hiroshi Nakatani
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 58:1400-7. 2009
    ..These hormonal changes might explain the mechanism(s) of improved glucose tolerance after bariatric surgery in morbidly obese subjects...
  57. doi request reprint Use of home blood pressure monitoring and exercise, diet and medication compliance in Japan
    Ikuo Saito
    Keio University Health Center, Yokohama, Japan
    Clin Exp Hypertens 32:210-3. 2010
    ..Compared to patients with poor adherence to HBPM, patients with satisfactory adherence to HBPM were more likely to have satisfactory compliance with exercise, diet and medication but no significant difference in BP control...
  58. ncbi request reprint OS 33-01 RELATIONSHIPS OF VISCERAL FAT AREA AND INSULIN RESISTANCE INDEX WITH BLOOD PRESSURE STATUS
    Hiroshi Hirose
    1Department of Internal Medicine, Health Center, Keio University, Japan 2Department of Internal Medicine, Center for Preventive Medicine, Keio University Hospital, Japan
    J Hypertens 34:e393. 2016
    ..We investigated the relationships of blood pressure (BP) status with various metabolic parameters, including VFA, subcutaneous fat area (SFA) and HOMA-IR, in participants in our health checkup program...
  59. ncbi request reprint [Apolipoprotein E deficiency associated with type III hyperlipoproteinemia--analysis of apolipoprotein E]
    Hideko Tsukamoto
    Department of Clinical Laboratory, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582
    Rinsho Byori 54:121-5. 2006
    ..No manifestations associated with arteriosclerotic disease other than mild xanthomas have been observed...
  60. ncbi request reprint Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes
    Yoshiko Motohashi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 88:3137-40. 2003
    ..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes...
  61. doi request reprint Effects of Aging on Visceral and Subcutaneous Fat Areas and on Homeostasis Model Assessment of Insulin Resistance and Insulin Secretion Capacity in a Comprehensive Health Checkup
    Hiroshi Hirose
    Health Center, Keio University
    J Atheroscler Thromb 23:207-15. 2016
    ....
  62. ncbi request reprint Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
    Hiroshi Hirose
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 51:314-7. 2002
    ..It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level...
  63. doi request reprint Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study
    Kazuaki Shimamoto
    Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 31:469-78. 2008
    ..BP was controlled below 140/90 mmHg in a half of the very elderly hypertensive patients in this study, and these patients also had a lower incidence of CV events...
  64. doi request reprint Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
    Hiromi Sakamoto
    Nat Genet 40:730-40. 2008
    ..90, 95% CI = 1.56-2.33, P = 8.01 x 10(-11)). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer...
  65. ncbi request reprint PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine and Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo
    Metabolism 51:1407-9. 2002
    ..It is suggested that the Pro12Ala polymorphism of the PPAR(gamma)2 gene may reduce serum adiponectin level in the Japanese population...
  66. doi request reprint Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
    Robert Nakayama
    Genetics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:333-9. 2008
    ....
  67. ncbi request reprint [Fatty acid binding protein-2 (FABP2) gene polymorphism in diabetes]
    Tatsuya Ishii
    Department of Internal Medicine, Tokyo Saiseikai Mukojima Hospital
    Nihon Rinsho 63:185-8. 2005
  68. ncbi request reprint Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    Shintaro Omori
    Laboratory for Diabetic Nephropathy, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetes 57:791-5. 2008
    ....
  69. ncbi request reprint Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
    Shiro Maeda
    Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Research, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    J Hum Genet 50:283-92. 2005
    ..These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes...
  70. ncbi request reprint Role of serotonergic mechanisms in leptin-induced suppression of milk intake in mice
    Jun Yamada
    Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita machi, Higashinada ku, 658 8558 Kobe, Japan
    Neurosci Lett 348:195-7. 2003
    ..Therefore, leptin-induced hypophagic effects may be mediated by enhancement of serotonergic neurons, resulting in activation of the 5-HT(2B/2C) receptor...
  71. ncbi request reprint Nitric oxide production in hypothalamus of 2-deoxy-D-glucose-treated and food deprived mice
    Jun Yamada
    Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Neurosci Lett 327:107-10. 2002
    ..These results suggest that NO production in the hypothalamus does not increase in 2-DG-elicited hyperphagia and that food deprivation reduces hypothalamic NO, probably by inhibiting NO synthase...
  72. ncbi request reprint Optic nerve atrophy after vitrectomy with indocyanine green-assisted internal limiting membrane peeling in diffuse diabetic macular edema. Adverse effect of ICG-assisted ILM peeling
    Fumitaka Ando
    EyeCare Nagoya, Nagoya Dia Building 3, Meieki 3 13 15, Nakamura ku, 450 0002 Nagoya, Japan
    Graefes Arch Clin Exp Ophthalmol 242:995-9. 2004
    ..To report anatomic and visual outcomes of vitrectomy and indocyanine green (ICG)-assisted peeling of the retinal internal limiting membrane (ILM) in the treatment of diffuse diabetic macular edema...
  73. ncbi request reprint Leptin inhibits food intake without affecting brain NOx levels in food-deprived mice
    Yumi Sugimoto
    Department of Pharmacology, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Biol Pharm Bull 26:105-7. 2003
    ..These results suggest that leptin reduces food intake in food-deprived mice without altering NO production in the hypothalamus, which plays an important role in regulation of feeding...