Toshifumi Hibi

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Endoscopic management of pancreatic duct injury by endoscopic stent placement: a case report and literature review
    Yasuhiro Ito
    Department of Surgery, Saiseikai Yokohamashi Tobu Hospital, 3 6 1, Shimosueyoshi, Tsurumi ku, Yokohama shi, Kanagawa, 230 8765, Japan
    World J Emerg Surg 7:21. 2012
  2. pmc A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature
    Takeyuki Wada
    Department of Surgery, Eiju General Hospital 2 23 16 Higashiueno Taitouku Tokyo 110 8645 Japan
    World J Surg Oncol 9:100. 2011
  3. pmc Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Crit Care 14:R159. 2010
  4. pmc Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities
    Hiroaki Yokomori
    Division of Gastroenterology of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Saitama, Japan
    BMC Gastroenterol 10:131. 2010
  5. ncbi request reprint Gastrointestinal cancer and sentinel node navigation surgery
    Yuko Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    J Surg Oncol 79:188-93. 2002
  6. ncbi request reprint Radio-guided sentinel node detection for gastric cancer
    Y Kitagawa
    Departments of Surgery, Radiology and Pathology, Keio University, Tokyo, Japan
    Br J Surg 89:604-8. 2002
  7. ncbi request reprint Significance of metastasis detected by molecular techniques in sentinel nodes of patients with gastrointestinal cancer
    Jun ichi Matsuda
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Ann Surg Oncol 11:250S-4S. 2004
  8. ncbi request reprint Sentinel node for gastrointestinal malignancies
    Yuko Kitagawa
    Department of Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Surg Oncol Clin N Am 16:71-80. 2007
  9. ncbi request reprint Current status and future prospects of sentinel node navigational surgery for gastrointestinal cancers
    Yuko Kitagawa
    Departments of Surgery, Keio University School of Medicine, Tokyo, Japan
    Ann Surg Oncol 11:242S-4S. 2004
  10. ncbi request reprint Sentinel node navigation in early stage gastric cancer--updated data and current status
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Scand J Surg 95:256-9. 2006

Collaborators

Detail Information

Publications183 found, 100 shown here

  1. pmc Endoscopic management of pancreatic duct injury by endoscopic stent placement: a case report and literature review
    Yasuhiro Ito
    Department of Surgery, Saiseikai Yokohamashi Tobu Hospital, 3 6 1, Shimosueyoshi, Tsurumi ku, Yokohama shi, Kanagawa, 230 8765, Japan
    World J Emerg Surg 7:21. 2012
    ..A pancreatic stent is useful for pancreatic ductal injury. If pancreatic ductal injury is managed appropriately, a pancreatic stent may improve the clinical condition, and also prevent unnecessary surgery...
  2. pmc A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature
    Takeyuki Wada
    Department of Surgery, Eiju General Hospital 2 23 16 Higashiueno Taitouku Tokyo 110 8645 Japan
    World J Surg Oncol 9:100. 2011
    ..The patient recovered uneventfully. Two months after the operation, multiple metastases occurred in the liver. He died 4 months after the operation...
  3. pmc Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Crit Care 14:R159. 2010
    ....
  4. pmc Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities
    Hiroaki Yokomori
    Division of Gastroenterology of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Saitama, Japan
    BMC Gastroenterol 10:131. 2010
    ..This study was undertaken to elucidate hepatic lymphatic vessels during progression of cirrhosis by examining the expression of D2-40 in LECs...
  5. ncbi request reprint Gastrointestinal cancer and sentinel node navigation surgery
    Yuko Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    J Surg Oncol 79:188-93. 2002
    ..Lymphatic mapping techniques are now used in the control of superficial malignancies, such as malignant melanoma and breast cancer, providing a novel tool that may also be of use for gastrointestinal cancers...
  6. ncbi request reprint Radio-guided sentinel node detection for gastric cancer
    Y Kitagawa
    Departments of Surgery, Radiology and Pathology, Keio University, Tokyo, Japan
    Br J Surg 89:604-8. 2002
    ..However, the validity of the SN hypothesis is still controversial for gastrointestinal cancers including gastric cancer. The aim of this study was to test the feasibility and accuracy of radio-guided mapping of SNs for gastric cancer...
  7. ncbi request reprint Significance of metastasis detected by molecular techniques in sentinel nodes of patients with gastrointestinal cancer
    Jun ichi Matsuda
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Ann Surg Oncol 11:250S-4S. 2004
    ..These findings suggest that nodal micrometastasis detected by nested RT-PCR has some clinical significance in GI cancer. Molecular assessment of the SN may be a valuable tool to complement routine histological examination for GI cancers...
  8. ncbi request reprint Sentinel node for gastrointestinal malignancies
    Yuko Kitagawa
    Department of Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Surg Oncol Clin N Am 16:71-80. 2007
    ..A combination of SN mapping and endoscopic surgery will contribute to the improvement in quality of life after surgical treatment of GI cancer...
  9. ncbi request reprint Current status and future prospects of sentinel node navigational surgery for gastrointestinal cancers
    Yuko Kitagawa
    Departments of Surgery, Keio University School of Medicine, Tokyo, Japan
    Ann Surg Oncol 11:242S-4S. 2004
    ..Large-scale multicenter prospective validation studies for SN mapping in GI cancer are essential. If these remaining issues can be solved, SN mapping for GI cancer will have great clinical impact...
  10. ncbi request reprint Sentinel node navigation in early stage gastric cancer--updated data and current status
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Scand J Surg 95:256-9. 2006
  11. ncbi request reprint Recent advances in sentinel node navigation for gastric cancer: a paradigm shift of surgical management
    Yuko Kitagawa
    Department of Surgery, Keio University, School of Medicine, Shinanomachi, Tokyo, Japan
    J Surg Oncol 90:147-51; discussion 151-2. 2005
    ..Although there are several remaining issues, SN navigation should provide a paradigm shift for the surgical management of early gastric cancer in near future...
  12. ncbi request reprint Gastroesophageal carcinoma: individualized surgical therapy
    Yuko Kitagawa
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Surg Oncol Clin N Am 15:793-802. 2006
    ..A novel technology to detect micrometastasis without extensive surgical resection is required to gastroesophageal carcinoma. The lymphatic mapping technique is one of the attractive candidates for a novel tool to approach this issue...
  13. ncbi request reprint Endoscopic treatment combined with laparoscopic sentinel node mapping for superficial gastrointestinal cancers
    Y Kitagawa
    Department of Surgery, Keio University, School of Medicine, Tokyo, Japan
    Endoscopy 39:471-5. 2007
  14. ncbi request reprint Intraoperative lymphatic mapping and sentinel lymph node sampling in esophageal and gastric cancer
    Yuko Kitagawa
    Department of Surgery, Keio University School of Medicine 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582
    Surg Oncol Clin N Am 11:293-304. 2002
    ..Well-designed clinical trials of lymphatic mapping for upper GI cancer will be essential to determine whether this technique is widely applicable in the management of these tumors...
  15. doi request reprint Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset
    Yasuhiro Takada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 184:2671-6. 2010
    ..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
  16. doi request reprint IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis
    Kaori Kameyama
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 40:2423-36. 2010
    ..These results show that IL-2 is critically involved in the establishment and maintenance of IL-7-dependent colitogenic memory CD4(+)IL-7R alpha(high) T cells...
  17. doi request reprint Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis
    Yohei Mikami
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Eur J Immunol 40:2409-22. 2010
    ....
  18. doi request reprint TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease
    Nobuhiko Kamada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 16:568-75. 2010
    ..In addition to Th1, recent studies have focused on the role of Th17 cells in the pathogenesis of CD. Here we tried to clarify the role of TL1A in Th1 and Th17 immunity in CD...
  19. ncbi request reprint Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells
    Hiroshi Chinen
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Gastroenterology 133:559-73. 2007
    ..Recent studies have revealed that murine intestinal mucosa contains several kinds of lineage markers (lin)(-) c-kit(+) immune precursor cells. However, immune precursors in the human adult intestine have not been studied extensively...
  20. ncbi request reprint Butter feeding enhances TNF-alpha production from macrophages and lymphocyte adherence in murine small intestinal microvessels
    Yoichi Fujiyama
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 22:1838-45. 2007
    ..The objective of this study was to assess the effect of butter feeding on lymphocyte migration in intestinal mucosa and the changes in adhesion molecules and cytokines involved in this effect...
  21. doi request reprint Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice
    Hitoshi Ichikawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 14:1483-90. 2008
    ..In this study we aimed to examine whether tetomilast could be a novel drug for inflammatory bowel diseases by further clarifying its antiinflammatory effects...
  22. doi request reprint MyD88-dependent interleukin-10 production from regulatory CD11b⁺Gr-1(high) cells suppresses development of acute cerulein pancreatitis in mice
    Yuji Koike
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Immunol Lett 148:172-7. 2012
    ..These results provide a new concept for therapeutic strategies against acute pancreatitis...
  23. ncbi request reprint Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis
    Kumi Kitamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 22:2022-33. 2007
    ..In this study, the involvement of the Rho/Rho kinase pathway on angiotensin II signaling in liver fibrogenesis and generation of steatosis was investigated...
  24. doi request reprint Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability
    Nobuhiko Kamada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 183:1724-31. 2009
    ..These observations highlight a role for LP Mphi in the enhanced Th1, and potentially in Th17 differentiation, at the inflammatory site of inflammatory bowel diseases...
  25. doi request reprint Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease
    Tetsuro Takayama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Gastroenterology 139:882-92, 892.e1-3. 2010
    ..However, their role in the pathogenesis of human inflammatory bowel diseases (IBDs) is not known. We investigated intestinal NK cells in intestinal mucosa samples of patients with Crohn's disease (CD)...
  26. doi request reprint IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 39:2737-47. 2009
    ..They also provide a basis for the timing of IL-7/IL-7R blockade for the treatment of inflammatory bowel diseases...
  27. pmc On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula
    Hidetsugu Saito
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 1608582, Japan
    World J Gastroenterol 16:89-97. 2010
    ..To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C...
  28. doi request reprint Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients
    Jun Miyoshi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan Department of Gastroenterology and Hepatology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
    J Crohns Colitis 7:e609-14. 2013
    ..Oral administration of tacrolimus is an effective remission induction therapy for steroid-refractory/dependent ulcerative colitis (UC)...
  29. doi request reprint The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Int J Cancer 132:1751-60. 2013
    ..Selective COX-2 inhibitors may have clinical promise for the treatment of gastric cancer via restoration of miR-29c...
  30. pmc TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
    Kazuaki Yoneno
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Immunology 139:19-29. 2013
    ..In isolated intestinal CD14(+) Mϕs, a TGR5 agonist could inhibit tumour necrosis factor-α production. These results indicate that TGR5 signalling may have the potential to modulate immune responses in inflammatory bowel disease...
  31. pmc Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Antimicrob Agents Chemother 56:1643-5. 2012
    ..The position of the gyrA mutation (N87 or D91) was determined to be a better marker than MIC levels for predicting outcomes of sitafloxacin-based treatment...
  32. doi request reprint Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia
    Hiroyuki Imaeda
    Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 25:706-11. 2010
    ....
  33. doi request reprint Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion
    Ayano Kabashima
    Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Cancer 124:2771-9. 2009
    ..EMT/MET, micro-invasion, and in vivo metastasis, as compared to MP cells. Because micro-invasion and metastasis are key mechanisms of cancer malignant potential, SP cells would be the attractive target for preventing cancer progression...
  34. doi request reprint Intermittent granulocyte and monocyte apheresis versus mercaptopurine for maintaining remission of ulcerative colitis: a pilot study
    Atsushi Sakuraba
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, School of Medicine, Keio University, Tokyo, Japan
    Ther Apher Dial 16:213-8. 2012
    ..Intermittent therapy with GMA was well tolerated and a substantial proportion of patients maintained remission. Intermittent GMA therapy in maintaining remission of UC merits further investigation...
  35. ncbi request reprint Cyclooxygenase-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo
    Nobuhiro Nakamoto
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Int J Oncol 29:625-35. 2006
    ..In conclusion, NS-398 is sufficient to overcome IFN resistance in hepatoma cells through the TRAIL/TRAIL receptor pathway, therefore, the combination would appear to be a new therapeutic regimen for HCC...
  36. doi request reprint Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages
    Ayatoshi Andou
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Gastroenterology 136:564-74.e2. 2009
    ..Although some of this effectiveness may be due to its low antigenic load and low fat content, the mechanisms remain unclear. We sought to assess the role of histidine, one of the constituent amino acids of ED, in controlling colitis...
  37. pmc Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
    Nobuhiko Kamada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Clin Invest 118:2269-80. 2008
    ..Collectively, these data suggest that this IL-23/IFN-gamma-positive feedback loop induced by abnormal intestinal macrophages contributes to the pathogenesis of chronic intestinal inflammation in patients with CD...
  38. doi request reprint Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori
    Kenro Hirata
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S75-9. 2010
    ..At least four gene clusters have been identified as efflux pump systems in H. pylori and the present study was designed to investigate their role in the CLR resistance of clinical isolates of H. pylori...
  39. doi request reprint Gatifloxacin-based triple therapy as a third-line regimen for Helicobacter pylori eradication
    Toshihiro Nishizawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S167-70. 2008
    ..pylori) eradication, according to the assessment of the susceptibility to GAT and gyrA mutation...
  40. doi request reprint Serum immunoglobulin a concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage
    Kengo Tomita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dig Dis Sci 56:3648-54. 2011
    ..We aimed to determine whether serum IgA concentrations allow a diagnosis of liver fibrosis in NASH...
  41. ncbi request reprint Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis
    Yuichi Morohoshi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Gastroenterol 41:318-24. 2006
    ....
  42. doi request reprint Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice
    Tango Handa
    Department of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Immunol Lett 150:123-9. 2013
    ..These results demonstrate that DCs actively communicate across the intestinal barrier, and highlight a potential technique for controlling colonic immune tolerance...
  43. pmc Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 7:e47396. 2012
    ..These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma...
  44. doi request reprint T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice
    Yuichi Ono
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Gastroenterology 143:1288-97. 2012
    ..We investigated their development and functions in intestines of mice...
  45. pmc Rapid detection of point mutations conferring resistance to fluoroquinolone in gyrA of Helicobacter pylori by allele-specific PCR
    Toshihiro Nishizawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Microbiol 45:303-5. 2007
    ..Moreover, genotyping by AS-PCR took less than 3 to 4 h. The AS-PCR method for the detection of gyrA mutations in H. pylori is useful for easy identification of fluoroquinolone-resistant strains of H. pylori...
  46. doi request reprint Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells
    Yasuyo Wada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Inflamm Bowel Dis 15:1548-56. 2009
    ..In the present study we focused on the effect of RA on the differentiation of the DC, and tried to clarify the role of DCs induced by RA in a murine colitis model...
  47. doi request reprint Past rifampicin dosing determines rifabutin resistance of Helicobacter pylori
    Shoji Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Digestion 79:1-4. 2009
    ....
  48. doi request reprint A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis
    Atsushi Sakuraba
    Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Gastroenterol 43:51-6. 2008
    ..We performed a pilot open-labeled prospective, randomized, controlled study comparing weekly and an intensive treatment schedule with three treatment sessions per week in the first 2 weeks...
  49. doi request reprint Reactivation of hepatitis B in a patient with Crohn's disease treated using infliximab
    Keisuke Ojiro
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 43:397-401. 2008
    ..However, liver dysfunction was not improved by lamivudine. Antiviral treatment should be considered before administration of infliximab for patients with HBV...
  50. doi request reprint Clinical results of observation of the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope
    Hiroyuki Imaeda
    Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 25:1850-4. 2010
    ..The aim of this study was to evaluate results for the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope...
  51. pmc An antioxidant resveratrol significantly enhanced replication of hepatitis C virus
    Mitsuyasu Nakamura
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 1608582, Japan
    World J Gastroenterol 16:184-92. 2010
    ..To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication...
  52. ncbi request reprint Effect of a herbal medicine on fatty liver in rats fed ethanol chronically
    Yoshinori Horie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 44:636-48. 2009
    ..The objective of this study was to determine whether Cardiotopic Pills (CP) affects fatty liver in rats fed ethanol chronically...
  53. doi request reprint CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion
    Yuji Nakamura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G700-7. 2013
    ..Collectively, the CCR2/CCL2 axis-mediated CD11b(+)-cell migration to the pancreas is critically involved in chronic pancreatitis-mediated hyperglycemia through the modulation of GLP-1 receptor expression and insulin secretion...
  54. ncbi request reprint Macrophage-derived IL-18 targeting for the treatment of Crohn's disease
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Curr Drug Targets Inflamm Allergy 2:131-6. 2003
    ..We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease...
  55. pmc IL-22-producing RORγt-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis
    Atsuhiro Matsumoto
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e62853. 2013
    ..1 mAb or anti-asialo GM1 Ab administration exacerbated liver damage in RAG-2(-/-) mice with the depletion of liver ILCs. Collectively, hepatic RORγt-dependent ILCs play a part of protective roles in hepatic immune response in mice...
  56. ncbi request reprint AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats
    Kengo Tomita
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Alcohol Clin Exp Res 29:240S-5S. 2005
    ..In this study, we examined the effects of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an AMPK activator, on an experimental model of ethanol-induced hepatic steatosis...
  57. doi request reprint A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis
    Yoshiyuki Yamagishi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 44:615-23. 2009
    ..We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess the value of liver volumetry and to generate a new prognostic formula...
  58. doi request reprint CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice
    Shinta Mizuno
    Department of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Immunol Lett 146:64-9. 2012
    ..These results suggest that CCR9(+) pDCs are possibly small, regulatory, antigen-presenting cells of the intestine that suppress intestinal inflammation...
  59. doi request reprint Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis
    Kayoko Kimura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 427:694-700. 2012
    ..Collectively, not only the presence of ILC22 cells but also the balance of protective and pathogenic ILCs may be involved in the prevention of colitis...
  60. ncbi request reprint Chemoresistance is associated with cancer stem cell-like properties and epithelial-to-mesenchymal transition in pancreatic cancer cells
    Motoko Izumiya
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Anticancer Res 32:3847-53. 2012
    ..The aim of this study was to evaluate whether apoptosis-resistant cancer cells have cancer stem cell (CSC)-like properties...
  61. doi request reprint CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice
    Keita Saeki
    Department of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan
    Gastroenterology 142:1010-1020.e9. 2012
    ..We investigated the pathologic roles of innate immune cells, especially macrophages, in cerulein- and L-arginine-induced acute pancreatitis in mice...
  62. doi request reprint FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach
    Hitoshi Tsugawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Free Radic Biol Med 52:1003-10. 2012
    ..pylori through Fe(2+) supply to SodB, suggesting that FecA1 may be a possible target for the development of a novel bactericidal drug...
  63. pmc Prediction of effect of pegylated interferon alpha-2b plus ribavirin combination therapy in patients with chronic hepatitis C infection
    Tetsuro Takayama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    PLoS ONE 6:e27223. 2011
    ..In conclusion, ANN was more accurate than MLRs in predicting the outcome of PEGIFN plus RBV therapy in patients with group 1b HCV...
  64. pmc Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease
    Tadakazu Hisamatsu
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e31131. 2012
    ..In order to facilitate the diagnosis of IBD and assess its disease activity, we investigated the potential of novel multivariate indexes using statistical modeling of plasma amino acid concentrations (aminogram)...
  65. doi request reprint Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease
    Takanori Kanai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Opin Gastroenterol 25:306-13. 2009
    ..We also discuss the close correlation between colitogenic Th17-type CD4+ T cells and inducible CD4+CD25+Foxp3+ regulatory T cells...
  66. doi request reprint Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Colorectal Cancer 10:134-41. 2011
    ..This study aimed to build a predictive model for the development of UC-Ca based on gene expression levels measured by reverse-transcription polymerase chain reaction (RT-PCR) analysis in nonneoplastic rectal mucosa...
  67. doi request reprint Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Gastroenterology 140:189-98. 2011
    ..Little is known about the pathogenic mechanisms of functional dyspepsia. We investigated the role of microRNAs (miRNAs) in gastric motility disorders associated with Helicobacter pylori infection...
  68. doi request reprint Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients
    Makoto Naganuma
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 45:936-43. 2010
    ..The usefulness of the EAI for choosing treatment options, such as intravenous corticosteroid or cyclosporine A (CsA), in severe UC patients was also evaluated...
  69. doi request reprint Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice
    Masanobu Nanno
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Gastroenterology 134:481-90. 2008
    ..Interestingly, there is a significant increase in gammadelta T cells in the inflamed mucosa of patients with ulcerative colitis (UC). However, the role of gammadelta T cells in chronic colitis has not been fully identified...
  70. ncbi request reprint [A case of metastatic esophageal cancer - endoscopic resection of the primary site following systemic chemotherapies]
    Motoko Izumiya
    Dept of Gastroenterology and Hepatology, Keio University, Japan
    Gan To Kagaku Ryoho 38:1167-70. 2011
    ..This patient has had no recurrence for four years since his initial diagnosis...
  71. ncbi request reprint Hepatocellular carcinoma in Keio affiliated hospitals--diagnosis, treatment, and prognosis of this disease
    Hidetsugu Saito
    Inaida Research Center for Anti aging Medicine in Hepato Gastroenterology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 58:161-75. 2009
    ..Antiviral therapies have decreased the incidence of HCC, indicating that treatment for chronic hepatitis is the best way to prevent HCC development at present...
  72. doi request reprint Evaluating the severity of nonalcoholic steatohepatitis with superparamagnetic iron oxide-enhanced magnetic resonance imaging
    Kengo Tomita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Magn Reson Imaging 28:1444-50. 2008
    ..To evaluate the utility of noninvasive assessment of human nonalcoholic fatty liver disease (NAFLD) patients using superparamagnetic iron oxide (SPIO)-enhanced MRI...
  73. ncbi request reprint Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria
    Nobuhiko Kamada
    Department of Internal Medicine, School of Medicine, Keio University, Japan
    J Immunol 175:6900-8. 2005
    ..Our data provide new insights into the intestinal Mphi to gut flora relationship in the development of colitis in IL-10-/- mice...
  74. ncbi request reprint Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication
    Tatsuhiro Masaoka
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hepatogastroenterology 52:1-4. 2005
    ..pylori eradication therapy, the observations suggesting that reduction of plasma ghrelin levels cannot be achieved merely by H. pylori eradication, without resolution of the gastric atrophy...
  75. ncbi request reprint Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: a novel and minimally invasive approach
    Y Kitagawa
    Department of Surgery, Keio University, Tokyo, Japan
    Ann Surg Oncol 8:86S-89S. 2001
    ....
  76. ncbi request reprint The role of the sentinel lymph node in gastrointestinal cancer
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Surg Clin North Am 80:1799-809. 2000
    ....
  77. doi request reprint Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty
    Naoteru Miyata
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Pancreas 41:745-52. 2012
    ....
  78. ncbi request reprint Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout
    Mamoru Arakawa
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Gastroenterol 42:711-8. 2007
    ..The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout...
  79. doi request reprint Etiological difference between ultrashort- and short-segment Barrett's esophagus
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 46:332-8. 2011
    ..While both LSBE and SSBE are thought to be induced by gastroesophageal reflux, the etiology of USBE is still unclear...
  80. ncbi request reprint Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis
    Shigeo Yoshizawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 13:865-73. 2007
    ..Here we evaluated clinical usefulness of the measurement of anti-p53 antibodies (Abs) by enzyme-linked immunosorbent assay (ELISA) using sera samples from UC patients...
  81. doi request reprint MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis
    Keisuke Ojiro
    Department of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 399:744-9. 2010
    ....
  82. ncbi request reprint Is chemoradiation effective or harmful for stage VI gastric cancer patients?
    Yoshiro Saikawa
    Department of Surgery, School of Medicine, Keio University, 35 Sinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Oncol Rep 13:865-70. 2005
    ..Chemoradiation may be a powerful regimen for obtaining histological response with tolerable toxicity and improved QOL in highly advanced gastric cancer patients...
  83. doi request reprint Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis
    Taku Kobayashi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Gastroenterol 45:1129-37. 2010
    ..In this study, we evaluated the overall experience with CSA treatment in UC patients, from their initial response to long-term prognosis...
  84. pmc Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia
    Miho Kikuchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    BMC Gastroenterol 10:65. 2010
    ..Lineage cells in the gastric mucosa are derived from progenitor cells, but this process can be altered after injury. Therefore, we explored DCAMKL1 expression under pathological conditions...
  85. ncbi request reprint Value of computed tomography-derived estimated liver volume/standard liver volume ratio for predicting the prognosis of adult fulminant hepatic failure in Japan
    Yoshiyuki Yamagishi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 20:1843-9. 2005
    ..The aim of this study was to assess the clinical value of the estimated liver volume (ELV) compared to the standard liver volume (SLV) in patients with FHF...
  86. doi request reprint Plasma free myristic acid proportion is a predictor of nonalcoholic steatohepatitis
    Kengo Tomita
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Dig Dis Sci 56:3045-52. 2011
    ..Therefore, we determined if the serum FFA composition can provide accurate diagnosis of NASH...
  87. doi request reprint Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome
    Eisuke Iwasaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medcine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S216-21. 2008
    ..The present study was designed to investigate the effect of metabolic disorders including obesity on the levels of functional gastroesophageal reflux by videoesophagography...
  88. doi request reprint Non-sentinel lymph node status and prognosis of breast cancer patients with micrometastatic sentinel lymph nodes
    T Onishi
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Eur Surg Res 45:344-9. 2010
    ..The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial...
  89. ncbi request reprint Further evidence that altered p16/CDKN2 gene expression is associated with lymph node metastasis in squamous cell carcinoma of the esophagus
    H Takeuchi
    Department of Surgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan
    Oncol Rep 8:627-32. 2001
    ..These results also suggest that tumor cells in metastatic lymph nodes may have more aggressive proliferation and higher malignant potential than tumor cells in primary lesions...
  90. ncbi request reprint Outlining the body contours with scattered photons in lymphoscintigraphy for sentinel nodes
    H Fujii
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    Ann Nucl Med 14:401-4. 2000
    ..The results of this study confirm that images obtained from scattered photons on lymphoscintigraphy are helpful in identifying the anatomical location of sentinel nodes...
  91. doi request reprint Medium-term results of neoadjuvant systemic chemotherapy using irinotecan, 5-fluorouracil, and leucovorin in patients with locally advanced rectal cancer
    Y Ishii
    Department of Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Eur J Surg Oncol 36:1061-5. 2010
    ....
  92. ncbi request reprint [Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer]
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Nippon Geka Gakkai Zasshi 102:753-7. 2001
    ..Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer...
  93. doi request reprint A phase II trial of capecitabine and docetaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (FEC) as preoperative treatment in women with stage II/III breast cancer
    H Jinno
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Ann Oncol 21:1262-6. 2010
    ..This study's purpose was to determine the efficacy of X and T followed by 5-fluorouracil/epirubicin/cyclophosphamide (FEC) in the preoperative setting...
  94. doi request reprint Preoperative lymphoscintigraphy for detection of sentinel lymph node in patients with gastric cancer--initial experience
    Tadaki Nakahara
    Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Ann Surg Oncol 15:1447-53. 2008
    ..Preoperative lymphoscintigraphy may be informative when assessing nodal status in patients with early gastric cancer, especially for surgeons who are scheduled to introduce or have just introduced SLN biopsy...
  95. ncbi request reprint Development of targeted therapy with paclitaxel incorporated into EGF-conjugated nanoparticles
    Toshiyuki Shimada
    Department of Surgery, Keio University School of Medicine, Tokyo, 160 8582, Japan
    Anticancer Res 29:1009-14. 2009
    ..A new targeted therapy has been developed by conjugating epidermal growth factor (EGF) to MPC polymer and its growth inhibitory and antitumor effects on cancer cells overexpressing EGF receptors (EGFR) has been investigated...
  96. ncbi request reprint Serum concentrations of high-mobility group box chromosomal protein 1 before and after exposure to the surgical stress of thoracic esophagectomy: a predictor of clinical course after surgery?
    K Suda
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Dis Esophagus 19:5-9. 2006
    ..Postoperative serum HMGB-1 concentrations were higher in patients who developed complications, and may be a predictive marker for complications in this setting...
  97. ncbi request reprint [Appropriate extent of lymphadenectomy in esophageal cancer]
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Nippon Geka Gakkai Zasshi 102:477-83. 2001
    ..Individualized surgical management of patients with esophageal cancer is essential to improve the quality of life of patients and long-term results...
  98. pmc Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years
    N Ando
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Ann Surg 232:225-32. 2000
    ....
  99. ncbi request reprint Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines
    M Osaku
    Department of Surgery, Kitasato Institute Hospital, Tokyo 108 8642, Japan
    Oncol Rep 8:855-60. 2001
    ..These observations suggest that EGF receptor expression is closely associated with the cytotoxic effect of PEP on SCC cells...
  100. doi request reprint Octreotide acetate successfully treated a bowel obstruction caused by peritoneally disseminated gastric cancer, thereby enabling the subsequent use of oral S-1 chemotherapy
    Koshi Kumagai
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Int J Clin Oncol 14:372-5. 2009
    ..She was discharged 2 months after admission. Seven months after beginning the chemotherapy, she was still doing well on outpatient chemotherapy with S-1 and CDDP, and had no decline in her quality of life or progression of her disease...
  101. doi request reprint Factors influencing the long-term survival in patients with esophageal cancer who underwent esophagectomy after chemoradiotherapy
    Hiroya Takeuchi
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    World J Surg 34:277-84. 2010
    ..We hypothesize that severe postoperative complications may affect not only surgical mortality but also tumor recurrence and long-term survival for patients with salvage esophagectomy after definitive CRT...