Masayuki Amagai

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi request reprint Pemphigus vulgaris and its active disease mouse model
    Masayuki Amagai
    Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
    Curr Dir Autoimmun 10:167-81. 2008
  2. ncbi request reprint Desmoglein as a target in autoimmunity and infection
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, USA
    J Am Acad Dermatol 48:244-52. 2003
  3. pmc Autoimmune and infectious skin diseases that target desmogleins
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:524-37. 2010
  4. doi request reprint Post-IID 2008 International Meeting on autoimmune bullous diseases
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 128:2135-7. 2008
  5. doi request reprint The molecular logic of pemphigus and impetigo: the desmoglein story
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Vet Dermatol 20:308-12. 2009
  6. ncbi request reprint Non-pathogenic anti-desmoglein 3 IgG autoantibodies in Fogo Selvagem
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 126:1931-2. 2006
  7. ncbi request reprint Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 118:845-50. 2002
  8. ncbi request reprint Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism
    Takayuki Ota
    Department of Dermatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Int Immunol 16:1487-95. 2004
  9. pmc Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 179:795-806. 2011
  10. doi request reprint Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris
    Tsuyoshi Hata
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 63:33-9. 2011

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Pemphigus vulgaris and its active disease mouse model
    Masayuki Amagai
    Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
    Curr Dir Autoimmun 10:167-81. 2008
    ....
  2. ncbi request reprint Desmoglein as a target in autoimmunity and infection
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, USA
    J Am Acad Dermatol 48:244-52. 2003
    ..In SSSS, exfoliative toxin produced by Staphylococcus aureus specifically binds and cleaves desmoglein 1 with resultant blister formation at the identical site...
  3. pmc Autoimmune and infectious skin diseases that target desmogleins
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:524-37. 2010
    ..Further investigation of desmoglein molecules will continue to provide insight into the unsolved pathophysiological mechanisms of diseases and aid in the development of novel therapeutic strategies with minimal side effects...
  4. doi request reprint Post-IID 2008 International Meeting on autoimmune bullous diseases
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 128:2135-7. 2008
  5. doi request reprint The molecular logic of pemphigus and impetigo: the desmoglein story
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Vet Dermatol 20:308-12. 2009
    ....
  6. ncbi request reprint Non-pathogenic anti-desmoglein 3 IgG autoantibodies in Fogo Selvagem
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 126:1931-2. 2006
    ....
  7. ncbi request reprint Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 118:845-50. 2002
    ..These findings demonstrate that exfoliative toxin A and exfoliative toxin B cause blister formation in staphylococcal scalded skin syndrome and bullous impetigo by identical molecular pathophysiologic mechanisms...
  8. ncbi request reprint Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism
    Takayuki Ota
    Department of Dermatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Int Immunol 16:1487-95. 2004
    ..These results indicate that auto-reactive B cells against peripheral antigen (Dsg3) are able to develop in the presence of Dsg3 but are ignored by the immune system...
  9. pmc Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 179:795-806. 2011
    ..These findings provide an important framework for improved understanding of B-cell tolerance and the pathophysiology of blister formation in pemphigus...
  10. doi request reprint Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris
    Tsuyoshi Hata
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 63:33-9. 2011
    ..The B6-Dsg3(-/-) mice did not grow old enough to provide splenocytes, probably due to severe oral erosions, with resulting inhibition of food intake...
  11. ncbi request reprint Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 170:2170-8. 2003
    ..These findings demonstrate the pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes, and suggest the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus...
  12. ncbi request reprint Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Eur J Immunol 32:627-33. 2002
    ..These results suggest that loss of tolerance against Dsg3 in both B and T cells is important for the development of autoimmune state of PV...
  13. doi request reprint Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance
    Takayuki Ota
    Department of Dermatology, Keio University School of Medicine, Tokyo160 8582, Japan
    Int Immunol 20:1351-60. 2008
    ....
  14. ncbi request reprint Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris
    Hidemi Anzai
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 35:133-42. 2004
    ..We have recently developed an active disease mouse model for PV by adoptive transfer of splenocytes from immunized or naive Dsg3-/- mice into Rag2-/- recipient mice...
  15. ncbi request reprint IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1145-53. 2004
    ..These findings indicate that anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in PV...
  16. pmc Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome
    Takeshi Nagasaka
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Clin Invest 114:1484-92. 2004
    ..These findings suggest that Dsg4 may play a role other than adhesion and that the cross-reactivity of desmoglein autoantibodies should be factored into the framework of future studies of autoimmune mechanisms in pemphigus...
  17. pmc Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:888-99. 2005
    ..Detailed characterization of these pemphigus mAbs should lead to a better understanding of the immunopathogenesis of disease and to more specifically targeted therapeutic approaches...
  18. ncbi request reprint Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:5268-77. 2004
    ..These data suggest that the exquisite specificity and efficiency of ETA may depend on the enzyme's binding upstream of the cleavage site with a very specific fit, like a key in a lock...
  19. doi request reprint A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
    Takashi Sasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 132:1111-1120.e4. 2013
    ..These mice possess another recessive hair mutation, matted (ma), and develop spontaneous dermatitis under specific pathogen-free conditions, whereas genetically engineered Flg(-/-) mice do not...
  20. doi request reprint Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus
    Tsuyoshi Hata
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 191:83-90. 2013
    ..These findings demonstrate that squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in PNP. ..
  21. doi request reprint Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo
    Ophelia Veraitch
    Department of Dermatology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 133:1479-88. 2013
    ..The current study suggests a, to our knowledge, previously unrecognized advantage of using hiPSCs to enhance epithelial-mesenchymal interactions in HF bioengineering...
  22. doi request reprint Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice
    Hitoshi Saito
    Department of Dermatology, Saitama Municipal Hospital, 2460 Mimuro, Midori ku, Saitama shi, Saitama 336 8522, Japan
    J Dermatol Sci 55:108-15. 2009
    ..The desmoglein 3 (Dsg3) knockout mouse and pemphigus vulgaris (PV) mouse model present a similar type of supra-basal acantholysis, even though the subcellular mechanism is considered to be completely different...
  23. ncbi request reprint Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 181:1526-35. 2008
    ..This strategy is useful for evaluating the effector function of autoreactive T cells involved in the pathogenesis of various autoimmune diseases...
  24. doi request reprint Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation
    Koji Nishifuji
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 59:184-91. 2010
    ..ETs are known to cleave specifically a single peptide bond in the extracellular domains 3 and 4 of desmoglein (Dsg) 1. However, the precise mechanisms underlying ET-induced epidermal blister formation remain poorly understood...
  25. ncbi request reprint Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid
    Mariko Yoshida
    Department of Dermatology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 41:21-30. 2006
    ..We produced different recombinant glutathione-S-transferase-fusion proteins, which roughly presented N-terminal domain, central rod domain and C-terminal domain of human BP230...
  26. pmc Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome
    Takeshi Ouchi
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 208:2607-13. 2011
    ..Targeting this immunological process confers protection with minimal invasiveness and should have a marked impact on future strategies for development of percutaneous vaccines...
  27. ncbi request reprint In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris
    Ken Ishii
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 124:939-46. 2005
    ..These findings indicate that this dissociation assay will provide a simple and objective biological method to measure the pathogenic strength of pemphigus autoantibodies...
  28. ncbi request reprint Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy
    Manabu Ohyama
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 120:610-5. 2003
    ....
  29. ncbi request reprint Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arch Dermatol Res 294:318-23. 2002
    ....
  30. ncbi request reprint Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation
    Hiroshi Kawasaki
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 126:2621-30. 2006
    ..These mAbs will provide a valuable tool to investigate the molecular mechanisms of blister formation, mimicking the effects of the polyclonal IgG antibodies found in patients...
  31. doi request reprint Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance
    Naoko Wada
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 131:410-7. 2011
    ..These findings indicate that Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus...
  32. ncbi request reprint Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model
    Miyo Aoki-Ota
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 126:105-13. 2006
    ....
  33. doi request reprint Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis
    Kazue Yoshida
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Dermatol Sci 71:89-99. 2013
    ..We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined...
  34. pmc Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
    Keisuke Nagao
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Nat Immunol 13:744-52. 2012
    ..Pre-LCs failed to enter hairless skin in mice or humans, which establishes hair follicles as portals for LCs...
  35. doi request reprint Epitope spreading is rarely found in pemphigus vulgaris by large-scale longitudinal study using desmoglein 2-based swapped molecules
    Bungo Ohyama
    Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan
    J Invest Dermatol 132:1158-68. 2012
    ..These results suggest that, after onset, intramolecular and intermolecular epitope spreading among extracellular domains on Dsg3 and Dsg1 is rare in PV and has no correlation with disease course...
  36. ncbi request reprint IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus
    Koji Nishifuji
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Vet Immunol Immunopathol 117:209-21. 2007
    ..The present study indicates for the first time that circulating anti-Dsg3 IgG antibodies capable of dissociating keratinocytes are present in dogs with PV and PNP...
  37. ncbi request reprint Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity
    Yukari Yamamoto
    Department of Dermatology, Gifu University School of Medicine, Gifu City 501 1194, Japan
    J Biol Chem 282:17866-76. 2007
    ....
  38. pmc Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Clin Invest 121:3677-88. 2011
    ....
  39. doi request reprint Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients
    Marwah Adly Saleh
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 62:169-75. 2011
    ..It was reported that major epitopes reside within the NC1 domain and minor epitopes reside within NC2 domain...
  40. pmc Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Clin Invest 110:53-60. 2002
    ..aureus to spread under the stratum corneum, the main barrier of the skin, explaining how, although they circulate through the entire body in SSSS, they cause pathology only in the superficial epidermis...
  41. ncbi request reprint In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line
    Atsushi Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 124:984-9. 2005
    ..These results indicate that the N-terminal regions of Dsg3 from opposing cells interact at the dense mid-line of desmosomes where EC1 overlaps...
  42. pmc Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis
    Tetsuro Kobayashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, PC160 8582 Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 42:756-66. 2015
    ..aureus inoculation. These results characterize differential contributions of dysbiotic flora during eczema formation, and highlight the microbiota-host immunity axis as a possible target for future therapeutics in eczematous dermatitis...
  43. doi request reprint Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation
    Shuhei Nishimoto
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjyuku ku, Tokyo 160 8582, Japan
    J Immunol 191:3065-72. 2013
    ..These results demonstrate that cutaneous psoriasis-like immunopathology can be developed by epidermis-specific recognition of Th17 cells, which is strictly dependent on IL-17 but not IFN-γ...
  44. doi request reprint Characterization of canine filaggrin: gene structure and protein expression in dog skin
    Satoko Kanda
    Laboratory of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Vet Dermatol 24:25-31.e7. 2013
    ..Although similar pathogenesis and clinical manifestation have been argued in canine atopic dermatitis, our understanding of canine FLG is limited...
  45. doi request reprint Restoration of the intrinsic properties of human dermal papilla in vitro
    Manabu Ohyama
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Sci 125:4114-25. 2012
    ..The study reported here revealed previously unreported molecular mechanisms contributing to human DP properties and describes a useful technique for the investigation of human DP biology and hair follicle bioengineering...
  46. doi request reprint Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice
    Hiroshi Kawasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 129:1538-46.e6. 2012
    ..Although various reports suggest a critical role for filaggrin in stratum corneum (SC) barrier formation, the lack of filaggrin-null (Flg(-/-)) mice has hampered detailed in vivo analysis of filaggrin's functions...
  47. doi request reprint Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display
    Marwah A Saleh
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 132:1141-8. 2012
    ..These mAbs reflect the unique polyclonal nature of anti-Dsg3 antibodies in PNP and represent an important tool for detailing the pathophysiological mechanisms of blister formation in PNP...
  48. ncbi request reprint No activation of urokinase plasminogen activator by anti-desmoglein 3 monoclonal IgG antibodies in cultured human keratinocytes
    Yukari Yamamoto
    Department of Dermatology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
    J Dermatol Sci 47:119-25. 2007
    ....
  49. ncbi request reprint Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus
    Yuko Futei
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Am Acad Dermatol 49:1023-8. 2003
    ..It has been demonstrated that in PV, dominant epitopes reside in N-terminal adhesive regions of Dsg3 and that the dominant IgG subclass against Dsg3 is IgG4...
  50. doi request reprint Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies
    Yujiro Takae
    Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Exp Dermatol 18:252-60. 2009
    ..Knowing the advantages and limitations of this model will provide an important foundation for the future evaluation and development of novel therapeutic strategies...
  51. doi request reprint Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris
    Tomoaki Yokoyama
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Int Immunol 23:365-73. 2011
    ..Our observation implies that Tregs capable of suppressing T(h) cells that drive autoantibody production can develop in the absence of the target antigen...
  52. ncbi request reprint Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation
    Yasushi Hanakawa
    Department of Dermatology, School of Medicine, Ehime University, Ehime, Japan
    J Invest Dermatol 119:1231-6. 2002
    ..Our findings provide biologic evidence that desmoglein 1 and desmoglein 3 play a different functional role in cell-cell adhesion of keratinocytes...
  53. ncbi request reprint No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases
    Takayuki Ota
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, 160 8582, Tokyo, Japan
    J Dermatol Sci 32:137-41. 2003
    ..About 20-30% of patients with PNP develop fatal bronchiolitis obliterans, in which autoantibody-mediated injury is suspected because of in vivo IgG deposition on cell surfaces of bronchial epithelia...
  54. doi request reprint Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris
    Jun Yamagami
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 52:98-107. 2008
    ..Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by anti-desmoglein 3 (Dsg3) IgG autoantibodies; however, the Dsg3-specific B cells that produce anti-Dsg3 IgG are not well characterized...
  55. doi request reprint Canine follicle stem cell candidates reside in the bulge and share characteristic features with human bulge cells
    Tetsuro Kobayashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 130:1988-95. 2010
    ..Our findings demonstrate a unique strategy utilizing canine bulge cells to investigate human stem cell biology and intractable hair disorders that involve the bulge region...
  56. pmc Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis
    Akiharu Kubo
    Department of Dermatology, Keio University School of Medicine, Tokyo 160 8582, Japan Keio Maruho Laboratory of Skin Barriology, Keio University School of Medicine, Tokyo 160 8582, Japan Center for Integrated Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan Electronic address
    Am J Hum Genet 93:945-56. 2013
    ..These findings provide an important framework for developing pathogenesis-based therapies for NPPK. ..
  57. pmc A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis
    Meryem Bektas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599 7287, USA
    J Biol Chem 288:9447-56. 2013
    ..This study provides the experimental rationale for investigating the use of EGFR inhibitors in pemphigus...
  58. doi request reprint Molecular biological and immunohistological characterization of canine dermal papilla cells and the evaluation of culture conditions
    Tetsuro Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Vet Dermatol 22:414-22. 2011
    ..This study provides crucial information necessary for further optimization of culture conditions of canine DP...
  59. doi request reprint Immune dysregulation of pemphigus in humans and mice
    Tomoaki Yokoyama
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol 37:205-13. 2010
    ..Thus, delicate balance between self-reactive lymphocytes and regulatory T cells may be a key element in determining whether individuals produce pathogenic antibodies and develop pemphigus phenotypes or not...
  60. ncbi request reprint A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 182:1740-5. 2009
    ..These findings provide an important framework for examining immunological mechanisms in Ab-mediated autoimmune diseases...
  61. ncbi request reprint Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome
    John R Stanley
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    N Engl J Med 355:1800-10. 2006
  62. ncbi request reprint Pathogenicity and epitope characteristics of anti-desmoglein-1 from pemphigus foliaceus patients expressing only IgG1 autoantibodies
    Mary K Hacker-Foegen
    Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Invest Dermatol 121:1373-8. 2003
    ..In conclusion, our study reveals that the isotype of IgG does not necessarily determine the epitopes and pathogenicity of pemphigus autoantibodies...
  63. doi request reprint In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus
    Ken Ishii
    Department of Dermatology, Toho University, School of Medicine, Tokyo, Japan
    Methods Mol Biol 961:219-25. 2013
    ....
  64. doi request reprint Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis
    Takashi Sasaki
    Center for Integrated Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Dermatol Sci 68:36-44. 2012
    ..Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be associated with PDP. However, mutations in HPGD have not been identified in Japanese PDP patients...
  65. pmc Autoimmunity to desmocollin 3 in pemphigus vulgaris
    Xuming Mao
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
    Am J Pathol 177:2724-30. 2010
    ....
  66. ncbi request reprint [Loss of adhesive function of desmosomal cadherin and skin diseases in humans and animals]
    Koji Nishifuji
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Seikagaku 78:609-14. 2006
  67. pmc G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
    Keiji Tanese
    Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 173:835-43. 2008
    ..These results suggest that GPR49 is expressed downstream of HH signaling and promotes cell proliferation and tumor formation in cases of BCC...
  68. ncbi request reprint [Autoimmune blistering diseases]
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine
    Nihon Rinsho 63:540-6. 2005
  69. doi request reprint Loss-of-function mutations within the filaggrin gene and atopic dermatitis
    Hiroshi Kawasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Curr Probl Dermatol 41:35-46. 2011
    ..Taken together, these findings provide novel perspectives on the pathophysiology of AD and effective therapeutic methods for the treatment and/or prevention of AD through the modification of skin barrier dysfunction...
  70. ncbi request reprint Comparative study of autoantigen profile between Colombian and Brazilian types of endemic pemphigus foliaceus by various biochemical and molecular biological techniques
    Yoshiko Hisamatsu
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 32:33-41. 2003
    ..Our previous study suggested that Colombian EPF seemed to react various plakin family proteins, such as envoplakin, periplakin and BP230...
  71. pmc Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract
    Catharina Sagita Moniaga
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Pathol 176:2385-93. 2010
    ..These results suggest that the Flg(ft) mouse genotype has potential as an animal model of AD corresponding with filaggrin mutation in human AD...
  72. ncbi request reprint BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid
    Masakazu Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 30:224-32. 2002
    ..These findings indicate that NC16a ELISA will be a valuable tool not only for the diagnosis of patients with BP but also for the monitoring of the disease activity...
  73. pmc Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence
    Mariko Yokouchi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 129:2156-66. 2009
    ..These findings support the idea that at least some pathogenic pemphigus autoantibodies induce the loss of cell adhesion by directly binding the trans-interaction site of Dsgs...
  74. ncbi request reprint T helper type 2-biased natural killer cell phenotype in patients with pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 127:324-30. 2007
    ..Together these findings suggest that NK cells contribute to a T helper type 2-biased immune response in PV patients through impaired IL-12 signaling and an upregulation of IL-10 and IL-5...
  75. doi request reprint Autoimmunity against M₂muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype
    Akihiro Yoshizawa
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Eur J Immunol 42:1152-63. 2012
    ..Our mouse model will be useful in the analysis of the molecular mechanisms of disease progression and the development of new therapies for DCM...
  76. ncbi request reprint Cutaneous type pemphigus vulgaris: a rare clinical phenotype of pemphigus
    Kazue Yoshida
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Am Acad Dermatol 52:839-45. 2005
    ..This expression can be a transient phenotype that may develop from, or evolve into, other subtypes of pemphigus...
  77. ncbi request reprint Staphylococcal exfoliative toxins: "molecular scissors" of bacteria that attack the cutaneous defense barrier in mammals
    Koji Nishifuji
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 49:21-31. 2008
    ..The species-specificity of staphylococcal exfoliative toxins to cleave Dsg1 in certain mammalian species is discussed...
  78. ncbi request reprint Cloning of swine desmoglein 1 and its direct proteolysis by Staphylococcus hyicus exfoliative toxins isolated from pigs with exudative epidermitis
    Koji Nishifuji
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Vet Dermatol 16:315-23. 2005
    ..Recognition and digestion of calcium-stabilized structure on the extracellular domains of swine Dsg1 by Exhs indicated that EE shares similar molecular pathophysiological mechanisms of intra-epidermal splitting with SSSS in humans...
  79. pmc Simple PCR-based DNA microarray system to identify human pathogenic fungi in skin
    Tomotaka Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Clin Microbiol 48:2357-64. 2010
    ....
  80. ncbi request reprint Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis
    Itaru Dekio
    Department of Dermatology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Med Microbiol 56:1675-83. 2007
    ....
  81. doi request reprint Sequence analysis of filaggrin gene by novel shotgun method in Japanese atopic dermatitis
    Takashi Sasaki
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 51:113-20. 2008
    ..This unique gene structure has hampered the precise DNA sequence determination...
  82. ncbi request reprint [Updates in autoimmune bullous skin diseases]
    Masayuki Amagai
    Department of Dermatology, Keio University
    Nihon Rinsho Meneki Gakkai Kaishi 25:28-31. 2002
  83. ncbi request reprint [Desmoglein, the target molecule in autoimmunity and infection]
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 29:325-33. 2006
    ..It is not clear why so many diseases are clustered in desmogleins, but there must be a reason for this. Studies on desmogleins will provide an important framework to understand the mysteries between autoimmunity and infection...
  84. ncbi request reprint Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris
    Manabu Ohyama
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 118:199-204. 2002
    ..Pemphigus vulgaris model mice reflect several of the histopathologic and immunologic features seen in pemphigus vulgaris patients, and provide a valuable tool to investigate the pathophysiologic mechanisms of pemphigus vulgaris...
  85. ncbi request reprint Pemphigus as a paradigm of autoimmunity and cell adhesion
    Masayuki Amagai
    Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 51:133-9. 2002
    ..This model will be valuable not only for dissecting the cellular and molecular mechanisms in pathogenic antibody production but also for developing novel therapeutic strategies...
  86. ncbi request reprint Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma
    Yoshinobu Aisa
    Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Int J Hematol 82:266-9. 2005
    ..A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT...
  87. ncbi request reprint [Immunological tests: Anti desmoglein 1 and 3 antibody]
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine
    Nihon Rinsho 63:571-4. 2005
  88. ncbi request reprint Production of recombinant extracellular domains of canine desmoglein 1 (Dsg1) by baculovirus expression
    Koji Nishifuji
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo 183 8509, Japan
    Vet Immunol Immunopathol 95:177-82. 2003
    ....
  89. doi request reprint Pemphigus treatment in Japan
    Akiko Tanikawa
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Dermatol Clin 29:685-6. 2011
    ..In 2010, new Japanese guidelines for the management of pemphigus were published for dermatologists. Systemic corticosteroids are the gold standard and the first choice of treatment of pemphigus...
  90. ncbi request reprint Cloning of canine desmoglein 3 and immunoreactivity of serum antibodies in human and canine pemphigus vulgaris with its extracellular domains
    Koji Nishifuji
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwaicho, Fuchu, Tokyo 183 8509, Japan
    J Dermatol Sci 32:181-91. 2003
    ..The autoimmune target in human PV has been identified as desmoglein (Dsg) 3, a desmosomal cell-cell adhesion molecule, whereas the autoimmune target in canine PV has not yet been identified clearly...
  91. ncbi request reprint Abnormal keratin expression in circumscribed palmar hypokeratosis
    Akira Ishiko
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Am Acad Dermatol 57:285-91. 2007
    ..Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described...
  92. ncbi request reprint Paraneoplastic pemphigus associated with Castleman's disease and asymptomatic bronchiolitis obliterans
    Wataru Fujimoto
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Dermatol 12:355-9. 2002
    ..The expiratory images of high resolution computed tomography showed air trapping, indicating the presence of asymptomatic but gradually progressive bronchiolitis obliterans...
  93. ncbi request reprint A case of herpetiform pemphigus with anti-desmoglein 3 IgG autoantibodies
    Rieko Isogai
    Department of Dermatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Dermatol 31:407-10. 2004
    ..It remains to be clarified why the anti-Dsg3 IgG autoantibodies in this patient induced this unique features of HP, rather than the mucosal dominant type of pemphigus vulgaris...
  94. ncbi request reprint Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns
    Thomas Parlowsky
    Department of Dermatology, University of Luebeck
    J Am Acad Dermatol 48:623-5. 2003
    ..This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates...
  95. ncbi request reprint Paraneoplastic pemphigus with widespread mucosal involvement
    Mami Wakahara
    Acta Derm Venereol 85:530-2. 2005
  96. ncbi request reprint Analysis of gene expression in Arabidopsis thaliana by array hybridization with genomic DNA fragments aligned along chromosomal regions
    Shigeru Hanano
    Department of Biological Sciences, University of Warwick, Gibbet Hill, Coventry CV4 7AL, UK
    Plant J 30:247-55. 2002
    ....
  97. ncbi request reprint Desmosomes and disease: pemphigus and bullous impetigo
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, 415 Curie Boulevard, 211 Clinical Research Building, Pennsylvania, 19104 USA
    Curr Opin Cell Biol 16:536-43. 2004
    ..These studies offer new insight into the potential mechanisms of acantholysis in pemphigus and staphylococcal-associated blistering disease, with implications for the role of desmogleins in desmosomal structure and function...
  98. ncbi request reprint Production of low titers of anti-desmoglein 1 IgG autoantibodies in some patients with staphylococcal scalded skin syndrome
    Hidemi Anzai
    J Invest Dermatol 126:2139-41. 2006
  99. ncbi request reprint [Loss of adhesive function of desmogleins in bullous diseases: pemphigus and impetigo]
    Koji Nishifuji
    Tanpakushitsu Kakusan Koso 51:796-802. 2006
  100. ncbi request reprint Staphylococcus hyicus exfoliative toxins selectively digest porcine desmoglein 1
    Yasuyuki Fudaba
    Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Microb Pathog 39:171-6. 2005
    ..These findings strongly suggest that Exhs cause blister formation of porcine skin by digesting porcine desmoglein 1 in a similar fashion to exfoliative toxins from S. aureus...
  101. pmc Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B
    Takayuki Yamaguchi
    Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1 2 3, Minami ku Hiroshima, Hiroshima, Japan
    Infect Immun 70:5835-45. 2002
    ..This strongly suggests that ETD might play a pathogenic role in a broader spectrum of bacterial infections than previously considered...