Yukinari Kato

Summary

Country: Japan

Publications

  1. ncbi request reprint Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma
    Hiroyuki Suzuki
    Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    FEBS Lett 582:341-5. 2008
  2. doi request reprint Focused differential glycan analysis with the platform antibody-assisted lectin profiling for glycan-related biomarker verification
    Atsushi Kuno
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, 1 1 1, Umezono, Ibaraki 305 8568, Japan
    Mol Cell Proteomics 8:99-108. 2009
  3. doi request reprint Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
    Yukinari Kato
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Brain Tumor Pathol 32:3-11. 2015
  4. pmc The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model
    Hui Liu
    Department of Cancer Biology, The University of Texas, MD, Anderson Cancer Center, Houston, TX 77030, USA
    BMC Cancer 12:583. 2012
  5. doi request reprint Generation of a novel monoclonal antibody WMab-1 specific for IDH2-R172W mutation
    Yukinari Kato
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 433:374-8. 2013
  6. doi request reprint A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation
    Yukinari Kato
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 432:564-7. 2013
  7. pmc A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation
    Yukinari Kato
    Department of Pathology, Duke University Medical Center, DUMC 3156, Durham, NC 27710, USA
    Biochem Biophys Res Commun 390:547-51. 2009
  8. pmc Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas
    Yukinari Kato
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Nucl Med Biol 37:785-94. 2010
  9. ncbi request reprint Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain
    Yukinari Kato
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 349:1301-7. 2006
  10. ncbi request reprint Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    Yukinari Kato
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Cancer Sci 99:54-61. 2008

Detail Information

Publications68

  1. ncbi request reprint Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma
    Hiroyuki Suzuki
    Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    FEBS Lett 582:341-5. 2008
    ..TGF-beta type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-beta. These results suggest that TGF-beta is a physiological regulator of podoplanin in tumor cells...
  2. doi request reprint Focused differential glycan analysis with the platform antibody-assisted lectin profiling for glycan-related biomarker verification
    Atsushi Kuno
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, 1 1 1, Umezono, Ibaraki 305 8568, Japan
    Mol Cell Proteomics 8:99-108. 2009
    ..Thus, the established system should provide a powerful pipeline in support of on-going efforts in glyco-biomarker discovery...
  3. doi request reprint Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
    Yukinari Kato
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Brain Tumor Pathol 32:3-11. 2015
    ..Another mAb, MsMab-2, recognizes IDH1-R132L and IDH2-R172M. These IDH1/2 mutation-specific mAbs are useful for the immunohistochemical determination of IDH1/2 mutation-bearing gliomas...
  4. pmc The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model
    Hui Liu
    Department of Cancer Biology, The University of Texas, MD, Anderson Cancer Center, Houston, TX 77030, USA
    BMC Cancer 12:583. 2012
    ..In this study, we show that the targeted knockdown of MMP-1 in breast cancer cells with enhanced brain metastatic ability not only reduced primary tumor growth, but also significantly inhibited brain metastasis...
  5. doi request reprint Generation of a novel monoclonal antibody WMab-1 specific for IDH2-R172W mutation
    Yukinari Kato
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 433:374-8. 2013
    ..WMab-1 also specifically stained the IDH2-R172W-expressing glioma cells in immunohistochemistry. This is the first report to establish an anti-IDH2-R172W-specific mAb, which could be useful in the diagnosis of IDH2-R172W-bearing tumors...
  6. doi request reprint A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation
    Yukinari Kato
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 432:564-7. 2013
    ..This is the first report to establish anti-IDH1-R132G-specific mAbs, which is useful in immunohistochemistry of IDH1-R132G-bearing tumors...
  7. pmc A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation
    Yukinari Kato
    Department of Pathology, Duke University Medical Center, DUMC 3156, Durham, NC 27710, USA
    Biochem Biophys Res Commun 390:547-51. 2009
    ..In conclusion, we established an anti-IDH1(R132H)-specific monoclonal antibody IMab-1, which should be significantly useful for diagnosis and biological evaluation of mutation-bearing gliomas...
  8. pmc Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas
    Yukinari Kato
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Nucl Med Biol 37:785-94. 2010
    ..The purpose of this study was to determine whether an anti-podoplanin antibody is suitable to target radionuclides to malignant gliomas...
  9. ncbi request reprint Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain
    Yukinari Kato
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 349:1301-7. 2006
    ..We infer that NZ-1 is useful to determine whether platelet aggregation is podoplanin-specific or not. Furthermore, podoplanin might become a therapeutic target of glioblastoma for antibody-based therapy...
  10. ncbi request reprint Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    Yukinari Kato
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Cancer Sci 99:54-61. 2008
    ..Podoplanin and CLEC-2 might represent promising therapeutic targets in cancer metastasis...
  11. doi request reprint Diagnostic advantage of double immunohistochemistry using two mutation-specific anti-IDH antibodies (HMab-1 and MsMab-1) in gliomas
    Shingo Takano
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Brain Tumor Pathol 32:169-75. 2015
    ..IDH sequencing procedures are popular but inconsistent across laboratories. By contrast, double IHC screening using HMab-1 and MsMab-1 is very reliable for detecting IDH1/2 mutations and can predict survival in grade III glioma patients...
  12. ncbi request reprint Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor
    Mika Kato Kaneko
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    FEBS Lett 581:331-6. 2007
    ..Sialic acid-deficient podoplanin recovered its activity after additional sialylation. These results indicated that the sialylated Corel at Thr52 is critical for podoplanin-induced platelet aggregation...
  13. ncbi request reprint PMab-38 Recognizes Canine Podoplanin of Squamous Cell Carcinomas
    Mika K Kaneko
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:263-266. 2016
    ..PMab-38 is expected to be useful for investigating the function of podoplanin in canine tumors...
  14. doi request reprint Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors
    Shingo Takano
    Department of Neurological Surgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, 305 8575, Ibaraki, Tsukuba, Japan
    J Neurooncol 108:361-73. 2012
    ....
  15. ncbi request reprint Establishment of a multi-specific monoclonal antibody MsMab-1 recognizing both IDH1 and IDH2 mutations
    Mika Kato Kaneko
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Tohoku J Exp Med 230:103-9. 2013
    ..This report is the first to establish a multi-specific anti-mutated IDH1/2 mAb, that is expected to be useful for immunohistochemical determination of IDH1/2 mutation-bearing tumors...
  16. ncbi request reprint Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells
    Mika Kaneko
    Department of Experimental and Forensic Pathology, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    J Biol Chem 279:38838-43. 2004
    ..This oligosaccharide structure is known as tumor-associated antigen, which is potentially related to the metastasis process of cancer cells...
  17. doi request reprint Novel monoclonal antibodies GMab-r1 and LMab-1 specifically recognize IDH1-R132G and IDH1-R132L mutations
    Mika Kato Kaneko
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 32:224-8. 2013
    ..This is the first report to establish anti-IDH1-R132G-specific or IDH1-R132L-specific MAbs, which could be useful in the diagnosis of mutation-bearing tumors...
  18. doi request reprint Chimeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity
    Mika Kato Kaneko
    Molecular Tumor Marker Research Team, Global COE Program, Yamagata University Faculty of Medicine, Yamagata, Japan
    Cancer Sci 103:1913-9. 2012
    ..Targeting therapy to podoplanin-expressing tumors should be useful as a novel immunotherapy...
  19. ncbi request reprint Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor
    Mika Kato Kaneko
    Department of Experimental and Forensic Pathology, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    Gene 378:52-7. 2006
    ..In conclusion, we provide evidence that Aggrus homologues conserved the segment of EDxxVTPG in their extracellular domain which are critical for their platelet aggregation-inducing activities...
  20. doi request reprint Characterization of Monoclonal Antibody LpMab-7 Recognizing Non-PLAG Domain of Podoplanin
    Hiroharu Oki
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:174-80. 2015
    ..Because LpMab-7 has high sensitivity against podoplanin, LpMab-7 is expected to be useful for molecular targeting therapy for podoplanin-expressing cancers. ..
  21. doi request reprint Monoclonal Antibody LpMab-9 Recognizes O-glycosylated N-Terminus of Human Podoplanin
    Mika K Kaneko
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:310-7. 2015
    ..Taken together, these results indicate that LpMab-9 recognizes O-glycosylation of Thr25 in the N-terminus of PDPN. LpMab-9 could be useful for uncovering the physiological function of O-glycosylated N-terminus of human PDPN. ..
  22. doi request reprint Critical Epitope of Anti-Rabbit Podoplanin Monoclonal Antibodies for Immunohistochemical Analysis
    Ryusuke Honma
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:65-72. 2016
    ..PMab-32 could be useful for uncovering the function of rabbit PDPN. ..
  23. ncbi request reprint PMab-44 Detects Bovine Podoplanin in Immunohistochemistry
    Ryusuke Honma
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother . 2016
    ..PMab-44 also detected bovPDPN specifically in flow cytometry. PMab-44 is expected to be useful for investigating the function of bovPDPN...
  24. doi request reprint Development of Monoclonal Antibody LpMab-10 Recognizing Non-glycosylated PLAG1/2 Domain Including Thr34 of Human Podoplanin
    Satoshi Ogasawara
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:318-26. 2015
    ..By using monoclonal antibodies against different Ser/Thr, including epitopes of PDPN, it becomes possible to determine whether Ser/Thr residues of PDPN are O-glycosylated. ..
  25. doi request reprint Establishment of Novel Monoclonal Antibody PMab-32 Against Rabbit Podoplanin
    Ryusuke Honma
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:41-7. 2016
    ..Immunohistochemical analysis showed that PMab-32 is useful for detecting podocytes, type I alveolar cells, and lymphatic endothelial cells in normal rabbit tissues. PMab-32 is expected to be useful for various rabbit experiments...
  26. pmc Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors
    Vidyalakshmi Chandramohan
    Preston Robert Tisch Brain Tumor Center at Duke and Department of Pathology, Duke University Medical Center, Durham, NC
    Int J Cancer 132:2339-48. 2013
    ..001). In preclinical studies, NZ-1-(scdsFv)-PE38KDEL exhibited significant potential as a targeting agent for malignant brain tumors...
  27. doi request reprint Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN
    Mika K Kaneko
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Cancer Med . 2017
    ..LpMab-21 combined with other anti-hPDPN antibodies that recognize different epitopes may therefore be useful for determining the physiological function of sialylated hPDPN...
  28. ncbi request reprint Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin
    Satoshi Ogasawara
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother . 2016
    ..The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy...
  29. doi request reprint Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin
    Yukinari Kato
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:109-16. 2016
    ..The combination of different epitope-possessing mAbs could be advantageous for the PDPN-targeting diagnosis or therapy. ..
  30. doi request reprint Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin
    Satoshi Ogasawara
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:155-62. 2016
    ..The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy. ..
  31. doi request reprint Development of Sensitive Monoclonal Antibody PMab-2 Against Rat Podoplanin
    Hiroharu Oki
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:396-403. 2015
    ..PMab-2 showed extraordinarily high sensitivity in immunohistochemistry, indicating that PMab-2 is very advantageous for functional analysis of rPDPN...
  32. doi request reprint A novel monoclonal antibody SMab-2 recognizes endogenous IDH2-R172S of chondrosarcoma
    Xing Liu
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 459:636-42. 2015
    ..Furthermore, SMab-2 recognized endogenous IDH2-R172S protein expressed in SW1353 chondrosarcoma cells in Western blot and immunocytochemical analyses. SMab-2 is expected to be useful for diagnosis of IDH2-R172S-bearing tumors. ..
  33. pmc Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone
    Mika Kato Kaneko
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 105:744-8. 2014
    ..This is the first report to describe IDH mutations in GCTB, and MsMab-1 can be anticipated for use in immunohistochemical determination of IDH1/2 mutation-bearing GCTB. ..
  34. doi request reprint Establishment of novel monoclonal antibodies KMab-1 and MMab-1 specific for IDH2 mutations
    Mika Kato Kaneko
    Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 432:40-5. 2013
    ..In immunohistochemical analysis, MMab-1 specifically stained IDH2-R172M-expressing glioma. This is the first report to establish anti-IDH2-mutation-specific mAbs, which could be useful in diagnosis of mutation-bearing tumors...
  35. pmc GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice
    Yukinari Kato
    Department of Pathology, Duke University Medical Center, DUMC 3156, Durham, NC 27710, USA
    Biochem Biophys Res Commun 391:750-5. 2010
    ....
  36. doi request reprint Multi-specific monoclonal antibody MsMab-2 recognizes IDH1-R132L and IDH2-R172M mutations
    Satoshi Ogasawara
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 32:377-81. 2013
    ..Taken together, the combination of MsMab-1 and MsMab-2 could be useful in diagnosis of mutated IDH1/2-bearing tumors. ..
  37. ncbi request reprint Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma
    Yukinari Kato
    Department of Experimental and Forensic Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Tumour Biol 26:195-200. 2005
    ..These findings indicated that overexpression of Aggrus occurred in squamous cell carcinoma of the lung. Therefore, Aggrus could be a useful diagnostic marker for squamous cell carcinoma of the lung...
  38. pmc Engineering of mucin-type human glycoproteins in yeast cells
    Koh Amano
    Research Center for Medical Glycoscience and Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Proc Natl Acad Sci U S A 105:3232-7. 2008
    ..The yeast system we describe here is able to produce glycoproteins modified at different glycosylation sites and has the potential for use in basic research and pharmaceutical applications...
  39. doi request reprint Specific Detection of Dog Podoplanin Expressed in Renal Glomerulus by a Novel Monoclonal Antibody PMab-38 in Immunohistochemistry
    Ryusuke Honma
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:212-6. 2016
    ..PMab-38 also detected dPDPN specifically in flow cytometry and Western blot analysis. PMab-38 is expected to be useful for investigating the function of dPDPN, which is expressed in podocytes. ..
  40. pmc LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-Glycan on Thr52 of Platelet Aggregation-Stimulating Domain of Human Podoplanin
    Yukinari Kato
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    PLoS ONE 11:e0152912. 2016
    ..Thus, LpMab-12 could serve as a new diagnostic tool for determining whether hPDPN possesses the sialylation on Thr52, a site-specific post-translational modification critical for the hPDPN association with CLEC-2. ..
  41. doi request reprint Immunohistochemistry on IDH 1/2, ATRX, p53 and Ki-67 substitute molecular genetic testing and predict patient prognosis in grade III adult diffuse gliomas
    Shingo Takano
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Brain Tumor Pathol 33:107-16. 2016
    ..e., Grade II and III). ..
  42. doi request reprint Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors
    Yukinari Kato
    Research Center for Medical Glycoscience RCMG, National Institute of Advanced Industrial Science and Technology AIST, Open Space Laboratory C 2, 1 1 1, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 369:1041-6. 2008
    ..In immunohistochemistry, KS is highly expressed in cell surface of malignant astrocytic tumors. Taken together, KS might be associated with the malignancy of astrocytic tumors, and be useful for a prognostic factor of astrocytic tumors...
  43. pmc Establishment of Anti-Human ATRX Monoclonal Antibody AMab-6
    Satoshi Ogasawara
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother 35:254-258. 2016
    ..Furthermore, AMab-6 sensitively detects ATRX in Western blot and immunohistochemical analyses, indicating that AMab-6 could become the standard marker to determine the ATRX mutation status of gliomas in immunohistochemical analyses...
  44. doi request reprint Anti-podoplanin Monoclonal Antibody LpMab-7 Detects Metastatic Lesions of Osteosarcoma
    Mika K Kaneko
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:154-61. 2015
    ..Because LpMab-7 has high sensitivity against podoplanin, it is expected to be useful for molecular targeting therapy for osteosarcomas. ..
  45. pmc The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity
    Yukinari Kato
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Oncotarget 6:36003-18. 2015
    ..These results indicated that chLpMab-7 suppressed tumor development and hematogenous metastasis in a neutralization-independent manner. In conclusion, hPDPN shows promise as a target in the development of a novel antibody-based therapy...
  46. doi request reprint A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas
    Yuki Fujii
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 466:733-9. 2015
    ..HMab-2 detected endogenous IDH1-R132H protein expressed in glioblastoma in immunohistochemical analysis. HMab-2 is expected to be useful for the diagnosis of IDH1-R132H-bearing tumors. ..
  47. pmc IDH2 and TP53 mutations are correlated with gliomagenesis in a patient with Maffucci syndrome
    Kunihiko Moriya
    Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 105:359-62. 2014
    ..This case is unique and supports the IDH2-dependent genetic pathway and second-hit model for gliomagenesis. ..
  48. doi request reprint Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells
    Norihito Hayatsu
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 368:217-22. 2008
    ..Taken together, these results suggest that LN229 produces 5D4-reactive highly sulfated KS and is useful to investigate the KS structure and function in glioblastoma...
  49. pmc Podoplanin Expression in Canine Melanoma
    Satoshi Ogasawara
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother . 2016
    ..PMab-38 could be useful for uncovering the function of PDPN in canine melanomas...
  50. pmc Characterization of monoclonal antibody LpMab-3 recognizing sialylated glycopeptide of podoplanin
    Hiroharu Oki
    1 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother 34:44-50. 2015
    ..Because LpMab-3 detects only sialylated podoplanin, it could be useful for uncovering the physiological function of sialylated human podoplanin. ..
  51. pmc Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1
    Xing Liu
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Cancer Med 2:803-14. 2013
    ..Taken together, these results show that MsMab-1 can be anticipated for use in immunohistochemical determination of IDH1/2 mutation-bearing osteosarcoma. ..
  52. doi request reprint Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Brain Tumor Pathol 28:115-23. 2011
    ..Therefore, IMab-1 is likely to be useful for the diagnosis of mutation-bearing gliomas and for determining the treatment strategy of grade III gliomas...
  53. doi request reprint Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state
    Yuki Fujii
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Cell Sci 129:1512-22. 2016
    ..Thus, we succeeded in converting a general anti-tag antibody into a special anti-integrin antibody that can be classified as a ligand-induced binding site antibody...
  54. doi request reprint Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation
    Mika Kato Kaneko
    Molecular Tumor Marker Research Team, The Oncology Research Center, Advanced Molecular Epidemiology Research Institute, Yamagata University Faculty of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 406:608-13. 2011
    ..We newly established an anti-IDH1-R132S-specific mAb SMab-1 for use in diagnosis of mutation-bearing gliomas...
  55. pmc MAP Tag: A Novel Tagging System for Protein Purification and Detection
    Yuki Fujii
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Monoclon Antib Immunodiagn Immunother . 2016
    ..Taken together, these findings indicate that the MAP tag system could be a powerful tool for protein purification and detection...
  56. ncbi request reprint LpMab-19 Recognizes Sialylated O-Glycan on Thr76 of Human Podoplanin
    Satoshi Ogasawara
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Monoclon Antib Immunodiagn Immunother . 2016
    ..LpMab-19 could be useful for investigating the physiological function of O-glycosylated hPDPN...
  57. ncbi request reprint Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type
    Mika Kaneko
    Department of Forensic Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Immunol Lett 86:45-51. 2003
    ..We think that this method is suitable for cDNA preparation of human monoclonal antibodies to blood group antigens and for sequence analysis...
  58. doi request reprint Deletion polymorphism of SIGLEC14 and its functional implications
    Masahiro Yamanaka
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Glycobiology 19:841-6. 2009
    ..The forced expression of Siglec-14 in a monocytic cell line-enhanced TNF-alpha secretion elicited by lipopolysaccharide. These results imply that Siglec-14 may play some role in bacterial infection...
  59. doi request reprint Immunohistochemistry using monoclonal antibody MsMab-2 is useful to detect IDH1 R132L in intrahepatic cholangiocarcinoma
    Akimasa Hayashi
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pathol Int 66:578-582. 2016
    ..We consider immunohistochemical analysis using MsMab-2 to be a useful means of detecting IDH1 R132L. Further analysis of its effectiveness against IDH2 R172M is necessary because of the small sample size in this study...
  60. pmc A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin
    Yukinari Kato
    Department of Regional Innovation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Sci Rep 4:5924. 2014
    ....
  61. doi request reprint Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis
    Youya Nakazawa
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo
    Blood 112:1730-9. 2008
    ..Therefore, CD9 may act as a metastasis suppressor, at least in part, by neutralizing Aggrus-mediated platelet aggregation...
  62. ncbi request reprint Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
    ..These findings suggest that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplanin...
  63. ncbi request reprint Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors
    Yukinari Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 278:51599-605. 2003
    ..These results suggest that Aggrus/T1alpha is a newly identified, platelet aggregation-inducing factor expressed in colorectal tumors...
  64. doi request reprint Neutralization of blood group A-antigen by a novel anti-A antibody: overcoming ABO-incompatible solid-organ transplantation
    Yasushi Hasegawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Transplantation 85:378-85. 2008
    ..Various strategies to reduce antiblood group antibody by overcoming ABO-incompatible transplantation have been tried. However, antigen-suppressing procedures have not been performed...
  65. ncbi request reprint Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression
    Kazuhiko Mishima
    Department of Neurosurgery, Saitama Medical School, Saitama, 350 0495, Japan
    Acta Neuropathol 111:483-8. 2006
    ..Podoplanin mRNA and protein expression were markedly higher in glioblastomas than in anaplastic astrocytomas. These data suggest that podoplanin expression might be associated with malignancy of astrocytic tumors...
  66. ncbi request reprint Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma
    Kazuhiko Mishima
    Department of Neurosurgery, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, 350 0495, Saitama, Japan
    Acta Neuropathol 111:563-8. 2006
    ..Thus, podoplanin expression may be a sensitive immunohistochemical marker for germinoma in CNS GCTs. As such, it may be useful for diagnosis, for monitoring the efficacy of treatment, and as a potential target for antibody-based therapy...
  67. ncbi request reprint Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors
    Yukinari Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Oncogene 23:8552-6. 2004
    ..Specific markers for seminomas have not been reported, and Aggrus is a potential diagnostic marker for seminomas and may be associated with malignancies of the testis...
  68. pmc The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis
    Akiko Kunita
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Am J Pathol 170:1337-47. 2007
    ..Thus, Aggrus could serve as an ideal therapeutic target for drug development to block metastasis...