Shinji Nakao

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Clinical significance of a small population of paroxysmal nocturnal hemoglobinuria-type cells in the management of bone marrow failure
    Shinji Nakao
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Hematol 84:118-22. 2006
  2. ncbi request reprint Immune pathophysiology of aplastic anemia
    Shinji Nakao
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    Int J Hematol 82:196-200. 2005
  3. ncbi request reprint Myelodysplastic syndrome
    Shinji Nakao
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa City, Ishikawa 920 8641, Japan
    Int J Hematol 82:412-6. 2005
  4. ncbi request reprint Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma
    Hiroyuki Takamatsu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    J Immunol 182:703-10. 2009
  5. doi request reprint Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation
    Kanako Mochizuki
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Blood 112:2160-2. 2008
  6. ncbi request reprint Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal-antigen-complementary HLA-mismatched siblings
    Hirokazu Okumura
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 78:157-60. 2007
  7. ncbi request reprint Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia
    Chiharu Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Blood 107:1308-14. 2006
  8. ncbi request reprint Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministration of tranexamic acid
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    Intensive Care Med 30:1950-5. 2004
  9. doi request reprint Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure
    Chiharu Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Br J Haematol 147:102-12. 2009
  10. pmc Increased plasma thrombopoietin levels in patients with myelodysplastic syndrome: a reliable marker for a benign subset of bone marrow failure
    Yu Seiki
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Haematologica 98:901-7. 2013

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Clinical significance of a small population of paroxysmal nocturnal hemoglobinuria-type cells in the management of bone marrow failure
    Shinji Nakao
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Hematol 84:118-22. 2006
    ..A sensitive flow cytometric analysis for detection of a small population of PNH-type cells in peripheral blood cells is one of the most important examinations in the management of bone marrow failure...
  2. ncbi request reprint Immune pathophysiology of aplastic anemia
    Shinji Nakao
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    Int J Hematol 82:196-200. 2005
    ..Moreover, antibody screening of patients' serum with a complementary DNA library derived from hematopoietic cells has identified several proteins as candidate autoantigens in AA...
  3. ncbi request reprint Myelodysplastic syndrome
    Shinji Nakao
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa City, Ishikawa 920 8641, Japan
    Int J Hematol 82:412-6. 2005
  4. ncbi request reprint Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma
    Hiroyuki Takamatsu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    J Immunol 182:703-10. 2009
    ..Anti-moesin Abs may therefore indirectly contribute to the suppression of hematopoiesis in AA patients by inducing myelosuppressive cytokines from immunocompetent cells...
  5. doi request reprint Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation
    Kanako Mochizuki
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Blood 112:2160-2. 2008
    ....
  6. ncbi request reprint Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal-antigen-complementary HLA-mismatched siblings
    Hirokazu Okumura
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 78:157-60. 2007
    ..The findings suggest that intensive conditioning and immunosuppression after stem cell transplantation are needed in NIMA-mismatched SCT even if donor and recipient microchimerisms is detectable in the donor and recipient before SCT...
  7. ncbi request reprint Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia
    Chiharu Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Blood 107:1308-14. 2006
    ..Furthermore, immune attack against hematopoietic stem cells that allows PNH clonal expansion might occur only at the onset of AA...
  8. ncbi request reprint Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministration of tranexamic acid
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    Intensive Care Med 30:1950-5. 2004
    ....
  9. doi request reprint Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure
    Chiharu Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Br J Haematol 147:102-12. 2009
    ....
  10. pmc Increased plasma thrombopoietin levels in patients with myelodysplastic syndrome: a reliable marker for a benign subset of bone marrow failure
    Yu Seiki
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Haematologica 98:901-7. 2013
    ..In conclusion, increased plasma thrombopoietin levels were associated with a favorable prognosis of bone marrow failure and could, therefore, represent a reliable marker for a benign subset of myelodysplastic syndrome...
  11. doi request reprint Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies
    J Luis Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    Biol Blood Marrow Transplant 19:240-6. 2013
    ..58; 95% CI, 0.40-0.85), which did not influence survival. Our findings suggest that PTPN22 genotyping could be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of allogeneic BMT...
  12. ncbi request reprint EGFR mutation of tumor and serum in gefitinib-treated patients with chemotherapy-naive non-small cell lung cancer
    Hideharu Kimura
    Respiratory Medicine, Kanazawa University Hospital, Ishikawa, Japan
    J Thorac Oncol 1:260-7. 2006
    ..A secondary endpoint is to evaluate the relationship between clinical manifestations and epidermal growth factor receptor (EGFR) mutation status...
  13. ncbi request reprint Roles of DRB1 *1501 and DRB1 *1502 in the pathogenesis of aplastic anemia
    Chiharu Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Exp Hematol 35:13-20. 2007
    ..We herein clarify the difference between DRB1( *)1501 and DRB1( *)1502, the two DRB1 alleles that determine the presentation of HLA-DR15, in the pathophysiology of AA...
  14. ncbi request reprint The molecular mechanism of arsenic trioxide-induced apoptosis and oncosis in leukemia/lymphoma cell lines
    Jiebin Zhu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Acta Haematol 110:1-10. 2003
    ..These results suggest that As(2)O(3) inhibits the growth of these leukemia/lymphoma cell lines by inducing apoptosis or oncosis that is partially mediated by the CD95/CD95L pathway...
  15. doi request reprint The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice
    Hazuki Takato
    Department of Respiratory Medicine, Division of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Exp Lung Res 37:101-8. 2011
    ..These results show that the chymase inhibitor TY51469 suppresses the migration of neutrophils, which results in the suppression of lung fibrosis...
  16. doi request reprint Late response to low-dose imatinib in patients with chronic phase chronic myeloid leukemia
    Akiyoshi Takami
    Department of Hematology and Oncology, Kanazawa University Hospital, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Int J Hematol 96:357-63. 2012
    ..These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose...
  17. ncbi request reprint Beneficial effects of urokinase on lipopolysaccharide-induced disseminated intravascular coagulation in rats: focus on organ function and endothelin levels
    Hidesaku Asakura
    Department of Internal Medicine, Kanazawa, Ishikawa 920 8641, Japan
    Thromb Haemost 93:724-8. 2005
    ..Enhanced fibrinolysis and depressed endothelin induced by UK thus appear to play an important role in preventing the development of organ failure in the LPS-induced DIC model...
  18. ncbi request reprint Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm
    Yasuo Ontachi
    Department of Internal Medicine III, Kanazawa University School of Medicine, Kanazawa, Japan
    Circ J 69:1150-3. 2005
    ..5 g x 3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip...
  19. doi request reprint The recipient CXCL10 + 1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation
    Katsuya Nakata
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    Clin Immunol 146:104-11. 2013
    ..CXCL10 genotyping could therefore be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of patients who undergo allogeneic BMT...
  20. ncbi request reprint Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
    Hiroyuki Takamatsu
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Blood 109:2514-20. 2007
    ....
  21. ncbi request reprint Effect of montelukast in a guinea pig model of cough variant asthma
    Masaru Nishitsuji
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, 920 8641 Kanazawa, Japan
    Pulm Pharmacol Ther 21:142-5. 2008
    ..In conclusion, cysLTs may play an important part in antigen-induced cough associated with bronchoconstriction and airway inflammation in cough variant asthma...
  22. ncbi request reprint Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid
    Yasuo Ontachi
    Department of Internal Medicine III, Kanazawa University School of Medicine, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Haematologica 90:ECR29. 2005
    ..The therapy did not restrict the behavior of the patient by continuous drip and angiography could be performed without bleeding. Such therapy may be beneficial in chronic DIC with activation of fibrinolysis...
  23. doi request reprint Expression of annexin II in experimental abdominal aortic aneurysms
    Tomoe Hayashi
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Int J Hematol 90:336-42. 2009
    ..It has been suggested that alteration of fibrinolytic activity regulated by annexin II within the aortic wall may be associated with aneurysm formation...
  24. doi request reprint Sputum eosinophilia, airway hyperresponsiveness and airway narrowing in young adults with former asthma
    Johsuke Hara
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Ishikawa, Japan
    Allergol Int 57:211-7. 2008
    ..30-80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function of lower airway in adolescents with former asthma...
  25. ncbi request reprint Living-donor lobar lung transplantation for broncho-bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: does bronchiolitis obliterans recur in transplanted lungs?
    Hirokazu Okumura
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8641, Japan
    Int J Hematol 86:369-73. 2007
    ..LDLLT may therefore be considered a viable therapeutic option for the treatment of BO after allogeneic HSCT...
  26. doi request reprint CD16+ CD56- NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect
    Xuzhang Lu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Eur J Haematol 81:18-25. 2008
    ....
  27. doi request reprint Relationship between tumor-infiltrating T lymphocytes and clinical response after reduced-intensity allogeneic hematopoietic stem cell transplantation for advanced renal cell carcinoma: a single center prospective study
    Ken Ishiyama
    Division of Cancer Medicine, Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Jpn J Clin Oncol 39:807-12. 2009
    ..We performed an institutional clinical study of HSCT for refractory RCC patients...
  28. doi request reprint Effects of KF19514, a phosphodiesterase 4 and 1 Inhibitor, on bronchial inflammation and remodeling in a murine model of chronic asthma
    Toshiyuki Kita
    Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Ishikawa, Japan
    Allergol Int 58:267-75. 2009
    ..Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling...
  29. doi request reprint Aberrant increase in the immature platelet fraction in patients with myelodysplastic syndrome: a marker of karyotypic abnormalities associated with poor prognosis
    Naomi Sugimori
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 82:54-60. 2009
    ..To determine the significance of such an unbalanced increase in the IPF%, we investigated the IPF% and other laboratory findings of 51 patients recently diagnosed with MDS...
  30. doi request reprint Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages
    Takamasa Katagiri
    Clinical Laboratory Science, Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Stem Cells 31:536-46. 2013
    ..Our computer simulation based on this model successfully recapitulated the observed clinical data...
  31. ncbi request reprint Mycophenolate mofetil is effective and well tolerated in the treatment of refractory acute and chronic graft-versus-host disease
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, University Graduate School of Medicine, Kanazawa, Japan
    Int J Hematol 83:80-5. 2006
    ..This preliminary study suggests that MMF is a well-tolerated agent and has a beneficial effect in the treatment of refractory acute and chronic GVHD...
  32. doi request reprint Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis
    Xuzhang Lu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cancer Sci 101:609-15. 2010
    ..These data suggest that VPA and HU might enhance the NK cell-mediated antileukemia effect by increasing the susceptibility of myeloid leukemic cells to NK cells...
  33. ncbi request reprint Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Ishikawa, Japan
    Crit Care Med 34:2421-5. 2006
    ..We attempted to clarify the effect of immunoglobulin concentrates on the rat lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) model...
  34. ncbi request reprint Comparative analysis of epidermal growth factor receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall cell lung cancer
    Takashi Sone
    Respiratory Medicine, School of Medicine, Kanazawa University, Kanazawa, and Shien Lab, National Cancer Center Hospital, Tokyo, Japan
    Cancer 109:1836-44. 2007
    ....
  35. pmc Favorable outcome of patients who have 13q deletion: a suggestion for revision of the WHO 'MDS-U' designation
    Kohei Hosokawa
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Haematologica 97:1845-9. 2012
    ....
  36. pmc A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation
    J Luis Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    PLoS ONE 6:e26229. 2011
    ....
  37. pmc Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies
    Luis J Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    PLoS ONE 6:e23827. 2011
    ..These data suggest that there is an association between the granzyme B genotype and better clinical outcomes in patients with myeloid malignancies after unrelated BMT...
  38. ncbi request reprint Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells
    Xingmin Feng
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Blood 104:2425-31. 2004
    ..These findings indicate that DRS-1 may serve as an autoantigen eliciting immune attack against hematopoietic stem cells in a subset of AA patients characterized by increased PNH-type cells...
  39. ncbi request reprint Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells
    Ken Ishiyama
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Blood 102:1211-6. 2003
    ..026). These results suggest that AA and RA with a minor population of PNH-type cells are benign types of BM failure with immune pathophysiology that have little relationship to clonal disorders such as RAEB or acute myeloid leukemia...
  40. doi request reprint Autoantibodies specific to hnRNP K: a new diagnostic marker for immune pathophysiology in aplastic anemia
    Zhirong Qi
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Ann Hematol 89:1255-63. 2010
    ..The detection of anti-hnRNP K Abs as well as PNH-type cells may therefore be useful for diagnosing the immune pathophysiology of AA...
  41. doi request reprint Increased glycosylphosphatidylinositol-anchored protein-deficient granulocytes define a benign subset of bone marrow failures in patients with trisomy 8
    Kohei Hosokawa
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 95:230-8. 2015
    ..Examining the peripheral blood for the presence of increased GPI-AP(-) cells may thus be helpful for choosing the optimal treatment for +8 patients with AA or low-risk MDS...
  42. ncbi request reprint Post-transplantation consolidation and maintenance therapy with lenalidomide for Japanese patients with multiple myeloma
    Hiroyuki Takamatsu
    Cellular Transplantation Biology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Anticancer Res 33:5681-5. 2013
    ..However, there have been no reports of Japanese patients with MM treated with post-ASCT consolidation/maintenance therapies...
  43. doi request reprint TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Nature 463:676-80. 2010
    ..Our results demonstrate a critical role for the TGF-beta-FOXO pathway in the maintenance of LICs, and strengthen our understanding of the mechanisms that specifically maintain CML LICs in vivo...
  44. doi request reprint MET increases the sensitivity of gefitinib-resistant cells to SN-38, an active metabolite of irinotecan, by up-regulating the topoisomerase I activity
    Asao Sakai
    Respiratory Medicine, Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Thorac Oncol 7:1337-44. 2012
    ..The purpose of this study was to investigate the mechanisms responsible for the increased sensitivity of the gefitinib-resistant cell line to SN-38...
  45. doi request reprint An Epstein-Barr virus-associated leukemic lymphoma in a patient treated with rabbit antithymocyte globulin and cyclosporine for hepatitis-associated aplastic anemia
    Kinya Ohata
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
    Acta Haematol 127:96-9. 2012
    ..We also review the pertinent literature on EBV-LPD after immunosuppressive therapy and document the efficacy of EBV viral load monitoring and the need for preemptive therapy...
  46. pmc Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice
    Yuko Waseda
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Respir Res 9:43. 2008
    ..The role of angiotensin II type 2 receptor (AT2) in pulmonary fibrosis is unknown. To evaluate the influence of angiotensin II type 1 receptor (AT1) and AT2 antagonists in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis...
  47. doi request reprint Mycophenolic acid inhibits natural killer cell proliferation and cytotoxic function: a possible disadvantage of including mycophenolate mofetil in the graft-versus-host disease prophylaxis regimen
    Kinya Ohata
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Biol Blood Marrow Transplant 17:205-13. 2011
    ..These results suggest that MPA is a potent inhibitor of NK cells, and that its inclusion in the GVHD prophylaxis regimen might diminish the graft-versus-leukemia effect of NK cells...
  48. doi request reprint Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway
    J Luis Espinoza
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int Immunol 21:913-23. 2009
    ..These results indicate that anti-moesin antibodies induce TNF-alpha secretion from monocytes through the activation of the ERK1/2 pathway provoked by direct binding to moesin on the cells...
  49. doi request reprint Bronchoconstriction-triggered cough in conscious guinea pigs
    Noriyuki Ohkura
    Department of Respiratory Medicine, Division of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Lung Res 35:296-306. 2009
    ..Bronchoconstriction causes cough via RARs, but not C-fibers. Neither RARs nor C-fibers are involved in Mch-induced bronchoconstriction itself...
  50. doi request reprint Increased macrophage colony-stimulating factor levels in patients with Graves' disease
    Eriko Morishita
    Department of Clinical Laboratory Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
    Int J Hematol 88:272-7. 2008
    ..05). The close correlation between serum M-CSF and serum thyroid hormone levels suggests that high circulating levels of thyroid hormones may directly or indirectly potentiate the production of M-CSF in patients with GD...
  51. doi request reprint Aplastic anemia successfully treated with rituximab: the possible role of aplastic anemia-associated autoantibodies as a marker for response
    Hiroyuki Takamatsu
    Department of Hematology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan
    Eur J Haematol 86:541-5. 2011
    ..Anti-CD20 monoclonal antibody therapy may be effective in a subset of patients with AA characterized by the presence of autoantibodies...
  52. ncbi request reprint Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer
    Akihiro Yoshimoto
    Department of Hematology Oncology and Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Jpn J Clin Oncol 35:233-8. 2005
    ....
  53. doi request reprint Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia
    Hiroyuki Maruyama
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Exp Hematol 44:931-939.e3. 2016
    ....
  54. doi request reprint A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation
    Haruka Nomoto
    Department of Clinical Laboratory Science, Kanazawa University School of Medical Sciences, Kanazawa, Japan
    Int J Hematol 102:460-70. 2015
    ....
  55. pmc Comparison of cough reflex sensitivity after an inhaled antigen challenge between actively and passively sensitized guinea pigs
    Johsuke Hara
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, 920 8641, Japan
    Cough 1:6. 2005
    ..The aim of this study was to compare the cough reflex sensitivity to inhaled capsaicin after an inhaled antigen challenge between actively and passively sensitized guinea pigs...
  56. ncbi request reprint Surfactant degradation activity in bronchoalveolar lavage fluid from guinea pigs challenged with antigen
    Miki Abo
    Department of Respiratory and Hematology Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Respirology 12:828-33. 2007
    ..The aim of this study was to examine whether bronchoalveolar lavage fluid (BALF) has surfactant degradation activity after antigen challenge, using an animal model of asthma...
  57. doi request reprint Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B
    Junko Ishizaki
    Department of Clinical Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Japan
    Biopharm Drug Dispos 29:195-203. 2008
    ..It is suggested that careful monitoring of CyA levels is necessary in the event of AMB administration to patients receiving immunotherapy with CyA...
  58. ncbi request reprint Successful treatment of minimal residual disease-positive Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib followed by reduced-intensity unrelated cord blood transplantation after allogeneic peripheral blood stem cell transplant
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    Int J Hematol 84:170-3. 2006
    ....
  59. ncbi request reprint Cyclosporine therapy for acquired aplastic anemia: predictive factors for the response and long-term prognosis
    Hirohito Yamazaki
    Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Hematol 85:186-90. 2007
    ..Given its low toxicity and because the effectiveness of CsA can be judged within 2 months of therapy, CsA may be the first drug of choice at outpatient clinics for AA patients not requiring transfusions...
  60. doi request reprint Efficacy and safety of micafungin as an empirical therapy for invasive fungal infections in patients with hematologic disorders: a multicenter, prospective study
    Masaki Yamaguchi
    Department of Hematology, Ishikawa Prefectural Central Hospital, 2 1 Kuratsukihigashi, Kanazawa City, Ishikawa, Japan
    Ann Hematol 90:1209-17. 2011
    ..These results indicate the effectiveness and safety of micafungin as an empirical therapy for suspected IFIs, including FN, and the usefulness of monitoring both BG and GM to detect breakthrough IFIs...
  61. doi request reprint Cord blood transplantation using minimum conditioning regimens for patients with hematologic malignancies complicated by severe infections
    Takeshi Yamashita
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Int J Hematol 89:238-42. 2009
    ....
  62. pmc NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies
    J Luis Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Haematologica 94:1427-34. 2009
    ....
  63. ncbi request reprint A phase II study of combination chemotherapy with docetaxel and carboplatin for patients with advanced or metastatic non-small cell lung cancer
    Kazuo Kasahara
    Respiratory Medicine, Kanazawa University Hospital, Takara machi 13 1, Kanazawa, Ishikawa, Japan
    Anticancer Res 26:3723-8. 2006
    ..The aim of this phase II study was to evaluate the efficacy of combination chemotherapy consisting of docetaxel and carboplatin in patients with inoperable non-small cell lung cancer (NSCLC)...
  64. ncbi request reprint Isolated hyperkalemia associated with cyclosporine administration in allogeneic stem cell transplantation for renal cell carcinoma
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Int J Hematol 81:159-61. 2005
    ..We propose that the presence of a single functional kidney may be a risk factor for isolated hyperkalemia due to CSP...
  65. doi request reprint Hypersensitivity pneumonitis and bronchial asthma attacks caused by environmental fungi
    Nobuyuki Katayama
    Respiratory Medicine, Kanazawa University Hospital, Ishikawa, Japan
    Allergol Int 57:277-80. 2008
    ..adusta and bronchial asthma attacks caused by B. adusta and A. fumigatus. After cleaning the entire house, the patient has had no recurrence of the symptoms on returning home...
  66. ncbi request reprint Prospective trial of high-dose chemotherapy followed by infusions of peripheral blood stem cells and dose-escalated donor lymphocytes for relapsed leukemia after allogeneic stem cell transplantation
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    Int J Hematol 82:449-55. 2005
    ..The low induction rate of GVHD and extramedullary relapse after remission is achieved with DLI are problems yet to be solved...
  67. ncbi request reprint Airway wall structure assessed by endobronchial ultrasonography and bronchial hyperresponsiveness in patients with asthma
    Toshiyuki Kita
    Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa Department of Chest Surgery, St Marianna University, School of Medicine, Kanagawa, Japan
    J Bronchology Interv Pulmonol 17:301-6. 2010
    ..The purpose of this study was to evaluate the relationship between the wall structure assessed by using endobronchial ultrasonography (EBUS) and bronchial hyperresponsiveness in patients with asthma...
  68. doi request reprint Expression of annexin II in human atherosclerotic abdominal aortic aneurysms
    Tomoe Hayashi
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1, Takaramachi, Kanazawa, 920 8641, Japan
    Thromb Res 123:274-80. 2008
    ..Therefore, we examined annexin II localization in the wall of human atherosclerotic AAAs...
  69. ncbi request reprint Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease: a case report
    Tomoe Hayashi
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Hematol 81:121-3. 2006
    ..After SH treatment, his plasma PDGF and total TGF-beta levels decreased, and he noticed improvement in his skin pigmentation. In the present case, SH may have improved the skin lesion by inhibiting the synthesis of PDGF and TGF-beta...
  70. ncbi request reprint Danazol therapy for aplastic anemia refractory to immunosuppressive therapy
    Tatsuya Chuhjo
    Department of Internal Medicine, NTT Kanazawa Hospital, Kanazawa, Ishikawa, Japan
    Am J Hematol 83:387-9. 2008
    ..These findings indicate that danazol is effective for a subset of AA patients, and particularly for female patients with AA refractory to IST...
  71. ncbi request reprint A case of acute hypersensitivity pneumonitis associated with an oil fan heater
    Johsuke Hara
    Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa City, Ishikawa, Japan
    Am J Med Sci 331:35-6. 2006
    ..Intradermal reaction and precipitin results to sugar antigen of those fungi were positive only in the patient. This is the first described case of acute hypersensitivity pneumonitis caused by an oil fan heater...
  72. doi request reprint GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure
    Takamasa Katagiri
    Clinical Laboratory Science, Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Eur J Haematol 86:226-36. 2011
    ..The presence of GPI-AP(-) T cells, as well as GPI-AP(-) myeloid cells, may therefore reflect the immunopathophysiology of BMF in which cytokine-mediated suppression of hematopoietic stem cells via GPI-AP-type receptors takes place...
  73. ncbi request reprint Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: two case reports
    Chiharu Sugimori
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Hematol 77:391-4. 2003
    ....
  74. doi request reprint Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia
    Takamasa Katagiri
    Clinical Laboratory Science, Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    Blood 118:6601-9. 2011
    ..Our results provide a novel insight into the genetic basis of the pathogenesis of AA...
  75. ncbi request reprint Bronchial asthma showing reduction in FEV1 after inhalation of Qvar
    Kouichi Nobata
    Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
    J Asthma 43:427-8. 2006
    ..These findings would be noteworthy when using Qvar for Japanese patients with asthma known to have a relatively high frequency of the complication of alcohol-induced asthma...
  76. doi request reprint Ischemic heart disease associated with bortezomib treatment combined with dexamethasone in a patient with multiple myeloma
    Hiroyuki Takamatsu
    Department of Internal Medicine, NTT West Kanazawa Hospital, 6 26 Shimoshinmachi, Kanazawa, Ishikawa, 920 0910, Japan
    Int J Hematol 91:903-6. 2010
    ..It is, therefore, important to carefully monitor patients being treated with bortezomib for the potential occurrence of ischemic heart disease...
  77. ncbi request reprint Randomized phase II trial of OK-432 in patients with malignant pleural effusion due to non-small cell lung cancer
    Kazuo Kasahara
    Respiratory Medicine, Kanazawa University Hospital, 13 1, Takara machi, Kanazawa, Ishikawa, 920 8641, Japan
    Anticancer Res 26:1495-9. 2006
    ..Although the malignant pleural effusion control rate was equivalent in each treatment arm, faster control and less drainage were achieved in arm A. A dose of OK-432 10 KE/body is, therefore, recommended for further trial...
  78. ncbi request reprint Inhaled lysophosphatidylcholine provokes bronchoconstriction in guinea pigs in vivo
    Kouichi Nobata
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Eur J Pharmacol 520:150-5. 2005
    ....
  79. ncbi request reprint Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases
    Akihiro Yoshimoto
    Department of Hematology Oncology, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Oncol Rep 13:1049-57. 2005
    ..Prostaglandin biosynthetic pathway markers may act synergistically and enhance tumor angiogenesis, the expression of angiogenic factors, and metastases in patients with NSCLC...
  80. ncbi request reprint B-cell neurolymphomatosis confined to the peripheral nervous system
    Ayumi Shibata-Hamaguchi
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    J Neurol Sci 260:249-52. 2007
    ..This was a very rare case of B-cell neurolymphomatosis with lymphomatous infiltration confined to the PNS, suggesting specific affinity of the lymphoma cells for the PNS in this patient...
  81. ncbi request reprint Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes
    Shigeru Shimadoi
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:1368-72. 2007
    ..6- and 1.5-fold, whereas the expression of Fcgamma receptor II remained unchanged. These results suggest that pretreatment with M-CSF can improve the therapeutic efficacy of rituximab against intractable CD20(+) lymphoma...
  82. ncbi request reprint A guinea pig model for cough variant asthma and role of tachykinins
    Masaru Nishitsuji
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, Kanazawa, Japan
    Exp Lung Res 30:723-37. 2004
    ..Tachykinins may not play an important part in antigen-induced cough associated with bronchoconstriction and airway inflammation in cough variant asthma...
  83. ncbi request reprint Atorvastatin reduces plasma levels of factor VII activity and factor VII antigen in patients with hyperlipidemia
    Eriko Morishita
    Department of Laboratory Sciences, School of Health Science, Kanazawa University, Japan
    J Atheroscler Thromb 9:72-7. 2002
    ..The effects of atorvastatin on FVII may contribute to a decreased thrombotic potential, resulting in fewer thromboembolic events, including a reduction in coronary heart disease...
  84. ncbi request reprint A phase I study of carboplatin and docetaxel for advanced non-small cell lung cancer using the continual reassessment method
    Kazuo Kasahara
    Respiratory Medicine, School of Medicine, Kanazawa University, Japan
    Jpn J Clin Oncol 32:512-6. 2002
    ....
  85. ncbi request reprint Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder simultaneously affecting both B and T cells after allogeneic bone marrow transplantation
    Tatsuya Chuhjo
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
    Am J Hematol 72:255-8. 2003
    ..This case clearly indicates that EBV can simultaneously infect B and T cells and can induce clonal proliferation of both lymphocyte subsets in severely immunocompromised patients...
  86. ncbi request reprint Pulmonary hypertension after splenectomy in hereditary stomatocytosis
    Akihiro Yoshimoto
    Department of Hematology Oncology and Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Am J Med Sci 330:195-7. 2005
    ..It is important to confirm the diagnosis of hemolytic anemia, and splenectomy should be performed with due consideration of whether patients have hemolytic anemia...
  87. ncbi request reprint Induction of vasoactive substances differs in LPS-induced and TF-induced DIC models in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    Thromb Haemost 88:663-7. 2002
    ..Our results suggest that modulator of vasoactive substances should be examined in the treatment of DIC...
  88. ncbi request reprint Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome
    Hongbo Wang
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
    Blood 100:3897-902. 2002
    ..To choose an appropriate therapy, peripheral blood should be tested using sensitive flow cytometry for the presence of PNH-type cells in all patients with bone marrow failure before treatment...
  89. ncbi request reprint Treatment of primary central nervous system lymphoma with induction of complement-dependent cytotoxicity by intraventricular administration of autologous-serum-supplemented rituximab
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa Univeristy Graduate School of Medicine, Kanazawa 920 8641, Japan
    Cancer Sci 97:80-3. 2006
    ....
  90. ncbi request reprint Marked difference in pathophysiology between tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University, School of Medicine, Ishikawa, Japan
    Crit Care Med 30:161-4. 2002
    ....
  91. ncbi request reprint Primary tracheal lymphoma: case report and literature review
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Japan
    Int J Hematol 82:338-42. 2005
    ..Various histological subtypes of primary tracheal lymphoma exist and are likely to determine prognosis...
  92. ncbi request reprint Pulmonary T-cell lymphoma with pulmonary arterial hypertension
    Satoshi Watanabe
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Sciences, Japan
    Intern Med 50:1733-6. 2011
    ..We should include pulmonary lymphoma in the differential diagnosis of patients with PAH and chest CT findings of diffuse ground-glass opacities and interlobular septal thickening...
  93. ncbi request reprint Effect of intranasal administration of CV-11974, a type 1 angiotensin II receptor antagonist, on airway hyperresponsiveness and airway inflammation induced by antigen inhalation in guinea pigs
    Shigeharu Myou
    Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
    Int Arch Allergy Immunol 129:86-92. 2002
    ..Angiotensin II is a putative mediator in asthma, but the effect of topical administration of type 1 angiotensin II (AT1) receptor antagonists on allergic airway reactions is not known...
  94. ncbi request reprint Pathophysiology of disseminated intravascular coagulation (DIC) progresses at a different rate in tissue factor-induced and lipopolysaccharide-induced DIC models in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Ishikawa, Kanazawa 920 8641, Japan
    Blood Coagul Fibrinolysis 14:221-8. 2003
    ....
  95. ncbi request reprint [Comparison of the bronchodilator effect of salbutamol between pressure metered dosed inhaler and dry powder inhaler in patients with stable bronchial asthma]
    Yuzo Yoshimi
    Pulmonary Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
    Arerugi 53:502-7. 2004
    ..These results may reflect the correlation of inspiratory flow rate and drug deposition. PMDI is still useful on the part of asthmatic patients with decreased pulmonary function...
  96. ncbi request reprint Significance of decreased plasma D-dimer levels following lipopolysaccharide-induced disseminated intravascular coagulation in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
    Int J Hematol 79:394-9. 2004
    ..Thus care should be taken when evaluating the significance of plasma DD levels, because suppressed levels can occur with progressive fibrin deposition and worsening organ dysfunction or improvement in the course of DIC...
  97. ncbi request reprint [Immune pathophysiology of refractory anemias]
    Shinji Nakao
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 66:453-9. 2008
    ..Identification of auto-antigens capable of inducing cytotoxic T cells against hematopoietic stem cells is necessary to prove the escape of PIG-A mutant clone from the immune system attack using animal models...
  98. ncbi request reprint Eosinophilic pneumonia (EP) associated with rheumatoid arthritis in which drug-induced eosinophilic pneumonia could be ruled out
    Yuichi Tambo
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
    Intern Med 47:527-31. 2008
    ..After increasing the dose of prednisolone to 30 mg daily again, consolidation was promptly resolved. It was considered to be important to rule out drug-induced EP...
  99. ncbi request reprint Antithrombotic role of nitric oxide in rats under physiological conditions
    Hidesaku Asakura
    Department of Internal Medicine III Kanazawa University School of Medicine Takaramachi 13 1, Kanazawa Ishikawa 920 8641, Japan
    Thromb Haemost 91:71-5. 2004
    ..These findings suggest that NO, in addition to regulating blood pressure, is involved in prevention of thrombus formation under physiological circumstances...
  100. ncbi request reprint Peripheral neuropathy associated with chronic natural killer cell lymphocytosis
    Moeko Noguchi
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Neurol Sci 232:119-22. 2005
    ..Our observations suggest that the infiltrating NK cells may directly damage myelin and Schwann cells, thus causing demyelination...
  101. ncbi request reprint A case of hypersensitivity pneumonitis caused by Humicola fuscoatra
    Toshiyuki Kita
    Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa University School of Medicine, Kanazawa, Japan
    Respirology 8:95-8. 2003
    ..Based on these results, we advised the patient to cleanse her entire house. Since cleaning, her symptoms have not worsened upon returning home. This is the first report of hypersensitivity pneumonitis caused by H. fuscoatra antigen...