Takahiro Higuchi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Imaging of angiogenesis in cardiology
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur J Nucl Med Mol Imaging 34:S9-19. 2007
  2. ncbi request reprint Characterization of normal and infarcted rat myocardium using a combination of small-animal PET and clinical MRI
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
    J Nucl Med 48:288-94. 2007
  3. doi request reprint Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Cardiovasc Res 78:395-403. 2008
  4. doi request reprint A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats
    Takahiro Higuchi
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:1715-22. 2008
  5. doi request reprint Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1088-94. 2009
  6. doi request reprint Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1881-6. 2009
  7. doi request reprint Initial characterization of an 18F-labeled myocardial perfusion tracer
    Marc C Huisman
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:630-6. 2008
  8. doi request reprint Evaluation of a novel (18)F-labeled positron-emission tomography perfusion tracer for the assessment of myocardial infarct size in rats
    Hossam M Sherif
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circ Cardiovasc Imaging 2:77-84. 2009
  9. doi request reprint Molecular imaging of early αvβ3 integrin expression predicts long-term left-ventricle remodeling after myocardial infarction in rats
    Hossam M Sherif
    Nuklearmedizinische Klinik, Technischen Universitat Munchen, Munich, Germany
    J Nucl Med 53:318-23. 2012
  10. doi request reprint Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 54:1142-6. 2013

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Imaging of angiogenesis in cardiology
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur J Nucl Med Mol Imaging 34:S9-19. 2007
    ..Although few clinical imaging results are currently available, animal studies suggest the potential role of molecular imaging for characterisation of the angiogenetic process in vivo and for the monitoring of therapeutic effects...
  2. ncbi request reprint Characterization of normal and infarcted rat myocardium using a combination of small-animal PET and clinical MRI
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
    J Nucl Med 48:288-94. 2007
    ..We sought to determine the feasibility of PET and MRI for the quantification of ischemic injury in the rat model...
  3. doi request reprint Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Cardiovasc Res 78:395-403. 2008
    ....
  4. doi request reprint A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats
    Takahiro Higuchi
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:1715-22. 2008
    ..To investigate the potential of a new (18)F-labeled pyridazinone analog ((18)F-BMS-747158-02), we characterized this tracer in a rat model of permanent and transient coronary occlusion using small-animal PET...
  5. doi request reprint Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1088-94. 2009
    ..This study assessed the feasibility and usefulness of combined PET and MRI for monitoring cell engraftment and survival after cell transplantation...
  6. doi request reprint Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1881-6. 2009
    ..We investigated whether reporter gene PET can be used to detect the effects of atorvastatin and VEGF on survival of EPCs after transplantation in the rat heart...
  7. doi request reprint Initial characterization of an 18F-labeled myocardial perfusion tracer
    Marc C Huisman
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:630-6. 2008
    ..Here, the biodistribution and imaging quality of a new 18F-labeled myocardial perfusion agent (18F-BMS-747158-02) in an animal model are described...
  8. doi request reprint Evaluation of a novel (18)F-labeled positron-emission tomography perfusion tracer for the assessment of myocardial infarct size in rats
    Hossam M Sherif
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circ Cardiovasc Imaging 2:77-84. 2009
    ..The goal of this study was to evaluate a new (18)F-labeled positron-emission tomography (PET) perfusion tracer, (18)F BMS747158-02, for the assessment of myocardial infarct (MI) size...
  9. doi request reprint Molecular imaging of early αvβ3 integrin expression predicts long-term left-ventricle remodeling after myocardial infarction in rats
    Hossam M Sherif
    Nuklearmedizinische Klinik, Technischen Universitat Munchen, Munich, Germany
    J Nucl Med 53:318-23. 2012
    ..We studied whether myocardial (18)F-RGD uptake early after MI is associated with long-term left-ventricle (LV) remodeling in a rat model...
  10. doi request reprint Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 54:1142-6. 2013
    ..The aim of this study was to investigate the mechanisms of (18)F-LMI1195 cardiac uptake in the rat, which is known to contain norepinephrine uptake mechanisms beyond uptake-1...
  11. doi request reprint Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG
    Rudolf A Werner
    Department of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany Comprehensive Heart Failure Center CHFC, University of Wuerzburg, Wuerzburg, Germany
    J Nucl Med 56:1429-33. 2015
    ..Highly specific neural uptake of (18)F-LMI1195 has previously been established, but the retention kinetics are not yet fully understood...
  12. ncbi request reprint Initial Preclinical Evaluation of 18F-Fluorodeoxysorbitol PET as a Novel Functional Renal Imaging Agent
    Hiroshi Wakabayashi
    Department of Nuclear Medicine, University of Wurzburg, Wurzburg, Germany
    J Nucl Med 57:1625-1628. 2016
    ..Furthermore, it can be synthesized via simple reduction of widely available 18F-FDG. We tested the feasibility of 18F-FDS renal PET imaging in rats...
  13. ncbi request reprint 11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis
    Yoshifumi Maya
    Department of Nuclear Medicine, University of Wurzburg, Wurzburg, Germany
    J Nucl Med 57:1985-1990. 2016
    ..In this study, we explored the potential of radiolabeled methionine to assess myocardial inflammatory activity in a rat model of experimental autoimmune myocarditis (EAM)...
  14. doi request reprint Sympathetic nerve damage and restoration after ischemia-reperfusion injury as assessed by (11)C-hydroxyephedrine
    Rudolf A Werner
    Department of Nuclear Medicine, University of Wurzburg, Oberdurrbacher Strasse 6, 97080, Wurzburg, Germany
    Eur J Nucl Med Mol Imaging 43:312-8. 2016
    ..The aim of this study was to investigate regional sympathetic nerve damage and restoration utilizing a rat model of myocardial transient ischemia and a catecholamine analog PET tracer, (11)C-hydroxyephedrine ((11)C-HED)...
  15. doi request reprint Small-animal PET imaging of isolated perfused rat heart
    Tomohiko Yamane
    Department of Nuclear Medicine, University of Wurzburg, Wurzburg, Germany
    J Nucl Med 55:495-9. 2014
    ..Analysis of the isolated perfused rat heart by a high-resolution small-animal PET system may offer both reliable evaluation of cardiac tracer kinetics and tomographic images...
  16. doi request reprint Impact of tissue photon attenuation in small animal cardiac PET imaging
    Nobuyuki Hayakawa
    Department of Nuclear Medicine, University Hospital Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University Hospital Wurzburg, Wurzburg, Germany
    Int J Cardiol . 2016
    ..The present cardiac PET study compares lean and obese rats to determine the influence of tissue attenuation on quantitative assessment as well as regional tracer distribution...
  17. pmc The impact of 177Lu-octreotide therapy on 99mTc-MAG3 clearance is not predictive for late nephropathy
    Rudolf A Werner
    Department of Nuclear Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Oncotarget 7:41233-41241. 2016
    ..TER assessed by 99mTc-MAG3-clearance prior to and during PRRT is not suitable as early predictor of renal injury and an increased risk for late nephropathy...
  18. ncbi request reprint Imaging cardiac neuronal function and dysfunction
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Strasse 22, 81675 Munchen, Germany
    Curr Cardiol Rep 8:131-8. 2006
    ....
  19. ncbi request reprint Effect of the angiotensin receptor blocker Valsartan on coronary microvascular flow reserve in moderately hypertensive patients with stable coronary artery disease
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
    Microcirculation 14:805-12. 2007
    ..To noninvasively investigate the effects of the angiotensin receptor blocker (ARB) Valsartan. on myocardial microcirculation in moderately hypertensive patients with stable coronary artery disease (CAD)...
  20. doi request reprint Survival prediction in patients undergoing radionuclide therapy based on intratumoral somatostatin-receptor heterogeneity
    Rudolf A Werner
    Department of Nuclear Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Oncotarget . 2016
    ..Imaging-based heterogeneity assessment provides prognostic information in PRRT candidates and outperformed conventional PET parameters. Its implementation in clinical practice can pave the way for individualized patient management...
  21. doi request reprint Assessment of coronary flow reserve using a combination of planar first-pass angiography and myocardial SPECT: Comparison with myocardial (15)O-water PET
    Naoko Nose
    Department of Nuclear Medicine, University Hospital Wuerzburg, Wuerzburg, Germany Comprehensive Heart Failure Center, University Hospital Wuerzburg, Wuerzburg, Germany
    Int J Cardiol 222:209-12. 2016
    ..Myocardial perfusion PET is a well-established technology for CFR measurement, however, availability is still limited. The aim of this study is to introduce and validate myocardial flow reserve measurement by myocardial perfusion SPECT...
  22. doi request reprint Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma
    Christina Bluemel
    Department of Nuclear Medicine, University Hospital of Wurzburg, Wurzburg, Germany
    Head Neck 36:E112-6. 2014
    ....
  23. ncbi request reprint Noninvasive imaging of heart failure: neuronal dysfunction and risk stratification
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munchen, Germany
    Heart Fail Clin 2:193-204. 2006
  24. doi request reprint Assessment of tumor heterogeneity in treatment-naïve adrenocortical cancer patients using (18)F-FDG positron emission tomography
    Rudolf A Werner
    Department of Nuclear Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Endocrine 53:791-800. 2016
    ..In this pilot study in treatment-naïve ACC patients, conventional (18)F-FDG PET-derived parameters and textural tumor heterogeneity features were not suitable to identify high-risk patients. ..
  25. pmc 68Gallium- and 90Yttrium-/ 177Lutetium: "theranostic twins" for diagnosis and treatment of NETs
    Rudolf A Werner
    Department of Nuclear Medicine, Universitatsklinikum Wurzburg, Oberdürrbacher Str 6, 97080, Wurzburg, Germany
    Ann Nucl Med 29:1-7. 2015
    ....
  26. doi request reprint Advances in PET myocardial perfusion imaging: F-18 labeled tracers
    Christoph Rischpler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Nucl Med 26:1-6. 2012
    ..These longer half-life F-18 labeled perfusion tracers can overcome the production and protocol limitations of currently used radiotracers for PET MPI...
  27. ncbi request reprint Usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography in a patient with Takayasu's arteritis associated with antiphospholipid syndrome
    Bunji Kaku
    Division of Cardiology, Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Japan
    Int Heart J 47:311-7. 2006
    ..18FDG PET was useful for evaluating the efficacy of the steroid therapy in addition to making a diagnosis of Takayasu's arteritis associated with antiphospholipid syndrome...
  28. ncbi request reprint (99m)Tc-Annexin-V uptake in a rat model of variable ischemic severity and reperfusion time
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    Circ J 71:1141-6. 2007
    ....
  29. ncbi request reprint Time course of discordant BMIPP and thallium uptake after ischemia and reperfusion in a rat model
    Takahiro Higuchi
    PET Center, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
    J Nucl Med 46:172-5. 2005
    ..Serial changes in fatty acid metabolism or use associated with acute ischemia and reperfusion were examined in rat hearts...
  30. ncbi request reprint 11C-acetate PET imaging of lung cancer: comparison with 18F-FDG PET and 99mTc-MIBI SPET
    Kotaro Higashi
    Department of Radiology, Kanazawa Medical University, 1 1 Daigaku, 920 0293 Uchinada, Kahokugun, Ishikawa, Japan
    Eur J Nucl Med Mol Imaging 31:13-21. 2004
    ..AC PET is less diagnostically informative than FDG PET in patients with lung cancer. However, AC PET may play a complementary role in the identification of low-grade malignancies that are not FDG avid...
  31. ncbi request reprint Detection of cardiomyocyte death in a rat model of ischemia and reperfusion using 99mTc-labeled annexin V
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Nucl Med 45:1536-41. 2004
    ..To determine the time course, location, and extent of this process, we studied groups of rats after a 20-min interval of coronary occlusion and reperfusion...
  32. ncbi request reprint Changes in myocardial oxidative metabolism after biventricular pacing as evaluated by [11C]acetate positron emission tomography
    Tsutomu Araki
    Department of Cardiology, Kanazawa Cardiovascular Hospital, Ishikawa, Japan
    Ann Nucl Med 17:605-8. 2003
    ..11C]acetate PET is a useful method of evaluating global and regional myocardial oxidative metabolism in patients who have undergone BVP therapy...
  33. ncbi request reprint Effect of postconditioning on myocardial 99mTc-annexin-V uptake: comparison with ischemic preconditioning and caspase inhibitor treatment
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Nucl Med 48:1301-7. 2007
    ....
  34. ncbi request reprint Electrocardiographic gated (99m)Tc-MIBI SPECT for functional assessment of patients after coronary artery bypass surgery: comparison of wall thickening and wall motion analysis
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Nucl Med 43:589-95. 2002
    ....
  35. ncbi request reprint [Value of FDG PET in diagnosis and management of lung cancer]
    Gencho Kuga
    Nihon Ronen Igakkai Zasshi 42:37-9. 2005
  36. ncbi request reprint Brown adipose tissue: evaluation with 201Tl and 99mTc-sestamibi dual-tracer SPECT
    Takahiro Higuchi
    Department of Kanazawa, PET Center, Kanazawa Cardiovascular Hospital, Ishikawa, Japan
    Ann Nucl Med 18:547-9. 2004
    ..Therefore, the activity of mitochondria in activated brown adipose tissue may explain the discrepant uptake between 99mTc-sestamibi and 201Tl...
  37. ncbi request reprint What is the diagnosis? Metastasis of right lung from osteosarcoma
    Takahiro Higuchi
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences
    Ann Nucl Med 16:Front cover, 142. 2002
  38. ncbi request reprint Discrepant uptake between fluorine-18 fluorodeoxy glucose and Tc-99m sestamibi in bronchioloalveolar cell carcinoma
    Takahiro Higuchi
    Department of Kanazawa PET Center, Kanazawa Cardiovascular Hospital, Japan
    Ann Nucl Med 17:499-501. 2003
    ..This case clearly indicates that the FDG uptake and MIBI uptake might provide different information regarding characteristics of lung cancer...
  39. ncbi request reprint Prediction of myocutaneous adverse side effect due to intra-arterial chemotherapy by intra-arterial (99m)Tc-macroaggregated albumin administration in patients with bone and soft-tissue tumors
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan
    J Nucl Med 43:1452-6. 2002
    ..99m)Tc-macroaggregated albumin (MAA) imaging with intra-arterial tracer administration was performed to evaluate drug distribution, and the ability of (99m)Tc-MAA imaging to predict local side effects was assessed...
  40. ncbi request reprint Multifactorial analysis on the short-term side effects occurring within 96 hours after radioiodine-131 therapy for differentiated thyroid carcinoma
    Tamotsu Kita
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan
    Ann Nucl Med 18:345-9. 2004
    ..This study was performed to clarify factors that might influence short-term side effects occurring within 96 hours after administration of 131I for patients with thyroid carcinoma...
  41. ncbi request reprint Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection
    Xiao Feng Li
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan
    Ann Nucl Med 17:489-93. 2003
    ..The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT...
  42. ncbi request reprint Characterization of cartilaginous tumors with 201Tl scintigraphy
    Takahiro Higuchi
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan
    Ann Nucl Med 19:95-9. 2005
    ..We attempted to clarify the characteristics of 201Tl uptake in various histological types of cartilaginous tumors and to assess its clinical value...
  43. ncbi request reprint 18F-FDG uptake by primary tumor as a predictor of intratumoral lymphatic vessel invasion and lymph node involvement in non-small cell lung cancer: analysis of a multicenter study
    Kotaro Higashi
    Department of Radiology, Kanazawa Medical University, Ishikawa 920 0293, Japan
    J Nucl Med 46:267-73. 2005
    ..The aim of this multicenter study was to determine whether (18)F-FDG uptake of the primary tumor is a predictor of intratumoral lymphatic vessel invasion and lymph node metastasis in patients with non-small cell lung cancer...