Kenichi Harada

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Intrahepatic bile duct loss in immune-mediated ductopenic biliary diseases with an emphasis on biliary epithelial apoptosis
    K Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Minerva Gastroenterol Dietol 49:41-51. 2003
  2. pmc Biliary innate immunity: function and modulation
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Mediators Inflamm 2010:. 2010
  3. pmc Cholangiopathy with respect to biliary innate immunity
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Int J Hepatol 2012:793569. 2012
  4. doi request reprint Clinicopathological significance of serum fractalkine in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    Dig Dis Sci 58:3037-43. 2013
  5. doi request reprint Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    J Clin Pathol 66:386-91. 2013
  6. doi request reprint Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: national data from Japan
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 57:1942-9. 2013
  7. ncbi request reprint Innate immunity in the pathogenesis of cholangiopathy: a recent update
    Kenichi Harada
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, Japan
    Inflamm Allergy Drug Targets 11:478-83. 2012
  8. doi request reprint Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: molecular mechanism of IgG4 reaction in cancer tissue
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 56:157-64. 2012
  9. doi request reprint Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Virchows Arch 460:281-9. 2012
  10. doi request reprint Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Clin Pathol 64:660-5. 2011

Detail Information

Publications92

  1. ncbi request reprint Intrahepatic bile duct loss in immune-mediated ductopenic biliary diseases with an emphasis on biliary epithelial apoptosis
    K Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Minerva Gastroenterol Dietol 49:41-51. 2003
    ..We review here the pathogenetic processes of immune-mediated ductopenic biliary diseases...
  2. pmc Biliary innate immunity: function and modulation
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Mediators Inflamm 2010:. 2010
    ..Moreover, the epithelial-mesenchymal transition (EMT) of biliary epithelial cells is also evoked by the biliary innate immune response to dsRNA...
  3. pmc Cholangiopathy with respect to biliary innate immunity
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Int J Hepatol 2012:793569. 2012
    ..Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems...
  4. doi request reprint Clinicopathological significance of serum fractalkine in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    Dig Dis Sci 58:3037-43. 2013
    ..We have reported that fractalkine expression associated with chronic inflammation is observed in the damaged bile ducts and periductal vessels of PBC patients, which is closely associated with chronic cholangitis...
  5. doi request reprint Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    J Clin Pathol 66:386-91. 2013
    ..In this study, the role of the Notch1-Hes1 signalling axis in the histogenesis of biliary NETs was examined...
  6. doi request reprint Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: national data from Japan
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 57:1942-9. 2013
    ..In addition, histological stage at the time of HCC diagnosis was an independent risk factor for HCC in females, whereas no risk factors were identified in males...
  7. ncbi request reprint Innate immunity in the pathogenesis of cholangiopathy: a recent update
    Kenichi Harada
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, Japan
    Inflamm Allergy Drug Targets 11:478-83. 2012
    ....
  8. doi request reprint Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: molecular mechanism of IgG4 reaction in cancer tissue
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 56:157-64. 2012
    ..Moreover, the number of IgG4-positive cells was larger in these cases than in other groups. In cultured cells, the presence of a splicing variant of Foxp3 messenger RNA and the expression of IL-10 were demonstrated...
  9. doi request reprint Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Virchows Arch 460:281-9. 2012
    ..Since the neuroendocrine component in biliary MANEC defines the prognosis, it is important to identify it and consider the indications for adjunctive therapy with somatostatin analogues...
  10. doi request reprint Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Clin Pathol 64:660-5. 2011
    ..In this study, among several fibrogenetic factors derived from biliary epithelial cells (BECs), MCP-1 produced by the biliary innate immune system was found to be most critical in the histogenesis of hepatic fibrogenesis...
  11. ncbi request reprint Molecular mechanisms of cholangiopathy in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    Med Mol Morphol 39:55-61. 2006
    ....
  12. doi request reprint Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma
    Manabu Onodera
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Lab Invest 89:1261-74. 2009
    ..Overexpression of fascin may have an important function in the progression of CC, and fascin expression might be involved in the signaling pathway in TNF-alpha-dependent production of MMP9 in CC...
  13. ncbi request reprint Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
    Shusaku Ohira
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 56:381-9. 2006
    ..In conclusion, local mutual influence of TGF-beta1 secreted from carcinoma cells and SDF-1 expressed by stromal fibroblasts may be involved in invasion of CC cells...
  14. doi request reprint Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 29:291-8. 2009
    ..In this study, we examined which signalling pathways are involved in TNF-alpha-induced MMP-9 upregulation in cholangiocarcinoma (CC)...
  15. doi request reprint Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Pathol 217:654-64. 2009
    ....
  16. pmc Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat
    Yasunori Sato
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, Japan
    Am J Pathol 171:1859-71. 2007
    ....
  17. pmc Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma
    Shusaku Ohira
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Am J Pathol 168:1155-68. 2006
    ..CXCR4 could be a therapeutic target to prevent ICC invasion...
  18. ncbi request reprint Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture
    Hiroko Ikeda
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Lab Invest 87:559-71. 2007
    ....
  19. pmc Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib
    Yasunori Sato
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, USA
    Am J Pathol 169:1238-50. 2006
    ..These results suggest that signaling pathways mediated by epidermal growth factor receptor are involved in biliary dysgenesis of the PCK rat, with the mechanisms of cyst progression being different between the liver and kidney...
  20. ncbi request reprint Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 27:1174-84. 2007
    ....
  21. pmc Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Am J Pathol 177:141-52. 2010
    ..These results suggest that epithelial-mesenchymal transition induced by TGF-beta1/Snail activation is closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis...
  22. doi request reprint Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis
    Saya Igarashi
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Histopathology 61:266-76. 2012
    ..In this study, the role of Pdx1 was examined in cholangiocarcinogenesis...
  23. doi request reprint Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma
    Junpei Yamaguchi
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Cancer Sci 101:355-62. 2010
    ....
  24. doi request reprint Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis
    Jing Xu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa University Hospital, Kanazawa, Japan
    Histopathology 59:1090-9. 2011
    ..The aim of this study was to compare the histological and immunohistochemical ICCs arising inCALD with those arising in livers with non-specific reactive (NSR) changes...
  25. ncbi request reprint Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction
    Seiko Sawada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 57:652-63. 2007
    ....
  26. doi request reprint Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin
    Junpei Yamaguchi
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Lab Invest 89:1018-31. 2009
    ..In conclusion, PHP in PBM may act as a barrier to malignant transformation for decades. EZH2 may be responsible for the escape from cellular senescence followed by malignant transformation in the gallbladder of PBM...
  27. pmc Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat
    Xiang Shan Ren
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Pathol 179:2845-54. 2011
    ..Biliary infection may thus exacerbate biliary cystogenesis in PCK rats...
  28. doi request reprint Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 31:245-53. 2011
    ....
  29. pmc Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Am J Pathol 174:829-41. 2009
    ..In conclusion, we propose a novel signaling pathway of MMP-9 up-regulation in CC cells such that TNF-alpha induces the activation of COX-2 and PGE2 via TNF-R1 followed by the up-regulation of MMP-9 via the PGE2 (EP2/4) receptor...
  30. ncbi request reprint Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 40:925-32. 2004
    ....
  31. doi request reprint Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    J Hepatobiliary Pancreat Sci 17:211-22. 2010
    ..More comparative studies between IPNB and pancreatic IPMN are recommended for further analysis of these papillary neoplasms...
  32. doi request reprint Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma
    Norihide Yoneda
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Lab Invest 91:262-72. 2011
    ....
  33. ncbi request reprint Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Histol Histopathol 25:223-35. 2010
    ..Comprehensive and analytical studies of ARPKD and BA using human materials and animal models may lead to the clarification of their etiopathogenesis and open the way for new therapeutic strategies...
  34. doi request reprint Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 39:710-9. 2008
    ..Underexpression of MMPs in papillary cholangiocarcinoma might be associated with a favorable prognosis...
  35. ncbi request reprint Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 41:1329-38. 2005
    ..Immunosuppression using PPARgamma ligands may be of therapeutic benefit to attenuate biliary inflammation in PBC...
  36. ncbi request reprint Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Lab Invest 83:1657-67. 2003
    ....
  37. doi request reprint Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease
    Mitsue Yasoshima
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Pathol 217:442-51. 2009
    ....
  38. doi request reprint Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    J Clin Pathol 67:396-402. 2014
    ..In this study, we investigated the PGC-1α-ERRα axis to clarify PDC dysfunction in CNSDC of PBC...
  39. doi request reprint Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules
    Chihiro Gandou
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 44:811-21. 2013
    ..Further studies on the carcinogenesis of these carcinomas based on their similarities are warranted...
  40. doi request reprint Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts
    Takashi Matsubara
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 43:2177-86. 2012
    ....
  41. doi request reprint Participation of liver cancer stem/progenitor cells in tumorigenesis of scirrhous hepatocellular carcinoma--human and cell culture study
    Takahiko Fujii
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 39:1185-96. 2008
    ..Small tumor cells with stem cell features in scirrhous hepatocellular carcinoma may correspond to side population of culture cells and might be involved in fibrogenesis of scirrhous hepatocellular carcinoma...
  42. doi request reprint Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis
    Hiroko Ikeda
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Fukui, Japan
    Pathol Int 59:471-8. 2009
    ..Zonal proliferation of CK7-positive small neoplastic hepatocytes resembling hepatic progenitor cells may develop during early hepatocarcinogenesis...
  43. doi request reprint Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 28:614-21. 2008
    ..g. endotoxin tolerance). Viral infections of the Reoviridae genus with a dsRNA genome are suspected to be part of the aetiology of biliary atresia (BA), but the negative biliary mechanisms remain unexplored...
  44. doi request reprint Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 61:298-305. 2011
    ..Some unique environmental factors in Seoul may be responsible for the frequent development of IPNB...
  45. ncbi request reprint Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor)
    Satoshi Kitagawa
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Am J Surg Pathol 29:783-91. 2005
    ..The abundance of IgG4-positive plasma cells in the lesions would be useful for distinguishing CSS from other forms of sialadenitis...
  46. ncbi request reprint Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 26:935-42. 2006
    ..Our aim here is to clarify the presence and molecular mechanisms of endotoxin tolerance of biliary epithelium...
  47. ncbi request reprint Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 46:1146-54. 2007
    ....
  48. doi request reprint α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression
    Hiroko Ikeda
    Section of Diagnostic Pathology, Kanazawa University Hospital, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8641, Japan
    Hum Pathol 43:1955-63. 2012
    ..These 2 tumors seem to differ in their histogenesis with respect to SALL4 expression.1...
  49. ncbi request reprint IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Surg Pathol 28:1193-203. 2004
    ..Their pathogenesis may be similar or closely related to that of SP, and in that respect they may represent an IgG4-related biliary disease. They may respond to steroid therapy as SP does...
  50. doi request reprint Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Pathol Int 60:167-74. 2010
    ..In conclusion, this new staging and grading system for PBC seems to be more convenient and practical than those used at present, but more instruction and guidance are recommended for the grading of necroinflammatory activity in practice...
  51. doi request reprint Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion
    Hiroko Ikeda
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hum Pathol 40:1774-82. 2009
    ....
  52. ncbi request reprint Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver
    Koichi Nakamura
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 38:1532-46. 2007
    ..Increased expression of Flk-1 and HIF-1alpha associated with VEGF may be involved in sinusoidal capillarization and the increased numbers of unpaired arteries in these areas...
  53. doi request reprint Clinicopathological significance of S100 protein expression in cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Gastroenterol Hepatol 28:1422-9. 2013
    ..This study examined the expression of S100 proteins in the multistep cholangiocarcinogenesis to clarify their clinicopathological significance...
  54. doi request reprint Tissue culture correlational study of genetic cholangiopathy of autosomal recessive polycystic kidney disease
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Methods Mol Biol 945:303-18. 2013
    ..Detailed tissue culture correlation studies of ARPKD and PCK rats are mandatory to evaluate the pathogenesis of this genetic cholangiopathy...
  55. doi request reprint Intrahepatic cholangiocarcinoma with predominant "ductal plate malformation" pattern: a new subtype
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graudate School of Medicine, Kanazawa, Japan
    Am J Surg Pathol 36:1629-35. 2012
    ..Neural cell adhesion molecule was also expressed variably. The Ki-67 labeling index was <10% and p53 was scarcely expressed. In conclusion, a new subtype of intrahepatic cholangiocarcinoma with predominant DPM pattern was identified...
  56. ncbi request reprint Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 41:506-16. 2005
    ....
  57. ncbi request reprint Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takarama chi, Kanazawa 920 8640, Japan
    Hepatology 45:1538-46. 2007
    ..CONCLUSION: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs...
  58. pmc Metachronous intracystic and intraductal papillary neoplasms of the biliary tree
    Hirohide Sato
    Hirohide Sato, Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    World J Gastroenterol 19:6125-6. 2013
    ..This case showed a papillary tumor of the gallbladder of gastric phenotype, and confirmed that the gallbladder is a target of IPN in addition to the bile ducts. ..
  59. doi request reprint Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Virchows Arch 462:421-7. 2013
    ..In conclusion, carcinoma in situ in the biliary tract is morphologically heterogeneous, and it is important to distinguish BilIN-3 and intraepithelial carcinoma spreading as distinct lesions, to better understand their biology...
  60. ncbi request reprint Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 53:8-17. 2003
    ....
  61. ncbi request reprint Combined hepatocellular and cholangiocarcinoma with marked squamous cell carcinoma components arising in non-cirrhotic liver
    Koichi Tsuneyama
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 53:90-7. 2003
    ..This is an interesting case of combined hepatocellular and cholangiocarcinoma with marked SCC components arising in a non-cirrhotic fibrotic liver...
  62. ncbi request reprint Diffuse expression of heparan sulfate proteoglycan and connective tissue growth factor in fibrous septa with many mast cells relate to unresolving hepatic fibrosis of congenital hepatic fibrosis
    Satoru Ozaki
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 25:817-28. 2005
    ..In this study, the roles and significance of fibrosis-related cells and molecules in the process of progressive and unresolving fibrosis of CHF were examined in comparison with other fibrotic liver diseases...
  63. pmc Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension
    Azusa Kitao
    MD, PhD, Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Am J Pathol 175:616-26. 2009
    ....
  64. doi request reprint Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis
    Hiroko Ikeda
    Departments of Human Pathology, Kanazawa University Graduate School of Medicine, Nagoya, Japan
    Hepatol Res 38:1006-17. 2008
    ..In this study, we clarified the role of inflammatory cytokines in the expression of MUC2 in lining biliary epithelial cells (BEC) in chronic cholangitis with an emphasis on CDX2, an intestine-specific transcription factor...
  65. ncbi request reprint IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 27:672-80. 2007
    ..Recently, biliary epithelial cells have been shown to secrete cytokines and chemokines and to express components of the mucosal immune system such as Toll-like receptors...
  66. ncbi request reprint Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Dig Dis Sci 52:1987-94. 2007
    ..These results suggest that NO liberated in spleen, rather than ET-1, is responsible for the dilatation of splenic sinuses, leading to splenomegaly, and thereby contributes to portal hypertension in IPH...
  67. ncbi request reprint Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    J Gastroenterol 40:164-70. 2005
    ..Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH)...
  68. ncbi request reprint Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Japan
    Hum Pathol 34:857-63. 2003
    ..We conclude that expression of syndecan-1 could correlate with some aspects of the biologic behaviors of ICCs and may be a useful prognostic marker...
  69. ncbi request reprint Characterization of biliary intra-epithelial lymphocytes at different anatomical levels of intrahepatic bile ducts under normal and pathological conditions: numbers of CD4+CD28- intra-epithelial lymphocytes are increased in primary biliary cirrhosis
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 56:17-24. 2006
    ..Altered distribution and phenotypes of bIEL in PBC and hepatolithiasis may reflect their participation in biliary lesions. Increased CD4(+)CD28(-)bIEL in damaged bile ducts of PBC may be related to immune-mediated biliary damage...
  70. doi request reprint Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation
    Yasunori Sato
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 40:181-8. 2009
    ..In addition, vascular endothelial growth factor may contribute to the proliferation of abnormal vessels as an angiogenic inducer...
  71. ncbi request reprint Biliary innate immunity in the pathogenesis of biliary diseases
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Japan
    Inflamm Allergy Drug Targets 9:83-90. 2010
    ..Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems...
  72. doi request reprint Pathologic significance of immunoglobulin G4-positive plasma cells in extrahepatic cholangiocarcinoma
    Yasushi Kimura
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 43:2149-56. 2012
    ....
  73. pmc Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease
    Yasunori Sato
    Department of Human Pathology, Kanazawa University, Graduate School of Medicine, Kanazawa 920 8640, Japan
    Am J Pathol 166:49-60. 2005
    ..As the MEK5-ERK5 interaction is highly specific, it may represent a potential target of therapy...
  74. doi request reprint Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Pathol 180:123-30. 2012
    ..These results suggest that HSP27 and HSP70 could be used as biliary biomarkers for the detection of cholangiocarcinoma including BilIN...
  75. ncbi request reprint Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Lab Invest 85:572-81. 2005
    ..ICC cells could escape the growth inhibitory effect of TGF-beta1 by overexpression of cyclin D1...
  76. ncbi request reprint Anatomic and molecular pathology of intrahepatic cholangiocarcinoma
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Hepatobiliary Pancreat Surg 10:265-81. 2003
    ..Evasion of immune surveillance involving the Fas/FasL system is important in the malignant progression of ICC. Further molecular and genetic studies are mandatory to evaluate the pathogenesis and progression of ICC...
  77. ncbi request reprint Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change
    Takahiko Fujii
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 55:206-9. 2005
    ..This is the third case of multicystic mucinous ICC and the present case might have been derived from intrahepatic peribiliary glands...
  78. ncbi request reprint Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatol Res 38:325-34. 2008
    ....
  79. ncbi request reprint Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 23:94-100. 2003
    ..It is generally believed that cellular immune mechanisms, particularly T cells, cause the bile duct damage in PBC...
  80. doi request reprint Intraductal tubular neoplasm of the common bile duct
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 60:516-9. 2010
    ..Although more case studies of ITN in the biliary tracts are required to clarify the tumorigenesis and pathological features, the lesion may be the biliary counterpart to pancreatic ITN...
  81. pmc Intraductal papillary neoplasm of the bile duct in liver cirrhosis with hepatocellular carcinoma
    Jing Xu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    World J Gastroenterol 17:1923-6. 2011
    ....
  82. ncbi request reprint Retroperitoneal mucinous cystadenoma: report of two cases and review of the literature
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 54:132-8. 2004
    ..We believe the retroperitoneal mucinous cystadenoma might have arisen from the peritoneum via mucinous epithelial metaplasia with a phenotype of extragenital Mullerian system...
  83. pmc Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Pathol 161:1475-84. 2002
    ..This mechanism might be involved in the lithogenesis of hepatolithiasis...
  84. pmc Pathological classification of intrahepatic cholangiocarcinoma based on a new concept
    Yasuni Nakanuma
    Yasuni Nakanuma, Yasunori Sato, Kenichi Harada, Mokoto Sasaski, Jing Xu, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    World J Hepatol 2:419-27. 2010
    ..This classification of ICC may open up a new field of research of ICC and contribute to the clinical approach to ICC...
  85. ncbi request reprint Primary cholangiohepatitis as an alternative name for primary biliary cirrhosis
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 53:412-4. 2003
  86. ncbi request reprint Autoimmune hepatitis associated with bile duct injury resembling chronic non-suppurative destructive cholangitis
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Japan
    Pathol Int 52:478-82. 2002
    ..Although the possibility of an overlapping syndrome of AIH- and AMA-negative PBC could not be excluded, this case was diagnosed as AIH with CNSDC-like bile duct lesions...
  87. ncbi request reprint Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal
    Koichi Tsuneyama
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Japan
    J Hepatol 37:176-83. 2002
    ..Chronic inflammation induces oxidative stress by producing reactive oxygen species. We investigated how the oxidative stress associated with chronic cholangitis induce bile duct damages in primary biliary cirrhosis...
  88. ncbi request reprint Helicobacter genus DNA fragments are commonly detectable in bile from patients with extrahepatic biliary diseases and associated with their pathogenesis
    Takashi Kobayashi
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Dig Dis Sci 50:862-7. 2005
    ..bilis are commonly detectable in the bile of patients with extrahepatic biliary diseases, whether benign or malignant, implying that the Helicobacter genus may be directly or indirectly involved in the pathogenesis of these diseases...
  89. ncbi request reprint Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory
    Shinji Shimoda
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Gastroenterology 131:606-18. 2006
    ..Understanding the mechanism for activation of autoreactive T cells will be critical in the treatment of autoimmune diseases...
  90. ncbi request reprint Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis
    Takashi Kamihira
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 101 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gastroenterology 125:1379-87. 2003
    ....
  91. pmc Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 105:10895-900. 2008
    ..Thus, TRAIL/DR5-mediated apoptosis may substantially contribute to chronic cholestatic disease, particularly primary sclerosing cholangitis...
  92. doi request reprint Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells
    Shinji Shimoda
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatology 47:958-65. 2008
    ..Furthermore, the addition of autologous LMNCs to PBC BECs led to the production of higher levels of chemokines and enhanced the expression of CD40 and HLA-DRalpha...