Kanazawa University

Summary

Organization: Kanazawa University
Country: Japan

Top Publications

  1. ncbi Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
    Phytochemistry 53:379-82. 2000
  2. ncbi Glycosidase inhibitors: update and perspectives on practical use
    Naoki Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Glycobiology 13:93R-104R. 2003
  3. ncbi Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger
    H Nakamura
    Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa, Japan
    Int Angiol 22:243-9. 2003
  4. ncbi Irrigational therapy of a dentigerous cyst in a geriatric patient: a case report
    Naoto Nishide
    Department of Stomatology, Tatsunokuchi Houju Memorial General Hospital 11 71 Midorigaoka, Tatsunokuchi, Ishikawa Pref 923 1226, Japan
    Spec Care Dentist 23:70-2. 2003
  5. ncbi An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation
    Yasuo Ontachi
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa 920 8641, Japan
    Blood Coagul Fibrinolysis 15:255-9. 2004
  6. ncbi The immunohistochemical distribution of vimentin in human temporomandibular joint samples
    H Yoshida
    Department of Oral and Maxillofacial Surgery, Fukui Prefectural Hospital, Fukui, Japan
    J Oral Rehabil 31:47-51. 2004
  7. ncbi Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana
    Naoki Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    J Nat Prod 67:846-50. 2004
  8. ncbi Physiological involvement of placental endothelin-1 and prostaglandin F2alpha in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress
    Hiroyuki Nakamura
    Department of Environmental Medicine, Kochi University School of Medicine, Japan
    Can J Physiol Pharmacol 82:225-30. 2004
  9. ncbi Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis
    Hiroyuki Nakamura
    Department of Environmental Medicine, Kochi University School of Medicine, Kohasu, Okoh cho, Nankoku 783 8505, Japan
    Int Arch Allergy Immunol 135:40-3. 2004
  10. ncbi Primary non-Hodgkin's lymphoma of the gallbladder
    Toru Yamamoto
    Department of Radiology, Yawata Medical Center, 12 7 Yawata, Komatsu 923 8511, Japan
    AJR Am J Roentgenol 184:S86-7. 2005

Scientific Experts

  • N Asano
  • Hiroyuki Nakamura
  • Y Bando
  • Takafumi Kohama
  • Shigeru Ishikawa
  • K Komura
  • Kenji Sakata
  • O Yokoyama
  • Toru Yamamoto
  • H Fujii
  • H Yoshida
  • Masashi Demura
  • Y Nakamura
  • Tokio Wakabayashi
  • Yasuo Ontachi
  • T Iizuka
  • M Nishida
  • Naoto Nishide
  • S Fujita
  • Yoshiyu Takeda
  • Kenji Furukawa
  • Takashi Yoneda
  • Hiroshi Mabuchi
  • N Nishide
  • Norio Sawabu
  • Hiroyuki Watanabe
  • Yoshitake Satomura
  • Takeshi Urabe
  • Yukimitsu Kawaura
  • Yoshiharu Motoo
  • Shinji Nakao
  • Masanori Saito
  • Y Fukumura
  • Masahide Yamazaki
  • Minori Kaneda
  • Tomoe Mizutani
  • Hisashi Funada
  • Hidesaku Asakura
  • Akiyoshi Takami
  • Takako Ito
  • Eriko Morishita
  • M Namiki
  • Norio Miyoshi
  • Y Ishiura
  • W C de Groat
  • Aiko Tachi
  • Gonjiro Hitomi
  • T Sakakura
  • Mikiya Usukura
  • Yuji Itoh
  • T Yoshida
  • N Hori
  • H Nishikawa
  • S Baba
  • K Shiraishi
  • R Kato
  • N Shinozaki
  • K Usuda
  • T Ishikawa
  • M Hirasawa
  • H Kida

Detail Information

Publications37

  1. ncbi Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
    Phytochemistry 53:379-82. 2000
    ..6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM)...
  2. ncbi Glycosidase inhibitors: update and perspectives on practical use
    Naoki Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Glycobiology 13:93R-104R. 2003
    ..In this review, the past and current applications of glycosidase inhibitors to agricultural and medical fields and the prospect for new therapeutic applications are reconsidered...
  3. ncbi Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger
    H Nakamura
    Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa, Japan
    Int Angiol 22:243-9. 2003
    ..However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated...
  4. ncbi Irrigational therapy of a dentigerous cyst in a geriatric patient: a case report
    Naoto Nishide
    Department of Stomatology, Tatsunokuchi Houju Memorial General Hospital 11 71 Midorigaoka, Tatsunokuchi, Ishikawa Pref 923 1226, Japan
    Spec Care Dentist 23:70-2. 2003
    ..After one year, remarkable bone regeneration was observed. We conclude that irrigational therapy appears to be an effective, less-invasive alternative to surgery for geriatric patients...
  5. ncbi An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation
    Yasuo Ontachi
    Department of Internal Medicine III, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa 920 8641, Japan
    Blood Coagul Fibrinolysis 15:255-9. 2004
    ..But our patient developed this uncommon skin eruption on his face. Patients with an idiopathic skin eruption resembling a butterfly rash in a septic patient should be considered to complicate DIC as in the present case...
  6. ncbi The immunohistochemical distribution of vimentin in human temporomandibular joint samples
    H Yoshida
    Department of Oral and Maxillofacial Surgery, Fukui Prefectural Hospital, Fukui, Japan
    J Oral Rehabil 31:47-51. 2004
    ..The findings of the present study suggest that vimentin might be an important marker of pathological hypertrophy of the synovial membrane and/or connective tissue with internal derangement of TMJ...
  7. ncbi Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana
    Naoki Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    J Nat Prod 67:846-50. 2004
    ..Alkaloids 4 and 6 were potent inhibitors of yeast alpha-glucosidase, with IC(50) values of 6.6 and 6.3 microM, respectively, and alkaloid 6 was also a potent inhibitor of bacterial beta-glucosidase with an IC(50) value of 5.1 microM...
  8. ncbi Physiological involvement of placental endothelin-1 and prostaglandin F2alpha in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress
    Hiroyuki Nakamura
    Department of Environmental Medicine, Kochi University School of Medicine, Japan
    Can J Physiol Pharmacol 82:225-30. 2004
    ..PGF2alpha systems activated by heat may be involved in the vasoconstricting effects of endothelin-A and -B receptors during heat exposure...
  9. ncbi Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis
    Hiroyuki Nakamura
    Department of Environmental Medicine, Kochi University School of Medicine, Kohasu, Okoh cho, Nankoku 783 8505, Japan
    Int Arch Allergy Immunol 135:40-3. 2004
    ....
  10. ncbi Primary non-Hodgkin's lymphoma of the gallbladder
    Toru Yamamoto
    Department of Radiology, Yawata Medical Center, 12 7 Yawata, Komatsu 923 8511, Japan
    AJR Am J Roentgenol 184:S86-7. 2005
  11. ncbi Duct-narrowing chronic pancreatitis without immunoserologic abnormality: comparison with duct-narrowing chronic pancreatitis with positive serological evidence and its clinical management
    Tokio Wakabayashi
    Department of Gastroenterology and Surgery, Saisekai Kanazawa Hospital, Akatsuchi machi Ni, Kanazawa, Japan
    Dig Dis Sci 50:1414-21. 2005
    ..In particular, the disease with bile duct involvement should be treated clinically as autoimmune pancreatitis, for which steroid therapy is recommended, even if an autoimmune mechanism is not demonstrated serologically...
  12. ncbi The effect of soybeans on the anovulatory cycle
    Takafumi Kohama
    Department of Obstetrics and Gynecology, Keiju Medical Center, Nanao, Japan
    J Med Food 8:550-1. 2005
    ..On the other hand, in the C group, improved ovulation was seen in two patients, and two patients had anovular menstruation. In conclusion, black soybean has the potential to improve the anovular menstrual cycle...
  13. ncbi Visualization of flow resistance in physiological nasal respiration: analysis of velocity and vorticities using numerical simulation
    Shigeru Ishikawa
    Department of Otolaryngology, Kanazawa Municipal Hospital, Kanazawa, Japan
    Arch Otolaryngol Head Neck Surg 132:1203-9. 2006
    ..To visualize the velocity gradients and the vorticities of physiological unsteady nasal flow using the computational fluid dynamics method and to compare the inspiratory phase and expiratory phase flow patterns...
  14. ncbi Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis
    Hiroyuki Nakamura
    Department of Environmental Medicine, Kochi University School of Medicine, Kochi, Nankoku, Japan
    Int Arch Allergy Immunol 142:329-34. 2007
    ..The frequency of haplotype 64Ile/780C/51C in pollinosis was significantly higher than in controls. Our results suggest that CCR2 and CCR3 genes are candidate genes for Japanese cedar pollinosis...
  15. ncbi Atomic bomb induced 152Eu: reconciliation of discrepancy between measurements and calculation
    K Komura
    Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Wake, Tatsunokuchi machi, Ishikawa 923 1224, Japan
    Health Phys 92:366-77. 2007
    ..Measurements agreed well with theoretical calculations based on DS02 up to 1.4 km from hypocenter...
  16. ncbi Measurements of short-lived cosmic-ray-produced radionuclides in rainwater
    K Komura
    Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology K INET, Kanazawa University, Wake, Tatsunokuchi, Ishikawa 923 1224, Japan
    J Environ Radioact 96:103-9. 2007
    ..4mBqL(-1)]), 400 to 1900L(-1) for (39)Cl (n=6, mean; 1200 [250mBqL(-1)]), 1x10(6) to 4x10(7)L(-1) for (7)Be (n=16, mean; 7x10(6) [1.05BqL(-1)]) and 2x10(3) to 1x10(5)L(-1) for (22)Na (n=9, mean; 2x10(4) [0.2mBqL(-1)])...
  17. ncbi Exercise-induced systolic dysfunction in patients with non-obstructive hypertrophic cardiomyopathy and mutations in the cardiac troponin genes
    K Sakata
    Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Heart 94:1282-7. 2008
    ..The aim of this study was to investigate left ventricular (LV) function reserve in hypertrophic cardiomyopathy (HCM) patients with and without cardiac troponin gene mutations before transition to the dilated phase...
  18. ncbi Completely skewed X-inactivation in a mentally retarded young female with pseudohypoparathyroidism type IB and juvenile renin-dependent hypertension
    Masashi Demura
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa 920 8640, Japan
    J Clin Endocrinol Metab 88:3043-9. 2003
    ..A mutation of the X-chromosome might be correlated with this phenotype because of a close association between completely SXI and X-chromosomal mutation...
  19. ncbi Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats
    Hiroyuki Nakamura
    Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8640, Japan
    Reprod Toxicol 17:321-6. 2003
    ....
  20. ncbi Naturally occurring iminosugars and related compounds: structure, distribution, and biological activity
    Naoki Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Curr Top Med Chem 3:471-84. 2003
    ....
  21. ncbi Prevalence of migraine and Raynaud's phenomenon in Japanese patients with vasospastic angina
    Y Nakamura
    Department of Cardiology, Kanazawa National Hospital, Japan
    Jpn Circ J 64:239-42. 2000
    ..This may be partially explained by racial differences...
  22. ncbi Alkaloidal sugar mimetics: biological activities and therapeutic applications
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
    J Enzyme Inhib 15:215-34. 2000
    ..In this review, the structural basis of the specificity of alkaloidal sugar mimics and their current and potential applications to biomedical problems are reviewed...
  23. ncbi Heat produces uteroplacental circulatory disturbance in pregnant rats through action of corticotropin releasing hormone (CRH)
    H Nakamura
    Department of Public Health, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa, Japan
    Placenta 21:510-5. 2000
    ..The placental opioid system seems unlikely to be involved in the mediation of uteroplacental circulation...
  24. ncbi Large uterine myoma with erythropoietin messenger RNA and erythrocytosis
    T Kohama
    Department of Obstetrics and Gynecology, Keiju Medical Center, Nanao, Japan
    Obstet Gynecol 96:826-8. 2000
    ..Myomatous erythrocytosis syndrome (erythrocytosis associated with a uterine myoma) has multiple proposed etiologies, one of which is altered erythropoietin production...
  25. ncbi Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae)
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa machi, Kanazawa, Japan
    Eur J Biochem 268:35-41. 2001
    ..Interestingly, Rha-DMJ was a 70-fold more potent inhibitor of alpha-L-fucosidase than DMJ. This implies that the lysosomal alpha-L-fucosidase may have subsites recognizing oligosaccharyl structures in natural substrates...
  26. ncbi Histological study of rat masseter muscle following experimental occlusal alteration
    N Nishide
    Department of Stomatology, Tatsunokuchi Houju Memorial General Hospital, Midorigaoka, Tatsunokuchi, Ishikawa Pref, Japan
    J Oral Rehabil 28:294-8. 2001
    ....
  27. ncbi Dihydroxynortropane alkaloids from calystegine-producing plants
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Phytochemistry 57:721-6. 2001
    ..Although neither of these were detectable in three species tested in the Solanaceae, 3alpha,7beta-dihydroxynortropane was, however, isolated from Duboisia leichhardtii...
  28. ncbi The relationship of fasting plasma glucose values and other variables to 2-h postload plasma glucose in Japanese subjects
    Y Bando
    Department of Internal Medicine, Fukui Ken Saiseikai Hospital, Fukui, Japan
    Diabetes Care 24:1156-60. 2001
    ..To investigate the relationship between fasting plasma glucose (FPG) values and other variables (e.g., age, sex, and BMI) to 2-h post-75-g oral glucose load glycemia (PG) in Japanese subjects...
  29. ncbi Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.)
    N Asano
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    J Agric Food Chem 49:4208-13. 2001
    ..The possibility of preventing the onset of diabetes and obesity using natural dietary supplements containing 1-deoxynojirimycin and other alpha-glucosidase inhibitors in high concentration is of great potential interest...
  30. ncbi Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus
    Masashi Demura
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Hum Mutat 19:23-9. 2002
    ..Both patients, despite lacking ARHGAP4, had no morphological, clinical, or laboratory abnormalities except for those usually found in patients with NDI...
  31. ncbi Radiochemical approach to the JCO criticality accident in Tokai-mura, 1999--an overview of the radiochemistry group
    K Komura
    Low Level Radioactivity Laboratory, Kanazawa University, Tatsunokuchi, Ishikawa, Japan
    J Radiat Res 42:S17-29. 2001
    ..Some of the topical results and our remaining tasks concerning the JCO accident are discussed...
  32. ncbi Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature
    H Fujii
    Second Department of Surgery, Fukui Medical University, Matsuoka cho, Yoshida gun, Fukui, 910 1193 Japan
    Hepatogastroenterology 48:1588-93. 2001
    ..Chemotherapy is effective in general and intraarterial chemotherapy performed in the present case may be particularly useful to improve survival...
  33. ncbi The expression of tenascin mRNA in human temporomandibular joint specimens
    H Yoshida
    Department of Oral and Maxillofacial Surgery, Fukui Prefectural Hospital, Fukui City, Japan
    J Oral Rehabil 29:765-9. 2002
    ..The present study demonstrates that tenascin is produced specifically in synovial cells, vascular endothelial cells and fibroblasts affected in the portion of TMJ with internal derangement...
  34. ncbi Therapeutic applications of sugar-mimicking glycosidase inhibitors
    N Asano
    Faculty of Pharmaceudical Sciences, Hokuriku University, Kaanazawa, Japan
    Mini Rev Med Chem 1:145-54. 2001
    ..The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention...
  35. ncbi Non-autoimmune primary hypothyroidism in diabetic and non-diabetic chronic renal dysfunction
    Y Bando
    Department of Internal Medicine, Fukui Ken Saiseikai Hospital, Funabashi 7 1, Wadanaka machi, Fukui 918 8503, Japan
    Exp Clin Endocrinol Diabetes 110:408-15. 2002
    ..The mechanisms by which this phenomenon develops more frequently in diabetic than in non-diabetic renal dysfunction remain to be elucidated...
  36. ncbi Role of protein kinase C in central muscarinic inhibitory mechanisms regulating voiding in rats
    Y Nakamura
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuroscience 116:477-84. 2003
    ..On the other hand, facilitatory muscarinic mechanisms which previous studies showed were tonically active are not mediated by chelerythrine chloride or H-7 sensitive signaling pathways...
  37. doi Flow mechanisms in the human olfactory groove: numerical simulation of nasal physiological respiration during inspiration, expiration, and sniffing
    Shigeru Ishikawa
    Department of Otolaryngology Kanazawa Municipal Hospital, 3 7 3 Heiwa machi Kanazawa, Ishikawa 921 8105, Japan
    Arch Otolaryngol Head Neck Surg 135:156-62. 2009
    ....