Shigeki Kuriyama

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. ncbi request reprint Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 27:505-11. 2005
  2. ncbi request reprint Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model
    Shigeki Kuriyama
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 19:317-24. 2007
  3. ncbi request reprint Safe and efficient transgene expression in rat hepatocytes induced by adenoviral administration into the biliary tract
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Oncol Rep 13:825-30. 2005
  4. ncbi request reprint Repetitive and safe transgene expression in rat liver is achievable by adenoviral infusion into the common bile duct
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 16:503-8. 2005
  5. ncbi request reprint Adenovirus-mediated gene transfer into rat livers: comparative study of retrograde intrabiliary and antegrade intraportal administration
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 13:69-74. 2005
  6. ncbi request reprint Combination of interferon-beta and angiotensin-converting enzyme inhibitor, perindopril, attenuates the murine liver fibrosis development
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Japan
    Liver Int 25:153-61. 2005
  7. ncbi request reprint Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 42:687-93. 2005
  8. ncbi request reprint Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Int J Mol Med 17:899-904. 2006
  9. ncbi request reprint Suppression of renin-angiotensin system attenuates hepatocarcinogenesis via angiogenesis inhibition in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Anticancer Res 25:3335-40. 2005
  10. ncbi request reprint Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, School of Medicine, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 14:213-8. 2005

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 27:505-11. 2005
    ..These results also indicate that vitamins K2, K3 and K5 may be useful agents for the treatment of patients with HCC...
  2. ncbi request reprint Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model
    Shigeki Kuriyama
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 19:317-24. 2007
    ....
  3. ncbi request reprint Safe and efficient transgene expression in rat hepatocytes induced by adenoviral administration into the biliary tract
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Oncol Rep 13:825-30. 2005
    ....
  4. ncbi request reprint Repetitive and safe transgene expression in rat liver is achievable by adenoviral infusion into the common bile duct
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 16:503-8. 2005
    ....
  5. ncbi request reprint Adenovirus-mediated gene transfer into rat livers: comparative study of retrograde intrabiliary and antegrade intraportal administration
    Shigeki Kuriyama
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 13:69-74. 2005
    ....
  6. ncbi request reprint Combination of interferon-beta and angiotensin-converting enzyme inhibitor, perindopril, attenuates the murine liver fibrosis development
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Japan
    Liver Int 25:153-61. 2005
    ..The combination treatment of the clinically used PE and IFN may provide a new strategy for anti-liver fibrosis therapy...
  7. ncbi request reprint Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 42:687-93. 2005
    ....
  8. ncbi request reprint Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Int J Mol Med 17:899-904. 2006
    ..Since both agents are widely used in clinical practice, this combination therapy may provide a new strategy against liver fibrosis in the future...
  9. ncbi request reprint Suppression of renin-angiotensin system attenuates hepatocarcinogenesis via angiogenesis inhibition in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Anticancer Res 25:3335-40. 2005
    ..These results suggested that RAS plays an important role in hepatocarcinogenesis, at least partly through VEGF-mediated angiogenesis...
  10. ncbi request reprint Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, School of Medicine, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 14:213-8. 2005
    ..Because both agents are widely used in clinical practice, the combination regimen may represent a potential new strategy for CRC therapy in the future...
  11. ncbi request reprint Proliferative capability of hepatocytes and expression of G1-related cell cycle molecules in the development of liver cirrhosis in rats
    Fumi Funakoshi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 13:779-87. 2004
    ....
  12. ncbi request reprint Amelioration of carcinogenesis and tumor growth in the rat liver by combination of vitamin K2 and angiotensin-converting enzyme inhibitor via anti-angiogenic activities
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Japan
    Oncol Rep 15:155-9. 2006
    ..Since both VK and ACE-I are widely used in clinical practice without serious side effects, this combination therapy may be an effective new therapeutic strategy against hepatocarcinogenesis and HCC growth in the future...
  13. ncbi request reprint Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c-Met in the course of cirrhosis development in rats
    Hideyuki Inoue
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 17:857-64. 2006
    ....
  14. ncbi request reprint Involvement of the vascular endothelial growth factor receptor-1 in murine hepatocellular carcinoma development
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, 634 8522 Nara, Japan
    J Hepatol 41:97-103. 2004
    ..The aim of this study was to examine the role of VEGFR-1 in VEGF-mediated HCC development and angiogenesis as compared to that of VEGFR-2...
  15. ncbi request reprint In vitro and in vivo antitumor effects of vitamin K5 on hepatocellular carcinoma
    Misuzu Hitomi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 26:1337-44. 2005
    ..The results demonstrated here indicate that vitamin K5 may be a useful agent for the treatment of patients with HCC...
  16. ncbi request reprint Loss of p57KIP2 is associated with colorectal carcinogenesis
    Jia Qing Li
    Department of Pathology and Host Defense, Kagawa Medical University, Kagawa 761 0793, Japan
    Int J Oncol 23:1537-43. 2003
    ..0007), elevated cyclin B1 (p=0.0007), reduced CDK2 (p=0.0021), and increased Ki67 (p=0.0013) in adenomas. Thus, loss of p57KIP2 expression appears associated with colorectal carcinogenesis...
  17. ncbi request reprint The copper-chelating agent, trientine, attenuates liver enzyme-altered preneoplastic lesions in rats by angiogenesis suppression
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 10:1369-73. 2003
    ....
  18. ncbi request reprint Combination of interferon-beta and the angiotensin-converting enzyme inhibitor, perindopril, attenuates murine hepatocellular carcinoma development and angiogenesis
    Ryuichi Noguchi
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 9:6038-45. 2003
    ....
  19. ncbi request reprint Extracellular matrix remodeling may predominate over hepatocyte injury in hepatocellular carcinoma development
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 10:957-62. 2003
    ..These results suggested that the ECM remodeling plays a more important role than the persistent hepatocyte injury in the liver enzyme-altered preneoplastic lesion development in the rat...
  20. ncbi request reprint Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Tumour Biol 23:348-56. 2002
    ..Since ACE inhibitor is used widely in clinical practice without serious side effects, it may provide an alternative new strategy for the treatment of liver fibrosis and HCC...
  21. ncbi request reprint Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats
    Shuhei Yoshida
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 25:1089-96. 2004
    ....
  22. ncbi request reprint Diffuse large B-cell primary gastric lymphoma treated successfully with the CD20 monoclonal antibody (rituximab): a case with severe liver dysfunction due to liver cirrhosis and hepatocellular carcinoma
    Seiji Nakai
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0973, Japan
    Oncol Rep 13:1065-8. 2005
    ..This case indicates that monotherapy using only rituximab may be a promising option for the treatment of patients with diffuse large B-cell lymphoma accompanied by severe liver dysfunction...
  23. pmc Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 11:1426-32. 2005
    ....
  24. ncbi request reprint Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo
    Misuzu Hitomi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Int J Oncol 26:713-20. 2005
    ..The results indicate that vitamins K2 and K3 may be useful agents for the treatment of patients with HCC...
  25. ncbi request reprint How many cytological examinations should be performed for the diagnosis of malignant biliary stricture via an endoscopic nasobiliary drainage tube?
    Naohito Uchida
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    J Gastroenterol Hepatol 23:1501-4. 2008
    ..The aim of this study is to determine the optimal number of repeated cytological sampling of bile obtained via an endoscopic nasobiliary drainage (ENBD) tube for the diagnosis of malignant biliary stricture...
  26. ncbi request reprint Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats
    Yuko Kita
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Int J Oncol 24:1205-11. 2004
    ..These results indicate that cyclin D1 may be involved in the regeneration of hepatocytes rather than hepatocarcinogenesis, while Cdk4 but not Cdk6 may play an important role in the development of HCC...
  27. pmc A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 14:2037-43. 2008
    ....
  28. ncbi request reprint Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 28:971-6. 2006
    ..Thus, time-lag performance of RFA after PEI may make RFA treatment more effective and less invasive for the treatment of patients with HCC...
  29. ncbi request reprint Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma
    Asahiro Morishita
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan
    Hepatology 40:677-86. 2004
    ..In conclusion, the loss of p18INK4C expression may play a role in the differentiation and development of HCC through the up-regulation of Cdk4 activity...
  30. ncbi request reprint Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Hepatology 39:1517-24. 2004
    ..In conclusion, these results suggest that VEGF and receptor interaction plays an important role in hepatocarcinogenesis and in spontaneous lung metastasis from HCC...
  31. pmc Successful treatment of hypovascular advanced hepatocellular carcinoma with lipiodol-targetting intervention radiology
    Kazutaka Kurokohchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 13:4398-400. 2007
    ..Thus, this case expressing the tremendous effect might give us insight into the effectiveness of the novel combination therapy of PELI and IVR for the treatment of hypovascular HCC...
  32. ncbi request reprint Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 24:381-7. 2004
    ....
  33. ncbi request reprint Efficacy of combination therapies of percutaneous or laparoscopic ethanol-lipiodol injection and radiofrequency ablation
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 25:1737-43. 2004
    ..Therefore, it is critical to evaluate whether enough safety margin could be obtained with RFA therapy, and PELI-RFA and LELI-RFA are helpful in visualizing the safety margin area...
  34. ncbi request reprint Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver
    Jin Yuji
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 13:721-8. 2004
    ..Therefore, it is suggested that p46 Shc expressed in hepatocellular nuclei may be a useful marker for detecting hepatocytes with high proliferative activity...
  35. ncbi request reprint Comparative study of the effects of percutaneous ethanol injection and radiofrequency ablation in cases treated with a straight or expandable electrode
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 18:1275-9. 2007
    ..Thus, prior injection of ethanol before RFA may make RFA treatment less invasive in the time-lag PEI-RFA using the expandable electrode as previously shown HCC cases treated with straight electrode...
  36. ncbi request reprint Analysis of CD28 and bcl-2 expression on peripheral blood and liver-infiltrating mononuclear cells in patients with autoimmune hepatitis
    Kazutaka Kurokohchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Miki cho, Kagawa, Japan
    J Clin Immunol 26:323-30. 2006
    ..By contrast, CD8(+) LIMC were shown not to express bcl-2. Taken collectively, these results suggest that bcl-2(+)CD28(+)CD4(+) and bcl-2(-)CD28(-)CD8(+) cells may play critical and distinct roles in hepatocellular damage in AIH...
  37. ncbi request reprint Estimation of the stent placement above the intact sphincter of Oddi against malignant bile duct obstruction
    Naohito Uchida
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    J Gastroenterol 40:291-6. 2005
    ..Stent blockage occurs as a result of bacterial adherence to the inner wall of the stent. We evaluated the stent placement above the intact sphincter of Oddi to retain the function of the sphincter of Oddi as a bacteriological barrier...
  38. ncbi request reprint Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model
    Yasuhide Ikenaka
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Int J Cancer 105:340-6. 2003
    ..These results suggested that the ectopically overexpressed TIMP-1 inhibited the tumor growth by angiogenesis suppression...
  39. ncbi request reprint Successful laparoscopic radiofrequency ablation of hepatocellular carcinoma adhered to the mesentery after transcatheter arterial embolization
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 13:65-8. 2005
    ..The tumor was successfully abrogated by PEI-RFA and the sufficient safety margin was confirmed by computed tomography after the treatment...
  40. ncbi request reprint Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 37:22-30. 2002
    ..The aim of the present study was to examine the effect of RAS inhibition on the liver enzyme-altered preneoplastic lesions and fibrosis development...
  41. ncbi request reprint Successful treatment of large-size advanced hepatocellular carcinoma by transarterial chemoembolization followed by the combination therapy of percutaneous ethanol-lipiodol injection and radiofrequency ablation
    Kazutaka Kurokohchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Ikenobe, Kagawa 761 0793, Japan
    Oncol Rep 16:1067-70. 2006
    ..PELI-RFA and PELI may be effective for the treatment of large-size HCC of patients with poor hepatic reserve...
  42. ncbi request reprint Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis
    Tsutomu Masaki
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan
    Hepatology 37:534-43. 2003
    ..Cyclin D1, Cdk4, and cyclin E activation may be closely related to the histopathologic grade and progression of HCC...
  43. ncbi request reprint Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells
    Mutsumi Ogawa
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 31:323-31. 2007
    ....
  44. ncbi request reprint Coexistence of splenic non-Hodgkin's lymphoma with hepatocellular carcinoma in a patient with chronic hepatitis C
    Takashi Himoto
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Dig Dis Sci 51:70-6. 2006
  45. ncbi request reprint Thoracoscopic ethanol injection and radiofrequency ablation for the treatment of hepatocellular carcinoma located immediately under the diaphragm
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 29:375-80. 2006
    ..Although HCC located immediately under the diaphragm is difficult to treat with a percutaneous approach due to the poor visualization by ultrasonography, T-EI-RFA is considered to be an effective treatment modality...
  46. ncbi request reprint Enhanced expression of p46 Shc in the nucleus and p52 Shc in the cytoplasm of human gastric cancer
    Satoko Yukimasa
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 26:905-11. 2005
    ..Furthermore, unlike p52 Shc, p46 Shc was shown to be expressed solely in the nucleus, suggesting that p46 Shc expressed in the nucleus may play an important role in gastric carcinogenesis...
  47. ncbi request reprint Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 13:491-5. 2005
    ..These results suggested that the combination treatment with IFN and PE may be an effective new strategy for chemoprevention against HCC...
  48. ncbi request reprint Utility of pancreatic duct brushing for diagnosis of pancreatic carcinoma
    Naohito Uchida
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun 761 0793, Japan
    J Gastroenterol 42:657-62. 2007
    ..The aim of this study was to evaluate the usefulness of pancreatic duct brushing for diagnosis of pancreatic carcinoma...
  49. ncbi request reprint Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Scand J Gastroenterol 42:1078-87. 2007
    ..We therefore examined the effects of zinc administration on inflammatory activity and fibrosis in the liver of patients with HCV-related CLD...
  50. ncbi request reprint Imatinib mesylate (STI-571) attenuates liver fibrosis development in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8521, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G907-13. 2005
    ..Because STI-571 is widely used in clinical practice, it may provide an effective new strategy for antifibrosis therapy...
  51. ncbi request reprint Usefulness of single and repetitive percutaneous transhepatic gallbladder aspiration for the treatment of acute cholecystitis
    Kunihiko Tsutsui
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Gastroenterol 42:583-8. 2007
    ..The aim of this study was to evaluate the safety and usefulness of single and repetitive percutaneous transhepatic gallbladder aspiration (PTGBA) for the treatment of acute cholecystitis...
  52. ncbi request reprint Changes of parvalbumin immunoreactive neurons and GFAP immunoreactive astrocytes in the rat lateral geniculate nucleus following monocular enucleation
    Daniel Gonzalez
    Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Neurosci Lett 395:149-54. 2006
    ....
  53. ncbi request reprint Enlargement of thermal ablation zone by the combination of ethanol injection and radiofrequency ablation in excised bovine liver
    Seishiro Watanabe
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 24:279-84. 2004
    ..For a given amount of energy and current administered, ethanol injection caused a better ablation effect, in terms of the size and shape of the ablated zone, than RFA with Radionics and RITA equipment...
  54. pmc Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Japan
    World J Gastroenterol 12:2523-9. 2006
    ..Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH...
  55. ncbi request reprint Comparison study of the expressions of myristoylated alanine-rich C kinase substrate in hepatocellular carcinoma, liver cirrhosis, chronic hepatitis, and normal liver
    Tsutomu Masaki
    Third Department of Internal Medicine, Kagawa Medical University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 26:661-71. 2005
    ....
  56. ncbi request reprint Assessment of autonomic dysfunction of multiple system atrophy with laryngeal abductor paralysis as an early manifestation
    Kazushi Deguchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Clin Neurol Neurosurg 109:892-5. 2007
    ..Diagnosis of atypical MSA with LAP in the early stages might be accelerated by a detailed investigation focused on urinary symptoms and neuroendocrine approaches...
  57. ncbi request reprint Effect of an aldose reductase inhibitor on esophageal dysfunction in diabetic patients
    Fumihiko Kinekawa
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa, Japan
    Hepatogastroenterology 52:471-4. 2005
    ..The aim of the present study is to examine the effect of an ARI on the esophageal dysfunction in diabetic patients by monitoring pH and motility of the esophagus...
  58. ncbi request reprint Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis
    Takako Nonomura
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 30:105-11. 2007
    ..In conclusion, nuclear c-Yes expression was found in cancer cells at the early stages of hepatocarcinogenesis, suggesting that nucleus-located c-Yes may be a useful marker to detect early-stage HCC...
  59. doi request reprint Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Dig Dis Sci 54:360-8. 2009
    ..18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA...
  60. doi request reprint Paraneoplastic necrotizing myelopathy in a patient with advanced esophageal cancer: An autopsied case report
    Yoshiteru Urai
    Department of Gastroenterology and Neurology, School of Medicine, Kagawa University, Japan
    J Neurol Sci 280:113-7. 2009
    ..Taken together, these results suggest that there is an underlying autoimmune mechanism in paraneoplastic necrotizing myelopathy...
  61. ncbi request reprint Pre-cutting using a noseless papillotome with independent lumens for contrast material and guidewire
    Naohito Uchida
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Gastroenterol Hepatol 20:947-50. 2005
    ..The technical success of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) depends on selective cannulation into the bile duct. We have developed a new type of precut papillotome for selective cannulation...
  62. ncbi request reprint CYFRA 21-1 is released in TNF-alpha-induced apoptosis in the hepatocellular carcinoma cell line HuH-7
    Fei Wu
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan
    Int J Oncol 21:441-5. 2002
    ..Levels of CYFRA 21-1 decreased significantly after caspase-3 was inhibited in TNF-alpha-treated cells. Thus, the release of CYFRA 21-1 may suggest cellular apoptosis in the process of tumor growth...
  63. ncbi request reprint CD28-negative CD8-positive cytotoxic T lymphocytes mediate hepatocellular damage in hepatitis C virus infection
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa Medical University, Kita gun, Kagawa, Japan
    J Clin Immunol 23:518-27. 2003
    ..CD28(-)CD8(+) T cells may finally function as effector T cells causing the hepatocellular damage in HCV infection...
  64. ncbi request reprint Combination therapy of percutaneous ethanol injection and radiofrequency ablation against hepatocellular carcinomas difficult to treat
    Kazutataka Kurokohchi
    Third Department of Internal Medicine, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Int J Oncol 21:611-5. 2002
    ..These results indicate that PEI-RFA may be effective for the treatment of HCCs located in the regions that are difficult to treat with RFA alone as well as large-sized HCCs...
  65. ncbi request reprint Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara Nara, Japan
    Hepatology 35:834-42. 2002
    ..In conclusion, these results suggest that bFGF synergistically augments VEGF-mediated HCC development and angiogenesis at least partly by induction of VEGF through KDR/Flk-1...
  66. doi request reprint The interaction between somatosensory and auditory cognitive processing assessed with event-related potentials
    Tetsuo Touge
    Health Sciences, School of Nursing, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Clin Neurophysiol 25:90-7. 2008
    ..We speculate that the subtracted positive and negative peaks reflect different cognitive processing of bimodal and bifocal sensory information...
  67. ncbi request reprint Abundance of microRNA target motifs in the 3'-UTRs of 20527 human genes
    Hisakazu Iwama
    Information Technology Center, Kagawa University, Ikenobe 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 581:1805-10. 2007
    ....
  68. ncbi request reprint Expression of cytokeratin 19 in human hepatocellular carcinoma cell lines
    Fei Wu
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan
    Int J Oncol 20:31-7. 2002
    ..These results partially clarify the mechanism by which some hepatocellular carcinoma cell lines produce CK19 and others do not...
  69. pmc Successful treatment of advanced hepatocellular carcinoma by combined administration of 5-fluorouracil and pegylated interferon-alpha
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 11:5401-3. 2005
    ....
  70. ncbi request reprint Multidisciplinary treatment of patients with hepatocellular carcinoma
    Tsutomu Masaki
    Kagawa Medical University, Third Department of Internal Medicine, 1750 1 Ikenobe Miki cho, Kita gun, Kagawa 761 0793, Japan
    Expert Rev Anticancer Ther 6:1377-84. 2006
    ..Radiofrequency ablation may become a standard nonsurgical treatment option for patients with early hepatocellular carcinoma...
  71. ncbi request reprint Expression of p57(KIP2) in hepatocellular carcinoma: relationship between tumor differentiation and patient survival
    Seiji Nakai
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa 761 0793, Japan
    Int J Oncol 20:769-75. 2002
    ..New therapeutic options might be provided by the combination of the loss of p57(KIP2) and expression of PCNA...
  72. ncbi request reprint Effects of serial visuomotor tasks on contingent negative variation
    Tetsuo Touge
    Third Department of Internal Medicine, Kagawa Medical University, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Int J Neurosci 113:431-43. 2003
    ..The present results suggest that the frontoparietal area involving the prefrontal and sensorimotor cortices, plays an important role in visuomotor learning...
  73. ncbi request reprint Further resolution of alpha-fetoprotein glycoforms by two-dimensional isoelectric focusing and lectin affinity electrophoresis
    Eriko Ichikawa
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Electrophoresis 27:3480-7. 2006
    ..Monosialo-AFP (AFP+II) was recovered in all the glycoforms of AFP-P2, -P3, -P4, and -P5; thus, AFP-P4 is more specific to HCC than monosialylated AFP+II...
  74. ncbi request reprint Stage I mantle-cell lymphoma that was difficult to differentiate from abdominal tuberculous lymphadenitis and metastatic pancreatic cancer
    Satoshi Yoneda
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8521, Japan
    J Gastroenterol 37:859-62. 2002
    ..Herein, we report this case of stage-I mantle cell lymphoma that was difficult to differentiate from metastatic pancreatic cancer and abdominal tuberculous lymphadenitis...
  75. ncbi request reprint Painful legs and moving toes syndrome associated with herpes zoster myelitis
    Kazuyo Ikeda
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, 761 0793 Kagawa, Japan
    J Neurol Sci 219:147-50. 2004
    ....
  76. ncbi request reprint Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes
    Jia Qing Li
    Department of Pathology and Host Defense, Kagawa Medical University, Kagawa 761 0793, Japan
    Int J Oncol 22:1101-10. 2003
    ..The unchanged expressions were confirmed by Western blot. Thus, increased cyclin B1, but not cyclin G1, may promote colorectal carcinogenesis and later metastasis to lymph nodes...
  77. ncbi request reprint Effects of successive repetitive transcranial magnetic stimulation on motor performances and brain perfusion in idiopathic Parkinson's disease
    Michiko Ikeguchi
    Third Department of Internal Medicine, Kagawa Medical University, 1750 1, Ikenobe, Miki cho Kita gun, Kagawa, 761 0793, Japan
    J Neurol Sci 209:41-6. 2003
    ..2 Hz rTMS on subcortical structures are related to improved parkinsonian symptoms. Further studies recruiting large numbers of subjects are required to confirm the efficacy of 0.2 Hz rTMS on PD...
  78. ncbi request reprint Effects of daily water drinking on orthostatic and postprandial hypotension in patients with multiple system atrophy
    Kazushi Deguchi
    Dept of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa, 761 0793, Japan
    J Neurol 254:735-40. 2007
    ..The aim of this study was to evaluate the practical effect of daily water drinking on OH and PPH in the morning when patients with AF are usually most affected...
  79. ncbi request reprint Significance of reduction surgery in multidisciplinary treatment of advanced hepatocellular carcinoma with multiple intrahepatic lesions
    Hisao Wakabayashi
    Department of Surgery, Takamatsu National Hospital, Takamatsu City, Kagawa, Japan
    J Surg Oncol 82:98-103. 2003
    ....
  80. ncbi request reprint Development of hepatocytes from ES cells after transfection with the HNF-3beta gene
    Shigeaki Ishizaka
    Program in Tissue Engineering and Department of Parasitology, Nara Medical University, Kashihara, Nara, Japan
    FASEB J 16:1444-6. 2002
    ....
  81. ncbi request reprint Fulminant hepatic failure caused by malignant melanoma of unknown primary origin
    Misuzu Tanaka
    J Gastroenterol 39:804-6. 2004
  82. ncbi request reprint Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma
    Takashi Himoto
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Oncol 26:311-7. 2005
    ....
  83. ncbi request reprint Enhancing and suppressing effects of dexamethasone on transgene expression in vitro
    Manabu Akahane
    Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Int J Mol Med 10:107-12. 2002
    ..These results indicate that dexamethasone may play an important role for achieving successful gene therapy. Furthermore, these observations may also have important implications for future clinical applications of gene therapy...
  84. ncbi request reprint Different cascades in the signaling pathway of two vascular endothelial growth factor (VEGF) receptors for the VEGF-mediated murine hepatocellular carcinoma development
    Hitoshi Yoshiji
    The Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 13:853-7. 2005
    ..These results suggested that both VEGFR-1 and VEGFR-2 play important roles, and lie in the different signaling cascades by which VEGF augments HCC development and angiogenesis...
  85. doi request reprint Outer arm fucosylation of N-glycans increases in sera of hepatocellular carcinoma patients
    Kazuhiro Tanabe
    Analytical Services Division, Mitsubishi Chemical Group Science and Technology Research Center Inc, 1000 Kamoshida cho, Aoba ku, Yokohama shi, Kanagawa 227 8502, Japan
    Biochem Biophys Res Commun 374:219-25. 2008
    ..Normalizing the level of outer arm fucosylation by taking into account platelet concentration allowed us to distinguish more clearly between HCC and LC patients...
  86. pmc Activation of c-Yes in hepatocellular carcinoma: a preliminary study
    Han Feng
    World J Gastroenterol 12:5743-5. 2006
  87. pmc Percutaneous local therapies for hepatocellular carcinoma impair gastric function
    Fumihiko Kinekawa
    World J Gastroenterol 12:157-8. 2006