Hisakazu Iwana

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. pmc Human microRNAs originated from two periods at accelerated rates in mammalian evolution
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Kita gun, Kagawa, Japan
    Mol Biol Evol 30:613-26. 2013
  2. doi request reprint Coordinated networks of microRNAs and transcription factors with evolutionary perspectives
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Kagawa, Japan
    Adv Exp Med Biol 774:169-87. 2013
  3. doi request reprint MicroRNA networks alter to conform to transcription factor networks adding redundancy and reducing the repertoire of target genes for coordinated regulation
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
    Mol Biol Evol 28:639-46. 2011
  4. pmc ReAlignerV: web-based genomic alignment tool with high specificity and robustness estimated by species-specific insertion sequences
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Ikenobe 1750 1, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    BMC Bioinformatics 9:112. 2008
  5. ncbi request reprint Abundance of microRNA target motifs in the 3'-UTRs of 20527 human genes
    Hisakazu Iwama
    Information Technology Center, Kagawa University, Ikenobe 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 581:1805-10. 2007
  6. pmc Transcriptional double-autorepression feedforward circuits act for multicellularity and nervous system development
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    BMC Genomics 12:228. 2011
  7. doi request reprint The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3',5'-cyclic adenosine 5'-monophosphate
    Koji Murao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, Kita gun, Kagawa 761 0793, Japan
    Endocrinology 149:6103-12. 2008
  8. doi request reprint Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway
    Junhua Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki cho, Kita gun, Kagawa, Japan
    J Cell Mol Med 14:1083-7. 2010
  9. doi request reprint The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells
    Xiao Yu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Endocrine 38:53-9. 2010
  10. doi request reprint Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate
    Yukiko Nishiuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Atherosclerosis 212:418-25. 2010

Collaborators

Detail Information

Publications20

  1. pmc Human microRNAs originated from two periods at accelerated rates in mammalian evolution
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Kita gun, Kagawa, Japan
    Mol Biol Evol 30:613-26. 2013
    ....
  2. doi request reprint Coordinated networks of microRNAs and transcription factors with evolutionary perspectives
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Kagawa, Japan
    Adv Exp Med Biol 774:169-87. 2013
    ....
  3. doi request reprint MicroRNA networks alter to conform to transcription factor networks adding redundancy and reducing the repertoire of target genes for coordinated regulation
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
    Mol Biol Evol 28:639-46. 2011
    ..The results indicate that the redundancy-adding role might serve as a niche for many miRNA connections to survive, avoiding conflicts with the stable TF regulatory networks...
  4. pmc ReAlignerV: web-based genomic alignment tool with high specificity and robustness estimated by species-specific insertion sequences
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Ikenobe 1750 1, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    BMC Bioinformatics 9:112. 2008
    ..However, recently such TEs have been reported to influence the gene regulatory network evolution. Therefore, an alignment approach that is robust to TE insertions is meaningful for finding novel conserved TFBSs in TEs...
  5. ncbi request reprint Abundance of microRNA target motifs in the 3'-UTRs of 20527 human genes
    Hisakazu Iwama
    Information Technology Center, Kagawa University, Ikenobe 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 581:1805-10. 2007
    ....
  6. pmc Transcriptional double-autorepression feedforward circuits act for multicellularity and nervous system development
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    BMC Genomics 12:228. 2011
    ....
  7. doi request reprint The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3',5'-cyclic adenosine 5'-monophosphate
    Koji Murao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, Kita gun, Kagawa 761 0793, Japan
    Endocrinology 149:6103-12. 2008
    ..In summary, our data showed that in the adrenal gland, PREB regulates the transcription of the SR-BI gene via cAMP...
  8. doi request reprint Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway
    Junhua Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki cho, Kita gun, Kagawa, Japan
    J Cell Mol Med 14:1083-7. 2010
    ..Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells...
  9. doi request reprint The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells
    Xiao Yu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Endocrine 38:53-9. 2010
    ..In summary, we have shown that TRH stimulated PREB expression in GH3 cells via the PKA pathway. PREB can function as a transcriptional regulator of PRL promoter activity and might be involved in TRH-induced PRL gene transcription...
  10. doi request reprint Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate
    Yukiko Nishiuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Atherosclerosis 212:418-25. 2010
    ..In the present study, we have examined the role of PREB in regulating ABCA1 expression mediated by 3',5'-cyclic adenosine-5'-monophosphate (cAMP)...
  11. ncbi request reprint Use of protein array to investigate receptor tyrosine kinases activated in gastric cancer
    Jian Gong
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 36:101-6. 2010
    ..These data suggest that ErbB2 is activated in gastric cancer, and the ErbB2-targeting drug trastuzumab may be related to the reduction of Ang 1, FGFalpha, FGFbeta, TGFalpha and IL-8...
  12. doi request reprint The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene
    Hitomi Imachi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, Kita gun, Kagawa 761 0793, Japan
    Biochem Biophys Res Commun 376:531-5. 2008
    ..The knockdown of PREB expression attenuated the effects of cAMP on CYP11B1 expression. In summary, our data showed that in the adrenal gland, PREB regulates the transcription of the CYP11B1 gene via cAMP...
  13. ncbi request reprint Novel mutations in the gene encoding acid α-1,4-glucosidase in a patient with late-onset glycogen storage disease type II (Pompe disease) with impaired intelligence
    Tomie Muraoka
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Japan
    Intern Med 50:2987-91. 2011
    ..0 nmol/4 MU/mg/30 min (control range, 7.3 ± 2.2). Genetic analysis revealed a novel compound heterozygous missense mutation in GAA--c.1814 G >A (p.Gly605Asp) and c.1846 G >A (p.Asp616Asn) both in exon 13...
  14. doi request reprint The role of calcium/calmodulin-dependent protein kinase cascade on MIP-1alpha gene expression of ATL cells
    Kensuke Matsumoto
    Division of Endocrinology, Metabolism and Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Exp Hematol 36:390-400. 2008
    ..In this study, we investigated the effect of extracellular calcium on MIP-1alpha secretion in ATL cells and the role of Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaM-K) cascade in transcriptional activation of MIP-1alpha...
  15. ncbi request reprint Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma
    Hamdy Saad Mohammad
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 33:1157-63. 2008
    ..These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC...
  16. ncbi request reprint Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis
    Takako Nonomura
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 30:105-11. 2007
    ..In conclusion, nuclear c-Yes expression was found in cancer cells at the early stages of hepatocarcinogenesis, suggesting that nucleus-located c-Yes may be a useful marker to detect early-stage HCC...
  17. pmc Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees
    Akihiro Matsuya
    Integrated Database Group, Japan Biological Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan
    Nucleic Acids Res 36:D787-92. 2008
    ..We expect the Evola to serve as a comprehensive and reliable database to be utilized in comparative analyses for obtaining new knowledge about human genes. Evola is available at http://www.h-invitational.jp/evola/...
  18. pmc Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region
    Takaaki Yokomine
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Genome Res 15:154-65. 2005
    ..Our findings show that the imprinted genes were clustered before the emergence of imprinting and that the elements associated with imprinting probably evolved after the divergence of mammals and birds...
  19. ncbi request reprint The genome sequence and structure of rice chromosome 1
    Takuji Sasaki
    Rice Genome Research Program, National Institute of Agrobiological Sciences, 1 2, Kannondai 2 chome, Tsukuba, Ibaraki 305 8602, Japan
    Nature 420:312-6. 2002
    ..Comparison with a draft sequence indicates the importance of a high-quality finished sequence...
  20. ncbi request reprint Identification of neurotransmitter receptor genes under significantly relaxed selective constraint by orthologous gene comparisons between humans and rodents
    Hisakazu Iwama
    Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima shi, Shizuoka ken, Japan
    Mol Biol Evol 19:1891-901. 2002
    ..Thus, it suggests that the relaxed-constraint neuroreceptor genes have evolved, assuring that the nervous system responds to a variety of stimuli with proper flexibility...