Hideo Yagita

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint TRAIL and its receptors as targets for cancer therapy
    Hideo Yagita
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:777-83. 2004
  2. pmc Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis
    H Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Exp Med 191:375-80. 2000
  3. ncbi request reprint The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
  4. ncbi request reprint Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:6344-8. 2003
  5. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
  6. doi request reprint Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules
    Kazuyoshi Takeda
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:5493-501. 2010
  7. ncbi request reprint Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1586-92. 2005
  8. ncbi request reprint TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation
    Tatsuya Saitoh
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Biol Chem 278:36005-12. 2003
  9. ncbi request reprint Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death
    Masafumi Nakayama
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 170:341-8. 2003
  10. doi request reprint Notch signaling confers antigen-presenting cell functions on mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 123:74-81.e1. 2009

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint TRAIL and its receptors as targets for cancer therapy
    Hideo Yagita
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:777-83. 2004
    ..In this review, we summarize recent knowledge about TRAIL and its receptors as promising targets for cancer therapy...
  2. pmc Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis
    H Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Exp Med 191:375-80. 2000
    ..These results indicate that anti-OX40L mAb abrogated progressive leishmaniasis in BALB/c mice by suppressing the development of Th2 responses, substantiating a critical role of OX40-OX40L interaction in Th2 development in vivo...
  3. ncbi request reprint The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
  4. ncbi request reprint Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:6344-8. 2003
    ..Our results demonstrated, for the first time, the potent immunostimulatory effect of the RANK-L gene to improve the CD8(+) T cell-mediated immunity against infectious agents...
  5. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
    ....
  6. doi request reprint Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules
    Kazuyoshi Takeda
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:5493-501. 2010
    ..Thus, the blockade of the CTLA-4-mediated inhibitory signal in tumor infiltrating CTL may be the most effective strategy to augment the effect of immune therapies that generate tumor-specific CTL...
  7. ncbi request reprint Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1586-92. 2005
    ....
  8. ncbi request reprint TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation
    Tatsuya Saitoh
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Biol Chem 278:36005-12. 2003
    ..Our results thus identify TWEAK as a novel physiological regulator of the non-canonical pathway for NF-kappaB activation...
  9. ncbi request reprint Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death
    Masafumi Nakayama
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 170:341-8. 2003
    ..These results revealed that the multiple pathways of TWEAK-induced cell death are solely mediated by Fn14...
  10. doi request reprint Notch signaling confers antigen-presenting cell functions on mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 123:74-81.e1. 2009
    ..Notch signaling is involved in cell fate determination along with the development of the immune system. However, very little is known about the role for Notch signaling in mast cells...
  11. doi request reprint Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD
    Junya Fujimura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Transplant 14:540-8. 2010
    ....
  12. ncbi request reprint Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease
    Tsunekazu Oikawa
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 177:4281-7. 2006
    ..Our results suggest that Tim-3 may play a crucial role in the regulation of CD8+ T cells responsible for the maintenance of hepatic homeostasis and tolerance...
  13. ncbi request reprint Eradication of established tumors in mice by a combination antibody-based therapy
    Tomoyasu Uno
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 12:693-8. 2006
    ..These results in mice indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans...
  14. pmc NKG2A inhibits invariant NKT cell activation in hepatic injury
    Toshihiko Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    J Immunol 182:250-8. 2009
    ..Overall, these results indicated that a NKG2A-mediated signal negatively regulates iNKT cell activation and hepatic injury...
  15. doi request reprint TIM-4 has dual function in the induction and effector phases of murine arthritis
    Yoshiyuki Abe
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Immunol 191:4562-72. 2013
    ....
  16. pmc Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 71:1234-41. 2003
    ..cruzi. Our results, in contrast to previous reports demonstrating the protective roles of NK T cells against other infectious agents, suggest that these cells might even exhibit adverse effects on vaccine-mediated protective immunity...
  17. pmc Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection
    Yasushi Miyahira
    Atopy Research Center, Department of Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 73:7356-65. 2005
    ..cruzi. These results indicated, for the first time, that the induction of immune responses against a single CD8+-T-cell epitope derived from an intrinsic T. cruzi antigen was sufficient to control lethal T. cruzi infection...
  18. ncbi request reprint B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma
    Osamu Nagashima
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 181:4062-71. 2008
    ..These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma...
  19. ncbi request reprint Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  20. ncbi request reprint The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
    Yoshihiko Usui
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:3071-81. 2006
    ..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU...
  21. pmc Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity
    Taisuke Sawada
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 283:26820-8. 2008
    ..Collectively, these functional and spatial changes of OTT and BSAC caused by the fusion might perturb their functions, culminating in the development of acute megakaryoblastic leukemia...
  22. ncbi request reprint Differential binding properties of B7-H1 and B7-DC to programmed death-1
    Pornpan Youngnak
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 307:672-7. 2003
    ..Our results suggest that the differential binding properties of B7-H1 and B7-DC may be responsible for differential contributions of these two PD-1 ligands to immune responses...
  23. pmc Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 71:3131-7. 2003
    ..cruzi infection but also to DNA vaccine-induced protective immunity to Chagas' disease...
  24. doi request reprint Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands
    Chiyoko Sekine
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 21:295-301. 2009
    ..All these Notch ligands are expressed predominantly in the red pulp of the spleen where CD8- DCs reside. These results indicate a differential regulation of CD8- DCs and MZ B cells by Notch ligands in the spleen...
  25. ncbi request reprint Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells
    Norihiro Harada
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 299:488-93. 2002
    ..These results indicated that TWEAK could induce pro-inflammatory reactions via Fn14 on HUVEC...
  26. pmc Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Department of Immunology, Juntendo Univesity School of Medicine, Tokyo, Japan
    J Biol Chem 286:12042-8. 2011
    ..These findings indicate that activation of CIITA pIII plays an important role in MHC class II expression in mast cells...
  27. ncbi request reprint TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage
    Yuki Kaduka
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 331:384-90. 2005
    ..On the other hand, TWEAK expression in tumor cells had no significant effect on subcutaneous tumor growth. These results indicate that TWEAK mediates anti-tumor effect of macrophages in vivo...
  28. ncbi request reprint Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes
    Long Jin
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1175-9. 2004
    ..Because RANTES has been implicated in inflammation, TWEAK/Fn14 interaction in human keratinocytes may be involved in the pathophysiology of inflammatory skin disorders...
  29. doi request reprint Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK cell-mediated antitumor activity through the tumor necrosis factor-alpha pathway
    Eijiro Nagasaki
    Department of Oncology, Institute of DNA Medicine daggerDivision of Oncology and Hematology double daggerDivision of Gastroenterology and Hepatology, Department of Internal Medicine section signInstitute of Clinical Medicine and Research, The Jikei University School of Medicine parallelDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunother 33:467-74. 2010
    ..These results indicate that combined therapy with a DC vaccine and 5-FU is a promising strategy for cancer treatment mediated by the tumoricidal activity of NK cells through the TNF-alpha pathway...
  30. ncbi request reprint TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches
    Jiang Hu Piao
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 178:2272-7. 2007
    ..These results underscore a crucial role for the TNFR1-TRAF2-RelA-dependent canonical pathway in the development of PP through up-regulation of cxcl13 mRNA...
  31. ncbi request reprint TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system...
  32. doi request reprint Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice
    Yuko Moriyama
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 20:763-73. 2008
    ....
  33. ncbi request reprint Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells
    Hiroki Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Eur J Immunol 35:2358-66. 2005
    ..These results suggested that the CD94/NKG2A inhibitory receptor expressed on host-reactive donor T cells can be a novel target for the amelioration of aGVHD...
  34. ncbi request reprint Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies
    Masafumi Nakayama
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 306:819-25. 2003
    ..The anti-murine TWEAK and Fn14 mAbs will be useful for further investigating the physiological and pathological functions of TWEAK and Fn14...
  35. doi request reprint Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
    Masafumi Nakayama
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Blood 113:3821-30. 2009
    ..These results indicate a crucial role for Tim-3 in phagocytosis of apoptotic cells and cross-presentation, which may be linked to peripheral tolerance...
  36. ncbi request reprint Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha
    Xin Xue
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421
    J Biol Chem 280:33917-25. 2005
    ..Collectively, some, but not all, oxidative stresses induce the UPR, and pre-emptive UPR counteracts TNFalpha-induced ROS accumulation...
  37. pmc Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes
    Chiyoko Sekine
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, 113 8421, Japan
    Arthritis Res Ther 14:R45. 2012
    ..However, the responsible Notch ligands have not been identified yet. This study was undertaken to determine the role of individual Notch receptors and ligands in osteoclastogenesis...
  38. ncbi request reprint Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses
    Tatsuma Okazaki
    Department of Immunology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 300:807-12. 2003
    ..Moreover, TNF-induced phosphorylation of p65 was severely impaired in S276A mutant, indicating that S276 is the major phosphorylation site of p65 and its phosphorylation is essential for p65-dependent cellular responses...
  39. ncbi request reprint Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis
    Koichi Kamata
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 177:6433-9. 2006
    ..These results indicated anti-inflammatory and antiangiogenic effects of the TWEAK blockade in CIA, which may be also beneficial for the treatment of RA...
  40. ncbi request reprint Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T
    Shunsuke Kanada
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 180:8204-10. 2008
    ..The findings demonstrate that a -315 SNP significantly affects human FcepsilonRI alpha-chain promoter activity and expression level of FcepsilonRI on basophils by binding different transcription factors to the SNP site...
  41. ncbi request reprint ICOS costimulates invariant NKT cell activation
    Hiroshi Kaneda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 327:201-7. 2005
    ..Moreover, blockade of both B7RP-1-ICOS and CD80/86-CD28 interactions mostly abolished the alpha-GalCer-induced immune responses. These findings indicate that iNKT cell activation is regulated by CD28 and IOCS independently...
  42. pmc Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    J Exp Med 199:437-48. 2004
    ....
  43. ncbi request reprint Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)
    Nobuhiko Kayagaki
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cell Immunol 219:82-91. 2002
    ..These results suggest a new role for TRAIL in the suppression of Ab production...
  44. pmc TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells
    Takashi Ando
    Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Arthritis Res Ther 8:R146. 2006
    ..Collectively, TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in MC3T3-E1 cells. TWEAK may thus be a novel cytokine that regulates several aspects of osteoblast function...
  45. pmc Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells
    Yuko Kojima
    Laboratory of Biomedical Imaging Research, Biomedical Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 286:43383-93. 2011
    ....
  46. pmc An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway
    Akihito Nakajima
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    EMBO J 25:5549-59. 2006
    ..Taken that ROS promote JNK activation and activation of the JNK pathway may promote ROS accumulation, c-FLIPL might block this positive feedback loop, thereby suppressing ROS accumulation...
  47. doi request reprint Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis
    Yasuhiro Nemoto
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Juntendo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 14:1491-503. 2008
    ..Based on this background we here investigate whether granulocytes promote or suppress the expansion of colitogenic CD4(+) T cells...
  48. doi request reprint Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors
    Shiki Takamura
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Immunol 184:4696-707. 2010
    ..These results highlight FV's unique ability to evade virus-specific CD8(+) T cell responses and the importance of an early prophylactic approach for preventing terminal exhaustion of CD8(+) T cells...
  49. pmc Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells
    Toshio Kawamoto
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arthritis Res Ther 13:R47. 2011
    ..In this study, we investigated the effects of anti-TIM-2 monoclonal antibodies (mAbs) in collagen-induced arthritis (CIA) to determine whether TIM-2 contributes to the development of T helper (Th) 1 or Th17 cells and joint inflammation...
  50. pmc Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death
    Akihito Nakajima
    Departments of Immunology and Anatomy, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Biol Chem 283:24128-35. 2008
    ..Thus, elucidating the mechanism underlying mitochondrial extrusion will open a novel avenue leading to better understanding of various diseases caused by mitochondrial malfunction as well as mitochondrial biology...
  51. ncbi request reprint Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors
    Chinatsu Kasuga
    Department of Neurosurgery, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:840-4. 2004
    ....
  52. ncbi request reprint Beta2-microglobulin required for cell surface expression of blastocyst MHC
    Toshitaka Tanaka
    Department of Gynecology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 332:311-7. 2005
    ..The results suggested that beta2m as well as TAP was necessary for the transportation of blastocyst MHC from endoplasmic reticulum to cell surfaces through the Golgi apparatus, similar to other MHC class I molecules...
  53. doi request reprint TIM-1 signaling in B cells regulates antibody production
    Juan Ma
    Department of Immunology, Juntendo University, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 406:223-8. 2011
    ..These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation...
  54. ncbi request reprint Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Immunol Lett 89:193-9. 2003
    ..These results suggest the crucial role of this costimulatory pathway in the regulation of Th2-biased T cell differentiation and in host immune responses against L. major and N. brasiliensis infections...
  55. ncbi request reprint Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS
    Tomonari Sasazuki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Mol Immunol 41:547-51. 2004
    ..Taken that TNF induces accumulation of ROS in DKO, but not wild-type MEFs, upregulation of antioxidant enzyme(s) might play a crucial role in elimination of ROS...
  56. pmc NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
    Sachiko Sakon
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    EMBO J 22:3898-909. 2003
    ..or prolonged MAPK activation in wild-type MEFs, indicating that TRAF-mediated NF-kappaB activation normally suppresses the TNF-induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death..
  57. doi request reprint Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice
    Jiang Hu Piao
    Department of Immunology, Juntendo University School Graduate School of Medicine, Tokyo, Japan
    Immunol Cell Biol 90:881-8. 2012
    ..Together, abrogation of immunosuppressive conditions mediated by IL-10-secreting neutrophils might be an alternative strategy to treat chronic inflammatory diseases at least under certain conditions...
  58. pmc c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis
    Xuehua Piao
    Department of Immunology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Sci Signal 5:ra93. 2012
    ..Together, these results suggest that c-FLIP controls the homeostasis of IECs and hepatocytes by preventing cell death induced by TNF-α, FasL, and TRAIL...
  59. doi request reprint Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice
    Tamami Sakanishi
    Division of Cell Biology, Bio Medical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 393:829-35. 2010
    ..These results indicate that a non-depleting agonistic mAb against CD27 is promising for cancer therapy by co-stimulating tumor-specific CTL induction...
  60. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
    ..Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors...
  61. doi request reprint Development of monoclonal antibodies for analyzing immune and hematopoietic systems of common marmoset
    Yoshie Kametani
    Department of Immunology, Tokai University School of Medicine, Isehara, Japan
    Exp Hematol 37:1318-29. 2009
    ..We developed several monoclonal antibodies (mAbs) directed to CD molecules to gain initial insight into the immune and hematopoietic systems of this organism, and analyzed the basic cellularity and characters of marmoset lymphocytes...
  62. ncbi request reprint Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo
    Atsushi Tajima
    Department of Immunology and Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1715-21. 2003
    ..These results suggested a role for blastocyst MHC in protecting TAP-deficient trophoblasts and tumor cells from NK cell attack in vivo...
  63. ncbi request reprint Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation
    Hideyuki Iwai
    Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 169:4332-9. 2002
    ....
  64. pmc Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy
    Masaharu Katae
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 70:4833-40. 2002
    ..cruzi infection. These results reinforced the utility of immunomodulatory adjuvants such as IL-12 gene for eliciting protective immunity against intracellular parasites by DNA vaccination...
  65. pmc A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
    Arnaud Couzinet
    Departments of Immunology and Molecular Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:2556-61. 2008
    ..Thus, these findings reveal a cell-type-specific function for IRF5 in the complex regulatory mechanism of death-receptor-induced apoptosis...
  66. ncbi request reprint TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF
    Hongri Xu
    Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 318:422-7. 2004
    ..Because IL-8 and GM-CSF are associated with inflammatory conditions, these results suggest that TWEAK/Fn14 interaction may play some roles in airway inflammatory responses...
  67. doi request reprint Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate
    Natsumi Abe
    Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Eur J Immunol 40:2608-17. 2010
    ..Furthermore, the magnitude of Notch signaling induced is critical for the determination of T-cell fate...
  68. doi request reprint Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice
    Fumihiko Makino
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Respir Cell Mol Biol 47:298-305. 2012
    ..These results indicate an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation...
  69. ncbi request reprint Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity
    Yuko Kojima
    Division of Pathology, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 296:328-36. 2002
    ..Moreover, TN16 markedly inhibited the FasL-mediated cytotoxicity by CD8+ T cell clones and NK cells. These results suggested a substantial contribution of FasL to granule exocytosis-mediated target cell lysis by CD8+ CTL and NK cells...
  70. ncbi request reprint Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
    Toshiro Futagawa
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 14:275-86. 2002
    ..Moreover, IL-12 production by anti-CD40-stimulated DC was partially inhibited by TKS-1. These results suggest that 4-1BB expressed on DC may be involved in DC activation through DC--tumor interaction and DC--DC interaction...
  71. doi request reprint Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis
    Michio Onizawa
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G850-9. 2009
    ....
  72. pmc Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 105:10895-900. 2008
    ..Thus, TRAIL/DR5-mediated apoptosis may substantially contribute to chronic cholestatic disease, particularly primary sclerosing cholangitis...
  73. doi request reprint Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α
    Jun Ito
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 412:109-14. 2011
    ..These findings highlight an important collaborative mechanism between TGF-β and EGFR in maintaining airway epithelial homeostasis...
  74. ncbi request reprint Multiple pathways of TWEAK-induced cell death
    Masafumi Nakayama
    Department of Immunology, Allergy Research Center, Division of Pathology, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 168:734-43. 2002
    ..These results indicated that TWEAK could induce multiple pathways of cell death, including both caspase-dependent apoptosis and cathepsin B-dependent necrosis, in a cell type-specific manner via TWEAK receptor(s) distinct from DR3...
  75. ncbi request reprint Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death
    Tomonari Sasazuki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 277:28853-60. 2002
    ..Collectively, BSAC is a novel transcriptional activator with antiapoptotic function, which may be involved in the leukemogenesis...
  76. doi request reprint CD27 and CD70 do not play a critical role in the development of experimental allergic conjunctivitis in mice
    Tamaki Sumi
    Department of Ophthalmology and Visual Science, Kochi Medical School, Juntendo University School of Medicine, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 119:91-6. 2008
    ..In vitro treatment of RW-primed splenocytes with anti-CD27 or anti-CD70 Ab did not affect the EC-inducing capability of the splenocytes. Taken together, CD27 and CD70 do not play a critical role in the development of EC...
  77. ncbi request reprint Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy
    Chiharu Nishiyama
    Atopy Allergy Research Center, Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 173:6458-64. 2004
    ..These results suggest that the SNPs in the FcepsilonRIbeta promoter are causally linked with atopy via regulation of FcepsilonRI expression...
  78. ncbi request reprint Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy
    Yoshinori Seko
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Yokyo 113 8655, Japan
    Cardiovasc Pathol 11:166-70. 2002
    ..Recently, we found that tumor necrosis factor (TNF) ligand superfamily costimulatory molecules, especially 4-1BBL, played an important role in the myocardial damage of murine acute viral myocarditis...
  79. pmc Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
    Hisashi Bashuda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Clin Invest 115:1896-902. 2005
    ..This strategy may be applicable to the design of safe clinical trials in humans...
  80. ncbi request reprint Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody
    Seiji Kamijo
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 347:124-32. 2006
    ..These results suggest the utility of anti-RANKL mAb for the prevention of osteoporosis associated with joint inflammation in RA...
  81. ncbi request reprint Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis
    Masato Yamada
    Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
    Arthritis Rheum 46:735-40. 2002
    ....
  82. pmc PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection
    Katsunori Tanaka
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:5204-10. 2007
    ..Expression of PDL1 in donor tissue is critical for prevention of in situ graft pathology and chronic rejection...
  83. pmc Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction
    Mika Kijima
    Department of Immunology and Parasitology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 105:7010-5. 2008
    ..Furthermore, manipulation of this interaction may provide an approach to induce potent tumor immunity or to inhibit certain autoimmune diseases caused by NK cell activation...
  84. ncbi request reprint TRAIL/Apo-2 ligand induces primary plasma cell apoptosis
    Josie Ursini-Siegel
    Departments of Pathology and Microbiology and Immunology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Immunol 169:5505-13. 2002
    ..These results provide the first evidence that primary plasma cells synthesize TRAIL and are direct targets of TRAIL-mediated apoptosis, which may relate to the inactivation of the NF-kappaB survival pathway...
  85. pmc Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects
    Chih Wen Tseng
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Vaccine 26:4314-9. 2008
    ..Our findings serve as an important foundation for future clinical translation...
  86. ncbi request reprint Blockade of the OX40 ligand prolongs corneal allograft survival
    Takaaki Hattori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Eur J Immunol 37:3597-604. 2007
    ..These results demonstrate that OX40L blockade is effective for prolongation of corneal allograft survival by inhibiting recipient T cell activation...
  87. doi request reprint Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy
    Jun Yang
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Circulation 117:660-9. 2008
    ..We investigated the role of recipient versus donor PD-1 ligands in the pathogenesis of allograft rejection with emphasis on the role of tissue expression in regulating this alloimmune response in vivo...
  88. doi request reprint NK cells contribute to the skin graft rejection promoted by CD4+ T cells activated through the indirect allorecognition pathway
    Akiko Ito
    Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Int Immunol 20:1343-9. 2008
    ..Expression of NKG2D ligands was up-regulated in the rejecting grafts. These results suggest that NK cells activated through NKG2D contribute to the skin allograft rejection promoted by indirectly primed CD4(+) T cells...
  89. doi request reprint Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hosts
    Jean Sébastien Delisle
    Institute for Research in Immunology and Cancer, Montreal, QC, Canada
    Blood 112:2111-9. 2008
    ..We conclude that IFN-gamma produced by alloreactive T cells may entail a severe graft-versus-graft reaction and could be responsible for cytopenias that are frequently observed in subjects with GVHD...
  90. ncbi request reprint Combined natural killer T-cell based immunotherapy eradicates established tumors in mice
    Michele W L Teng
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 67:7495-504. 2007
    ..In summary, sequential tumor cell apoptosis and amplification of dendritic cell function by NKT cell agonists represents an exciting and novel approach for cancer treatment...
  91. pmc A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo
    Helena Soares
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1095-106. 2007
    ..The results indicate that two DC subsets have innate propensities to differentially affect the Th1/Th2 balance in vivo and by distinct mechanisms...
  92. ncbi request reprint Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3
    Yoshinori Seko
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Cardiovasc Res 75:158-67. 2007
    ..PD-1/PD-L belong to the CD28/B7 superfamily, and the PD-1/PD-L pathway is known to transduce a negative immunoregulatory signal that antagonizes the T-cell receptor-CD28 signal and inhibits T-cell activation...
  93. ncbi request reprint Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:4156-63. 2003
    ....
  94. ncbi request reprint CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen
    Osamu Aramaki
    Third Department of Surgery, Nihon University, Tokyo, Japan
    Transplantation 76:772-6. 2003
    ..We investigated whether blockade of tumor necrosis factor receptor-ligand pathways could generate regulatory cells induced by intratracheal delivery of alloantigen...
  95. ncbi request reprint Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade
    Yuichi Matsui
    Department of Hepato Biliary Pancreatic and Transplantation Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Physiol Genomics 15:199-208. 2003
    ..These results provide evidence that immunologic tolerance can be induced and maintained in the presence of prominent pro-inflammatory gene expression in vivo...
  96. ncbi request reprint Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer
    Hideki Tsuji
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Gene Ther 10:717-25. 2003
    ..These findings collectively support the therapeutic value of adenovirus-mediated B7-1/Fas gene transfer on poorly immunogenic osteosarcoma, which is resistant to a treatment protocol using transduction of B7-1 alone...
  97. ncbi request reprint Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, MN 55455, USA
    J Immunol 171:1272-7. 2003
    ..These data indicate that PD-1 ligation down-regulates GVHD through modulation of IFN-gamma production and suggest a novel therapeutic target for inhibiting GVHD lethality...
  98. pmc The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    Hiroshi Harada
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 112:234-43. 2003
    ..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo...
  99. pmc Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
    Alan D Salama
    Laboratory of Immunogenetics and Transplantation, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:71-8. 2003
    ..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE...
  100. pmc Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor
    Tahiro Shin
    Sidneu Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 198:31-8. 2003
    ..Finally, costimulation with B7-DC alone or in conjunction with B7-1 is PD-1 independent, indicating that B7-DC costimulates T cells via a second receptor...
  101. ncbi request reprint Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells
    Kyung Mi Lee
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:4881-5. 2003
    ..Therefore, 2B4 functions as a costimulator of CD8(+) T cells in MHC-restricted cytotoxicity. We conclude that 2B4/CD48 interactions among T cells themselves can augment CTL lysis of their specific targets...