Hidetsugu Wakabayashi

Summary

Affiliation: Josai University
Country: Japan

Publications

  1. ncbi request reprint Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones
    Shota Sekine
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    Anticancer Res 34:1743-50. 2014
  2. ncbi request reprint Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 24:39-44. 2010
  3. ncbi request reprint Cytotoxic activity of azulenes against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4747-55. 2003
  4. ncbi request reprint Cytotoxic activity of tropolones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4757-63. 2003
  5. ncbi request reprint Cytotoxic activity of azulenequinones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:305-12. 2005
  6. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenes
    Kana Hashiba
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3939-44. 2004
  7. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones
    Masayuki Nishishiro
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:4157-63. 2005
  8. ncbi request reprint Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulene derivatives
    Juri Takahashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:171-8. 2008
  9. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones
    Keiko Yokoyama
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3917-22. 2004
  10. ncbi request reprint Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulenes
    Nobuharu Ohshima
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:2921-7. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones
    Shota Sekine
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    Anticancer Res 34:1743-50. 2014
    ....
  2. ncbi request reprint Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 24:39-44. 2010
    ..These data suggest the occurrence of a hormetic response only at restricted times and concentrations as has been previously reported, although the biological significance is yet to be elucidated...
  3. ncbi request reprint Cytotoxic activity of azulenes against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4747-55. 2003
    ..These data suggest that a radical-mediated oxidation mechanism may not be involved in the apoptosis induction by methyl 7-isopropyl-2-methoxyazulene-1-carboxylate [24]...
  4. ncbi request reprint Cytotoxic activity of tropolones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4757-63. 2003
    ..These data suggest that 5-aminotropolone may induce cytotoxicity by radical-mediated redox reaction...
  5. ncbi request reprint Cytotoxic activity of azulenequinones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:305-12. 2005
    ..None of the twenty-seven azulenequinones showed anti-HIV activity. These results suggest [12] and [24] as possible candidates for future cancer chemotherapy...
  6. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenes
    Kana Hashiba
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3939-44. 2004
    ..These data suggest that the inhibitory effect of [11] may be produced via a mechanism other than iNOS induction and a radical-mediated mechanism...
  7. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones
    Masayuki Nishishiro
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:4157-63. 2005
    ..These data suggest that the inhibitory effect of NO production by compounds [8, 13] might be generated mostly via the inhibition of iNOS expression, rather than the radical-mediated mechanism...
  8. ncbi request reprint Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulene derivatives
    Juri Takahashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:171-8. 2008
    ....
  9. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones
    Keiko Yokoyama
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3917-22. 2004
    ..These data suggested that the inhibitory effect of [21] on NO production might be generated via the inhibition of iNOS expression, rather than a radical-mediated mechanism...
  10. ncbi request reprint Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulenes
    Nobuharu Ohshima
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:2921-7. 2006
    ..The present study showed the inhibitory effects of trifluoroacetylazulenes and trichloroacetylazulenes on NO production by activated macrophages...
  11. ncbi request reprint Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives
    Taichi Narita
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    Anticancer Res 29:1123-30. 2009
    ....
  12. ncbi request reprint Relationship between electronic structure and cytotoxic activity of tropolones
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    In Vivo 20:391-5. 2006
    ..The results of the present study suggest the applicability of theoretical calculations such as frontier molecular orbital, dipole moments and deltadeltaHf in the prediction of the cytotoxic activity of tropolone derivatives...
  13. ncbi request reprint Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines
    Takashi Sekine
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 27:133-43. 2007
    ..These results suggest the diversity of cell death type induced in human tumor cell lines by trihaloacetylazulene derivatives...
  14. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by benzocycloheptoxazines
    Kaori Miyahara
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:2657-62. 2008
    ..These results suggest the possible anti-inflammatory action of benzocyclo-heptoxazines via inhibition of LPS-activated macrophages...
  15. ncbi request reprint Quantitative structure-cytotoxicity relationship of newly synthesized tropolones determined by a semiempirical molecular-orbital method (PM5)
    Mariko Ishihara
    Division of Basic Chemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Anticancer Res 30:129-33. 2010
    ..Particular descriptors could be used to evaluate the biological activity of newly synthesized tropolones...
  16. ncbi request reprint Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines
    Yoshiaki Akatsu
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:1917-23. 2006
    ..None of the 26 compounds showed anti-HIV activity. These results suggest [5b] and [11b] as possible candidates for future cancer chemotherapy...
  17. ncbi request reprint Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure
    Ayako Takano
    Faculties of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 29:455-64. 2009
    ..Quantitative structure-activity relationship (QSAR) analysis suggests the applicability of the theoretical calculations such as frontier molecular orbital, dipole moments and hydrophobicity in predicting their cytotoxic activity...
  18. ncbi request reprint Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by benzo[b]cyclohept[e] [1,4]oxazine and 2-aminotropone derivatives
    Akina Suga
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 23:691-7. 2009
    ..These data suggest that [16] but not [5] exerts its anti-inflammatory action against macrophages via the inhibition of iNOS and COX-2 protein expressions...
  19. ncbi request reprint Estimation of relationship between the structure of trihaloacetylazulene derivatives determined by a semiempirical molecular-orbital method (PM5) and their cytotoxicity
    Mariko Ishihara
    Division of Basic Chemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Anticancer Res 30:837-41. 2010
    ..The descriptors determined by the present method are useful in evaluating the biological activity of trihaloacetylazulenes...
  20. ncbi request reprint Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines
    Hiromi Murayama
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:1069-78. 2008
    ..These results indicate the diversity of the type of cell death induced by benzocycloheptoxazine derivatives in human tumor cell lines...
  21. ncbi request reprint Anti-UV activity of newly-synthesized water-soluble azulenes
    Jun Ichi Ueki
    Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 27:119-26. 2013
    ..In the present study, we newly-synthesized a total of nine derivatives with higher water solubility, and re-investigated their anti-UV activity...
  22. ncbi request reprint Effect of tropolone, azulene and azulenequinone derivatives on prostaglandin E2 production by activated macrophage-like cells
    Masayuki Nishishiro
    Department of Chemistry, Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 29:379-83. 2009
    ..These data demonstrate the lack of correlation between the extent of inhibition of iNOS protein expression by tropolone or azulene derivatives and that of PGE2, and suggest the possible antiinflammatory potency of A-9...
  23. ncbi request reprint Quest for anti-inflammatory substances using IL-1β-stimulated gingival fibroblasts
    Manami Ono
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 25:763-8. 2011
    ..We investigated here whether they can inhibit pro-inflammatory cytokine production, by activated human gingival fibroblast (HGF)...
  24. ncbi request reprint Cytotoxic activity of benzo[b]cyclohept[e][1,4]oxazines
    Masanori Ohno
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 27:507-12. 2013
    ....
  25. ncbi request reprint Hormetic and UV-protective effects of azulene-related compounds
    Jun Ichi Ueki
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 25:41-8. 2011
    ..To further pursue the newly discovered biological activity of these compounds, five compounds that inhibited nitric oxide production by activated macrophages were investigated for their possible hormetic and anti-radiation effects...
  26. ncbi request reprint Relationship between electronic structure and cytotoxic activity of azulenes
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 20:385-9. 2006
    ..relationship (QSAR) parameters: deltadeltaHf, HOMO energy and muw Whereas, for the other ten compounds [3-5, 7-8, 10, 15-18], the cytotoxic activity might be related to the three QSAR parameters, deltadeltaHf, LUMO energy and muG..
  27. ncbi request reprint Factors that affect the type of cell death induced by chemicals
    Hiroshi Sakagami
    Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan
    Autophagy 3:493-5. 2007
    ..This suggests that the nature of the chemical structure as well as the type of target cells is another factor that determines the type of cell death induced by chemicals...
  28. ncbi request reprint Relationship between electronic structure and cytotoxic activity of azulenequinones and trihaloacetylazulenes
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 21:715-20. 2007
    ..The cytotoxic activity of trihaloacetylazulenes was correlated to DeltaDeltaH(f) LUMO energy and mu(ESP-W). QSAR may be applicable to predict the cytotoxicity of azulenequinones and trihaloacetylazulenes...
  29. ncbi request reprint Hormetic and anti-radiation effects of tropolone-related compounds
    Kaori Kantoh
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    In Vivo 24:843-51. 2010
    ..Three group I compounds and two group II compounds significantly protected the cells from UV-induced injury, suggesting their possible anti-UV effect...
  30. ncbi request reprint Quantitative structure-cytotoxicity relationship of newly synthesised trihaloacetylazulenes determined by a semi-empirical molecular-orbital method (PM5)
    Mariko Ishihara
    Division of Basic Chemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Anticancer Res 31:515-20. 2011
    ..In order to extend the search for tumour-targeting compounds, this study performed a quantitative structure-activity relationship (QSAR) analysis of 26 newly synthesised trihaloacetylazulenes...
  31. ncbi request reprint Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex
    Hiroshi Sakagami
    Division of Pharmacology, Meikai University School of Dentistry, Sakado, Japan Meikai Pharmaco Medical Laboratory MPL, Meikai University School of Dentistry, Sakado, Japan
    In Vivo 30:331-9. 2016
    ..SE has been utilized to manufacture tooth paste, soap and gel cosmetic to increase the level of quality of life (QOL). ..
  32. ncbi request reprint Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama 350 0295, Japan
    Anticancer Res 23:3237-41. 2003
    ..These data suggest that the inhibitory effect on NO production by Barbados cherry extracts is partly due to the inhibition of iNOS expression, and scavenging of O2- and NO radicals...
  33. ncbi request reprint Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone
    Yukiko Tomikoshi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 30:645-50. 2016
    ..The present study suggests that BOT may enhance the anti-tumor activity of apoptosis-inducing agents, while reducing its cytotoxicity against normal cells. ..
  34. ncbi request reprint Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper
    Noboru Motohashi
    Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Phytother Res 17:348-52. 2003
    ..Thus, this study suggests the effective and selective antitumor potential of 'Anastasia Red' of sweet pepper for further phytochemical and biological investigation...
  35. ncbi request reprint Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions
    Noboru Motohashi
    Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan
    Phytother Res 18:212-23. 2004
    ..The tumor specific cytotoxic activity and MDR reversal activity of barbados cherry may suggest its possible application for cancer therapy...