Mitsutoshi Kimura

Summary

Affiliation: Josai University
Country: Japan

Publications

  1. ncbi request reprint Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama, Japan
    J Pharmacol Sci 103:398-407. 2007
  2. ncbi request reprint Inhibitory effects of dexamethasone on epidermal growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    Biol Pharm Bull 34:682-7. 2011
  3. ncbi request reprint Inhibitory effects of dexamethasone on hepatocyte growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    J Pharmacol Sci 115:390-8. 2011
  4. doi request reprint Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-alpha
    Hiroshi Okamoto
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University 1 1 Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 604:12-9. 2009
  5. doi request reprint Signal transduction mechanism for potentiation by α1- and β2-adrenoceptor agonists of L-ascorbic acid-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Eur J Pharmacol 700:2-12. 2013
  6. ncbi request reprint Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1, Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 510:167-80. 2005
  7. ncbi request reprint Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama 350 02, Japan
    Biol Pharm Bull 34:1542-52. 2011
  8. ncbi request reprint IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    J Pharmacol Sci 109:618-29. 2009
  9. doi request reprint Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado City, Saitama, Japan
    Eur J Pharmacol 643:267-73. 2010
  10. doi request reprint Signal transduction pathway for L-ascorbic acid- and L-ascorbic acid 2-glucoside-induced DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 683:276-84. 2012

Collaborators

  • Hiroshi Okamoto
  • Katsuyoshi Sunaga
  • Hideo Inoue
  • Hajime Moteki
  • Masahiko Ogihara
  • Kota Naito
  • Hideshi Natsume
  • Tsutomu Yamaki
  • Manami Mitsuhashi
  • Chizuru Tanaka
  • Tadashi Tsuda
  • Kazuo Ohtake
  • Masaki Uchida
  • Jun Kobayashi
  • Hiroyuki Uchida
  • Yohei Shimazaki
  • Yasunori Morimoto
  • Yusuke Kuwahara
  • Yuya Shimamura

Detail Information

Publications17

  1. ncbi request reprint Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama, Japan
    J Pharmacol Sci 103:398-407. 2007
    ..These results suggest that direct or indirect activation of both PKA and PKC represent a positive regulatory mechanism for stimulating MAPK induction by HGF...
  2. ncbi request reprint Inhibitory effects of dexamethasone on epidermal growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    Biol Pharm Bull 34:682-7. 2011
    ..These results indicate that dexamethasone concentration-dependently delays and inhibits the EGF-induced DNA synthesis and proliferation through its own intracellular receptor in primary cultures of adult rat hepatocytes...
  3. ncbi request reprint Inhibitory effects of dexamethasone on hepatocyte growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    J Pharmacol Sci 115:390-8. 2011
    ..These results indicate that dexamethasone dose-dependently delays and inhibits HGF-induced DNA synthesis and proliferation through its own intracellular receptor in primary cultures of adult rat hepatocytes...
  4. doi request reprint Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-alpha
    Hiroshi Okamoto
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University 1 1 Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 604:12-9. 2009
    ....
  5. doi request reprint Signal transduction mechanism for potentiation by α1- and β2-adrenoceptor agonists of L-ascorbic acid-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Eur J Pharmacol 700:2-12. 2013
    ....
  6. ncbi request reprint Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1, Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 510:167-80. 2005
    ..The secreted TGF-alpha then stimulates hepatocyte DNA synthesis and proliferation through activation of TGF-alpha receptor to induce tyrosine kinase/MAP kinase activity and other downstream growth-related signal transducers...
  7. ncbi request reprint Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama 350 02, Japan
    Biol Pharm Bull 34:1542-52. 2011
    ..These results suggest that direct or indirect activation of PKA represents a positive regulatory mechanism for EGF stimulation of ERK2 induction...
  8. ncbi request reprint IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
    J Pharmacol Sci 109:618-29. 2009
    ..These results indicate that the IP receptor agonist-induced hepatocyte mitogenesis is mediated by autocrine secretion of TGF-alpha followed by activation of a receptor tyrosine kinase / ERK pathway...
  9. doi request reprint Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Sakado City, Saitama, Japan
    Eur J Pharmacol 643:267-73. 2010
    ..These results demonstrate that of the three retinoids, NIK-333 was the most potent in promoting the regeneration of liver mass and function with full recovery after 70% partial hepatectomy...
  10. doi request reprint Signal transduction pathway for L-ascorbic acid- and L-ascorbic acid 2-glucoside-induced DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 683:276-84. 2012
    ....
  11. ncbi request reprint Activation of extracellular-signal regulated kinase by platelet-derived growth factor is potentiated by phenylephrine in primary cultures of adult rat hepatocytes
    Hajime Moteki
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Biol Pharm Bull 34:980-6. 2011
    ..These results suggest that activation of PLC/PKC by phenylephrine represent an indirect positive regulatory mechanism for stimulating ERK induced by 10 ng/ml PDGF...
  12. ncbi request reprint In vivo glycyrrhizin accelerates liver regeneration and rapidly lowers serum transaminase activities in 70% partially hepatectomized rats
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1, Keyakidai, Sakado City, Saitama 350 0295, Japan
    Eur J Pharmacol 579:357-64. 2008
    ..These results demonstrate that injection of glycyrrhizin or EGF significantly enhances regeneration of liver mass and function, as well as recovery from the liver damage induced by surgical resection...
  13. doi request reprint Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes
    Kota Naito
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University
    Biol Pharm Bull 39:570-7. 2016
    ..These results indicate that the proliferative mechanism of action of 5-HT is mediated mainly through a 5-HT2B receptor/Gq/PLC-stimulated increase in autocrine secretion of TGF-α from primary cultured hepatocytes...
  14. ncbi request reprint L-ascorbic Acid- and L-ascorbic Acid 2-glucoside accelerate in vivo liver regeneration and lower serum alanine aminotransaminase activity in 70% partially hepatectomized rats
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University
    Biol Pharm Bull 37:597-603. 2014
    ..These results demonstrate that L-ascorbic acid and L-ascorbic acid 2-glucoside significantly promote the regeneration of liver mass and function with full recovery after liver injury. ..
  15. doi request reprint Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes
    Kota Naito
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University
    Biol Pharm Bull 39:121-9. 2016
    ....
  16. doi request reprint Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation
    Mitsutoshi Kimura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado City 350 0290, Japan
    Eur J Pharmacol 745:223-33. 2014
    ..Secreted TGF-α, in turn, acts as a complete mitogen to induce hepatocyte mitogenesis through the receptor tyrosine kinase/phosphatidylinositol 3-kinase/MAP kinase/mammalian target of rapamycin pathway...
  17. ncbi request reprint Effect of poly-L-arginine on intestinal absorption of hydrophilic macromolecules in rats
    Tsutomu Yamaki
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Biol Pharm Bull 36:496-500. 2013
    ..In the colon, the reduced effect of PLA on the absorption of FD-4 may be related to the smaller surface area for absorption and the higher expression of occludin compared with other segments...