Kazuki Takakura

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4849-55. 2014
  2. doi request reprint Clinical usefulness of diffusion-weighted MR imaging for detection of pancreatic cancer: comparison with enhanced multidetector-row CT
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Abdom Imaging 36:457-62. 2011
  3. pmc Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e63498. 2013
  4. pmc Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0142981. 2015
  5. doi request reprint [Corrigendum] Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 46:2679. 2015
  6. pmc Immunotherapy for colorectal cancer
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:8531-42. 2013
  7. pmc Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy
    Shintaro Tsukinaga
    Shintaro Tsukinaga, Mikio Kajihara, Kazuki Takakura, Zensho Ito, Tomoya Kanai, Keisuke Saito, Shinichiro Takami, Hiroko Kobayashi, Yoshihiro Matsumoto, Shunichi Odahara, Kan Uchiyama, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa City, Chiba 277 8567, Japan
    World J Gastroenterol 21:11168-78. 2015
  8. ncbi request reprint Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Institute of Clinical Medicine and Research, Jikei University School of Medicine, Tokyo, Japan Department of Oncology, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:6353-61. 2014
  9. doi request reprint Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 45:470-8. 2014
  10. pmc Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Mikio Kajihara, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 20:14420-9. 2014

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4849-55. 2014
    ..Application of the stratification concept to experimental animals will create new avenues to establish pharmacological intervention against HCC. ..
  2. doi request reprint Clinical usefulness of diffusion-weighted MR imaging for detection of pancreatic cancer: comparison with enhanced multidetector-row CT
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Abdom Imaging 36:457-62. 2011
    ....
  3. pmc Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e63498. 2013
    ..The alternative system is simple and may provide a platform for adoptive immunotherapy...
  4. pmc Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0142981. 2015
    ..Thus, CHST15-CS-E axis-mediated tumor cell proliferation could be a novel therapeutic target in the early stage of PDAC progression. ..
  5. doi request reprint [Corrigendum] Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 46:2679. 2015
    ..The corrected Fig. 3B and Fig. 6C are shown below. [the original article was published in the International Journal of Oncology 45: 470-478, 2014 DOI: 10.3892/ijo.2014.2433]. ..
  6. pmc Immunotherapy for colorectal cancer
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:8531-42. 2013
    ..The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. ..
  7. pmc Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy
    Shintaro Tsukinaga
    Shintaro Tsukinaga, Mikio Kajihara, Kazuki Takakura, Zensho Ito, Tomoya Kanai, Keisuke Saito, Shinichiro Takami, Hiroko Kobayashi, Yoshihiro Matsumoto, Shunichi Odahara, Kan Uchiyama, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa City, Chiba 277 8567, Japan
    World J Gastroenterol 21:11168-78. 2015
    ....
  8. ncbi request reprint Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Institute of Clinical Medicine and Research, Jikei University School of Medicine, Tokyo, Japan Department of Oncology, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:6353-61. 2014
    ..Chemoimmunotherapy has been used to treat intrahepatic cholangiocarcinoma (ICC). However, little is known about the phenomena underlying the immunomodulation of ICC cells elicited by chemoimmunotherapy...
  9. doi request reprint Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 45:470-8. 2014
    ....
  10. pmc Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Mikio Kajihara, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 20:14420-9. 2014
    ..To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation...
  11. ncbi request reprint Prognostic markers for patient outcome following vaccination with multiple MHC Class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 35:555-62. 2015
    ....
  12. pmc Clinical significance of serum procalcitonin in patients with ulcerative colitis
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Mikio Kajihara, Kan Uchiyama, Hiroshi Arakawa, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:8335-41. 2013
    ..To investigate the association of procalcitonin (PCT) with ulcerative colitis (UC) activity...
  13. doi request reprint Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Clinical Medicine and Research, Departments of Oncology
    Clin Cancer Res 20:4228-39. 2014
    ....
  14. ncbi request reprint Immunological assessment of cryotherapy in breast cancer patients
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4869-76. 2014
    ..In murine studies, cryotherapy has induced antitumor immune responses associated with the rejection of tumors. However, the effects of freezing-induced immunomodulation in breast cancer (BC) patients remain unclear...
  15. pmc Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 9:e86702. 2014
    ..Together, these results suggest that ATM therapy induces long-term alterations in the intestinal microbiota of patients with UC, which may be associated, at least in part, with clinical effects of the therapy. ..
  16. doi request reprint Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site
    Kazuki Takakura
    a Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 51:610-7. 2016
    ..397). Conclusions Our results demonstrated the validity of the NLR by IHC analyses and we determined that a higher value of NLR is a trustworthy prognostic factor for patients with PC. ..
  17. ncbi request reprint Dendritic-tumor fusion cells in cancer immunotherapy
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Discov Med 19:169-74. 2015
    ..We discuss the potential ability of DC-tumor fusion cells to activate antigen-specific T cells and strategies to improve the immunogenicity of DC-tumor fusion cells as anticancer vaccines. ..
  18. ncbi request reprint [A case of primary small cell carcinoma of the esophagus responding remarkably to carboplatin (CBDCA) + etoposide (VP-16) combination therapy and radiation therapy]
    Ryoichi Aizawa
    Division of Gastroenterology and Hepatology, The Jikei University Aoto Hospital
    Nihon Shokakibyo Gakkai Zasshi 106:1334-42. 2009
    ..This patient is alive without recurrence for 6 years and 3 months. This case seems to provide suggestions on deciding on the operative indications for small cell carcinoma of esophagus...
  19. doi request reprint The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies
    Mikio Kajihara
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Immunotherapy 7:1111-22. 2015
    ..This review addresses recent progress in improving clinical outcomes using DC-tumor FC-based cancer vaccines. ..
  20. pmc Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e59280. 2013
    ..Incorporating combined TLRs-activation and TGF-β1-blockade of DC/tumor may enhance the effectiveness of DC/tumor-based cancer vaccines and have the potential applicability to the field of adoptive immunotherapy...
  21. doi request reprint Is it safe to perform endoscopic band ligation for the duodenum? A pilot study in ex vivo porcine models
    Hiroshi Kakutani
    Department of Endoscopy, The JikeiUniversity School of Medicine, Tokyo, Japan
    Minim Invasive Ther Allied Technol 22:80-3. 2013
    ..We performed EBL procedures to evaluate the risks associated with the use of EBL in the duodenum...