Tomoyuki Nagata

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. doi request reprint Psychosocial or clinico-demographic factors related to neuropsychiatric symptoms in patients with Alzheimer's disease needing interventional treatment: analysis of the CATIE-AD study
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry . 2016
  2. pmc Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Tokyo, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:66-73. 2013
  3. doi request reprint Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8471, Japan
    J Neural Transm (Vienna) 121:433-41. 2014
  4. doi request reprint A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Int Psychogeriatr 25:1199-201. 2013
  5. doi request reprint Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:266-72. 2012
  6. doi request reprint Association between nerve growth factor gene polymorphism and executive dysfunction in Japanese patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 32:379-86. 2011
  7. doi request reprint Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 11:141-9. 2011
  8. doi request reprint Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 63:449-54. 2009
  9. ncbi request reprint Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 61:695-7. 2007
  10. ncbi request reprint Anorexia nervosa with chronic episodes for more than 30 years in a patient with a comorbid schizotypal personality disorder
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 61:434-6. 2007

Collaborators

Detail Information

Publications31

  1. doi request reprint Psychosocial or clinico-demographic factors related to neuropsychiatric symptoms in patients with Alzheimer's disease needing interventional treatment: analysis of the CATIE-AD study
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry . 2016
    ..These clusters were classified from 12 Neuropsychiatric Inventory (NPI) subscores in our previous study using the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) dataset...
  2. pmc Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Tokyo, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:66-73. 2013
    ..In the present study, we investigated whether apolipoprotein E (APOE) polymorphisms influenced the cognitive function of Japanese patients with Alzheimer's disease (AD) at certain ages...
  3. doi request reprint Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8471, Japan
    J Neural Transm (Vienna) 121:433-41. 2014
    ..The plasma BDNF level was robustly correlated with aggressiveness, implying that the plasma BDNF level might be useful as a behavioral state marker in patients with AD or A-MCI. ..
  4. doi request reprint A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Int Psychogeriatr 25:1199-201. 2013
    ..The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD...
  5. doi request reprint Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:266-72. 2012
    ....
  6. doi request reprint Association between nerve growth factor gene polymorphism and executive dysfunction in Japanese patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 32:379-86. 2011
    ....
  7. doi request reprint Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 11:141-9. 2011
    ....
  8. doi request reprint Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 63:449-54. 2009
    ....
  9. ncbi request reprint Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 61:695-7. 2007
    ..The efficacy of CBZ treatment in this patient suggests a method for controlling benzodiazepine-resistant impulsive aggression...
  10. ncbi request reprint Anorexia nervosa with chronic episodes for more than 30 years in a patient with a comorbid schizotypal personality disorder
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 61:434-6. 2007
    ..She was treated with low-dose antipsychotics, and her impulsive behavior improved. The patient's SPD was considered to have had a psychopathological contribution to her chronic episodes of anorexia nervosa...
  11. doi request reprint Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 22:463-9. 2010
    ....
  12. doi request reprint Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease
    Nobuyuki Kobayashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 34:190-7. 2012
    ....
  13. pmc Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population
    Ayako Suzuki
    Departments of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 6:90-7. 2016
    ..Nonsynonymous polymorphisms in the PSEN2 gene showed Lewy body dementia (LBD) phenotypes clinically. Therefore, we aimed to investigate whether PSEN2 gene polymorphisms were associated with AD or LBD...
  14. pmc Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0168816. 2016
    ..In conclusion, DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI...
  15. pmc Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0146449. 2016
    ..0001, ANCOVA). No association was found between methylation levels and APOE genotype. NCAPH2/LMF2 methylation levels were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI. ..
  16. doi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm (Vienna) 120:1599-603. 2013
    ..Our results suggest that the variation of the APOD gene modifies the risk for AD. Further association studies for APOD 3' UTR polymorphisms with other ethnic groups would be needed. ..
  17. doi request reprint Association between executive dysfunction and hippocampal volume in Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 23:764-71. 2011
    ..The aim of the present study was to evaluate how the hippocampal volume influences executive function as a non-memory cognitive function...
  18. doi request reprint Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry 30:927-33. 2015
    ..A functional COMT polymorphism, Val158Met (rs4680 G > A), affects the onset of AD and is associated with alcohol dependence through dopamine receptor sensitivity in the prefrontal cortex...
  19. doi request reprint Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Biochem Biophys Res Commun 430:907-11. 2013
    ....
  20. doi request reprint Differentiation between amnestic-mild cognitive impairment and early-stage Alzheimer's disease using the Frontal Assessment Battery test
    Ayumi Yamao
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Psychogeriatrics 11:235-41. 2011
    ..The aim of the present cross-sectional study is to evaluate executive dysfunction using the Frontal Assessment Battery (FAB) screening test in two groups and to investigate the interaction with other cognitive impairments...
  21. doi request reprint Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study
    Yoshihide Takeshita
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry . 2016
    ..Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs...
  22. doi request reprint Mirtazapine improves visual hallucinations in Parkinson's disease: a case report
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:103-7. 2013
    ..Mirtazapine improved the patient's refractory psychotic symptoms, especially her visual hallucinations, without worsening her motor symptoms. ..
  23. doi request reprint Classification of Neuropsychiatric Symptoms Requiring Antipsychotic Treatment in Patients with Alzheimer's Disease: Analysis of the CATIE-AD Study
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    J Alzheimers Dis 50:839-45. 2016
    ..The clinical rating scales with structured questionnaires have been useful to evaluate neuropsychiatric symptoms (NPSs) of patients with dementia over the past twenty year...
  24. doi request reprint Executive Dysfunction Correlated With 2-Year Treatment Response in Patients With Late-Life Undifferentiated Somatoform Disorders
    Keisuke Inamura
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan Electronic address
    Psychosomatics 57:378-89. 2016
    ..Treatment strategies for late-life SDs require these etiological factors to be considered. We hypothesized that the treatment response in patients with late-life SDs was associated with executive dysfunction...
  25. doi request reprint DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients
    Shunichiro Shinagawa
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan Electronic address
    Neurosci Lett 629:33-7. 2016
    ..Our results suggest that DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy through apoptosis. ..
  26. doi request reprint Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population
    Eri Kawai
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Neuromolecular Med 17:170-7. 2015
    ..The SPECT study revealed hyperperfusion in the C allele carrier group was detected in the right inferior frontal gyrus compared with the T/T group. KIBRA rs17070145 affects specific phenotypes of patients with AD. ..
  27. doi request reprint Cognitive Dysfunction in Patients With Late-Life Somatic Symptom Disorder: A Comparison According to Disease Severity
    Keisuke Inamura
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan KI, TN, Kazutaka Nukariya Electronic address
    Psychosomatics 56:486-94. 2015
    ..However, the details of the cognitive dysfunction that occur in late-life SSD are still unknown...
  28. doi request reprint Correlation between cognition and symptomatic severity in patients with late-life somatoform disorders
    Keisuke Inamura
    a Department of Psychiatry, Kashiwa Hospital, Jikei University School of Medicine, Chiba, Japan
    Aging Ment Health 19:169-74. 2015
    ..The aim of the present study was to evaluate how cognition is correlated with the severity of late-life SDs from a neuropsychological viewpoint...
  29. doi request reprint Correlation between both morphologic and functional changes and anxiety in Alzheimer's disease
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 38:153-60. 2014
    ..Although anxiety symptoms are often observed in Alzheimer's disease (AD), little attention has been paid to this symptom compared with other neuropsychiatric symptoms...
  30. ncbi request reprint [An elder case of neurosarcoidosis associated with brain infarction]
    Hideaki Nakagaki
    Department of Neurology, Aso Iizuka Hospital
    Rinsho Shinkeigaku 44:81-5. 2004
    ..The psychotic symptoms and consciousness disturbance rapidly ameliorated after the treatment with oral prednisolone, 40 mg/day. Neurosarcoidosis should be considered even in an elder case of sarcoidosis complicated with a stroke...