Shigeo Koido

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. pmc Dendritic-Tumor Fusion Cell-Based Cancer Vaccines
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, 277 8567 Chiba, Japan
    Int J Mol Sci 17:. 2016
  2. doi request reprint Cell fusion between dendritic cells and whole tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 8564, Japan
    Methods Mol Biol 1313:185-91. 2015
  3. ncbi request reprint Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Institute of Clinical Medicine and Research, Jikei University School of Medicine, Tokyo, Japan Department of Oncology, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:6353-61. 2014
  4. ncbi request reprint Immunological assessment of cryotherapy in breast cancer patients
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4869-76. 2014
  5. doi request reprint Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Clinical Medicine and Research, Departments of Oncology
    Clin Cancer Res 20:4228-39. 2014
  6. ncbi request reprint Tumor regression by CD4 T-cells primed with dendritic/tumor fusion cell vaccines
    Shigeo Koido
    Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan
    Anticancer Res 34:3917-24. 2014
  7. pmc Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers
    Desheng Weng
    Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Breast Cancer Res 14:R18. 2012
  8. pmc Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e63498. 2013
  9. pmc Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e59280. 2013
  10. ncbi request reprint Characterization of structure and direct antigen presentation by dendritic/tumor-fused cells as cancer vaccines
    Shigeo Koido
    Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba 277 8564, Japan
    Anticancer Res 33:347-54. 2013

Detail Information

Publications72

  1. pmc Dendritic-Tumor Fusion Cell-Based Cancer Vaccines
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, 277 8567 Chiba, Japan
    Int J Mol Sci 17:. 2016
    ..In this context, an effective fusion strategy also needs to produce immunogenic DC-tumor FCs. We discuss the potential ability of DC-tumor FCs and the recent progress in improving clinical outcomes by DC-tumor FC-based cancer vaccines. ..
  2. doi request reprint Cell fusion between dendritic cells and whole tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 8564, Japan
    Methods Mol Biol 1313:185-91. 2015
    ..The therapeutic efficacy of DC/tumor fusion cell vaccines requires the improved immunogenicity of both cells. Here, we describe the strategy to generate DC/tumor fusion cells. ..
  3. ncbi request reprint Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Institute of Clinical Medicine and Research, Jikei University School of Medicine, Tokyo, Japan Department of Oncology, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:6353-61. 2014
    ..Chemoimmunotherapy has been used to treat intrahepatic cholangiocarcinoma (ICC). However, little is known about the phenomena underlying the immunomodulation of ICC cells elicited by chemoimmunotherapy...
  4. ncbi request reprint Immunological assessment of cryotherapy in breast cancer patients
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4869-76. 2014
    ..In murine studies, cryotherapy has induced antitumor immune responses associated with the rejection of tumors. However, the effects of freezing-induced immunomodulation in breast cancer (BC) patients remain unclear...
  5. doi request reprint Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Clinical Medicine and Research, Departments of Oncology
    Clin Cancer Res 20:4228-39. 2014
    ....
  6. ncbi request reprint Tumor regression by CD4 T-cells primed with dendritic/tumor fusion cell vaccines
    Shigeo Koido
    Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan
    Anticancer Res 34:3917-24. 2014
    ..However, little is known about the function of Cluster of Differentiation (CD)4 T-cells primed with FC/MUC1 in MUC1 transgenic (MUC1.Tg) mice...
  7. pmc Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers
    Desheng Weng
    Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Breast Cancer Res 14:R18. 2012
    ..It is still uncertain whether metastasis is predominantly an early or late event in tumor progression. The detection of early metastases and cells responsible for the dissemination may therefore have significant clinical implications...
  8. pmc Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e63498. 2013
    ..The alternative system is simple and may provide a platform for adoptive immunotherapy...
  9. pmc Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e59280. 2013
    ..Incorporating combined TLRs-activation and TGF-β1-blockade of DC/tumor may enhance the effectiveness of DC/tumor-based cancer vaccines and have the potential applicability to the field of adoptive immunotherapy...
  10. ncbi request reprint Characterization of structure and direct antigen presentation by dendritic/tumor-fused cells as cancer vaccines
    Shigeo Koido
    Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba 277 8564, Japan
    Anticancer Res 33:347-54. 2013
    ..However, little is known on whether fused cells directly present tumor-associated antigens (TAAs) through major histocompatibility complex (MHC) class I and II pathways in the context of co-stimulatory molecules...
  11. pmc Current immunotherapeutic approaches in pancreatic cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Dev Immunol 2011:267539. 2011
    ..We offer our perspective on how to increase the clinical efficacy of immunotherapies for pancreatic cancer...
  12. pmc Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Biomed Biotechnol 2011:910836. 2011
    ..In this review, we will discuss immunologic monitoring of cellular responses for the evaluation of cancer vaccines including fusions of DC and whole tumor cell...
  13. pmc Regulation of tumor immunity by tumor/dendritic cell fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Dev Immunol 2010:516768. 2010
    ..This paper reviews tumor immune escape and current strategies employed in the field of tumor/DC fusions vaccine aimed at enhancing activation of TAAs-specific cytotoxic T cells in tumor microenvironment...
  14. pmc Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Biomed Biotechnol 2010:752381. 2010
    ..We will discuss perspectives for future development of DCs/tumor fusions for CTL induction...
  15. doi request reprint Cancer immunotherapy by fusions of dendritic cells and tumor cells
    Shigeo Koido
    Department of Internal Medicine, The Jikei University, Tokyo, Japan
    Immunotherapy 1:49-62. 2009
    ..This review deals with recent progress in the immunotherapy of cancer with fusions of DCs and tumor cells...
  16. doi request reprint Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Immunol 135:384-400. 2010
    ..However, fusions from patients with metastatic pancreatic cancer induced increased expression levels of TGF-beta1 in CD4+ CD25high T cells and low levels of CTLs with decreased IFN-gamma production...
  17. ncbi request reprint [Diagnosis of Helicobacter pylori infection: comparison with gold standard]
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 56:1007-13. 2008
    ..pylori infection. This review provides a general overview of the diagnostic methods and tests the characteristics (sensitivity and specificity) for H. pylori infection...
  18. ncbi request reprint Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int J Cancer 117:587-95. 2005
    ..Our report demonstrates the simultaneous induction of CRCA-specific CTL responses restricted by HLA-A2 and -A24...
  19. pmc In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Transl Med 6:51. 2008
    ..In this study, generation of cytotoxic T lymphocytes (CTL) and regulatory T cells (Treg) by fusions of dendritic cells (DCs) and HCC cells was examined...
  20. ncbi request reprint Dendritic/tumor fusion cell-based vaccination against cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Arch Immunol Ther Exp (Warsz) 55:281-7. 2007
    ..This review provides a general overview of the DC/tumor fusion cell-based vaccine and summarizes some of the recent advances in this field...
  21. ncbi request reprint Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Immunol 179:4874-83. 2007
    ..These results strongly suggest that synergism between OK-DCs and heat-treated tumor cells enhances the immunogenicity of FCs and provides a promising means of inducing therapeutic antitumor immunity...
  22. ncbi request reprint Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa, Chiba, Japan
    Clin Cancer Res 11:7891-900. 2005
    ....
  23. ncbi request reprint Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells
    Shigeo Koido
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jikei University School of Medicine, Tokyo, Japan
    J Immunol 178:613-22. 2007
    ..We conclude that DCs fused after stimulation by OK-432 may have the potential applicability to the field of antitumor immunotherapy and may provide a platform for adoptive immunotherapy in the clinical setting...
  24. doi request reprint Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK cell-mediated antitumor activity through the tumor necrosis factor-alpha pathway
    Eijiro Nagasaki
    Department of Oncology, Institute of DNA Medicine daggerDivision of Oncology and Hematology double daggerDivision of Gastroenterology and Hepatology, Department of Internal Medicine section signInstitute of Clinical Medicine and Research, The Jikei University School of Medicine parallelDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunother 33:467-74. 2010
    ..These results indicate that combined therapy with a DC vaccine and 5-FU is a promising strategy for cancer treatment mediated by the tumoricidal activity of NK cells through the TNF-alpha pathway...
  25. pmc Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy
    Shintaro Tsukinaga
    Shintaro Tsukinaga, Mikio Kajihara, Kazuki Takakura, Zensho Ito, Tomoya Kanai, Keisuke Saito, Shinichiro Takami, Hiroko Kobayashi, Yoshihiro Matsumoto, Shunichi Odahara, Kan Uchiyama, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa City, Chiba 277 8567, Japan
    World J Gastroenterol 21:11168-78. 2015
    ....
  26. pmc Immunotherapy for colorectal cancer
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:8531-42. 2013
    ..The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. ..
  27. pmc Cancer vaccine by fusions of dendritic and cancer cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 277 8567, Japan shigeo
    Clin Dev Immunol 2009:657369. 2009
    ..This review summarizes recent advances in concepts and techniques that are providing new impulses to DCs/tumor fusions-based cancer vaccination...
  28. ncbi request reprint Mechanism of antitumor effect on mouse hepatocellular carcinoma by intratumoral injection of OK-432, a streptococcal preparation
    Sadamu Homma
    Department of Oncology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Cancer Immunol Immunother 56:1265-74. 2007
    ..t.-OK-432 treatment induced IFN-gamma production from OK-432-sensitized CD4+T cells in tumor site, leading to apoptosis of MIH-2 cells susceptible to IFN-gamma...
  29. doi request reprint Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Cancer Immunol Immunother 63:459-68. 2014
    ..These results suggest that iVP cells from iPS cells could be used as a cancer vaccine targeting tumor vascular cells and tumor cells. ..
  30. pmc Dendritic cell-based cancer immunotherapy for colorectal cancer
    Mikio Kajihara
    Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Keisuke Saito, Shinichiro Takami, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital, Kashiwa, Chiba 277 8567, Japan
    World J Gastroenterol 22:4275-86. 2016
    ..In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients. ..
  31. pmc Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0142981. 2015
    ..Thus, CHST15-CS-E axis-mediated tumor cell proliferation could be a novel therapeutic target in the early stage of PDAC progression. ..
  32. doi request reprint [Corrigendum] Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 46:2679. 2015
    ..The corrected Fig. 3B and Fig. 6C are shown below. [the original article was published in the International Journal of Oncology 45: 470-478, 2014 DOI: 10.3892/ijo.2014.2433]. ..
  33. pmc Clinical significance of serum procalcitonin in patients with ulcerative colitis
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Mikio Kajihara, Kan Uchiyama, Hiroshi Arakawa, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:8335-41. 2013
    ..To investigate the association of procalcitonin (PCT) with ulcerative colitis (UC) activity...
  34. doi request reprint Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Chiba 277 8564, Japan
    Int J Oncol 45:470-8. 2014
    ....
  35. ncbi request reprint Nested culture method improves detection of Fusobacterium from stool in patients with ulcerative colitis
    Toyokazu Yukawa
    Department of Gastroenterology and Hepatology, The Jikei University Kashiwa Hospital, Kashiwa 277 8567, Chiba, Japan
    Jpn J Infect Dis 66:109-14. 2013
    ..This study suggests that the recovery of F. varium is related to UC, which aligns with results from previous studies that used mucosal culture, immunostaining, real-time PCR, and serological studies...
  36. doi request reprint The fatty acid profile of the erythrocyte membrane in initial-onset inflammatory bowel disease patients
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 0004, Japan
    Dig Dis Sci 58:1235-43. 2013
    ..Dietary fatty acid intake influences the fatty acid profiles of vital cell membranes, which might be a source of inflammatory mediators...
  37. doi request reprint Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response
    Akitaka Takahara
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Cancer Immunol Immunother 60:1289-97. 2011
    ..GEM enhanced WT1 expression in human PC cells and sensitized PC cells with WT1-specific T-cell-mediated antitumor immune response...
  38. doi request reprint Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site
    Kazuki Takakura
    a Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 51:610-7. 2016
    ..By using IHC findings, we determined the value of the NLR as a prognostic factor in patients with PC...
  39. pmc Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer
    Mikio Kajihara
    Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Yoshihiro Matsumoto, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital, Chiba 277 8567, Japan
    World J Gastroenterol 22:4446-58. 2016
    ..In this review, we will discuss both the effect of cell-based cancer vaccines and advances in terms of future strategies of cancer vaccines for the treatment of PDA patients. ..
  40. pmc Hepatic Angiosarcoma Associated with Esophageal Variceal Hemorrhage
    Zensho Ito
    Department of Gastroenterology and Hepatology, The Jikei University Kashiwa Hospital, Kashiwa, Japan
    Case Rep Gastroenterol 10:440-445. 2016
    ..Histological diagnosis of hepatic angiosarcoma was obtained by percutaneous ultrasound-guided liver biopsy. To our knowledge, this is the first report of a patient with hepatic angiosarcoma and acute variceal hemorrhage...
  41. pmc Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells
    Shin Kan
    Division of Oncology, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo, Japan
    BMC Cancer 15:726. 2015
    ....
  42. doi request reprint Gemcitabine treatment enhances HER2 expression in low HER2-expressing breast cancer cells and enhances the antitumor effects of trastuzumab emtansine
    Shin Kan
    Division of Oncology, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo, Japan
    Oncol Rep 34:504-10. 2015
    ..Thus, the combined treatment with GEM and T-DM1 may be a promising therapeutic modality for low HER2-expressing breast cancers, which was facilitated by the unique HER2-upregulating effect of GEM...
  43. pmc Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Mikio Kajihara, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 20:14420-9. 2014
    ..To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation...
  44. pmc Factors associated with incomplete colonoscopy at a Japanese academic hospital
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kan Uchiyama, Hiroshi Arakawa, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 20:6961-7. 2014
    ..To evaluate significant risk factors for incomplete colonoscopy at a Japanese academic hospital...
  45. pmc A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD)
    Shunichi Odahara
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, The Jikei University School of Medicine Kashiwa Hospital, Chiba, Japan
    PLoS ONE 10:e0137798. 2015
    ..In addition, there are factors other than increased 6-TGN levels that are involved in the onset of leukopenia. ..
  46. ncbi request reprint Prognostic markers for patient outcome following vaccination with multiple MHC Class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 35:555-62. 2015
    ....
  47. ncbi request reprint [A case of extrahepatic portal vein aneurysm with the remarkably bent bile duct by its displacement]
    Tateki Yamane
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital
    Nihon Shokakibyo Gakkai Zasshi 103:1067-72. 2006
    ..By combining the finding of endoscopic ultrasonography, we considered that the portal vein aneurysm had displaced the bile duct. We suspected that it also caused cholestasis and cholangitis...
  48. ncbi request reprint [A case of widespread ileal stenosis caused by metastatic disseminated peritoneal carcinomatosis from lung cancer resected 8 years previously]
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital
    Nihon Shokakibyo Gakkai Zasshi 104:381-7. 2007
    ....
  49. ncbi request reprint [A case of amyloidosis of the large intestine which showed remarkable calcification of the intestinal wall]
    Tateki Yamane
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokyo Jikei University School of Medicine, Kashiwa Hospital
    Nihon Shokakibyo Gakkai Zasshi 101:274-80. 2004
  50. doi request reprint Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors
    Hideo Komita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Oncol Rep 34:2099-105. 2015
    ..Blockade of the Tim-3/galectin-9 pathway may become a new strategy for GIST treatment. ..
  51. ncbi request reprint [A case of Zollinger-Ellison syndrome due to duodenal gastrinoma with incurable diarrhea which was led to diagnosis by endoscopic examination]
    Tateki Yamane
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokyo Jikei University School of Medicine Kashiwa Hospital
    Nihon Shokakibyo Gakkai Zasshi 101:1095-101. 2004
  52. doi request reprint N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Kashiwa Hospital, Chiba, Japan
    Inflamm Bowel Dis 16:1696-707. 2010
    ..We investigated the influence of diet therapy involving the use of an "n-3 PUFA food exchange table" (n-3DP) on the fatty acid composition of the erythrocyte membranes of IBD patients and its remission-maintaining effects...
  53. ncbi request reprint Dendritic-tumor fusion cells in cancer immunotherapy
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Discov Med 19:169-74. 2015
    ..We discuss the potential ability of DC-tumor fusion cells to activate antigen-specific T cells and strategies to improve the immunogenicity of DC-tumor fusion cells as anticancer vaccines. ..
  54. ncbi request reprint Photodynamic diagnosis of colitis-associated dysplasia in a mouse model after oral administration of 5-aminolevulinic acid
    Nobuhiko Komoike
    Department of Endoscopy, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    In Vivo 27:747-53. 2013
    ..Detection of dysplastic lesions in mouse colonic tissue was investigated by accumulation of photosensitizer protoporphyrin IX (PpIX) induced by oral administration of 5-aminolevulinic acid (5-ALA), a precursor of PplX...
  55. pmc Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 9:e86702. 2014
    ..Together, these results suggest that ATM therapy induces long-term alterations in the intestinal microbiota of patients with UC, which may be associated, at least in part, with clinical effects of the therapy. ..
  56. doi request reprint Inorganic-organic magnetic nanocomposites for use in preventive medicine: a rapid and reliable elimination system for cesium
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan
    Pharm Res 29:1404-18. 2012
    ..To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed "Prussian blueberry", to bring about the magnetic elimination of cesium...
  57. ncbi request reprint A Japanese case of familial Mediterranean fever with onset in the fifties
    Tateki Yamane
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Kashiwashita, Chiba
    Intern Med 45:515-7. 2006
    ..We were not able to analyze the entire MEFV gene, but detected only a heterozygous M694I mutation. Amyloidosis did not develop as a complication. The disease is rare in Japan, and its onset in the fifties is extremely rare in the world...
  58. ncbi request reprint Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma
    Yasuharu Akasaki
    Department of Neurosurgery, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Cancer Immunol Immunother 65:1499-1509. 2016
    ..This trial was designed to evaluate the safety and clinical responses to a combination of temozolomide (TMZ) chemotherapy and immunotherapy with fusions of DCs and glioma cells in patients with glioblastoma (GBM)...
  59. pmc Seasonal variations in the onset of ulcerative colitis in Japan
    Shigeo Koido
    Shigeo Koido, Toshifumi Ohkusa, Kan Uchiyama, Hiroshi Arakawa, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277 8567, Japan
    World J Gastroenterol 19:9063-8. 2013
    ..To investigate seasonal variations in the onset and relapse of ulcerative colitis (UC) in Japanese patients...
  60. doi request reprint Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma
    Yukino Kimura
    Research and Development Division, Tella Inc, Tokyo, Japan
    Pancreas 41:195-205. 2012
    ..In the current study, we have evaluated the clinical and immunological responses in patients with advanced pancreatic carcinoma who received dendritic cell (DC)-based immunotherapy in combination with gemcitabine and/or S-1...
  61. ncbi request reprint Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer
    Tetsuya Kobayashi
    Department of Surgery, Jikei University School of Medicine, Nishi Shinbashi 3 25 8, Minato ku, Tokyo 105 8461, Japan
    Hepatogastroenterology 55:2045-8. 2008
    ..Thymidine Phosphorylase (TP) expression in the tumor cells correlates with postoperative recurrence, but the significance of its expression in the stromal cells around the invasive front of the tumor is not clarified...
  62. doi request reprint A novel magnetic crystal-lipid nanostructure for magnetically guided in vivo gene delivery
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research, The Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba, Japan
    Nat Nanotechnol 4:598-606. 2009
    ..By delivering an optimized sequence of a silencing RNA that targets the epidermal growth factor receptor of tumour vessels, the intended therapeutic benefit was achieved with no evident adverse immune reaction or untoward side effects...
  63. doi request reprint The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies
    Mikio Kajihara
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Immunotherapy 7:1111-22. 2015
    ..This review addresses recent progress in improving clinical outcomes using DC-tumor FC-based cancer vaccines. ..
  64. pmc Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity
    Masaki Ito
    Department of Oncology, The Jikei University School of Medicine, Tokyo, Japan Division of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    PLoS ONE 9:e110425. 2014
    ..The method described here could be potentially used for developing vaccines for such intractable ailments as AIDS, malaria and cancer, ailments in which cellular immunity likely play a crucial role in prevention and treatment. ..
  65. ncbi request reprint Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice
    Kazuki Takakura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 34:4849-55. 2014
    ..Application of the stratification concept to experimental animals will create new avenues to establish pharmacological intervention against HCC. ..
  66. pmc Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer
    Sumiyuki Nishida
    Departments of Cancer Immunotherapy Surgery Respiratory Medicine, Allergy and Rheumatic Diseases Functional Diagnostic Science Cancer Stem Cell Biology Complementary and Alternative Medicine Clinical Application of Biologics, Graduate School of Medicine Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka Departments of Internal Medicine, Division of Gastroenterology and Hepatology Oncology, Institute of DNA Medicine Departments of Surgery Pathology, The Jikei University School of Medicine, Tokyo Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Kanagawa Department of Young Leaders Program in Medical Administration, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Immunother 37:105-14. 2014
    ..Further clinical investigation is warranted to determine the effectiveness of this combination therapy. ..
  67. ncbi request reprint [A case of Cronkhite-Canada syndrome in which contrast radiologic examinations of the digestive tract were performed at the time of development of the clinical symptoms]
    Masyu Aizawa
    Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Japan
    Nihon Shokakibyo Gakkai Zasshi 105:1344-52. 2008
    ..So we recognized that the clinical symptoms developed before appearance of the polyposis of the digestive tract and the polyposis progressed rapidly...
  68. ncbi request reprint [A case of esophageal pyogenic granuloma which showed change of form in a short-term]
    Tateki Yamane
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokyo Jikei University School of Medicine, Kashiwa Hospital
    Nihon Shokakibyo Gakkai Zasshi 100:562-6. 2003