Jun Araya

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. doi request reprint Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
  2. pmc Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    Satoko Fujii
    Division of Respiratory Diseases Department of Internal Medicine Jikei University School of Medicine Tokyo, Japan
    Oncoimmunology 1:630-641. 2012
  3. doi request reprint Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
  4. doi request reprint Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    Naoki Takasaka
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 192:958-68. 2014
  5. doi request reprint Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
  6. doi request reprint Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Japan
    Am J Physiol Lung Cell Mol Physiol 305:L737-46. 2013
  7. pmc Metformin attenuates lung fibrosis development via NOX4 suppression
    Nahoko Sato
    Division of Respiratory Diseases Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Respir Res 17:107. 2016
  8. pmc Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
  9. doi request reprint Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
  10. pmc Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011

Collaborators

  • Kazuyoshi Kuwano
  • Hiromichi Hara
  • Makoto Odaka
  • Jun Kojima
  • Nahoko Sato
  • Kazuma Kishi
  • Takahiro Ochiya
  • Takanori Numata
  • Katsutoshi Nakayama
  • Yutaka Yoshii
  • Makoto Kawaishi
  • Shunsuke Minagawa
  • Kenichiro Shimizu
  • Naoki Takasaka
  • Yu Fujita
  • Saburo Ito
  • Toshiaki Morikawa
  • Hiroshi Wakui
  • Yumi Kaneko
  • Satoko Fujii
  • Yoko Yumino
  • Kenji Kobayashi
  • Jun Hirano
  • Stephen L Nishimura
  • Nayuta Saito
  • Tsukasa Kadota
  • Yusuke Kurita
  • Keisuke Saito
  • Takeo Ishikawa
  • Makoto Yamashita
  • Hirofumi Utsumi
  • Kazuya Tsubouchi
  • Hisatoshi Asano
  • Mitsuo Hashimoto
  • Haruhiko Yanagisawa
  • Masahiro Yoshida
  • Naoko Chiba
  • Miyuki Morozumi
  • Yoshinori Kawabata
  • Hironori Uruga
  • Noboru Takayanagi
  • Nobuyoshi Kosaka
  • Shigeo Hanada
  • Kimiko Ubukata
  • Yutaka Sugita
  • Noriki Kamiya
  • Wakako Ishitobi
  • Yusuke Yoshioka
  • Naoko Takahashi
  • Chikako Tsurushige
  • Stephen Nishimura
  • Satoko Nojiri

Detail Information

Publications19

  1. doi request reprint Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
    ..Therapies that act upstream or downstream of TGF-beta activation have the therapeutic potential to treat all fibrogenic responses in the lung...
  2. pmc Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    Satoko Fujii
    Division of Respiratory Diseases Department of Internal Medicine Jikei University School of Medicine Tokyo, Japan
    Oncoimmunology 1:630-641. 2012
    ....
  3. doi request reprint Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
    ....
  4. doi request reprint Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    Naoki Takasaka
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 192:958-68. 2014
    ..These results suggest that SIRT6 is involved in CSE-induced HBEC senescence via autophagy regulation, which can be attributed to attenuation of IGF-Akt-mTOR signaling. ..
  5. doi request reprint Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
    ..Concomitant loss of enzymatic activity regulating energy homeostasis may lead to the acceleration of bronchial epithelial cell senescence, which is implicated in the pathogenesis of COPD...
  6. doi request reprint Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Japan
    Am J Physiol Lung Cell Mol Physiol 305:L737-46. 2013
    ..CSE-induced mitochondrial fragmentation is involved in cellular senescence through the mechanism of mitochondrial ROS production. Hence, disruption of mitochondrial dynamics may be a part of the pathogenic sequence of COPD development...
  7. pmc Metformin attenuates lung fibrosis development via NOX4 suppression
    Nahoko Sato
    Division of Respiratory Diseases Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Respir Res 17:107. 2016
    ..Therefore, we sought to investigate the inhibitory role of metformin in lung fibrosis development via modulating TGF-β signaling...
  8. pmc Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
    ..Accordingly, we attempt to determine if AIM is expressed in AM and whether AIM is involved in the regulation of apoptosis in the setting of cigarette smoke extract (CSE) exposure...
  9. doi request reprint Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
    ..These results indicate the significance of TLR3-mediated dsRNA-induced apoptosis in the pathogenesis of apoptosis-driven lung disease and provide evidence for a novel protective role of insulin...
  10. pmc Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011
    ..These findings suggest that accelerated epithelial senescence plays a role in IPF pathogenesis through perpetuating abnormal epithelial-mesenchymal interactions, which can be antagonized by SIRT6...
  11. ncbi request reprint Lung adenocarcinoma complicated by Trousseau's syndrome successfully treated by a combination of anticoagulant therapy and chemotherapy
    Yutaka Yoshii
    Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Intern Med 53:1835-9. 2014
    ....
  12. ncbi request reprint Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis
    Kenji Kobayashi
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan and
    J Immunol . 2016
    ....
  13. doi request reprint Clinical efficacy of anti-glycopeptidolipid-core IgA test for diagnosing Mycobacterium avium complex infection in lung
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Respirology 20:1277-81. 2015
    ..Only a few studies evaluate its clinical efficacy. We conducted retrospective evaluations of clinical characteristics of patients suspected of MAC infection to explore the usefulness of the anti-GPL-core IgA antibody test...
  14. ncbi request reprint Epithelial cell fate following lung injury
    Kazuyoshi Kuwano
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Expert Rev Respir Med 2:573-82. 2008
    ..Further understanding of mechanisms of cell death and its regulation may lead to the development of effective treatments against lung injury...
  15. doi request reprint Extracellular vesicles in lung microenvironment and pathogenesis
    Yu Fujita
    Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 19 18, Nishi Shinbashi, Minato ku, Tokyo 105 8471, Japan Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Trends Mol Med 21:533-42. 2015
    ..We summarize the novel findings of EV function in various lung diseases, primarily chronic obstructive pulmonary disease (COPD) and lung cancer. ..
  16. ncbi request reprint Autophagy in the pathogenesis of pulmonary disease
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Japan
    Intern Med 52:2295-303. 2013
    ..We herein review recent findings regarding the role of autophagy in cellular processes and cell fates and summarize the role that autophagy appears to play in the pathogenesis of pulmonary diseases. ..
  17. pmc Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods
    Kenichiro Shimizu
    Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Int J Chron Obstruct Pulmon Dis 10:2009-16. 2015
    ..Our results support the use of a combination of real-time PCR and conventional methods for determining both infectious etiologies and risk of extended hospitalization. ..
  18. doi request reprint Progressive diffuse pulmonary interstitial opacities due to complications of pulmonary tumor emboli: an autopsy case report
    Yutaka Yoshii
    Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Intern Med 54:955-60. 2015
    ..The ground-glass opacities in the chest computed tomography findings appear to correlate with the pathological ischemic changes associated with PTE. ..
  19. doi request reprint Intercellular communication by extracellular vesicles and their microRNAs in asthma
    Yu Fujita
    Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Clin Ther 36:873-81. 2014
    ....