Masanori Nakata

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. doi request reprint AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Electronic address
    Neuropeptides . 2016
  2. ncbi request reprint [Physiological and therapeutic roles of PACAP in glucose metabolism and diabetes]
    Masanori Nakata
    Department of Physiology, Jichi Medical School, School of Medicine, Kawachi, Japan
    Nihon Yakurigaku Zasshi 123:267-73. 2004
  3. ncbi request reprint Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
    Masanori Nakata
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 353:1046-51. 2007
  4. ncbi request reprint Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, School of Medicine, Minamikawachimachi, Kawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 70:209-16. 2005
  5. ncbi request reprint Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
    Daisuke Kohno
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 148:2251-63. 2007
  6. doi request reprint Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells
    Masashi Yoshida
    First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama 330 8503, Japan
    Biochem Biophys Res Commun 396:304-9. 2010
  7. doi request reprint Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
  8. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
  9. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
  10. doi request reprint Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons
    Kenichi Katsurada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 451:276-81. 2014

Collaborators

Detail Information

Publications45

  1. doi request reprint AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Electronic address
    Neuropeptides . 2016
    ..These results suggest that IL-10 gene transfer provides an effective approach for counteracting HFD-induced inflammation and leptin resistance in ARC to prevent progression of obesity...
  2. ncbi request reprint [Physiological and therapeutic roles of PACAP in glucose metabolism and diabetes]
    Masanori Nakata
    Department of Physiology, Jichi Medical School, School of Medicine, Kawachi, Japan
    Nihon Yakurigaku Zasshi 123:267-73. 2004
    ..This finding presents a possible therapeutic use of PACAP in the treatment of diabetes...
  3. ncbi request reprint Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
    Masanori Nakata
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 353:1046-51. 2007
    ..In conclusion, resistin induces insulin resistance in islet beta-cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion...
  4. ncbi request reprint Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, School of Medicine, Minamikawachimachi, Kawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 70:209-16. 2005
    ..The results indicate that leptin enhances ADP-induced [Ca(2+)](i) increases via JAK2 and tyrosine kinases in a megakaryoblast cell line. This mechanism may underlie the potentiation of platelet aggregation by leptin...
  5. ncbi request reprint Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
    Daisuke Kohno
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 148:2251-63. 2007
    ..This interaction may play an important role in regulating ARC NPY neuron activity and, thereby, feeding...
  6. doi request reprint Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells
    Masashi Yoshida
    First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama 330 8503, Japan
    Biochem Biophys Res Commun 396:304-9. 2010
    ..These results suggest that the cellular metabolism including MgATP production and/or channel phosphorylation/dephosphorylation underlie the physiological modulation of Kv2.1 channels during glucose-induced insulin secretion...
  7. doi request reprint Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
    ..The present results reveal the nesfatin-1-operative oxytocinergic signaling in the PVN that triggers leptin-independent melanocortin-mediated anorexia...
  8. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
    ..These results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses...
  9. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
    ....
  10. doi request reprint Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons
    Kenichi Katsurada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 451:276-81. 2014
    ..This study reveals a neuronal basis for the anorexigenic effect of endogenous GLP-1 in the brain. ..
  11. doi request reprint Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats
    Udval Sedbazar
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 434:434-8. 2013
    ..Furthermore, impaired NUCB2/nesfatin-1 rhythm may be related to dysregulated feeding pattern and hyperphagia in Zucker-fatty rats...
  12. doi request reprint Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus
    Darambazar Gantulga
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 420:811-5. 2012
    ..The results suggest that high glucose- and insulin-induced activation of PVN nesfatin-1 neurons serves as a mechanism through which meal ingestion stimulates nesfatin-1 neurons in the PVN and thereby produces satiety...
  13. ncbi request reprint Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  14. doi request reprint Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus
    Shigetomo Suyama
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi 320 0498, Japan
    Neuropeptides 56:115-23. 2016
    ..The present results suggest that feeding increases excitatory synaptic input on PVN Oxt neurons via mechanisms involving DYNLL2 upregulation and NMDA receptor-mediated synaptic reorganization. ..
  15. doi request reprint Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca (2+) signaling in mouse islets
    Kazunori Manaka
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi, 329 0498, Japan
    J Physiol Sci 64:77-83. 2014
    ..This long-term effect may mediate the KATP channel, while VPA can also attenuate the effect of the KATP channel blocker tolbutamide. ..
  16. ncbi request reprint Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells
    Ken Fujiwara
    Department of Integrative Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocrinology 148:2496-504. 2007
    ..The glucose-independent action of OA to stimulate glucagon release from alpha-cells may operate under hypoglycemic conditions when plasma free fatty acids levels are elevated, possibly playing a role in maintaining glucose metabolism...
  17. ncbi request reprint Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet β-cells
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Endocr J 58:305-13. 2011
    ..These results indicate that nesfain-1 potentiates glucose-induced insulin secretion by promoting Ca(2+) influx through L-type Ca(2+) channels independently of PKA and PLA(2) in mouse islet β-cells...
  18. ncbi request reprint Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Pharm Des 19:6960-5. 2013
    ..Here, we review the by now published studies on nesfatin-1/NUCB2 localization and action in islets and discuss the physiological and pathophysiological roles of the nesfatin-1/NUCB2 in glucose and energy metabolism. ..
  19. doi request reprint Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Mol Neurosci 42:404-10. 2010
    ..These data indicate that islet-produced PACAP protects β-cells from deteriorating action of high glucose and palmitate at least partly by blocking the elevation of UCP2, suggesting an anti-diabetic role for PACAP...
  20. ncbi request reprint Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Diabetes 55:3486-93. 2006
    ....
  21. doi request reprint Paraventricular NUCB2/Nesfatin-1 Supports Oxytocin and Vasopressin Neurons to Control Feeding Behavior and Fluid Balance in Male Mice
    Masanori Nakata
    Division of Integrative Physiology M N, D G, P S, B Z, T Y, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Department of Biochemistry and Molecular Biology C M, T O, Division of Gene Therapy, Research Center for Advanced Medical Technology, Nippon Medical School, Tokyo 113 8603, Japan Metabolic and Obese Research Institute M M, Maebashi, Gunma 371 0037, Japan and Department of Developmental Physiology T Y, Division of Adaptation Development, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Endocrinology 157:2322-32. 2016
    ..These results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP and oxytocin and consequently the fluid and energy balance. ..
  22. doi request reprint Bupropion can close KATP channel and induce insulin secretion
    Yifei Yang
    Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    J Pediatr Endocrinol Metab 26:343-6. 2013
    ..This study shows, for the first time, that bupropion has a direct electrophysiological action on pancreatic β-cells and can cause insulin secretion and also highlights the risk of using bupropion during pregnancy...
  23. ncbi request reprint PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, School of Medicine, Minamikawachi, Tochigi 329 0498, Japan
    Neurosci Lett 370:252-6. 2004
    ....
  24. pmc Endogenous prolactin-releasing peptide regulates food intake in rodents
    Yuki Takayanagi
    Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Clin Invest 118:4014-24. 2008
    ..These data suggest that PrRP relays satiety signals within the brain and that selective disturbance of this system can result in obesity and associated metabolic disorders...
  25. pmc High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    J Diabetes Res 2016:9321395. 2016
    ..Antagonism of VPAC1-R may prevent progression of HFD-induced insulin resistance in the liver, providing a novel antidiabetic strategy...
  26. doi request reprint Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice
    EnXu Li
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke 329 0498, Japan
    Endocr J 63:611-9. 2016
    ....
  27. doi request reprint Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons
    Hideharu Kurita
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan Department of Neurosurgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    Am J Physiol Endocrinol Metab 309:E320-33. 2015
    ..This study identifies ARC NKA as a hypothalamic sensor and converter of metabolic states to key neuronal activity and feeding behaviour, providing a new target to treat hyperphagic obesity and diabetes. ..
  28. pmc Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity
    Yusaku Iwasaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    PLoS ONE 8:e67198. 2013
    ..Pancreas-innervating NGNs may effectively sense dynamic changes of insulin released in response to nutritional states. These interactions could serve to convey the changes in pancreatic and systemic insulin to the brain...
  29. ncbi request reprint Endocrinology: nitric oxide-mediated insulin secretion in response to citrulline in islet beta-cells
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology Jichi Medical School, School of Medicine, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Pancreas 27:209-13. 2003
    ....
  30. ncbi request reprint Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi, 329 0498, Japan
    Regul Pept 145:49-53. 2008
    ..Both anandamide and ACPA inhibited glucose-induced cytosolic Ca(2+) oscillation in mouse pancreatic beta-cells. These results demonstrate a novel peripheral action of cannabinoids to inhibit insulin secretion via CB1 receptors...
  31. doi request reprint Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells
    Masashi Yoshida
    First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama, Japan
    FEBS Lett 583:2225-30. 2009
    ..1-specific blocker, guangxitoxin-1E, was unchanged by lowering or increasing glucose concentration. We conclude that glucose metabolism regulates Kv2.1 channels in rats beta-cells via altering MgATP levels...
  32. doi request reprint Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect
    Gantulga Darambazar
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 456:913-8. 2015
    ..Peripheral and central injections of leptin failed to significantly inhibit food intake in mice receiving AAV-NUCB2. These results indicate that PVN NUCB2/nesfatin-1 is directly targeted by leptin, and mediates its anorexigenic effect. ..
  33. ncbi request reprint Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats
    Hirotaka Aoki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocr J 60:571-81. 2013
    ..These results demonstrate that long-term ghrelin treatment counteracts salt-induced hypertension in DS rats primarily through diuretic action associated with increased renal NO production, thereby exerting cardio-protective effects...
  34. ncbi request reprint Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats
    Kazuko Momose
    Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi 329 0433, Japan
    Med Mol Morphol 39:146-53. 2006
    ..These results suggest that insulin deficiency in GK rats is not caused by simple dysfunction and/or degeneration of beta-cells but rather by more complicated events within cells...
  35. ncbi request reprint Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398
    Soichi Obara
    Department of Physiology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Cancer Lett 208:115-22. 2004
    ..The selective COX-2 inhibitor NS-398 was found capable of down-regulating ILK and PKB/Akt phosphorylation. Our data indicate that inhibition of ILK signaling may be beneficial in the treatment of PTEN-deficient glioblastoma...
  36. ncbi request reprint [Roles and functional interplay of the gut, brain stem, hypothalamus and limbic system in regulation of feeding]
    Shigetomo Suyama
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine
    Nihon Rinsho 67:277-86. 2009
    ..We here review how the hippocampus and amygdala as well as gut, brain stem and hypothalamus function and interact with each other to achieve integrative regulation of feeding...
  37. ncbi request reprint PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine, Yakushiji, Shimotsuke, Tochigi, Japan
    Curr Pharm Des 13:1105-12. 2007
    ..Dysfunction of expression, secretion and/or action of PACAP might be involved in the type 2 diabetes and metabolic syndrome. PACAP receptor subtype-specific agonists and/or antagonists are hopeful therapeutic agents...
  38. ncbi request reprint Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues
    Yukio Ikeda
    Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Tokyo 135 0064, Japan
    Biochem Biophys Res Commun 333:778-86. 2005
    ..These unique features will be useful for further development of insulinotropic factors and drugs for treating type 2 diabetes...
  39. ncbi request reprint The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value
    Satoshi Iino
    Department of Surgical Oncology, Kagoshima University Graduate School of Medicine and Dental Science, Kagoshima, Japan
    Clin Cancer Res 10:6179-88. 2004
    ..In addition, thrombomodulin is a clinically useful molecular marker not only for identifying beta-cell-origin islet cell tumors (i.e., insulinomas) but also for predicting disease prognosis of islet cell tumors...
  40. ncbi request reprint Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice
    Shuhei Tomimoto
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    J Pharmacol Sci 107:41-8. 2008
    ....
  41. ncbi request reprint [Ion channel mechanisms in insulin secretion]
    Masafumi Kakei
    Department of Geriatric Medicine, Akita University School of Medicine
    Nihon Rinsho 60:180-9. 2002
  42. ncbi request reprint Simvastatin induces heat shock factor 1 in vascular endothelial cells
    Tsuyoshi Uchiyama
    Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    Atherosclerosis 188:265-73. 2006
    ..These results indicate that statins improve vascular endothelial function via heat shock factor 1, which may contribute to their ability to improve cardiovascular disease...
  43. ncbi request reprint HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function)
    Tsuyoshi Uchiyama
    Department of Medicine and Biological Science, Gunma University Course of Medical Science Graduate School of Medicine, 3 39 15, Showa Machi Maebashi, Gunma, Japan
    Atherosclerosis 190:321-9. 2007
    ..These results show that the wild-type and constitutively active forms of HSF1 induce anticoagulation and relaxation factors in vascular endothelial cells and could therefore be used to treat cardiovascular disease...
  44. ncbi request reprint Inhibition of migration of human glioblastoma cells by cerivastatin in association with focal adhesion kinase (FAK)
    Soichi Obara
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, 890 8520, Kagoshima, Japan
    Cancer Lett 185:153-61. 2002
    ..Our data suggest that cerivastatin may be beneficial for combination therapy with conventional anti-cancer drugs by inhibiting the invasion of glioblastoma...
  45. ncbi request reprint The role of thrombin in the neo-vascularization of malignant gliomas: an intrinsic modulator for the up-regulation of vascular endothelial growth factor
    Hitoshi Yamahata
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Japan
    Int J Oncol 20:921-8. 2002
    ....