Genomes and Genes
Affiliation: Iwate University
- Cisplatin enhances the p53-independent apoptosis induced by a topoisomerase I inhibitor (CPT-11) in the lens epithelial tumors in transgenic miceTakafumi Nakamura
Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
Oncol Rep 12:253-8. 2004..Apoptosis in the p53-wild-type alphaT3 tumors was observed in a Cisplatin dose-dependent manner. In addition, it was found that Cisplatin augmented CPT-11-induced p53-independent apoptosis in p53-deficient alphaT3 mice...
- Replication origin of mitochondrial DNA in insectsShigeru Saito
Department of Biological Sciences, Tokyo Metropolitan University, Hachiouji, Tokyo 192 0397, Japan
Genetics 171:1695-705. 2005....
- Evolution of thermoTRP ion channel homologs in vertebratesShigeru Saito
Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
Physiol Genomics 27:219-30. 2006..g., thermoTRPs activated by noxious heat, warm, and cool temperatures. Our results suggest that thermosensation mechanisms have changed through vertebrate evolution with respect to thermosensor repertoires...
- Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammalsShigeru Saito
Laboratory of Bioscience, Faculty of Engineering, Iwate University, Morioka, Japan
Gene 408:37-44. 2008..Thus, our data demonstrate that novel gene function can evolve without de novo gene duplication event...
- Molecular phylogeny and expression of poplar circadian clock genes, LHY1 and LHY2Naoki Takata
United Graduate School of Agricultural Sciences, Iwate University, Morioka 020 8550, Japan
New Phytol 181:808-19. 2009..In addition, the transcript abundance and the evolutionary differences between Populus LHY1 and LHY2 imply that Populus LHY2, rather than LHY1, may have a major role in the Populus clock system...
- Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal NichesShigeru Saito
From the Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan, the Department of Physiological Sciences, Sokendai The Graduate University for Advanced Studies, Okazaki, Aichi 444 8787, Japan, and
J Biol Chem 291:11446-59. 2016..These combined subtle amino acid substitutions in peripheral thermal sensors potentially serve as a driving force for the evolution of thermal and chemical sensation. ..
- Phylogenetic footprint of the plant clock system in angiosperms: evolutionary processes of pseudo-response regulatorsNaoki Takata
United Graduate School of Agricultural Sciences, Iwate University, Morioka, Japan
BMC Evol Biol 10:126. 2010....
- Structure and hibernation-associated expression of the transient receptor potential vanilloid 4 channel (TRPV4) mRNA in the Japanese grass lizard (Takydromus tachydromoides)Kazuya Nagai
United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, Japan
Zoolog Sci 29:185-90. 2012..This is the first report, to our knowledge, to describe reptilian TRPV4 in relation to hibernation...
- Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cellsHiroyuki Kishi
Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
Blood 99:576-83. 2002..These results suggest that cooperative binding of c-Myb and Pax-5 to the RAG-2 promoter is one of the mechanisms to direct the restricted expression of the RAG-2 in immature B cells...
- A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell linesHiroyoshi Yuki
Department of Obstetrics and Gynecology, Yukiguniyamato General Hospital, 4415 Urasa, Yamato machi, Niigata 949 7302, Japan
Free Radic Res 37:631-43. 2003..Since it is known that cancer cells are generally resistant to physical and chemical stress-induced apoptosis, free radical generators like AAPH appear to be a useful thermosensitizer for hyperthermic cancer therapy...