Atsushi Toyoda

Summary

Affiliation: Ibaraki University
Country: Japan

Publications

  1. ncbi request reprint Cloning, nucleotide sequence and expression of the gene encoding the cellulose-binding protein A (CBPA) of Eubacterium cellulosolvens 5
    Atsushi Toyoda
    School of Agriculture, Ibaraki University, Ami, 300 0393, Ibaraki, Japan
    FEMS Microbiol Lett 207:141-6. 2002
  2. ncbi request reprint Identification of the cellulose-binding and the cell wall-binding domains of Eubacterium cellulosolvens 5 cellulose-binding protein A (CBPA)
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ami, Japan
    FEMS Microbiol Lett 214:113-8. 2002
  3. ncbi request reprint Cloning, nucleotide sequence and module structure of the gene encoding the cellulose-binding protein B (CBPB) of Eubacterium cellulosolvens 5
    Atsushi Toyoda
    Division of Animal Science, College of Agriculture, Ibaraki University, Japan
    J Gen Appl Microbiol 51:213-20. 2005
  4. doi request reprint The effects of oral taurine administration on behavior and hippocampal signal transduction in rats
    Wataru Iio
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Amino Acids 43:2037-46. 2012
  5. pmc Cloning, sequencing, and expression of a Eubacterium cellulosolvens 5 gene encoding an endoglucanase (Cel5A) with novel carbohydrate-binding modules, and properties of Cel5A
    Kazutoyo Yoda
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Appl Environ Microbiol 71:5787-93. 2005
  6. doi request reprint Effects of chronic mild food restriction on behavior and the hypothalamic malonyl-CoA signaling pathway
    Wataru Iio
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan College of Agriculture, Ibaraki University, Ami, Japan
    Anim Sci J 86:181-8. 2015
  7. doi request reprint Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ibaraki, Japan
    Adv Exp Med Biol 775:29-43. 2013
  8. doi request reprint Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats
    Wataru Iio
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Biochem Biophys Res Commun 421:301-4. 2012
  9. doi request reprint The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms
    Hikari Otabi
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Behav Processes . 2016
  10. ncbi request reprint A possible role of cellulose-binding protein A (CBPA) in the adhesion of Eubacterium cellulosolvens 5 to cellulose
    Atsushi Toyoda
    Division of Animal Science, College of Agriculture, Ibaraki University, Ibaraki 300 0393, Japan
    J Gen Appl Microbiol 49:245-50. 2003

Collaborators

  • Haruyoshi Takagi
  • Shigeru Chohnan
  • Hiroyuki Kawachi
  • K Osoegawa
  • Tomoyuki Yamada
  • Hideto Takami
  • Yutaka Suzuki
  • Yuichi Hongoh
  • Hiroyuki Yamaguchi
  • Takeharu Masaki
  • Tomomi Kuwahara
  • Jun Aruga
  • Fumihiko Sato
  • Tatsuhiko Goto
  • Wataru Iio
  • Yoshiyuki Sakaki
  • Tsuyoshi Okayama
  • Yoshifumi Kubota
  • Hikari Otabi
  • Masahira Hattori
  • Takamitsu Tsukahara
  • Noriko Matsukawa
  • Daisuke Kohari
  • Asao Fujiyama
  • Todd D Taylor
  • Tetsuya Sakurai
  • Yoko Kuroki
  • Yuka Tokutake
  • Takehiko Itoh
  • Toshiaki Watanabe
  • Katsuhiko Murakami
  • Kazuyoshi Kohu
  • Toshio Kojima
  • Taiji Nomura
  • Yasushi Totoki
  • Motoaki Seki
  • Ken Kurokawa
  • Miho Yoshimatsu
  • Kazuo Shinozaki
  • Tokihiko Nanjo
  • Hideki Noguchi
  • Yutaka Nakamura
  • Shinichi Morishita
  • Hajime Minato
  • Fumihito Miura
  • Jiro Ogura
  • Atsushi Kawakami
  • Kazutoyo Yoda
  • Naruya Saitou
  • Hong Seog Park
  • Yuki Hagiya
  • Shozo Tomonaga
  • Phan Thi Xinh
  • Hiroaki Koike
  • Naoko Moriya
  • Kunihiko Takamatsu
  • Yuki Tanaka
  • Sonoko Habu
  • Toru Nakano
  • Kanako Kawaura
  • Masa Toshi Yamamoto
  • Takashi R Endo
  • Muneo Matsuda
  • Hajime Iwamura
  • Hiroshi Suemizu
  • Yoshikuni Tanioka
  • Tomohiro Kono
  • Hatsune Chiba
  • Yuji Kohara
  • Toshiyuki Takai
  • Daisuke Suzuki
  • Masanobu Satake
  • Nobuhiko Kato
  • M Azim Surani
  • Erika Sasaki
  • Hiroyuki Sasaki
  • Yoshie Kametani
  • Masahiro Kaneda
  • Shuhei Nasuda
  • Eiji Yamabe
  • Yayoi Obata
  • Satomi Kuramochi-Miyagawa
  • Daisuke Onda
  • Hideo Yagita
  • Yasunari Ogihara
  • Ayako Matsuzawa
  • Tulika P Srivastava
  • Hidehiro Toh
  • Kikuji Itoh
  • Fausto RodrĂ­guez-Zapata

Detail Information

Publications42

  1. ncbi request reprint Cloning, nucleotide sequence and expression of the gene encoding the cellulose-binding protein A (CBPA) of Eubacterium cellulosolvens 5
    Atsushi Toyoda
    School of Agriculture, Ibaraki University, Ami, 300 0393, Ibaraki, Japan
    FEMS Microbiol Lett 207:141-6. 2002
    ..The cloned gene was inserted into an expression vector, pBAD-TOPO, and expressed in Escherichia coli as a fused protein. The fused protein was detected by immunoblotting using antiserum against CBPA...
  2. ncbi request reprint Identification of the cellulose-binding and the cell wall-binding domains of Eubacterium cellulosolvens 5 cellulose-binding protein A (CBPA)
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ami, Japan
    FEMS Microbiol Lett 214:113-8. 2002
    ..cellulosolvens 5, the region has been identified as the CWBD. However, the CWBD did not show a significant sequence similarity with any other proteins previously reported...
  3. ncbi request reprint Cloning, nucleotide sequence and module structure of the gene encoding the cellulose-binding protein B (CBPB) of Eubacterium cellulosolvens 5
    Atsushi Toyoda
    Division of Animal Science, College of Agriculture, Ibaraki University, Japan
    J Gen Appl Microbiol 51:213-20. 2005
    ..cellulosolvens 5. The amino acid sequence of CBPB had a significant homology (64.15% sequence identity) with that of CBPA. These results suggest that cbpA and cbpB genes descended from the same ancestral cellulase gene...
  4. doi request reprint The effects of oral taurine administration on behavior and hippocampal signal transduction in rats
    Wataru Iio
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Amino Acids 43:2037-46. 2012
    ..In conclusion, our findings suggest that taurine has an antidepressant-like effect and an ability to change depression-related signaling cascades in the hippocampus...
  5. pmc Cloning, sequencing, and expression of a Eubacterium cellulosolvens 5 gene encoding an endoglucanase (Cel5A) with novel carbohydrate-binding modules, and properties of Cel5A
    Kazutoyo Yoda
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Appl Environ Microbiol 71:5787-93. 2005
    ..Removal of the CBMs from rCel5A reduced the catalytic activities with various polysaccharides remarkably. These observations show that CBMs play an important role in the catalytic function of the enzyme...
  6. doi request reprint Effects of chronic mild food restriction on behavior and the hypothalamic malonyl-CoA signaling pathway
    Wataru Iio
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan College of Agriculture, Ibaraki University, Ami, Japan
    Anim Sci J 86:181-8. 2015
    ..Our findings suggest that chronic mild food restriction activates AMPK following a decreased hypothalamic malonyl-CoA. ..
  7. doi request reprint Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ibaraki, Japan
    Adv Exp Med Biol 775:29-43. 2013
    ..In conclusion, our discoveries suggest that taurine supplementation has an antidepressant-like effect and an ability to change depression-related signaling cascades in the hippocampus...
  8. doi request reprint Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats
    Wataru Iio
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Biochem Biophys Res Commun 421:301-4. 2012
    ..Our findings suggest that the suppression of body weight gain caused by social defeat stress is caused by anorexic feeding behavior via an increased concentration of malonyl-CoA in the hypothalamus...
  9. doi request reprint The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms
    Hikari Otabi
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Behav Processes . 2016
    ..Therefore, we conclude that the SNB paradigm is an another potential behavioral method for screening drugs for depressive-like symptoms including attention deficit, anxiety, low locomotion, and decreased motivation...
  10. ncbi request reprint A possible role of cellulose-binding protein A (CBPA) in the adhesion of Eubacterium cellulosolvens 5 to cellulose
    Atsushi Toyoda
    Division of Animal Science, College of Agriculture, Ibaraki University, Ibaraki 300 0393, Japan
    J Gen Appl Microbiol 49:245-50. 2003
    ..CBPA rapidly decreased the viscosity of CMC, indicating that CBPA was endoglucanase. The results obtained in this study indicate that CBPA plays an important role in the adhesion of E. cellulosolvens 5 cells to cellulose...
  11. pmc Isolation and identification of cellulose-binding proteins from sheep rumen contents
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Appl Environ Microbiol 75:1667-73. 2009
    ..The finding that four of the five CBPs isolated and identified from sheep rumen contents were from F. succinogenes indicates that F. succinogenes is significantly involved in cellulose degradation in the rumen...
  12. ncbi request reprint PCR detection of bovine mitochondrial DNA derived from meat and bone meal in feed
    Atsushi Toyoda
    College of Agriculture, Ibaraki University, Ibaraki 300 0393, Japan
    J Food Prot 67:2829-32. 2004
    ..However, the exclusion of this treatment improved the detection limit of bovine MBM in feed. This method appears suitable for the selective detection of bovine MBM in feed...
  13. doi request reprint Decreased hepatic contents of coenzyme A molecular species in mice after subchronic mild social defeat stress
    Yoshifumi Kubota
    a College of Agriculture, Ibaraki University, Ami, Ibaraki, Japan
    Stress 19:192-7. 2016
    ..Future studies should investigate the molecular mechanism(s) underlying the down-regulation of liver CoA pools in sCSDS mice. ..
  14. doi request reprint Subchronic and mild social defeat stress alter mouse nest building behavior
    Hikari Otabi
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Behav Processes 122:21-5. 2016
    ..However, our results demonstrate that nest building evaluation is a simple and useful assay for understanding behavior in socially defeated mice and screening drugs such as antidepressants. ..
  15. doi request reprint Influence of Chronic Social Defeat Stress on Digestive System Functioning in Rats
    Atsushi Toyoda
    College of Agriculture, Ibaraki University
    J Nutr Sci Vitaminol (Tokyo) 61:280-4. 2015
    ..Furthermore, in PI, expression of the aquaporin 1 gene was significantly higher in the CSDS group compared to the control group. Thus, absorption of some nutrients might be higher in the small intestine of the CSDS rat. ..
  16. doi request reprint Differential expression of genes encoding neurotrophic factors and their receptors along the septal-temporal axis of the rat hippocampus
    Atsushi Toyoda
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan College of Agriculture, Ibaraki University, Ibaraki, Japan Ibaraki University Cooperation between Agriculture and Medical Science IUCAM, Ibaraki, Japan
    Anim Sci J 85:986-93. 2014
    ..Finally, the results obtained in this study emphasize the importance of choosing the hippocampal portion along its septotemporal axis for any hippocampal molecular and biochemical experimental studies. ..
  17. pmc Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects
    Tatsuhiko Goto
    Department of Biological Production Science, College of Agriculture, Ibaraki UniversityAmi, Ibaraki, Japan Department of Biological Production Science, Ibaraki University Cooperation between Agriculture and Medical ScienceAmi, Ibaraki, Japan
    Front Neurosci 10:72. 2016
    ..The combination of sCSDS mice with 3D behavioral analysis is a powerful method for screening ingredients in foods and farm products for antidepressant-like effects. ..
  18. doi request reprint Effects of diet quality on vulnerability to mild subchronic social defeat stress in mice
    Tatsuhiko Goto
    a College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Nutr Neurosci 19:284-9. 2016
    ..sCSDS mice also show avoidance behavior in a social interaction test. In this study, we examined the effects of diet quality on susceptibility to sCSDS by feeding these mice semi- and non-purified diets...
  19. doi request reprint Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system
    Tatsuhiko Goto
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan Ibaraki University Cooperation between Agriculture and Medical Science IUCAM, Ami, Ibaraki 300 0393, Japan
    Behav Processes 119:86-92. 2015
    ..Future genetic analyses using the 3D assessment system will provide novel insights into the complex genetic basis for nesting and other behaviors in animals. ..
  20. doi request reprint Plasma and liver metabolic profiles in mice subjected to subchronic and mild social defeat stress
    Tatsuhiko Goto
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    J Proteome Res 14:1025-32. 2015
    ..Therefore, sCSDS induces various changes in metabolite concentrations, especially related to osmoregulation and inflammation, that may be used as biomarkers for stress-induced changes in animals...
  21. pmc A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
    Tatsuhiko Goto
    College of Agriculture, Ibaraki University Cooperation between Agriculture and Medical Science, Ibaraki University
    J Vis Exp . 2015
    ..This protocol will help establish the sCSDS mouse model, especially for studying the mechanisms underlying stress-induced weight gain and polydipsia- and hyperphagia-like symptoms...
  22. doi request reprint Assessing nest-building behavior of mice using a 3D depth camera
    Tsuyoshi Okayama
    College of Agriculture, Ibaraki University, Ami 300 0393, Ibaraki, Japan United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu city 183 8509, Tokyo, Japan Ibaraki University Cooperation between Agriculture and Medical Science IUCAM, Ami 300 0393, Ibaraki, Japan Electronic address
    J Neurosci Methods 251:151-7. 2015
    ..In future studies, we will evaluate nest-building behaviors of genetically modified, as well as several inbred, strains of mice, with several nesting materials. ..
  23. doi request reprint Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice
    Tatsuhiko Goto
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan Ibaraki University Cooperation between Agriculture and Medical Science IUCAM, Ami, Ibaraki 300 0393, Japan
    Behav Brain Res 270:339-48. 2014
    ..This study reports the first step toward an understanding of the mechanisms of stress-induced overhydration, over-eating and resultant weight gain. ..
  24. doi request reprint Effects of chronic social defeat stress on MAP kinase cascade
    Wataru Iio
    College of Agriculture, Ibaraki University, Ami, Ibaraki 300 0393, Japan
    Neurosci Lett 504:281-4. 2011
    ..In conclusion, our findings suggest that chronic psychosocial stress in Wistar rats induced depression-like behavior and downregulated the MAPK cascade in the hippocampus...
  25. ncbi request reprint Biochemical characterization of cellulose-binding proteins (CBPA and CBPB) from the rumen cellulolytic bacterium Eubacterium cellulosolvens 5
    Miho Yoshimatsu
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Japan
    Biosci Biotechnol Biochem 71:2577-80. 2007
    ..Both proteins bound to insoluble polysaccharides such as Avicel cellulose, acid swollen cellulose, lichenan, chitin, and oat spelt xylan. On the other hand, only recombinant CBPB bound to agarose and starch...
  26. ncbi request reprint Purification, characterization, and gene analysis of cellulase (Cel8A) from Lysobacter sp. IB-9374
    Jiro Ogura
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Japan
    Biosci Biotechnol Biochem 70:2420-8. 2006
    ..The amino acid sequence of the Cel8A, which contains the catalytic module of glycosyl hydrolase family 8, is homologous to beta-1,3-1,4-D-glucanase from Bacillus circulans WL-12 and endoglucanase N-257 from B. circulans KSM-N257...
  27. ncbi request reprint Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1
    Phan Thi Xinh
    Division of Molecular Cytogenetics, Department of Clinical Pathology, Research Institute of International Medical Center of Japan, Tokyo, Japan
    Genes Chromosomes Cancer 36:313-6. 2003
    ..This patient showed an unusual clinical profile, repeating progression to overt leukemia and conversion to MDS three times during the 29-month survival period, which might be related to a different molecular mechanism in this patient...
  28. ncbi request reprint Identification of two novel primate-specific genes in DSCR
    Kunihiko Takamatsu
    Laboratory of Functional Genomics Human Genome Center, Institute of Medical Science, University of Tokyo, Japan
    DNA Res 9:89-97. 2002
    ..These results strongly suggest that DSCR9 and DSCR10 have emerged as a new class of gene in the primate lineage during evolution...
  29. ncbi request reprint The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling
    Atsushi Kawakami
    Department of Biological Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Biol 15:480-8. 2005
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites...
  30. ncbi request reprint Effect of Helicobacter pylori on DNA synthesis of human epithelial cells
    Atsushi Toyoda
    Department of Otolaryngology, Kyorin University School of Medicine, Tokyo, Japan
    J Infect Chemother 11:129-35. 2005
    ..The results suggest that two proteins with molecular weights of 18 and 45 kDa, respectively, are associated with stimulation of DNA synthesis by MKN45 cells...
  31. ncbi request reprint Construction and analysis of a human-chimpanzee comparative clone map
    Asao Fujiyama
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Science 295:131-4. 2002
    ..We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes...
  32. ncbi request reprint An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin
    Jun Aruga
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    J Neurochem 102:1533-47. 2007
    ..These results suggest that LIF, cAMP signaling cascades and Myt1 play significant roles in the differentiation of oligodendrocytes through their action on the Opalin oligodendrocyte enhancer...
  33. ncbi request reprint Structures of the three homoeologous loci of wheat benzoxazinone biosynthetic genes TaBx3 and TaBx4 and characterization of their promoter sequences
    Taiji Nomura
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    Theor Appl Genet 116:373-81. 2008
    ..The promoter activity measured by transient assays in wheat protoplasts was similar among the three homoeologs of TaBx3 and TaBx4 in spite of their differential transcript levels in wheat seedlings...
  34. pmc Functional annotation of 19,841 Populus nigra full-length enriched cDNA clones
    Tokihiko Nanjo
    Department of Molecular and Cell Biology, Forestry and Forest Products Research Institute FFPRI, 1 Matsunosato, Tsukuba, Ibaraki 305 8687 JAPAN
    BMC Genomics 8:448. 2007
    ..ESTs from full-length cDNA clones are especially powerful for accurate molecular annotation. We promoted collection and annotation of the ESTs from Populus full-length enriched cDNA clones as part of functional genomics of tree species...
  35. pmc Sequencing analysis of 20,000 full-length cDNA clones from cassava reveals lineage specific expansions in gene families related to stress response
    Tetsuya Sakurai
    Metabolomics Research Group, RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan
    BMC Plant Biol 7:66. 2007
    ..A full-length cDNA library of cassava plants under normal, heat, drought, aluminum and post harvest physiological deterioration conditions was built; 19968 clones were sequence-characterized using expressed sequence tags (ESTs)...
  36. pmc Complete genome of the uncultured Termite Group 1 bacteria in a single host protist cell
    Yuichi Hongoh
    Environmental Molecular Biology Laboratory, RIKEN, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 105:5555-60. 2008
    ..Our results provide a breakthrough to clarify the functions of and the interactions among the individual members of this multilayered symbiotic complex...
  37. pmc A large-scale full-length cDNA analysis to explore the budding yeast transcriptome
    Fumihito Miura
    Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa 277 8561, Japan
    Proc Natl Acad Sci U S A 103:17846-51. 2006
    ..The budding yeast will serve as a versatile model for the studies on these aspects of transcriptome, and the full-length cDNA clones can function as an invaluable resource in such studies...
  38. ncbi request reprint Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse
    Kazuyoshi Kohu
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 215:167-80. 2008
    ..This suggests that these immunity-related genes do not evolve at a uniform rate. Interestingly, however, ligand/receptor pairs such as interleukin-6 and interleukin-6 receptor appear to have evolved simultaneously...
  39. ncbi request reprint BAC library construction and BAC end sequencing of five Drosophila species: the comparative map with the D. melanogaster genome
    Katsuhiko Murakami
    RIKEN Genomic Sciences Center, Kanagawa, Japan
    Genes Genet Syst 83:245-56. 2008
    ..Corresponding breakpoints were also identified in D. sechellia. The BAC clones described here will be an important addition to the Drosophila genomic resources...
  40. doi request reprint Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
    Toshiaki Watanabe
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 453:539-43. 2008
    ..Our results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous siRNAs from naturally occurring dsRNAs...
  41. ncbi request reprint Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway
    Yoko Kuroki
    RIKEN Genomic Sciences Center, Yokohama 230 0045, Japan
    Nat Genet 38:158-67. 2006
    ..Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation...
  42. pmc Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
    Ken Kurokawa
    Laboratory of Comparative Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    DNA Res 14:169-81. 2007
    ..In addition, we discovered a conjugative transposon family explosively amplified in human gut microbiomes, which strongly suggests that the intestine is a 'hot spot' for horizontal gene transfer between microbes...