Kenji Nakanishi

Summary

Affiliation: Hyogo College of Medicine
Country: Japan

Publications

  1. ncbi request reprint Induction of allergic inflammation by interleukin-18 in experimental animal models
    Hiroko Tsutsui
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Immunol Rev 202:115-38. 2004
  2. ncbi request reprint Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
  3. doi request reprint Importance of IL-18-induced super Th1 cells for the development of allergic inflammation
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan
    Allergol Int 59:137-41. 2010
  4. ncbi request reprint [IL-18 and atopic inflammation]
    Kenji Nakanishi
    Tanpakushitsu Kakusan Koso 47:2362-8. 2002
  5. doi request reprint Basophils are potent antigen-presenting cells that selectively induce Th2 cells
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Eur J Immunol 40:1836-42. 2010
  6. ncbi request reprint [Pathological role of super Th1 cells in induction of atopic dermatitis and bronchial asthma]
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine
    Arerugi 57:989-94. 2008
  7. doi request reprint Basophils as APC in Th2 response in allergic inflammation and parasite infection
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Curr Opin Immunol 22:814-20. 2010
  8. ncbi request reprint Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
    K Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine Growth Factor Rev 12:53-72. 2001
  9. ncbi request reprint Persistent secretion of IL-18 in the skin contributes to IgE response in mice
    Hiroki Nakano
    Department of Immunology and Medical Zoology, Second Department of Surgery, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Int Immunol 15:611-21. 2003
  10. ncbi request reprint Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways
    Junko Sawaki
    Department of Pediatrics, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    Int Immunol 19:311-20. 2007

Detail Information

Publications81

  1. ncbi request reprint Induction of allergic inflammation by interleukin-18 in experimental animal models
    Hiroko Tsutsui
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Immunol Rev 202:115-38. 2004
    ..The former type of asthma is categorized as Th1-associated allergy. Therefore, it is definitely necessary to evaluate whether individual allergic disorders involve either of these IL-18-mediated pathways or a Th2-mediated one...
  2. ncbi request reprint Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
    ..Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12...
  3. doi request reprint Importance of IL-18-induced super Th1 cells for the development of allergic inflammation
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan
    Allergol Int 59:137-41. 2010
    ..Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as "super Th1 cells"...
  4. ncbi request reprint [IL-18 and atopic inflammation]
    Kenji Nakanishi
    Tanpakushitsu Kakusan Koso 47:2362-8. 2002
  5. doi request reprint Basophils are potent antigen-presenting cells that selectively induce Th2 cells
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Eur J Immunol 40:1836-42. 2010
    ..In this review, we summarize what is known regarding basophil function in allergy and parasite infection, examine the novel Ag-presenting function of basophils and discuss potential clinical implications of this finding...
  6. ncbi request reprint [Pathological role of super Th1 cells in induction of atopic dermatitis and bronchial asthma]
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine
    Arerugi 57:989-94. 2008
  7. doi request reprint Basophils as APC in Th2 response in allergic inflammation and parasite infection
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Curr Opin Immunol 22:814-20. 2010
    ..In this review, I summarize and discuss the data on the role of basophils as Th2 cell-inducing APC in allergy and parasite infection...
  8. ncbi request reprint Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
    K Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine Growth Factor Rev 12:53-72. 2001
    ..Moreover, IL-18 also induces IL-13 and/or IL-4 production by NK cells, mast cells and basophils. Therefore, IL-18 should be seen as a unique cytokine that enhances innate immunity and both Th1- and Th2-driven immune responses...
  9. ncbi request reprint Persistent secretion of IL-18 in the skin contributes to IgE response in mice
    Hiroki Nakano
    Department of Immunology and Medical Zoology, Second Department of Surgery, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Int Immunol 15:611-21. 2003
    ..Cutaneous application of SpA increased serum levels of IL-18 and IgE. These results indicate that local accumulation of IL-18 triggers systemic IgE responses without exposure to antigen...
  10. ncbi request reprint Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways
    Junko Sawaki
    Department of Pediatrics, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    Int Immunol 19:311-20. 2007
    ..Thus, NK cells, like T cells, induce orchestrated immune responses in collaboration with macrophages to show potent host defense effects during early infectious phase...
  11. ncbi request reprint Endogenous interleukin-6, but not tumor necrosis factor alpha, contributes to the development of toll-like receptor 4/myeloid differentiation factor 88-mediated acute arthritis in mice
    Fumiyasu Kyo
    Hyogo College of Medicine, Nishinomiya, Japan
    Arthritis Rheum 52:2530-40. 2005
    ....
  12. ncbi request reprint Differential upregulation of interleukin-18 receptor alpha chain between CD4+ and CD8+ T cells during acute graft-versus-host disease in mice
    Hisayuki Itoi
    Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    J Interferon Cytokine Res 24:291-6. 2004
    ..These results suggest that IL-18Ralpha expression is differentially upregulated between CD4+ and CD8+ T cells during aGVHD, depending on endogenous IL-12 and TCR engagement, respectively...
  13. pmc Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice
    Makoto Terada
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 103:8816-21. 2006
    ..il18-/-BALB/c mice similarly evaded SDS/SpA-induced AD. Thus, IL-18 might be important for the development of infection-associated AD by induction of IL-3 from super Th1 cells...
  14. doi request reprint Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Nat Immunol 10:706-12. 2009
    ....
  15. ncbi request reprint Pathophysiological roles for IL-18 in inflammatory arthritis
    Kiyoshi Matsui
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Expert Opin Ther Targets 7:701-24. 2003
    ..As IL-18-deficient mice evade collagen-induced arthritis in a mouse RA model, therapeutics targeting IL-18 may be beneficial against RA/OA. Here, the authors review the possible roles of IL-18 in inflammatory arthritis...
  16. ncbi request reprint Erratum to "Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice" [J. Dermatol. Sci. 58 (2010) 28-35]
    Masahito Tartutani
    Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Dermatol Sci 59:64-71. 2010
    ..The induction of Raf in the epidermis causes the proliferation of keratinocytes and epidermal hyperplasia. However, skin inflammation accompanying Ras-induced epidermal reactions has not been fully delineated...
  17. ncbi request reprint Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration
    Ekihiro Seki
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Hepatology 41:443-50. 2005
    ..In conclusion, the TLR/MyD88 pathway is essential for incidental liver restoration, particularly its early phase...
  18. doi request reprint IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes
    Kosuke Kawa
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 22:157-66. 2010
    ..acnes-primed WT mice from endotoxin shock syndrome. These results demonstrated requirement of IFN-gamma to the development of endotoxin shock and suggested it as a potent therapeutic target for the treatment of septic shock...
  19. doi request reprint Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins
    Mai Kuroda-Morimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 22:561-70. 2010
    ..Neutralizing anti-human IL-18 antibodies protected against this airway inflammation. These results suggest the importance of IL-18 for the development of asthmatic inflammation associated with airway exposure to bacterial proteins...
  20. doi request reprint Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system
    Yuichi Kondo
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 20:791-800. 2008
    ..Thus, IL-33 induces asthma-like symptom entirely independent of acquired immune system...
  21. ncbi request reprint Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ V alpha 24+V beta 11+ natural killer T cells
    Yuka Fujibayashi
    Laboratory of Cell Transplantation, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Int J Mol Med 20:241-5. 2007
    ..Thus, IL-18 regulates the determination of the Th1 or Th2 immune response by human CD4+ V alpha 24+ NKT cells through different cytokine combinations...
  22. ncbi request reprint Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
    Ekihiro Seki
    First Department of Surgery and Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Immunol 169:3863-8. 2002
    ..These results indicated a critical role for TLRs/MyD88-dependent IL-12/TNF-alpha production and for IL-12- and IL-18-mediated IFN-gamma production in early phase clearance of LM...
  23. ncbi request reprint Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness
    Yuriko Ishikawa
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 18:847-55. 2006
    ..As airway epithelial cells store robust IL-18, IL-18 might be critically involved in pathogen-induced bronchial asthma, in which pathogens stimulate epithelial cells to produce IL-18 without IL-12 induction...
  24. pmc T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production
    Nobuki Hayashi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Proc Natl Acad Sci U S A 104:14765-70. 2007
    ..Thus, IL-18 becomes a key target molecule for the development of a therapeutic regimen for the treatment of Th1-cell-induced bronchial asthma...
  25. ncbi request reprint Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice
    Keishi Adachi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:787-98. 2004
    ..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms...
  26. doi request reprint Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice
    Michiko Imamura
    Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    J Hepatol 51:333-41. 2009
    ..Nalp3 inflammasome reportedly controls caspase-1 activation. Here we investigated the roles of MyD88 and TRIF in P. acnes-induced hepatic granuloma formation and LPS-induced caspase-1 activation for IL-18 release...
  27. ncbi request reprint Involvement of interleukin-18 in acute graft-versus-host disease in mice
    Hisayuki Itoi
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Transplantation 78:1245-50. 2004
    ..Antihost CTLs are major effectors in acute graft-versus-host disease (aGvHD), a potentially fatal complication after allogeneic stem-cell transplantation. We investigated the relevant role of IL-18 in the development of aGvHD in mice...
  28. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  29. pmc Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse
    Takaaki Sugimoto
    Department of Surgery, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, 663 8501, Japan
    J Exp Med 199:535-45. 2004
    ..Thus, Ag and IL-18 stimulate memory Th1 cells to induce severe airway inflammation and AHR in the naive host...
  30. ncbi request reprint Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings
    Ekihiro Seki
    Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    J Hepatol 48:237-45. 2008
    ..Here, we investigated this hypothesis by introducing suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative regulators of STAT3 signaling, selectively in hepatocytes...
  31. ncbi request reprint Role of innate immune response in liver regeneration
    Yuji Iimuro
    First Department of Surgery and Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol Hepatol 22:S57-8. 2007
    ..In conclusion, the TLR/MyD88 pathway is essential for liver restoration after PH, particularly its early phase...
  32. doi request reprint Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis
    Saori Matsuba-Kitamura
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 22:479-89. 2010
    ..Finally, we showed that conjunctival tissues constitutively express biologically active IL-33, suggesting that IL-33 might play a crucial role in the induction and augmentation of AC...
  33. pmc IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection
    Makoto Matsumoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Infect Immun 81:2518-27. 2013
    ..venezuelensis expulsion. Mast cell-deficient mice, even those equipped with immune serum-derived IgG or IgE, failed to expel S. venezuelensis promptly, suggesting that mast cells are cellular targets of IgG and IgE...
  34. doi request reprint Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation
    Hisashi Kosaka
    Department of Surgery, Hyogo College of Medicine, 1 1, Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Nat Med 14:437-41. 2008
    ..Additionally, hepatocyte growth factor, a potent mitogenic factor for hepatocytes, strongly inhibited intestinal adhesion by diminishing IFN-gamma production, providing a potential new way to prevent postoperative adhesions...
  35. pmc Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice
    Yasutomo Imai
    Departments of Dermatology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 110:13921-6. 2013
    ....
  36. doi request reprint A critical role of IL-33 in experimental allergic rhinitis
    Yoko Haenuki
    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Allergy Clin Immunol 130:184-94.e11. 2012
    ..We reported previously that serum levels of IL-33 are significantly increased in patients with allergic rhinitis (AR). However, very little is known about the role of IL-33 for the development of AR...
  37. ncbi request reprint IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1- and Th2-cytokines and IL-8
    Hitomi Hata
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:1733-9. 2004
    ..Thus, human Th1 cells may become very harmful cells, when stimulated with Ag and IL-18 in vivo, and produce IFN-gamma, IL-13, GM-CSF and IL-8, which in combination might induce severe inflammation such as airway inflammation...
  38. doi request reprint Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice
    Masahito Tarutani
    Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Dermatol Sci 58:28-35. 2010
    ..The induction of Raf in the epidermis causes the proliferation of keratinocytes and epidermal hyperplasia. However, skin inflammation accompanying Ras-induced epidermal reactions has not been fully delineated...
  39. pmc IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity
    Yuki Sasaki
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Exp Med 202:607-16. 2005
    ..Neutralization of IL-18 and IL-2 further reduces expulsion in infected STAT6(-/-) mice. These results suggest that collaboration between IL-18-dependent and Th2 cell-dependent mastocytosis is important for prompt parasite expulsion...
  40. ncbi request reprint Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model
    Ichiro Ogushi
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Hepatology 38:335-44. 2003
    ..In conclusion, NF-kappa B/decoy/ODN transfer in vivo effectively suppressed endotoxin-induced fatal liver injury in mice...
  41. pmc Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    Koubun Yasuda
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 109:3451-6. 2012
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  42. ncbi request reprint Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18
    Taku Inokuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine 33:21-7. 2006
    ..Further, they suggest that MSU crystals accelerate the processing of IL-18 from an inactive to active form via the activation of caspase 1...
  43. ncbi request reprint Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation
    Yoshihiro Fujimori
    Laboratory of Cell Transplantation, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    J Interferon Cytokine Res 22:751-4. 2002
    ..These findings suggest that the expression of IL-18R is upregulated in T cells in patients with aGVHD and that the IL-18/IL-18R system is active during aGVHD...
  44. ncbi request reprint Interferon-gamma production by human cord blood monocyte-derived dendritic cells
    Nobuko Yamaguchi
    Division of Hematology and Oncology, Department of Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663 8501, Japan
    Ann Hematol 84:423-8. 2005
    ..These findings suggest that IL-12 upregulates IL-18Ralpha expression on human DCs and acts synergistically with IL-18 to induce high levels of IFN-gamma, which subsequently enhances CD40 expression on DCs in an autocrine manner...
  45. ncbi request reprint Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model
    Koushi Oh
    First Dept of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G729-35. 2005
    ..HGF might prove useful for controlling inflammatory bowel disease...
  46. ncbi request reprint [Regulation of Th1 and Th2 immune responses by IL-18]
    Kenji Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya shi, Hyogo 663 8501, Japan
    Kekkaku 77:87-93. 2002
    ..These results indicate that caspase-1/IL-18 may be critically involved in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders...
  47. ncbi request reprint IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan
    J Immunol 179:4415-23. 2007
    ..Thus, IL-27 could provide us with a novel therapeutic way for treating Th2-associated diseases such as bronchial asthma...
  48. doi request reprint Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells
    Masakiyo Nakahira
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 23:761-72. 2011
    ..These findings suggest that Gata3, which is not originally expressed in T(h)1 cells, alters the cytokine production profile by T(h)1 cells...
  49. doi request reprint Contribution of interleukin 18 to the development of infection-associated atopic dermatitis
    Hiroko Tsutsui
    Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan
    Curr Probl Dermatol 41:93-103. 2011
    ..We found substantial efficacy of IL-18 blockade against this AD. Here, we review the recent finding that IL-18 is a possible therapeutic target of certain types of AD...
  50. doi request reprint The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy
    Taichiro Muto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 26:539-49. 2014
    ..In contrast, while IL-33 is dispensable for promoting cutaneous antigen sensitization, the cytokine is essential for inducing IgE-dependent anaphylaxis in the gut. ..
  51. ncbi request reprint Roles of IL-18 in basophils and mast cells
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Allergol Int 55:105-13. 2006
    ..Here we discuss the functional role of IL-18-induced "innate allergic response" in disease and host defense...
  52. doi request reprint Generation and characterization of mouse basophils from bone marrow and purification of basophils from spleen
    Tomohiro Yoshimoto
    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan
    Curr Protoc Immunol . 2012
    ..In this unit, protocols that will enable the study of mouse basophils are described...
  53. ncbi request reprint Cytokine-induced injury of the lacrimal and salivary glands
    Akiko Kimura-Shimmyo
    Department of Ophthalmology, Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    J Immunother 25:S42-51. 2002
    ..It is suggested that these cytokines can mediate apoptosis in glandular epithelial cells and that the elevated NO production is responsible for the change...
  54. ncbi request reprint Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation
    Hiroyuki Futani
    Department of Orthopedic Surgery, Hyogo College of Medicine, Hyogo, Japan
    J Immunother 25:S61-4. 2002
    ..Thus, targeting this cytokine appears to be an important therapeutic approach in OA...
  55. doi request reprint Pathogenic Th2-type follicular helper T cells contribute to the development of lupus in Fas-deficient mice
    Shizue Futatsugi-Yumikura
    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 26:221-31. 2014
    ....
  56. pmc The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
    Hiroko Tsutsui
    Department of Microbiology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    Gastroenterol Res Pract 2010:641865. 2010
    ..Here, we review the molecular mechanisms for the liver injuries, particularly focusing on the TLR4/NLRP3-mediated caspase-1 activation process, with a brief introduction of the mechanism underlying P. acnes-induced sensitization to LPS...
  57. doi request reprint Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis
    Jing Shan
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Gastroenterol 50:414-23. 2015
    ..The function of IL-33 in the esophageal mucosa has not been previously described. Accordingly, we examined the expression of IL-33 and its role in the pathogenesis of reflux esophagitis (RE)...
  58. doi request reprint Immunotherapeutic applications of IL-18
    Hiroko Tsutsui
    Department of Microbiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    Immunotherapy 4:1883-94. 2012
    ..In this review, recently identified features of IL-18 will be focused upon, followed by discussion of IL-18 as a possible therapeutic target...
  59. ncbi request reprint Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model
    Shohei Yoshikawa
    Division of Hepatobiliary and Pancreatic Diseases, Department of Internal Medicine, Hyogo College of Medicine, Tokyo, Japan
    Hepatol Res 40:823-31. 2010
    ..Conclusions: CEUS with Sonazoid is a powerful evaluation tool to diagnose NASH from an early stage of the disease...
  60. ncbi request reprint Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
    Minoru Fujimoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Int Immunol 16:303-14. 2004
    ..These findings suggest that dysfunction of SOCS-1 can be a pathogenic factor of systemic autoimmune diseases such as SLE...
  61. ncbi request reprint Human anti-human IL-18 antibody recognizing the IL-18-binding site 3 with IL-18 signaling blocking activity
    Takayuki Hamasaki
    Department of Bioengineering, Faculty of Engineering, Kagoshima University, Korimoto 1 21 40, Kagoshima 890 0065, Japan
    J Biochem 138:433-42. 2005
    ..The complete human Fab and IgG forms of h18-108 have been successfully constructed to attain increases in both binding affinity and inhibitory activity...
  62. ncbi request reprint Protective effect of IL-18 on kainate- and IL-1 beta-induced cerebellar ataxia in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Uniuversity of Toyama, 2630 Sugitani, Toyama, Japan
    J Immunol 180:2322-8. 2008
    ..Our data firstly show that IL-18 and IL-1beta display differential direct regulation in kainate-induced ataxia in mice. Our results might contribute toward the development of a new therapeutic strategy for cerebellar ataxia in humans...
  63. pmc IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
    Hiroshi Konishi
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    Proc Natl Acad Sci U S A 99:11340-5. 2002
    ..Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD...
  64. ncbi request reprint ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
    Masatatsu Yamamoto
    Department of Molecular Oncology Division of Molecular and Cellular Biology Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Genes Cells 9:1055-67. 2004
    ..These results demonstrate critical roles for ASC in the release of IL-1beta/IL-18 via activation of caspase-1 and provide new insights into the inflammatory responses for host defence and diseases...
  65. ncbi request reprint Adult Still's disease reflects a Th2 rather than a Th1 cytokine profile
    Osamu Saiki
    Department of Rehabilitation, Osaka Prefecture College of Nursing, Habikino, Osaka 583 8555, Japan
    Clin Immunol 112:120-5. 2004
    ..Moreover, the serum levels of IL-18 showed a good correlation with those of IL-4, suggesting that ASD reflects a Th2 rather than a Th1 cytokine profile...
  66. ncbi request reprint A potential role of interleukin 18 in severe falciparum malaria
    Somei Kojima
    Department of Parasitology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Acta Trop 89:279-84. 2004
    ..Based on these results, the role of IL-18 in severe falciparum malaria will be discussed in this review...
  67. ncbi request reprint Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice
    Kazuya Shimoda
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Blood 99:2094-9. 2002
    ....
  68. ncbi request reprint TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6
    Hidetoshi Hayashi
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya 467 8603, Japan
    Biochem Biophys Res Commun 300:980-5. 2003
    ..These results suggest that the destabilization of IFN-gamma mRNA induced by TGFbeta leads to the inhibition of antiviral activity and IFN-gamma production in IL-18 stimulated LNK5E6 cells...
  69. ncbi request reprint IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses
    Nobutaka Suzuki
    Advanced Medical Discovery Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Immunol 170:4031-5. 2003
    ..Moreover, AP-1 activation which is triggered by c-Jun N-terminal kinase activation is also completely inhibited in IRAK-4(-/-) Th1 cells. These results suggest that IRAK-4 is an essential component of the IL-18 signaling cascade...
  70. ncbi request reprint Roles of caspase-1 in Listeria infection in mice
    Noriko M Tsuji
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06510, USA
    Int Immunol 16:335-43. 2004
    ..These data shed light on the importance of caspase-1-mediated IL-18 processing in innate immunity against facultative intracellular pathogens...
  71. ncbi request reprint Involvement of interleukin-18 in severe Plasmodium falciparum malaria
    Yukiko Nagamine
    Department of Parasitology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Trans R Soc Trop Med Hyg 97:236-41. 2003
    ..These results suggest that IL-18 plays a key role in inducing severe malaria through another pathway, such as elevation of IFN-gamma, rather than its IgE inducing activity...
  72. ncbi request reprint A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo
    Minoru Fujimoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Int Immunol 14:1343-50. 2002
    ..These results suggest that SOCS-1 plays a regulatory role in both T(h)1 and T(h)2 polarizations...
  73. ncbi request reprint A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine
    Hideki Fujii
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Virchows Arch 446:663-73. 2005
    ..These results indicate that the present liver injury is characterized by parenchymal hemorrhage and hepatocyte apoptosis, and mediated by TNF-alpha secretion and direct cytotoxicity of alpha-GalCer-activated NKT cells...
  74. ncbi request reprint A novel acoustic evaluation system of scratching in mouse dermatitis: rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse
    Koji Umeda
    Department of Dermatology, Mie University, Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Life Sci 79:2144-50. 2006
    ..This novel motion analysis system will open a window for physiological and pathological analysis for animal models and development of anti-pruritic drugs...
  75. ncbi request reprint Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment
    Youichi Omoto
    Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    J Immunol 177:8315-9. 2006
    ..The human mast cell chymase and the novel IL-18-derived active peptide may be novel therapeutic targets in AD- and IL-18-associated diseases...
  76. ncbi request reprint A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages
    Toshihiko Suzuki
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 280:14042-50. 2005
    ..These results identify a novel cell death pathway induced by intracellular Gram-negative bacteria that may play a role in microbial-host interactions and inflammatory responses...
  77. doi request reprint Freshly isolated Langerhans cells negatively regulate naïve T cell activation in response to peptide antigen through cell-to-cell contact
    Yasutomo Imai
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    J Dermatol Sci 51:19-29. 2008
    ..However, LC-ablated mice reportedly suffer from severer contact hypersensitivity (CHS) upon cutaneous challenge with hapten than wild-type mice, suggesting LCs as regulators of adaptive immune responses in the skin...
  78. pmc Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy
    Yasunari Nakamoto
    Department of Gastroenterology, Graduate School of Medicine Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Ishikawa 920 0934, Japan
    J Exp Med 196:1105-11. 2002
    ..This is the first demonstration that amelioration of chronic inflammation by some treatment actually caused reduction of cancer development...
  79. ncbi request reprint SOCS-1 participates in negative regulation of LPS responses
    Reiko Nakagawa
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Immunity 17:677-87. 2002
    ....
  80. ncbi request reprint Higher levels of IL-18 circulate during primary infection of monkeys with a pathogenic SHIV than with a nonpathogenic SHIV
    Masahiko Kaizu
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    Virology 313:8-12. 2003
    ..Thus, the elevation of circulating IL-18 level during primary viral infection can be a good indicator of an active pathogenic viral infection. However, the role of increased IL-18 remains to be elucidated and needs further investigation...